Topical drug delivery systems include external formulations that are spread on the skin and internal formulations applied to mucous membranes. They have advantages like avoiding first-pass metabolism and providing localized treatment. Formulations include solid (powders, plasters), semi-solid (ointments, creams, gels), and liquid (lotions, solutions, emulsions) dosage forms. Absorption occurs mainly through the skin or via shunt pathways like hair follicles and sweat glands. Factors like skin properties, drug properties, and formulation design impact absorption and effects. Topical formulations are evaluated for properties like rheology, penetration, irritation potential, and stability.
SURFACTANTS - Classification and applicationsJaskiranKaur72
Surfactants, are wetting agents that lower the surface tension of a liquid, allowing easier spreading and dispersion, and can also lower the interfacial tension between two liquids.
SURFACTANTS - Classification and applicationsJaskiranKaur72
Surfactants, are wetting agents that lower the surface tension of a liquid, allowing easier spreading and dispersion, and can also lower the interfacial tension between two liquids.
Emollients are non-cosmetic moisturisers which come in the form of creams, ointments, lotions and gels. Emollients help skin to feel more comfortable and less itchy. They keep the skin moist and flexible, helping to prevent cracks.
Myself Omkar Tipugade , M -Pharm sem II , Department of Pharmaceutics . today i upload presentation on addressing dry skin , acne , pigmentation , prickly heat , body odor .
Emollients are non-cosmetic moisturisers which come in the form of creams, ointments, lotions and gels. Emollients help skin to feel more comfortable and less itchy. They keep the skin moist and flexible, helping to prevent cracks.
Myself Omkar Tipugade , M -Pharm sem II , Department of Pharmaceutics . today i upload presentation on addressing dry skin , acne , pigmentation , prickly heat , body odor .
his presentation delves into the formulation, advantages, and applications of semisolid dosage forms, including creams, ointments, and gels. Learn about their unique properties, manufacturing processes, and considerations for drug delivery. Whether you're a student or a pharmaceutical professional, this presentation offers valuable insights into this essential aspect of medication delivery.
Ppt for MD DERMATOLOGY Residency. includes basics of topical preparations in dermatology. made as a part of curriculum of MD dermatology. includes all definitions, classification, mechanism , uses and side effects. based on rooks, IADVL, and many articles.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
2. Introduction
• Topical drug delivery system is defined as the application of a drug
containing formulation to the skin or mucous membrane, to treat
specific cutaneous disorders (e.g. acne) or cutaneous manifestations of
a generalized disease (e.g. psoriasis), with the intent of containing the
pharmacological effect of the drug only to the surface or within the
layers of skin or mucous membrane.
3. Types of Topical Drug Delivery System
• Includes two types of Topical Drug Delivery System:
• External- that are spread or dispersed on the cutaneous surface covering the
affected area.
• Internal- that are applied to the mucous membrane of eye (conjunctiva), ear,
oropharyngeal cavity, nasal cavity, vagina or anorectal region for local activity.
• Classification Based on physical state-
• Solid: Powder, Aerosol, Plaster
• Liquid: Lotion, Liniment, Solution, Emulsion, Suspension, Aerosol
• Semi-solid: Ointment, Cream, Paste, Gel, Jelly, Suppository
4. Advantages of Topical Drug Delivery
System:
• Avoidance of first pass metabolism
• Easy application
• Avoidance of the risks and inconveniences of administration and the
varied conditions of absorption, like pH changes, presence of
enzymes, gastric emptying time etc. in enteral or parenteral routes
• Achievement of efficacy with lower total daily dosage of drug by
continuous drug input
• Avoids fluctuation in drug levels, inter- and intra-patient variations
• Easy termination of medications, when needed
5. Adv. Continue
• Relatively large area of application
• Drug can be delivered more selectively to a specific site
• Avoidance of gastro-intestinal incompatibility
• Provide utilization of drugs with short biological half-life & narrow
therapeutic window
• Improved physiological and pharmacological response
• Improved patient compliance
• Suitable for self-medication
6. Disadvantages of Topical Drug Delivery
System:
• Skin irritation/contact dermatitis due to drug and/or excipients
• Poor permeability of some drugs through the skin
• Possibility of allergic reactions
• Can be used only for those drugs which require low plasma
concentration for action
• Enzymes in epidermis may denature the drugs
• Drugs with larger particle size are difficult to get absorbed through the
skin
8. Absorption Through Skin
• Absorption through skin: Two principal absorption route are
identified:
• Trans-epidermal absorption: Principally responsible for diffusion
across the skin. The resistance encountered along this pathway mostly
arises in the stratum corneum. Maybe trans-cellular or inter-cellular.
