Topical medications are applied directly to the skin and are designed to achieve high drug concentrations in the skin with minimal systemic exposure. Some key points:
1) The skin is the largest organ of the body and topical absorption depends on the formulation and site of application, with the scrotum and forehead having the highest absorption.
2) Topical formulations include liquids, semisolids, and solids designed for different applications depending on the condition of the skin.
3) When prescribing topical medications, clinicians should specify the concentration, vehicle, application frequency, and quantity to maximize effectiveness and avoid side effects or overuse.
Multi-factorial disease characterized by abnormalities in sebum production, follicular desquamation, bacterial proliferation and inflammation.
Acne vulgaris is a disease of the pilosebaceous follicle characterized by non-inflammatory (open and closed comedones) and inflammatory lesions (papules, pustules, and nodules)
Ppt for MD DERMATOLOGY Residency. includes basics of topical preparations in dermatology. made as a part of curriculum of MD dermatology. includes all definitions, classification, mechanism , uses and side effects. based on rooks, IADVL, and many articles.
This is a seminar conducted by 4th year medical student under supervision of a lecturer. Sorry for not attaching the references.
Information were from few textbooks, google and also from previous dermatology posting group's seminar.
This is an excellent ppt on Dermatological pharmacology highlighting types of formulations, topical preparations and the treatment of individual skin disorders with illustrations...!!
Multi-factorial disease characterized by abnormalities in sebum production, follicular desquamation, bacterial proliferation and inflammation.
Acne vulgaris is a disease of the pilosebaceous follicle characterized by non-inflammatory (open and closed comedones) and inflammatory lesions (papules, pustules, and nodules)
Ppt for MD DERMATOLOGY Residency. includes basics of topical preparations in dermatology. made as a part of curriculum of MD dermatology. includes all definitions, classification, mechanism , uses and side effects. based on rooks, IADVL, and many articles.
This is a seminar conducted by 4th year medical student under supervision of a lecturer. Sorry for not attaching the references.
Information were from few textbooks, google and also from previous dermatology posting group's seminar.
This is an excellent ppt on Dermatological pharmacology highlighting types of formulations, topical preparations and the treatment of individual skin disorders with illustrations...!!
Semisolid, Ideal properties of semisolid, Advantage of semisolid dosage form, Ingredients used in semisolid preparation, Evaluations of ointment, cream and pastes, Equipment used in formulation of semisolid, Troubleshooting in semisolid dosage form.
this presentation aims at dermato pharmacotherapeutics.....at a pharmacologist's view point....only the key points are stressed.....not a complete guide....however it gives the reader, an essential basics....
The presentation contains brief explanation about the Emollients, its types with detailed examples. Brief classification of Rheological additives is also presented along with the applications in cosmeceuticals.
made as a part of residency programme in dermatology. includes latest classification.includes staining characteristics. good for revision. made from contents from Rooks and Bolognia
hanifin and rajka criteria, entymology, definition of AD, atopy, etiopathogenesis of AD, genetics in AD, filaggrin, epidermal barrier dysfunction, atopic march, hygiene hypothesis, infantile phase of AD, childhood phase of AD, adult phase of AD, pityriasis alba, denne morgan folds, dirty neck appearence, nipple dermatitis, hanifin and rajka criteria, UK refinement of hanifin and rajka criteria, millenium criteria of AD, japanese dermatological association criteria, management of AD, wet wrap therapy,
Made as a part of residency programme of MD Dermatology Venerology and leprology. includes diabetes, thyroid disorders, pituitary disorders, metabolic syndrome,
A concised information regarding use of photo therapy in dermatology. made by me as a part of MD dermatology residency. includes additional information about sunscreens.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
3. • Skin-the largest organ of body and most accessible organ
• Surface area 1.5 – 2m2
• Drug penetration is inversely proportional
to thickness of stratum corneum
5. ABSORPTION OF TOPICAL FORMULATIONS
Site
• Forearm
• Sole
• Palm
• Back
• Scalp
• Axilla
• Forehead
• Scrotum
Relative level of absorption
• 1.0
• 0.1
• 0.8
• 1.7
• 3.5
• 3.6
• 6.0
• 42
6. FACTORS AFFECTING TOPICAL ABSORPTION
• Drug concentration
• Site of application
• Age of patient
• Surface area applied
• Friction and heat
• Occlusion
• Hair follicles
• Cutaneous circulation
7. ADVANTAGES OF TOPICAL APPLICATIONS
• Achieve high concentration for drug in skin
• Minimal exposure to other organs
• Increase efficacy
9. HOW TO PRESCRIBE
A. Specify concentration of drug
B. Vehicle
C. Frequency
D. Quantity
10. A.CONCENTRATION OF DRUG:
Percentage representing the proportion of the formulation by weight or volume
• Weight– 1% W/W –1 gram of drug in 100 gram of formulation
• Volume- 1% W/V– solution contain 1 gram drug in 100 ml of formulation
• Parts- 1 part in 1000 solution - means 1 gram in 1000 solution
11. B.VEHICLE :
DEFINATION: Substance which is incorporated into a topical preparation in
order to facilitate the drug delivery by bringing the drug in contact with the
skin
AN IDEAL VEHICLE……….
