rotablation is procedure used in complex pci with heavily calcified lesion for adequate expansion of stent.if used in indicated case and well aware of contraindication is necessary for achieving good results.
Evaluation of prosthetic valve function and clinical utility.Ramachandra Barik
Many of the prosthesis-related complications can be prevented or their impact minimized through optimal prosthesis selection in the individual patient and careful medical management and follow-up after implantation.
This is a comprehensive description of coronay lesion assessment from routinely used angiography to advanced imaging modalities like IVUS/OCT including their functional significance by FFR
Catheters used in Angiography & angioplastySatya Shukla
Guide catheters are essential tools for Pecutaneous
Coronary Intervention
• Understanding construction, design & performance
characteristics facilitate their appropriate selection
• Selection of Guide catheters seems elementary but
makes the difference between a successful and failed
PCI procedure
Based on the principle that the distal coronary pressure measured during vasodilation is directly proportional to maximum vasodilated perfusion.
FFR is defined as the ratio of maximum blood flow in a stenotic artery to maximum blood flow in the same artery if there were no stenosis.
FFR is simply calculated as a ratio of mean pressure distal to a stenosis (Pd) to the mean pressure proximal stenosis, that is the mean pressure in the aorta (Pa), during maximal hyperaemia.
rotablation is procedure used in complex pci with heavily calcified lesion for adequate expansion of stent.if used in indicated case and well aware of contraindication is necessary for achieving good results.
Evaluation of prosthetic valve function and clinical utility.Ramachandra Barik
Many of the prosthesis-related complications can be prevented or their impact minimized through optimal prosthesis selection in the individual patient and careful medical management and follow-up after implantation.
This is a comprehensive description of coronay lesion assessment from routinely used angiography to advanced imaging modalities like IVUS/OCT including their functional significance by FFR
Catheters used in Angiography & angioplastySatya Shukla
Guide catheters are essential tools for Pecutaneous
Coronary Intervention
• Understanding construction, design & performance
characteristics facilitate their appropriate selection
• Selection of Guide catheters seems elementary but
makes the difference between a successful and failed
PCI procedure
Based on the principle that the distal coronary pressure measured during vasodilation is directly proportional to maximum vasodilated perfusion.
FFR is defined as the ratio of maximum blood flow in a stenotic artery to maximum blood flow in the same artery if there were no stenosis.
FFR is simply calculated as a ratio of mean pressure distal to a stenosis (Pd) to the mean pressure proximal stenosis, that is the mean pressure in the aorta (Pa), during maximal hyperaemia.
1. causes for heart malfuctions
2.Treaments for the malfunctions like holes in heart, Atrial septal defects and ventricular septral defects
3. prosthetic valve and Tissue valve
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
2. • Materials of Construction
•
The three main components of TTK Chitra Heart
Valve are:
• Frame
• Disc
• Sewing Ring
•
3. • Tilting Disc
– pivoted eccentrically in the metallic frame.
– MADE FROM ULTRA HMW POLY ETHYLENE
• The sewing ring
– POLYETHYLENE TEREPTHALATE (PET)
– fitted snugly around the frame
– used to suture the valve in the intended position in the
heart.
FRAME: COBALT CHROMIUM ALLOY( HAYNES 25)
• The frame and the disc are hydro dynamically
designed to reduce drag and inertia and polished
to minimize the chances of clotting.
4.
5.
6. Salient Features
• Complete Structural Integrity
• Absence of cavitation related damage.
• Silent operation
• Rotatable within the sewing ring to assure its
freedom to rotate if repositioning is required
• Low profile
7. CHALLENGES
• In 1976, with a project funded by the
Department of Science and Technology,
• M.S. Valiathan initiated efforts to make heart
valves within the country.
• Four years later, the Institute, which had been
started by the Kerala Government, was taken
over by the Central Government.
8. • The artificial valve must withstand the stress of
opening and closing some 40 million times a year.
• The materials used for the valve have to be
compatible with blood and human tissues.
• When open, the valve should allow the blood to flow
smoothly through.
• Once closed, the back flow of blood had to be
minimal.
9. • In the first model,
• the major and minor struts were electron beam welded
and the valve was expected to withstand 360 million cycles
of disc movement.
• Unfortunately, the major strut fractured at the weld after a
mere 100,000 cycles due to weld embrittlement.
• In the second model, the disk was made of single crystal
sapphire which was inert and blood compatible.
• The housing was carved out of a block of titanium.
• This model failed as well, because of the extensive wear of
titanium struts and the escape of the disc.
