Targeting a continuous learning process, this presentation helps ER workers to react with positive impacts applied, focusing at the patient for a better quality service
Presentation of Dr. Lluis Blanch at 8th Pulmonary Medicine Update Course, February 2008, Cairo, Egypt. Pulmonary Medicine Update Course is organized by Scribe : www.scribeofegypt.com
Optimising haemodynamics in septicaemia / HOCF saves lives! Optimising haemodynamics early saves even more lives!
Associate Professor Brendan E. Smith.
School of Biomedical Science, Charles Sturt University,
Specialist in Anaesthesia and Intensive Care, Bathurst Base Hospital, Bathurst, NSW, Australia.
Dilemma - Emergency Department
42 year old male with acute onset on breathlessness, inability to lie flat, headache and muscle aches and generally feeling flu-like for 36 hours.
Presentation of Dr. Lluis Blanch at 8th Pulmonary Medicine Update Course, February 2008, Cairo, Egypt. Pulmonary Medicine Update Course is organized by Scribe : www.scribeofegypt.com
Optimising haemodynamics in septicaemia / HOCF saves lives! Optimising haemodynamics early saves even more lives!
Associate Professor Brendan E. Smith.
School of Biomedical Science, Charles Sturt University,
Specialist in Anaesthesia and Intensive Care, Bathurst Base Hospital, Bathurst, NSW, Australia.
Dilemma - Emergency Department
42 year old male with acute onset on breathlessness, inability to lie flat, headache and muscle aches and generally feeling flu-like for 36 hours.
Improving survival from Sudden Cardiac Arrest – can it really work?Haydn Drake
Gary Strong's presentation at the Paramedics Australasia NZ CPD event in Auckland on 3 July 2013.
Gary is the Programme Leader BHSc Paramedic at Whitireia Polytechnic, and prior to that was the Education & Training Manager at Wellington Free Ambulance.
Prior to coming to New Zealand, Gary was the Paramedic Clinical Lead at the Great Western Ambulance Service, an Education and Development Tutor at the Gloucestershire Ambulance Service, and worked as a paramedic with the West Midlands Ambulance Service NHS Trust.
The right ventricle (RV) is not important, until it is. Under normal conditions RV function merely keeps central venous pressure low and delivers all the venous return per beat into the pulmonary circulation under low pressure. If pulmonary artery pressures increase due to pulmonary vascular disease (embolism, ARDS, COPD), over-distention (COPD, asthma) or ischemia (embolism, pulmonary hypertension), the RV rapidly dilates decreasing left ventricular (LV) diastolic compliance via ventricular interdependence. Most clinicians presume that the RV is merely a weaker version of the LV, but follows that same rules. But this in not true. Normally, RV filling occurs without any measurable change in RV distending pressure owing to conformational changes in its shape rather than distention of its wall fibers. This effect allows central venous pressure to remain low despite major dynamic change sin venous return associated with breathing. RV ejection is exquisitely dependent of RV ejection pressure. Thus, if disease processes increase pulmonary artery impedance then RV dilation and failure will eventually occur. Furthermore, most of RV coronary blood flow occurs during systole, unlike LV coronary blood flow, which primarily occurs in diastole. Thus, systemic hypotension or relative hypotension where in pulmonary artery pressures equal or exceed aortic pressure must cause RV ischemia. Clinically these findings carry a common end result. For cardiac output to increase RV volumes must increase. If increasing RV volumes also result in increasing filling pressures then RV over distention may be occurring causing RV free wall ischemia. If relative systemic hypotension exists then selective increases in arterial pressure will improve RV systolic function. Accordingly, fluid resuscitation, if associated with rapid increases in central venous pressure should be stopped until evidence of acute cor pulmonale is excluded. Acute cor pulmonale can be treated by improving LV systolic function, coronary perfusion pressure or reducing pulmonary artery outflow impedance. The normal response of the RV to slowly increasing pulmonary artery pressures is to increase its intrinsic contractility (Anrep effect), but if the pressure load exceeds such adaptation, RV hypertrophy develops in an asymmetric fashion initially in the infundibulum before progressing to the RV free wall and septum. In chronic RV failure, dilation and RV wall thinning occurs as the heart reverts to preload to sustain stroke volume (Starling effect). Importantly, all these effects and their response to therapies can be assessed at the bedside using echocardiography and pulmonary arterial catheterization.
