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Presentation made April 8, 2016 at the live webinar hosted by Alzforum - http://www.alzforum.org/webinars/webinar-pathogenic-protein-spread-lets-think-again
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David Harris -
- 1. Infectivity and toxicity are distinct PrPC PrPtoxic PrPSc Synaptic dysfunction Infectivity PrPC PrPSc PrPtoxic Synaptic dysfunction Infectivity Aβoligomer Aβmonomer Aβfibril Synaptic dysfunction Infectivity
- 2. • Selective targeting/uptake (receptors) • Selective propagation (chaperones) • Selective toxicity (downstream pathways) CNS inoculation Familial prion diseases Strain A Strain B Mutant A Mutant B Peripheral inoculation Patterns of selective neuropathology in prion diseases Y • Neuroanatomical spread (trans-synaptic)