10. • The third model had a housing made of a
• highly wear – resistant aerospace superalloy, called "Haynes-25",
a cobalt based alloy of chromium, nickel and tungsten.
• This model went through all the tests successfully and several sheep
with the implanted valve were alive and well for months
• until the death of one animal at 3 months after valve implantation.
• Necropsy showed that the sapphire disc had fractured in the
animal.
• This was a major crisis as critics and media did not spare the team
• and the search for a material to replace it had to start a new.
11. Mile Stones
• The first human implant was December 6, 1990 at Sree Chitra
Tirunal Institute for Medical Sciences and Technology, Trivandrum.
• In Clinical use for over 14 years.
• More than 55,000 TTK Chitra Heart Valve has been implanted so far in
India, Nepal, Sri Lanka, Bangladesh and South Africa, Thialand
• Crossed over 1,00,000 patient years
• Award for TTK Chitra heart valve prosthesis
Hinduonnet
• Award for TTK Chitra heart valve prosthesis
May 17, 2001, Medindia
12. • TTK Chitra Heart Valves bagged the following patents
• US patent No.5,458,826 dated October 17, 1995 for the
"method of producing a heart valve disc" - one of the three
major component of this critical, life saving device
• European patent No.0622060 relating to "Improvement in or
relating to Prosthetic Cardiac Valve and to the method of
manufacturing same“
• Nearly 250 centres using TTK Chitra Heart Valves.
• More than 300 Surgeons using our valves
13. Trial And Evaluation
• Invitro Evaluation
• A specially designed computerized accelerated durability test system is used to
validate the mechanical performance
• and wear of the valve in simulated use conditions for above 380 million cycles -
which is equal to 10 years in actual use.
• is also tested for its haemodynamic performance, which is an important factor in
artificial heart valves.
• A comprehensive evaluation is also done through a computerized special purpose
pulse duplicator and steady state and dynamic measurements are made for all sizes
of the valve.
• The results of all the tests conducted are comparable with the best international
brands of mechanical Heart Valves
• and the TTK Chitra Heart Valve has been proven to equal the best international
brand of mechanical heart valves.
14. Biocompatibility Evaluation
• All the materials used in the valve have undergone extensive
toxicological and implant evaluation that is applicable to
permanent implants.
• As per the ISO protocol for artificial heart valves, the TTK Chitra
Heart Valve has passed through rigorous in vivo animal trials in
sheep.
• During the trial, the valves were implanted in the mitral position
without any anticoagulation regimen for the animals.
• The long time survival of these animals even under these difficult
conditions was uneventful.
15. Clinical Trials
• Based on the data obtained from the evaluations and trials,
• the ethics committee of the Sree Chitra Tirunal Institute for Medical
Sciences and Technology, Trivandrum,
• chaired by a sitting judge of a high court of the land gave formal permission
for controlled clinical trials in 1990.
• The TTK Chitra Heart Valve was implanted in a human for the first time in
December 1990.
• Six institutions in India took part in a multicentric trial that lasted till 1995.
• N= 306
• The trials were monitored by a national level monitoring committee,
• and the results were periodically presented at the annual conference of the
society of the Indian Association of Cardiovascular Thoracic Surgeons.
• The ethics committee cleared the valve for commercial production during
1995.
16.
17.
18. Pressure Recovery:
Hemodynamic Conditions and Clinical Implications.
• can occur in two regions:
– downstream of a valve
• flow expands into the wider lumen beyond a valve, velocity
and kinetic energy will decrease and pressure will be
recovered
– within some prosthetic valves, typically bileaflet or
caged-ball valves
19. •The smaller central orifice in bileaflet valves may give rise to a high-velocity jet
• that corresponds to a localized pressure drop
• that is largely recovered once the central flow reunites with flows originating from
two lateral orifices
20.
21. Velocity and Gradients.
• Resemble those of mild native aortic stenosis
• maximal velocity usually >2 m/s
• Triangular shape of the velocity contour
• occurrence of the maximal velocity in early systole.
• Short AT
• High gradients may be seen with normally functioning valves with
• a small size,
• increased stroke volume,
• PPM,
• valve obstruction.
• Conversely, a mildly elevated gradient in the setting of severe LV
dysfunction
• may indicate significant stenosis.
22. • AT: the time from the onset of flow to maximal
• NORMAL: AT < 100MSECS
• AT/ET < .04
• EOA:
23. DVI
• DVI is a dimensionless ratio of
• the proximal velocity in the LVO tract to that
of flow velocity through the prosthesis:
DVI = V LVO / V PrAV
• much less dependent on valve size.
• HELPFUL when the CSA of the LVOT cannot be
obtained or valve size is not known.