• Elicits no pharmacological effect
• Solubilize the drug
• Releases the drug with appropriate kinetics
• Is chemically and physically stable
• Cosmetically appealing
• Non allergic and non irritating
12. CLASSIFICATION OF TOPICAL FORMULATIONS
Liquids Solutions A. Aqueous solution
Wet dressing
Soaks and baths
B. Alcoholic solution
1. tincture
2. Paints
3. Varnishes
4. Sprays
Lotions 1. solid in liquid
2. liquid in liquid
Liniments
14. DRESSING
A . WET DRESSING : antipruritic, vasoconstrictive
, cleansing and keratolytic
1. Open Wet dressing :acute inflammatory
conditions with exudation ans oozing.
2. Closed wet dressing : more maceration, less
evaporation
cellulitis and abscess
17. PAINTS:
• Liquid preparations,either aqueous, hydroalcoholic or alcoholic
• usually applied with a brush.
• Eg- gentian violet: antibiotic, anti candidial
- brilliant green: antibacterial
- castellani paint: intertrigo, paronychia,tinea
18. LOTIONS:
• Liquid formulations, suspension or solution of medication in water, alcohol or
other liquid.
• Advantages-convenient
- ratio of inert and active ingredients can be altered.
• Disadvantages- drying effect
- irritating
19. TINCTURES
• Alcoholic solutions designed to deliver large amount of active ingredients at a
site without any undesirable cosmetic effect.
• Used in areas which are not usually easily irritated such as scalp.
20. OINTMENTS:
• Semisolid vehicles composed of lipid such as White soft paraffin (BP
• Occlusive & emolient property
• Good hydration
• Used in chronic,dry,brittle,lichenified dermatoses
• Contain no water
• Do not sustain the growth of microorganisms
• Difficult to spread
• Decrease evaporation
• Can not be used in acute discharging lesions
21. LINIMENTS
• Nonalcoholic solutions of drugs in oil or alcoholic solutions of soap.
• Rubbed into the skin with friction
• Analgesics, counter irritants, astringent, emollient and antipruritic
22. CREAM:
Semisolid emulsions composed of both lipid and water
• Lipid in water-aqeous or vanishing cream
Water miscible cooling and soothing
• Water in oil- immiscible with water, more difficult to wash off,
Emollient lubricant and mildly occlusive
23. PASTES:
Semisolid preparations containing high proportion of finely powdered material
such as zinc oxide or starch
Protective paste: -Greasy ,water insoluble ,difficult to apply and remove.
-accurate localisation occlusive protective and hydrating
Drying paste: cooling paste
- mixture of powdered with liquid
- non greasy water miscible.
In comparison with ointments pastes are thicker, drier and more solid.
25. POWDERS
• Applied directly to skin
• Also known as dusting powders
• Reduce friction
• Absorb excessive moisture
26. POULTICES
• Wet solid masses of particles applied to
exudative lesions
• Bed sores,leg ulcers.
• May be heated before application
• Acts as cleansers and absorptive agents.
27. TRANSDERMAL DRUG DELIVERY SYSTEMS
Special methods of controlled
delivery of drugs into
circulation by topical route.
28. COLLODIONS:
Liquid preparation Consisting of cellulose nitrate in organic solvent.
• Evaporate easily to leave a flexible film.
• Most frequently used to apply salicylic and lactic acids to warts.
• May also be used as protectives ro seal minor cuts and abrasions.
• Easy to apply and water repellent.
• Inflammable.
29. MICROSPONGES:
Used as porous beads 10-25ùm in diameter to form a reservoir loaded with
drug
• Used for cosmetics and sunscreens
• Provide sustain release of drug while reducing irritation.
30. LIPOSOMES:
Aqueous phase surrounded by a lipid capsule
• Used as Penetration enhancing agents.
• Useful for reducing irritation from topical use of agents such as
tretinoin,benzoyl peroxide
• Reduces staining of skin and clothes from latter.
32. C. FREQUENCY:
• Maximize response while avoiding side effects.
• Excessive applications can lead to systemic effects
• Emollients-frequently
• Active preparations-OD / BID
• Pharmacological actions persists even after Drug has been wiped out
• Increasing interval between application is a effective way of tapering intensity
of treatment
• Rebound and tachyphylaxis
34. FINGER TIP UNIT
• Extending from the distal crease of
the forefinger to the ventral aspect
of the finger tip
• Approximately 0.5 gm.
• Covers an area of 300cm2.
49. Sunscreen =dose of UVB radiation producing minimal erythema with sunscreen
dose of UVB radiation producing minimal erythema without sunscreen
50. Humectants-
Compounds with high affinity for water.
Draw water into stratum corneum
Have emollient effect on dry skin
Eg: gelatin
glycerin
urea
Lacquer – liquid dissolved in alcohol that dries to form a hard protective
covering.
Emollients- derived from Latin word mollire which means to soften the skin.
51. CHOICE OF PREPARATION
Condition of skin Preparation of choice
Acute, inflamed,red,swollen, lesions with dischrge Lotions
Subacut, chronic, less inflamed Lotion, paste, cream.
Dry, scaly, thickened, lichenified Ointments, pastes
Generalized, widespread Eruptions Lotions
Soles Ointments
Hairy area Lotions
52. ADVICE TO PATIENT
• Where to use and where not to use
• How much to use
• When to use (timing)
• How to use
• Warning