Download to read offline
Uploaded byAlzforum
David Harris -
The document discusses the concepts of infectivity and toxicity in relation to prion diseases, emphasizing their distinct roles. It outlines mechanisms such as selective targeting, propagation, and toxicity that contribute to synaptic dysfunction. Additionally, it mentions the neuroanatomical spread of prion diseases and the involvement of various strains and mutations.
David Harris -
- 1. Infectivity and toxicityare distinct PrPC PrPtoxic PrPSc Synaptic dysfunction Infectivity PrPC PrPSc PrPtoxic Synaptic dysfunction Infectivity Aβoligomer Aβmonomer Aβfibril Synaptic dysfunction Infectivity
- 2. • Selective targeting/uptake (receptors) •Selective propagation (chaperones) • Selective toxicity (downstream pathways) CNS inoculation Familial prion diseases Strain A Strain B Mutant A Mutant B Peripheral inoculation Patterns of selective neuropathology in prion diseases Y • Neuroanatomical spread (trans-synaptic)