34. • There were 200 patients, 118 males and 82 females, who received
249 TTK Chitra valve implants in the mitral and/or aortic position
• The mean duration of followup was 2.5 years (range 1 month to 4.5
years)
• minimum follow-up of survivors was 1 year, and the total follow-up
observed was 451 patient-years (pt-yr).
• Assesed relative risk associated with 6 factors
• age, sex,
• Preoperative NYHA class
• primary valve lesion
• Preoperative atrial fibrillation and CCF
35.
36. Early mortality was low in all 3 groups
• there were 3 (1.5%) deaths overall.
• MVR group 2
– valve thrombosis
– intractable ventricular arrhythmias.
• DVR group 1
– due to myocardial dysfunction.
These patients were in an advanced NYHA class of disability
preoperatively.
• Late deaths occurred in 18 patients (4.0% 0.9%/ptyr)
37.
38.
39.
40.
41. CONCLUSIONS
• The striking features
• The patient profile in our study are the young age
(mean 28.9 years)
• advanced disability (75.6% in NYHA classes III and IV).
• Postoperative conversions to a lower NYHA class were
evident.
• The gradients for various valve sizes were found to be
comparable to those of other widely used valves
42. • The absence of any reports of paravalvular leak
or discomfort due to valve sounds is a notable
feature of the Chitra heart valve.
• The closing sounds are soft and dull due to the
use of an ultra-high molecular weight
polyethylene disc.
• This was clearly highlighted by the pressure
field and cavitation measurements of Chandran
and colleagues at the University of Iowa,
43. • They studied the in-vitro and in-vivo closing dynamics of
the current clinical models of mechanical heart valves,
including the Chitra heart valve.
• While the in-vitro studies showed an absence of cavitation
even at the highest valve closing rates,
• the in-vivo tests demonstrated that the negative transients
were relatively low and did not reach magnitudes close to
the vapor pressure for the fluid
• Therefore, compared to valves with rigid occluders, in-vivo
cavitation is regarded as unlikely.
44.
45. • CHV (n=65)
• between January 1992 and December 1995
• Forty three patients FOLLOWED UP.
• The age ranged from 8 to 62 yrs.
• The male to female ratio was 1.6:1
46.
47.
48.
49. • No structural complications were noted in this
group of patients.
• Conclusion CHV has good haemodynamics with
no structural
MORTALITY 20 % 9
VALVE
THROMBOSIS
4.6 % 2
I/E 4.6% 2
MI 2.3% 1
LV DYSFUNC 2.3% 1
UNKNOWN 6/9 3
50.
51.
52.
53.
54. CONCLUSIONS
• No structural deterioration
• Good hemodynamics and
• Acceptable thrombo-embolic events.
• LOW COST
55.
56. • to determine the normal Doppler parameters of
CHVP in the mitral position
• and to assess whether derivation of MVA using
the CE and PHT method is comparable in the
functional assessment.
• 40 consecutive patients
• Indications
– RHD 95% (38 patients)
– MVP in 5% (2 patients).
57. Doppler evaluation of mitral
prostheses
• Early velocity
• peak gradient
• mean gradient
• MVA derived by PHT and the CE.
• The actual orifice area
• (AOA) is calculated from the valve orifice
diameter (VOD) provided by the manufacturer as
• AOA = 0.785 X VOD2
58.
59.
60.
61.
62. • Mean and peak gradients did not show significant
correlation with MVA by PHT .
• Similarly, no correlation was noted between meanand
peak gradients and MVA by the CE.
• Peak gradient did not correlate well with AOA
• However, the mean gradient decreased significantly
with an Increase in the AOA.
• The MVA calculated by both PHTand CE increased
significantly with an increase in the AOA
63. • The MVA by PHT showed a significant linear correlation
– with MVA derived by CE (r ¼ 0.041, P ¼ 0.009)
– tends to be higher than that calculated by the CE,
– and this difference was statistically significant (P , 0.001, t-test).
• This difference was irrespective of whether PHT is > or<110 ms
• The subgroup analysis between groups with PHT is > or<110 ms
– showed no difference in the mean or peak mitral gradients.
– Calculation by CE also showed no difference for calculated MVA
between the two groups.
64. • Our study also showed significant correlation
between the valve area derived by CE and
AOA, similar to published studies of other
valves.
65.
66. 547 consecutive patients,
310 males 237 females
634 implants with the TTK Chitra
in mitral and/ or aortic positions.
Age -9 years to 64 years
(mean age = 26±5 years).