The two major causes of acute right ventricular (RV) failure in ICU patients are acute cor pulmonale (ACP) during acute respiratory distress syndrome (ARDS) and ACP during acute massive pulmonary embolism (PE).
The increase in pulmonary vascular resistance (PVR) in ARDS can be secondary either to « structural » mechanisms related to lung injury per se and to « functional » mechanisms related to the effects of mechanical ventilation with positive end expiratory pressure (PEEP). The latter mechanism is enhanced when PEEP overdistends more than it recruits lung volume and when tidal volume (VT) is high. The recommended protective ventilation with low VT and PEEP adjusted to driving pressure can also reduce the RV afterload. A reduced central blood volume can also play a role in the increase in PVR (extension of the West’s zone 2). In this case, volume administration can reduce the PVR and improve the RV function. Finally, prone positioning also exerts a beneficial effect on RV afterload through a decrease in PVR (lung recruitment, decrease in hypoxic vasoconstriction, increase in central blood volume with decrease in the extent of zone 2).
In acute PE, RV dysfunction is associated with poor outcome. Thrombolytic treatment, which is indicated in cases of severe PE with shock, prevents hemodynamic decompensation in patients with intermediate risk PE, but also results in increased risk of severe hemorrhage and stroke. In the case of PE with low cardiac output and no RV dilatation, fluid administration can be indicated to improve cardiac output. In cases of systemic arterial hypotension, vasopressors such as norepinephrine can be indicated to restore adequate RV perfusion pressure. Indication of inotropic agents such as dobutamine, which improves the RV-pressure artery coupling should be evaluated individually. Surgical pulmonary embolectomy can be indicated when the thrombolytic therapy is contra-indicated in acute PE with shock.
The Next Generation in Managing Emergency Department Patients: Non-Invasive Cardiac Output.
Jennifer Williams, MSN, RN, ACNS-BC, CEN, Clinical Nurse Specialist, Barnes-Jewish Hospital. Emergency Services
Sudden cardiac arrest (SCA)&Sudden cardiac death (SCD)Abdullah Ansari
INTRODUCTION
SCD : Definition
Epidemiology
Etiology
THE INITIAL ASSESSMENT
BASIC LIFE SUPPORT
CPR Steps
SELF-ASSESSMENT FOR BLS
ADVANCED CARDIAC LIFE SUPPORT
PRINCIPLES OF EARLY DEFIBRILLATION
AUTOMATED EXTERNAL DEFIBRILLATOR
SELF-ASSESSMENT FOR ACLS
Ventricular pump function is often compromised during critical illness and for a variety of reasons. The most common cause of a limited cardiac output in acutely ill patients is right ventricular (RV) dysfunction. Exacerbations of chronic obstructive lung disease or the use of high end-expiratory pressure sin acute lung injury to support arterial oxygenation can result in acute elevations of pulmonary arterial pressure impeding RV ejection, causing RV dilation, decreased left ventricular (LV) diastolic compliance. All these effects limit cardiac output and LV stroke volume. Importantly, the treatment is to sustain mean arterial pressure greater than pulmonary artery pressure to prevent RV ischemia and balance RV fluid status to avoid both over-distention (acute cor pulmonale) and under-filling. This delicate fluid balance is greatly facilitated by the immediate and repeated use of bedside echocardiography. Attempts to minimize lung over distention should be a primary focus of therapy. If one focuses only on the LV, these patients would be said to have a reversible form of diastolic dysfunction, in that LV ejection fraction would be normal but the LV not able to increase its end-diastolic volume without excess filling pressures promoting pulmonary edema. The second most common etiology of impaired heart functional reserve is chronic LV hypertrophy secondary to hypertension, wherein systemic afterload reduction is the primary treatment. Third, decreased systolic pump function is often seen in sepsis owing to reduced myocardial adrenergic responsiveness. However, this is often under-appreciated because of the usually co-existent peripheral vasodilation. In septic patients, measures aimed primarily to increase mean arterial pressure, such as the use of vasopressors often results in a decrease in cardiac output because the septic heart is not able to handle the increased load. Importantly, this form of systolic dysfunction is reversible once the sepsis state resolves, but may require inotropes during its height to sustain flow under pressure. Finally both chronic heart failure patients can also get sick and acute myocardial infarction will impair both diastolic and systolic function. Their treatments include reversing coronary ischemia, if present, afterload reduction and a balanced fluid response. A clear and logical approach to all critically ill patients is needed to quickly separate these diverse forms of heart failure from each other as they have markedly different therapies and clinical trajectories.
