Dr. Cavallari will present studies relevant to the recently discovered glymphatic pathway of clearance, with particular emphasis on ongoing studies at the Center for Neurological Imaging. The glymphatic pathway is considered to play a substantial role in the clearance of brain waste, including neurotoxins implicated in the pathobiology of neurodegenerative disease, such as Alzheimer’s disease. Studies in animal models showed that this mechanism of clearance is particularly active during sleep. The characterization of the glymphatic system in humans would have profound implications for our understanding of the core functions of sleep, as well as the pathogenesis of neurodegenerative diseases. Preliminary findings, including ours, support the presence of a similar mechanism of clearance in humans.
The glymphatic system, a recently-discovered immune system of the central nervous system that offers opportunities for the development of techniques to modulate immune response. An opportunity for osteopathic manipulation research.
Vagal Nerve stimulation
Vagus nerve stimulation (VNS) is a medical treatment that involves delivering electrical impulses to the vagus nerve. It is used as an add-on treatment for certain types of intractable epilepsy and treatment-resistant depression. Frequent side effects include coughing and shortness of breath. Serious side effects may include trouble talking and cardiac arrest.
This presentation looks at abnormal EEG patterns with examples for each. Benign variants, artifacts and focal ictal patterns are not part of this presentation.
Dr. Cavallari will present studies relevant to the recently discovered glymphatic pathway of clearance, with particular emphasis on ongoing studies at the Center for Neurological Imaging. The glymphatic pathway is considered to play a substantial role in the clearance of brain waste, including neurotoxins implicated in the pathobiology of neurodegenerative disease, such as Alzheimer’s disease. Studies in animal models showed that this mechanism of clearance is particularly active during sleep. The characterization of the glymphatic system in humans would have profound implications for our understanding of the core functions of sleep, as well as the pathogenesis of neurodegenerative diseases. Preliminary findings, including ours, support the presence of a similar mechanism of clearance in humans.
The glymphatic system, a recently-discovered immune system of the central nervous system that offers opportunities for the development of techniques to modulate immune response. An opportunity for osteopathic manipulation research.
Vagal Nerve stimulation
Vagus nerve stimulation (VNS) is a medical treatment that involves delivering electrical impulses to the vagus nerve. It is used as an add-on treatment for certain types of intractable epilepsy and treatment-resistant depression. Frequent side effects include coughing and shortness of breath. Serious side effects may include trouble talking and cardiac arrest.
This presentation looks at abnormal EEG patterns with examples for each. Benign variants, artifacts and focal ictal patterns are not part of this presentation.
This presentation looks at generalised periodic epileptiform discharges and the various disorders like Creutzfeldt Jacob disease (CJD), SSPE and metabolic encephalopathies in which it is seen. SIRPID is also discussed. Triphasic waves are described. Radermacker complexes in SSPE are described.
This lecture is all about the recognition of an abnormal EEG, its characteristics, its appearance and all about how to differentiate the abnormal activity with normal EEG background.
Transcranial Motor Evoked Potentials Monitoring per aACNS guidelinesAnurag Tewari MD
Motor evoked potentials (MEPs) are electrical signals recorded from neural tissue or
muscle following activation of central motor pathways. They complement other clinical
neurophysiology techniques, such as somatosensory evoked potentials (SEPs), in the assessment
of the nervous system, especially during intraoperative neurophysiologic monitoring (IONM).
Leaky Blood-Brain Barrier a Harbinger of Alzheimer s Disease - presentation made at Alzforum's live webinar of February 17, 2015. See details at: http://www.alzforum.org/webinars/leaky-blood-brain-barrier-harbinger-alzheimers
This presentation looks at generalised periodic epileptiform discharges and the various disorders like Creutzfeldt Jacob disease (CJD), SSPE and metabolic encephalopathies in which it is seen. SIRPID is also discussed. Triphasic waves are described. Radermacker complexes in SSPE are described.
This lecture is all about the recognition of an abnormal EEG, its characteristics, its appearance and all about how to differentiate the abnormal activity with normal EEG background.
Transcranial Motor Evoked Potentials Monitoring per aACNS guidelinesAnurag Tewari MD
Motor evoked potentials (MEPs) are electrical signals recorded from neural tissue or
muscle following activation of central motor pathways. They complement other clinical
neurophysiology techniques, such as somatosensory evoked potentials (SEPs), in the assessment
of the nervous system, especially during intraoperative neurophysiologic monitoring (IONM).
Leaky Blood-Brain Barrier a Harbinger of Alzheimer s Disease - presentation made at Alzforum's live webinar of February 17, 2015. See details at: http://www.alzforum.org/webinars/leaky-blood-brain-barrier-harbinger-alzheimers
Leaky Blood-Brain Barrier a Harbinger of Alzheimer s Disease - presentation made at Alzforum's live webinar of February 17, 2015. See details at: http://www.alzforum.org/webinars/leaky-blood-brain-barrier-harbinger-alzheimers
Leaky Blood-Brain Barrier a Harbinger of Alzheimer s Disease - presentation made at Alzforum's live webinar of February 17, 2015. See details at: http://www.alzforum.org/webinars/leaky-blood-brain-barrier-harbinger-alzheimers
Presentation delivered by Dr. Carol Manning at the live webinar hosted by AlzPossible at www.alzpossible.org on the 17th of March, 2014.
www.alzpossible.org
Prof. Mridul Panditrao's Peri-operative Management of Jehovah's Witness Patient Prof. Mridul Panditrao
A case report of Emergency Peri-operative Mnagement of a Jehovah's Witness patient.