• Trans-follicular (shunt pathway) absorption: The skin’s appendages,
mainly sebaceous glands, sweat glands, hair follicles offer secondary
avenues for permeation, which are considered as shunts bypassing the
trans-epidermal route.
9. Factors Affecting the Extent and Rate of Topical and
Percutaneous Drug Absorption and Transportation:-
• Skin physiology & pathology:- hydration, blood flow, lipid content
• Physio-chemical properties of drugs and excipients:-
• Partition coefficient
• pH-condition
• Drug solubility
• Concentration
• Particle size
• Polymorphism
• Molecular weight
• Fabrication and design of the delivery systems:- release characteristics,
composition, nature of vehicle, presence of penetration enhancers
• The rate of drug transport across the stratum corneum follows Fick’s Law of
Diffusion
10. Types of Topical Dosage Form
Topical Dosage Form
Solid
Semi Solid
Lotion
Powder
Ointment
Paste
Aerosol
Cream
Liquid
Liniment
Solution
Plaster
Emulsion
Suspension
Gel
Aerosol
Jelly
Suppository
11. Dusting Powder:
• Free flowing
• Applied on skin, wounds, ulcers
• Very fine particle size produces large surface area per unit weight
• Mechanical protective action against irritation/itching due to friction
• Dries the skin by absorbing water & adsorbs toxic material Medicated
powders are used for prickly heat or preventing microbial growth on
skin e.g. Starch, Talc
12. Fig: Evaluation of powder Shade control and lighting Pressure testing Breakage test Flow property Particle size
and abrasiveness Dispersion of color
13. Ointment:
• Ointment are viscous semisolid preparation.
• Applied externally to skin or mucous membrane (eye, nose, vagina,
rectum)
14. Vehicle of an ointment (ointment base )
• Hydrocarbon (oleaginous) bases: Emollient, occlusive, greasy, non water
washable, prolonged contact period E.g.- white/yellow petrolatum
• Absorption (anhydrous) bases: Permits the incorporation of additional
quantities of aqueous solutions E.g.- Lanolin
• Water removable Bases: Oil in water type, non occlusive, less greasy,
creamy in appearance, water-washable.
• Water soluble Bases: Do not contain oleaginous components, completely
water-washable, greaseless, mostly used for the incorporation of solid
substances. E.g.- Polyethylene Glycol
• Simple base: Wool fat (5%) + hard paraffin (10%) + yellow soft paraffin
(85%)
15. Fig: Evaluation of ointments Penetration Rate of release of medicaments Absorption of medicaments into
blood stream Irritant effect
16. Cream:
• Viscous semisolid emulsion- medicaments dissolved or suspended in
water removable bases.
• Applied to skin or mucous membrane (vagina, rectum)
• Most are O/W (small droplets of oil dispersed in a continuous aqueous
phase), only cold creams and emollients are W/O (small droplets of
water dispersed in a continuous oily phase).
• O/W (vanishing) - water washable, non greasy, non occlusive, more
cosmetically acceptable.
• W/O (oily) - for some hydrophobic drugs, more emollient.
17. Advantages
• Less greasy
• Spreads easily
• Soothing sensation.
• Easily washable
Uses:
• Physical or chemical barrier to protect the skin e.g. sunscreens
• Cleansing agent
• Emollient
• Retention of moisture (especially water-in-oil creams)
• Vehicle for drug substances such as local anaesthetics, anti-inflammatory
agents, hormones, steroids, antibiotics, antifungals or counter-irritants
19. Paste:
• Pastes are basically ointments into which a high percentage of
insoluble solids have been added
• Less greasy than ointments
• Provide protective coating on skin due to it’s stiff consistency
• Poorly occlusive, so suited for application around moist areas
• Absorb secretion from the oozing lesions
• Forms an unbroken, water impermeable, opaque film on the skin
• Effective sun filter & prevent excessive wind dehydration (windburn)
20. Fig: Evaluation of paste Abrasiveness Particle size Cleansing property Consistency pH of the
product Foaming character Limit test for arsenic and lead Volatile matters and moisture Effect of
special ingredients
21. Gels & Jellies:
• Semisolid systems- dispersions of small or large molecules in an
aqueous liquid vehicle by addition of gelling agent
• Gelling agents- either Synthetic macromolecules (Carbomer 934) or
Cellulose derivatives (Carboxymethylcellulose)
• Non greasy, moisture rich
• Compatible with many substances
• May contain penetration enhancers for anti-inflammatory and some
other medications
22. Applications:
• Sustained-release delivery system
• Dressings for healing of burn or other hard-to-heal wounds
• Reservoirs in topical drug delivery, particularly ionic drugs, delivered
by iontophoresis e.g. Diclofenac gel, Lignocaine jelly
23. Fig: Evaluation of gel Drug content Homogeneity of drug content Measurement of pH Viscosity
Spread ability Extrudability
24. Lotion:
• Clear solution/suspension/emulsion containing 25-50% alcohol
• Low to medium viscosity
• May contain extract of witch-hazel, menthol, glycerin, boric acid,
alum, chloroform etc. but NOT camphor
• Applied without friction
• Can be applied on abraded/wounded skin or on mucous membrane
• Antiseptic, anti inflammatory, astringent, emollient, cooling,
moisturizing or protective actions e.g. Calamine lotion
25. Fig: Evaluation of lotion Antiseptic property Determination of alcohol content
26. Liniment (Balm):
• Low- to medium-viscosity emulsions
• Formulated from quickly evaporating solvents, contain aromatic
chemical compounds
• As a rule contain camphor
• Always applied with friction
• Applied only on unbroken skin, never on mucus membrane
• Typically used to relieve pain and stiffness such as from sore muscle
cramp or arthritis e.g. Turpentine
27. Solution:
• Solutions are liquid preparations of soluble chemicals dissolved in
solvents such as water, alcohol or propylene glycol.