Here are two slideshows, head trauma, which gives a quick guide to ER team, how to prepare and manage a case with a 1st response, Then - a guideline for Tetanus prophylaxis and management, for suspected cases as hundreds of cases still are found annually. Spread the knowledge!
When the CSO (Central Statistics Office) released its report on crime this year Dublin was, once again, shown to be the capital of Ireland when it comes to burglaries. County Louth (Drogheda and Dundalk), Wicklow, Galway Waterford and Limerick also fared quite poorly in the latest statistical breakdowns.
Visit DeWARSecure.ie for more information.
Improving survival from Sudden Cardiac Arrest – can it really work?Haydn Drake
Gary Strong's presentation at the Paramedics Australasia NZ CPD event in Auckland on 3 July 2013.
Gary is the Programme Leader BHSc Paramedic at Whitireia Polytechnic, and prior to that was the Education & Training Manager at Wellington Free Ambulance.
Prior to coming to New Zealand, Gary was the Paramedic Clinical Lead at the Great Western Ambulance Service, an Education and Development Tutor at the Gloucestershire Ambulance Service, and worked as a paramedic with the West Midlands Ambulance Service NHS Trust.
The right ventricle (RV) is not important, until it is. Under normal conditions RV function merely keeps central venous pressure low and delivers all the venous return per beat into the pulmonary circulation under low pressure. If pulmonary artery pressures increase due to pulmonary vascular disease (embolism, ARDS, COPD), over-distention (COPD, asthma) or ischemia (embolism, pulmonary hypertension), the RV rapidly dilates decreasing left ventricular (LV) diastolic compliance via ventricular interdependence. Most clinicians presume that the RV is merely a weaker version of the LV, but follows that same rules. But this in not true. Normally, RV filling occurs without any measurable change in RV distending pressure owing to conformational changes in its shape rather than distention of its wall fibers. This effect allows central venous pressure to remain low despite major dynamic change sin venous return associated with breathing. RV ejection is exquisitely dependent of RV ejection pressure. Thus, if disease processes increase pulmonary artery impedance then RV dilation and failure will eventually occur. Furthermore, most of RV coronary blood flow occurs during systole, unlike LV coronary blood flow, which primarily occurs in diastole. Thus, systemic hypotension or relative hypotension where in pulmonary artery pressures equal or exceed aortic pressure must cause RV ischemia. Clinically these findings carry a common end result. For cardiac output to increase RV volumes must increase. If increasing RV volumes also result in increasing filling pressures then RV over distention may be occurring causing RV free wall ischemia. If relative systemic hypotension exists then selective increases in arterial pressure will improve RV systolic function. Accordingly, fluid resuscitation, if associated with rapid increases in central venous pressure should be stopped until evidence of acute cor pulmonale is excluded. Acute cor pulmonale can be treated by improving LV systolic function, coronary perfusion pressure or reducing pulmonary artery outflow impedance. The normal response of the RV to slowly increasing pulmonary artery pressures is to increase its intrinsic contractility (Anrep effect), but if the pressure load exceeds such adaptation, RV hypertrophy develops in an asymmetric fashion initially in the infundibulum before progressing to the RV free wall and septum. In chronic RV failure, dilation and RV wall thinning occurs as the heart reverts to preload to sustain stroke volume (Starling effect). Importantly, all these effects and their response to therapies can be assessed at the bedside using echocardiography and pulmonary arterial catheterization.
