The document discusses the goals of establishing a new research lab called RISELab to develop a secure real-time decision stack that can enable real-time decisions on live data with strong security guarantees. It outlines some of the challenges in building such a system and presents early work on Drizzle, a low-latency streaming engine, and Opaque, which leverages hardware enclaves to provide encryption and hide data access patterns. The goal is to build an open source platform and tools over the next 5 years to enable applications requiring sophisticated, accurate, and robust real-time decisions on private data.