Because of their peculear religious belief, these patients do not accept Blood and It's products. This can pose serious problems to the Anesthesiologist.
Details of Cerebrospinal Fluid special reference to cell count and alteration of CSF Hydrodynamics explained in brief and Different Diagnostic parameters to Hydrocephalus
Targeting a continuous learning process, this presentation helps ER workers to react with positive impacts applied, focusing at the patient for a better quality service
Cardiogenicshock by Dr.Afroza Prioty -140123092109-phpapp02Afroza Prioty
A small overview on cardiogenic shock which sometimes becomes a burning issue for the medical personnels and to combat the situation, the measures should be taken immediately and urgently.
First Identification of Role TMEM106B in FTDAlzforum
Presentation made by Rosa Rademakers on the 20th of April, 2017, at the live webinar hosted by Alzforum: http://www.alzforum.org/webinars/webinar-cortex-aging-too-fast-blame-tmem106b-and-progranulin
Presentation made by Jernej Ule on the 20th of April, 2017, at the live webinar hosted by Alzforum: http://www.alzforum.org/webinars/webinar-cortex-aging-too-fast-blame-tmem106b-and-progranulin
Presentation made by Tony Wyss-Coray on the 20th of April, 2017, at the live webinar hosted by Alzforum: http://www.alzforum.org/webinars/webinar-cortex-aging-too-fast-blame-tmem106b-and-progranulin
Presentation made by Abeliovich and Rhinn on the 20th of April, 2017, at the live webinar hosted by Alzforum: http://www.alzforum.org/webinars/webinar-cortex-aging-too-fast-blame-tmem106b-and-progranulin
Marc Dhenain Alzforum Webinar - Dec 7, 2016Alzforum
Presentation made at the Alzforum's live webinar of December 5, 2016, titled "Is Alzheimer’s Disease a Uniquely Human Disorder?" - review additional information and recording at www.alzforum.org/
Peter Nelson Alzforum Webinar - Dec 7, 2016Alzforum
Presentation made at the Alzforum's live webinar of December 5, 2016, titled "Is Alzheimer’s Disease a Uniquely Human Disorder?" - review additional information and recording at www.alzforum.org/
Elizabeth Head Alzforum Webinar - Dec 7, 2016Alzforum
Presentation made at the Alzforum's live webinar of December 5, 2016, titled "Is Alzheimer’s Disease a Uniquely Human Disorder?" - review additional information and recording at www.alzforum.org/
Patrick Hof Alzforum Webinar - Dec 7, 2016Alzforum
Presentation made at the Alzforum's live webinar of December 5, 2016, titled "Is Alzheimer’s Disease a Uniquely Human Disorder?" - review additional information and recording at www.alzforum.org/
Presentation made at the Alzforum's live webinar of December 5, 2016, titled "Is Alzheimer’s Disease a Uniquely Human Disorder?" - review additional information and recording at www.alzforum.org/
Presentation made at the live webinar of April 8, 2016 hosted by Alzforum - http://www.alzforum.org/webinars/webinar-pathogenic-protein-spread-lets-think-again
Dominic Walsh - A Critical Appraisal of the Pathogenic Protein Spread Hypothe...Alzforum
Presentation made April 8, 2016 at the live webinar hosted by Alzforum - http://www.alzforum.org/webinars/webinar-pathogenic-protein-spread-lets-think-again
Presentation made April 8, 2016 at the live webinar hosted by Alzforum - http://www.alzforum.org/webinars/webinar-pathogenic-protein-spread-lets-think-again
Patrik Brundin - Are Synucleinopathies Prion Diseases?Alzforum
Presentation made April 8, 2016 at the live webinar hosted by Alzforum - http://www.alzforum.org/webinars/webinar-pathogenic-protein-spread-lets-think-again
Virginia Lee - Cell-to-Cell Spread of Pathological TauAlzforum
Presentation made April 8, 2016 at the live webinar hosted by Alzforum - http://www.alzforum.org/webinars/webinar-pathogenic-protein-spread-lets-think-again
Presentation made by Dr. Cliff Brangwynne on October 30, 2015 at the Alzforum-hosted live webinar titled "Fluid Business: Could “Liquid” Protein Herald Neurodegeneration?"
More information and the recording of the session available at http://www.alzforum.org/webinars/fluid-business-could-liquid-protein-herald-neurodegeneration
Presentation made by Dr. Paul Taylor on October 30, 2015 at the Alzforum-hosted live webinar titled "Fluid Business: Could “Liquid” Protein Herald Neurodegeneration?"
More information and the recording of the session available at http://www.alzforum.org/webinars/fluid-business-could-liquid-protein-herald-neurodegeneration
Presentation made by Dr. Markus Zweckstetter on October 30, 2015 at the Alzforum-hosted live webinar titled "Fluid Business: Could “Liquid” Protein Herald Neurodegeneration?"