The two major causes of acute right ventricular (RV) failure in ICU patients are acute cor pulmonale (ACP) during acute respiratory distress syndrome (ARDS) and ACP during acute massive pulmonary embolism (PE).
The increase in pulmonary vascular resistance (PVR) in ARDS can be secondary either to « structural » mechanisms related to lung injury per se and to « functional » mechanisms related to the effects of mechanical ventilation with positive end expiratory pressure (PEEP). The latter mechanism is enhanced when PEEP overdistends more than it recruits lung volume and when tidal volume (VT) is high. The recommended protective ventilation with low VT and PEEP adjusted to driving pressure can also reduce the RV afterload. A reduced central blood volume can also play a role in the increase in PVR (extension of the West’s zone 2). In this case, volume administration can reduce the PVR and improve the RV function. Finally, prone positioning also exerts a beneficial effect on RV afterload through a decrease in PVR (lung recruitment, decrease in hypoxic vasoconstriction, increase in central blood volume with decrease in the extent of zone 2).
In acute PE, RV dysfunction is associated with poor outcome. Thrombolytic treatment, which is indicated in cases of severe PE with shock, prevents hemodynamic decompensation in patients with intermediate risk PE, but also results in increased risk of severe hemorrhage and stroke. In the case of PE with low cardiac output and no RV dilatation, fluid administration can be indicated to improve cardiac output. In cases of systemic arterial hypotension, vasopressors such as norepinephrine can be indicated to restore adequate RV perfusion pressure. Indication of inotropic agents such as dobutamine, which improves the RV-pressure artery coupling should be evaluated individually. Surgical pulmonary embolectomy can be indicated when the thrombolytic therapy is contra-indicated in acute PE with shock.
The Next Generation in Managing Emergency Department Patients: Non-Invasive Cardiac Output.
Jennifer Williams, MSN, RN, ACNS-BC, CEN, Clinical Nurse Specialist, Barnes-Jewish Hospital. Emergency Services
Sudden cardiac arrest (SCA)&Sudden cardiac death (SCD)Abdullah Ansari
INTRODUCTION
SCD : Definition
Epidemiology
Etiology
THE INITIAL ASSESSMENT
BASIC LIFE SUPPORT
CPR Steps
SELF-ASSESSMENT FOR BLS
ADVANCED CARDIAC LIFE SUPPORT
PRINCIPLES OF EARLY DEFIBRILLATION
AUTOMATED EXTERNAL DEFIBRILLATOR
SELF-ASSESSMENT FOR ACLS
Ventricular pump function is often compromised during critical illness and for a variety of reasons. The most common cause of a limited cardiac output in acutely ill patients is right ventricular (RV) dysfunction. Exacerbations of chronic obstructive lung disease or the use of high end-expiratory pressure sin acute lung injury to support arterial oxygenation can result in acute elevations of pulmonary arterial pressure impeding RV ejection, causing RV dilation, decreased left ventricular (LV) diastolic compliance. All these effects limit cardiac output and LV stroke volume. Importantly, the treatment is to sustain mean arterial pressure greater than pulmonary artery pressure to prevent RV ischemia and balance RV fluid status to avoid both over-distention (acute cor pulmonale) and under-filling. This delicate fluid balance is greatly facilitated by the immediate and repeated use of bedside echocardiography. Attempts to minimize lung over distention should be a primary focus of therapy. If one focuses only on the LV, these patients would be said to have a reversible form of diastolic dysfunction, in that LV ejection fraction would be normal but the LV not able to increase its end-diastolic volume without excess filling pressures promoting pulmonary edema. The second most common etiology of impaired heart functional reserve is chronic LV hypertrophy secondary to hypertension, wherein systemic afterload reduction is the