67. PREOPERATIVE DATA
• NYHA CLASS
• II 238
• III 235
• IV 74
• NSR 233
• AF 314
• PREVIOUS PROCEDURE
• PTMC 80
• OMC 6
• BIOPROS VALVE 8
• (MVR 6, AVR 2)
• ADDED SURGERY
• ASD CLOSURE 20
• TV REPAIR 47
• CAD 4
68. E ARLY DEATH < 30 DAYS NO PERCENTAGE
MVR 7 1.25
AVR 4 1.4
DVR 1 1
REXPLORATION 15 2.6
502 PTS 93% CAME FOR F/U
PERIOD 120-990 DAYS
MEAN 416+184
NO STRUCTURAL VALVE DETORIATION
NYHA CLASS I 391 78%
NYHA CLASS II 80 16%
NYHA CLASS II 31 6.2%
LINEARISED RATE MAJOR
HEMORRAGE
TEE
MVR 1 % 3.8%
AVR 2.1% 2.1%
DVR 1.75% 3.7%
75. • G.K.N.M. Hospital, Coimbatore
• Initially this valve was used as part of a multi-centric
trial and later it was the valve of choice in our
institution.
• Methods
• December 1992 and July 1998 -- a total of 152 Chitra
Valve
• 65 aortic and 64 mitral implants and the rest were
dou b le valves.
76. • 144 patients were followed up ( 10 EARLY DEATHS)
• (a total of 622 patient years of follow-up)
• There were 11 patients (7.2%) TEE
• (5 major events)
• a linearized rate of 1.8 percent patient year.
• Haemodynamic studies in postoperative patients were
comparable to other prosthetic valves.
• The thrombo-embolism free survival was 82% at 5 years. The
actuarial survival was 78% at 5 years.
• Conclusion
• The Chitra valve is comparable to other mechanical valves
77.
78. Conclusion: At 20 years the Medtronic Hall valve demonstrates excellent
durability, good hemodynamic performance, and very low thrombogenicity,
with a valve thrombosis rate lower than those reported for bileaflet designs.
With this prosthesis, both survival and thromboembolic events are
predominantly determined by patient risk factors.(J Thorac Cardiovasc Surg
2001;121:1090-100)
79. • Objective: To assess the performance of the Medtronic Hall valve
(Medtronic, Inc, Minneapolis, Minn) in one institution over a 20-year
period.
• Methods: Since 1979, Medtronic Hall valves have been used in 1766
procedures (736 aortic, 796 mitral, and 234 double). Patients were followed
up prospectively at 6- to 12-month intervals for a total of 12,688 follow-up
years. Anticoagulation data (international normalized ratio) were recorded
for all patients (approximately 95,000 observations).
• Results: Linearized rates of valve-related late death for aortic, mitral, and
double valve replacement were 0.8%/y, 0.9%/y, and 1.1%/y, respectively.
Risk factors for late mortality were (relative risk) diabetes (1.9), decade of
age (1.6), concomitant coronary artery bypass grafting (1.4), hypertension
(1.3), non-sinus rhythm (1.3), large valve size (1.1), valve regurgitation (1.3),
and male sex (1.2). For aortic, mitral, and double valve replacement,
linearized rates (percent per year) of adverse events were valve thrombosis
0.04, 0.03, and 0.0; all thromboembolism 2.3, 4.0, and 3.4; stroke 0.6, 0.8,
and 0.6; major hemorrhage 1.2, 1.4, and 1.6; and prosthetic endocarditis
0.4, 0.4, and 0.7. Risk factors for thromboembolism were (relative risk)
mitral valve replacement (1.9), diabetes (1.8), hypertension (1.5), and
history of embolism (1.4).
80.
81. • Tilting disk valves have separate projections into the orifice,
either single arms or closed loops to retain and guide the disk-
shaped occluder.
• Among the metals use for the housing are stainless steel and
titanium.
• The disks are graphite with a coating of pyrolitic carbon.
• The Bjork-Shiley valve was the first successful tilting valve.
• It became available in 1971 with a carbon-coated disk and both
struts (inflow and outflow) welded to the chromium alloy
orifice.
82. • The Medtronic Hall valve has a titanium housing
machined from a solid cylinder and a thin carbon
coated disk with flat parallel sides
• The Omniscience valve is a streamlined elegant
looking valve. It has a curved pyrolitic Carbon disk
with no indentations, a one- piece titanium cage,
and a seamless polyester knit sewin ring.
Editor's Notes
K E M Hospital, Mumbai A F M C Hospital, Pune G K N M Hospital, Coimbatore JIPMER, Pondicherry IPGMER, Calcutta SCTIMST, Trivandrum