• E.g.: Tincture of iodine
• Sterile Indian ink for surgical procedures
28. Emulsion:
• Two-phase preparations - the dispensed (internal) phase is finely
dispersed in the continuous (external) phase
• Because there are two incompatible phases in close conjunction, a
physical stabilizing system is needed- surfactant (ionic or nonionic),
polymers, polyelectrolytes etc.
• Types-
• Water-in-oil emulsion
• Oil-in-water emulsion
• Water-in-oil-in-water emulsion
• Oil-in-water-in-oil emulsion
29. Fig: valuation of emulsions Phase separation Globule size Rheological properties Effect of
thermal stresses
30. Suspension:
• Heterogeneous system consisting of two phases:
1. The continuous or external phase is generally a liquid or semisolid
2. The disperse or internal phase is made up of particulate matter that is dispersed
throughout the continuous phase
• Almost all suspension systems get separated on standing, the rate of settling
and ease of re-suspendability is the concern
• A satisfactory suspension must remain sufficiently homogenous for at least
the time necessary to remove and administer the dose after shaking its
container
• Types:
• Flocculated
• Deflocculated
32. Eye/Ear Drops:
• Solution/ suspension
• Relatively brief contact time with absorbing surface
• pH, tonicity, viscosity important for local comfort.
• Sterile; require aseptic handling
• Use droppers with attached or separate plastic nozzle, avoid touching
the application surface
• Use: to prevent or treat infections
• E.g. Ciprofloxacin eye/ear drop, Artificial tear
33. Ophthalmic Strips:
• Used for delivering diagnostic dyes topically for eye, by simply
touching the conjunctival surface
• e.g. Fluorescein sodium Ocular insertion:-
• Continuous release multilayered polymeric insertion in conjunctival
fornix
• Ocusert (pilocarpine- for treatment of glaucoma), Lacrisert (artificial
tear substitute- for treatment of dry eye)
34. Suppository:
• Solid dosage forms intended to deliver medicine into rectal, vaginal or
urethral orifice
• Prepared by cold compression or fusion technique
• An appropriate base is selected for its compatibility, stability, melting
point, and aesthetics.
• Commonly used bases are cocoa butter, glycerin, hydrogenated
vegetable oils, and polyethylene glycol
35. Advantages:
• Bypasses first pass metabolism
• Suitable when oral route cannot be used (e.g. patient unconscious, excessive
nausea, vomiting, malabsorption disorder)
• Suitable when drug is not suitable for oral use (unstable in GI tract,
degraded by digestive enzymes )
Disadvantages:
• Absorption slower & unpredictable (BA ~50%)
• Inconvenient & embarrassing
• The contained fat often melts at the high temperatures of the tropics
• Used in kids only where controlled delivery possible
36. Fig: Evaluation of suppository Melting range test Dissolution test Liquefaction or softening
time test
37. Medicated Vaginal Rings:
• Doughnut-shaped polymeric drug delivery devices designed to provide
controlled release of drugs to the vagina over extended periods of time
• Vaginal ring products are used for the treatment of vaginal atrophy,
relief of hot flashes and as a contraceptive
• Vaginal ring technology is currently being developed for the controlled
release of microbicides and vaccines for the prevention of HIV/HPV
infection
38. Aerosol:
• A system that depends on the power of compressed or liquefied gas to expel
the contents from the container.
• Topical pharmaceutical aerosols utilize hydrocarbon (propane, butane, and
isobutene) and compressed gases such as nitrogen, carbon dioxide, and
nitrous oxide.
