This document summarizes statistical tests for comparing two samples, including paired and independent samples t-tests, confidence intervals, and effect sizes. For paired samples from within-subject designs, a paired t-test is used to test for differences between means. For independent samples from between-subject designs, an independent samples t-test is used. Both tests calculate a t-statistic based on the mean difference and standard error. Confidence intervals and effect sizes can also be calculated for paired and independent sample designs. Examples are provided to demonstrate how to perform the statistical tests and calculations.