More information and the recording of the session available at http://www.alzforum.org/webinars/fluid-business-could-liquid-protein-herald-neurodegeneration
Presentation made by Dr. Simon Alberti on October 30, 2015 at the Alzforum-hosted live webinar titled "Fluid Business: Could “Liquid” Protein Herald Neurodegeneration?"
More information and the recording of the session available at http://www.alzforum.org/webinars/fluid-business-could-liquid-protein-herald-neurodegeneration
Presentation made by Dr. Peter St. George-Hyslop on October 30, 2015 at the Alzforum-hosted live webinar titled "Fluid Business: Could “Liquid” Protein Herald Neurodegeneration?"
More information and the recording of the session available at http://www.alzforum.org/webinars/fluid-business-could-liquid-protein-herald-neurodegeneration
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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3. CNS is a metabolic highly active organ
• ~ 2% of the body weight (3 pounds)
4. CNS is a metabolic highly active organ
• ~ 2% of the body weight (3 pounds)
• ~ 15% of the cardiac output
• ~ 20% of total body O2 consumption
• ~ 25% of total body glucose consumption
5. CNS is a metabolic highly active organ
• ~ 2% of the body weight (3 pounds)
• ~ 15% of the cardiac output
• ~ 20% of total body O2 consumption
• ~ 25% of total body glucose consumption
All biological activity is associated with production of waste products
6. CNS is a metabolic highly active organ
• ~ 2% of the body weight (3 pounds)
• ~ 15% of the cardiac output
• ~ 20% of total body O2 consumption
• ~ 25% of total body glucose consumption
All biological activity is associated with production of waste products
7. CNS is a metabolic highly active organ
• ~ 2% of the body weight (3 pounds)
• ~ 15% of the cardiac output
• ~ 20% of total body O2 consumption
• ~ 25% of total body glucose consumption
All biological activity is associated with production of waste products
Does the brain really recycle all cellular waste products?
46. Conclusion:
•The glymphatic system share many
functions with the system lymphatic
system
•AQP4 deletion suppress clearance of
beta-amyloid by 60%
•Glymphatic clearance peaks during
sleep or anesthesia, when
norepinephrine is low
Implications:
•Macroscopic glymphatic clearance may play a role in neurodegenerative
diseases. Is AQP4 a new therapeutic target?
•Sleep promotes removal of biological waste in CNS
•Glymphatic influx of CSF can also be used to deliver drugs to CNS
47. Jeff Iliff
Lulu Xie
Minghuan Wang
Ditte Lovatt
Nathan Smith
Karl Kasischke
Hongyi Kang
Nancy Oberheim
Martha Windrem
Xioaning Han
Takahiro Takano
Lane Bekar
Arnulfo Torres
Qiwu Xu
Marisa Cotrina
Marie Simard
Xiaohai Wang
Jane Lin
Guofeng Tian
Nanhong Liu
NINDS/NIH, Dana Foundation, Adelson,
Keck Foundation, Mathers Foundation
and NY State
Collaborators:
Helene Benveniste
Alcino Silva
Charles Nicholson
Gerald Dienel
Jian Kang
Klaus Willecke
Bruce Ransom
Steve Goldman
Editor's Notes
Astrocytes areelectrically non-excitable and have traditionally been regarded as the supportive cell of the brain. The glia field has made tremendous progress over the past decade and we have developed a much more sophisticated view on the multi-faceted function of astrocytes that is so than just 15 years. We know know that astrocytes can mudulatesynapric transmission and play important role in complex cognitive functions such as working memory and sleep – with several of the key studies done here at Penn. One concern is that essential the new data on organization, development, differentiation, and function have been generated in rodent. Even worse, essentially all our understanding of astrocytic calcium signaling and gliotransmissionhas been collected in mice or rat pups.
The influx of tracer can also be studied by injecting the tracer in CM follwoe by perfusion of the brain at various time points thereafter. We have here injected a small red tracer anda larger green tracer and harvested the brain just 5 min later. Most of the larger penetrating arteries are otline and it is clear that the red smaller tracer
The influx of tracer can also be studied by injecting the tracer in CM follwoe by perfusion of the brain at various time points thereafter. We have here injected a small red tracer anda larger green tracer and harvested the brain just 5 min later. Most of the larger penetrating arteries are otline and it is clear that the red smaller tracer
The influx of tracer can also be studied by injecting the tracer in CM follwoe by perfusion of the brain at various time points thereafter. We have here injected a small red tracer anda larger green tracer and harvested the brain just 5 min later. Most of the larger penetrating arteries are otline and it is clear that the red smaller tracer
The influx of tracer can also be studied by injecting the tracer in CM follwoe by perfusion of the brain at various time points thereafter. We have here injected a small red tracer anda larger green tracer and harvested the brain just 5 min later. Most of the larger penetrating arteries are otline and it is clear that the red smaller tracer
Despite decades of effort, one of the biggest mysteries in biology is still why sleep is restorative and conversely why lack of sleep impairs brain functions