• Advantages:
• Rapid onset at site delivery
• Less amount of drug required
• Less systemic absorption
• less side effects
• No first pass effect
• Dose titration possible
• Acceptable & convenient to patient
39. Fig: Evaluation of aerosol Flame projection Flash point Vapor pressure Density Moisture Aerosol valve discharge
rate Spray patterns Dosage with metered valves Net contents Foam stability Particle size determination
40. Hydrogels
• Hydrogels are three-dimensional network of hydrophilic cross-linked
polymer that do not dissolve but can swell in water or can respond to
the fluctuations of the environmental stimuli
• Hydrogels are highly absorbent (they can contain over 90% water)
natural or synthetic polymeric networks
• Hydrogels also possess a degree of flexibility very similar to natural
tissue, due to their significant water content Colorful hydrogels
42. Classification
• On the basis of Preparation
• homo-polymer
• copolymer
• Semi-interpenetrating network
• interpenetrating network
• On the basis of cross linking
• Chemical hydrogels
• Physical hydrogels
43. Advantages of Hydrogels
• Hydrogels possess a degree of flexibility very similar to natural tissue, due to their
significant water content
• Entrapment of microbial cells within Hydrogel beads has the advantage of low
toxicity
• Environmentally sensitive Hydrogels have the ability to sense changes of pH,
temperature, or the concentration of metabolite and release their load as result of
such a change
• Timed release of growth factors and other nutrients to ensure proper tissue growth
• Hydrogels have good transport properties
• Hydrogels are Biocompatible
• Hydrogels can be injected
• Hydrogels are easy to modify
44. Applications of Hydrogels in Drug Delivery
• Benefits of controlled drug delivery
• more effective therapies with reduced side effects
• the maintenance of effective drug concentration levels in the blood
• patient’s convenience as medicines hence increased patient compliance
• Hydrogels that are responsive to specific molecules, such as glucose or
antigens, can be used as biosensors as well as drug delivery systems
• Sensitive hydrogels like temperature, pH sensitive, which are used for the
targeted delivery of proteins to colon, and chemotherapeutic agents to
tumors
• Hydrogels will provide new and improved methods of regenerative
medicine, biotechnology, pharmacology, and biosensors in the near future
• Hydrogels can influence the cell behavior and its biochemical and
biophysical processes
45. Limitation of Hydrogels
• Hydrogels are expensive
• Hydrogels causes sensation felt by movement of the maggots
• The surgical risk associated with the device implantation and retrieval
• Hydrogels are non-adherent, they may need to be secured by a secondary
dressing
• Hydrogels used as contact lenses causes lens deposition, hypoxia,
dehydration and red eye reactions
• Hydrogels have low mechanical strength
• Difficulty in handling
• Difficulty in loading
46. Organo-gel
• An organo-gel is a class of gel composed of a liquid organic phase
within a three-dimensional, cross-linked network.
• Organo-gel networks can form in two ways.
• The first is classic gel network formation via polymerization.
• The gel is said to be a hydrogel or an organo-gel depending on the
nature of the liquid component: water in hydrogels and an organic
solvent in organo-gels.
47. Advantages
• Ease of administration
• Avoids first pass effect
• Absorption enhancement
• Overcome the problems of conventional dosage forms
• Site specific drug delivery
• Avoid systemic adverse effects associated with oral administration of
drug.
48. Application
• Ease of preparation & scale up, easier quality monitoring,
thermodynamic stability, enhanced topical performance,
biocompatibility, safety upon applications for prolonged period make
the organo-gels a vehicle of choice for topical drug delivery
• Ease of administration.
• Site specific drug delivery.
• Avoids first pass effect.
• Absorption enhancement.
• Overcome the problems of conventional dosage forms.
49. Limitation
• The major limitation in the formation of Los is the requirement of high
purity lecithin
• High purity lecithin is expensive
• Difficult to obtain in large quantities
• Inclusion of pluronics as co-surfactant makes organo-gelling feasible
with lecithin of relatively less purity
50. In situ gels
• It is a drug delivery system which is in a solution form before the
administration in the body but it converts in to a gel form after the
administration
• There are various routes such as oral, ocular, vaginal, rectal, I/V ,
intraperitoneal etc.
• The formation of gels depends on factors like temperature modulation,
pH change, presence of ions and ultra violet irradiation, from which
the drug gets released in a sustained and controlled manner.
• Various polymers that are used for the formulation of in situ gels
include gellan gum, alginic acid, xyloglucan, pectin etc.
51. Advantages
• Increased contact time
• Ease of administration
• Improved local bioavailability
• Reduced dose concentration
• Reduced dosing frequency
• Improved patient compliance and comfort
• Simple formulation and manufacturing so less investment and cost
53. Limitation
• Rapid precorneal elimination.
• Loss of drug by drainage.
• Non-sustained action.
• Patients non-compliance.
• Possible oil entrapment.
• Sticking of eyelids
• No rate control on diffusion.
• Drug choice limited by partition coefficient.