primary treatment. Third, decreased systolic pump function is often seen in sepsis owing to reduced myocardial adrenergic responsiveness. However, this is often under-appreciated because of the usually co-existent peripheral vasodilation. In septic patients, measures aimed primarily to increase mean arterial pressure, such as the use of vasopressors often results in a decrease in cardiac output because the septic heart is not able to handle the increased load. Importantly, this form of systolic dysfunction is reversible once the sepsis state resolves, but may require inotropes during its height to sustain flow under pressure. Finally both chronic heart failure patients can also get sick and acute myocardial infarction will impair both diastolic and systolic function. Their treatments include reversing coronary ischemia, if present, afterload reduction and a balanced fluid response. A clear and logical approach to all critically ill patients is needed to quickly separate these diverse forms of heart failure from each other as they have markedly different therapies and clinical trajectories.
Here are two slideshows, head trauma, which gives a quick guide to ER team, how to prepare and manage a case with a 1st response, Then - a guideline for Tetanus prophylaxis and management, for suspected cases as hundreds of cases still are found annually. Spread the knowledge!
When the CSO (Central Statistics Office) released its report on crime this year Dublin was, once again, shown to be the capital of Ireland when it comes to burglaries. County Louth (Drogheda and Dundalk), Wicklow, Galway Waterford and Limerick also fared quite poorly in the latest statistical breakdowns.
Visit DeWARSecure.ie for more information.
Ethics and behaviors of health care providing members, could always be better. This presentation describes a certain number of obligations that organize and may assist.
Your collaboration is valuable.
The average households contains a variety of materials which, if not looked after properly, could cause serious problems. Here we have listed some of the most common ones to look out for.
For more home health and safety tips visit:
www.dewarsecure.ie
True- and False-Self Manifestations in the Application Process for Internship...James Tobin
In this paper presented at the Western Psychological Association 2013 annual conference in Reno, NV, James Tobin, Ph.D. uses Winnicott's notions of the true and false self to conceptualize common dynamics that occur among clinical psychology graduate students applying for predoctoral internship and postdoctoral training programs.
Health Care Quality Improvement, is never enough, nor too much.
A vital hospital committee is Infection Control Committee, will lead teams to apply internal policies and procedures to meet better than expectations of patients and families.
هذه هى سلسلة من المحاضرات للتوعية الصحية لأجل العناية بأفضل مما يمكن لإنسان أن يحصل عليه - الصحة الجيدة - وأرجو منكم أن ننشر الخير سويا عبر الاصدقاء والعائلات والجيران وحتى الاطفال - فهذا واجب لمجتمعاتنا العربية فى زمن نحتاج فيه للوحدة والتكاتف والاعتدال والايجابية
Pemanfaatan Teknologi Informasi di PontianakEnda Esyudha
Pontianak sebagai salah satu kota berkembang mulai memanfaatkan teknologi untuk memajukan kotanya. Analisa terhadap pemanfaatan teknologi tersebut perlu diteliti lebih lanjut agar lebih dapat memberikan manfaat positif yang lebih optimal
This presentation is one of a series, aiming at controlling and hazard imposed by medical waste. Trying to reach an implementation of infection control committees while working at the health care quality improvement
Prof. Mridul Panditrao's Peri-operative Management of Jehovah's Witness Patient Prof. Mridul Panditrao
A case report of Emergency Peri-operative Mnagement of a Jehovah's Witness patient.
Because of their peculear religious belief, these patients do not accept Blood and It's products. This can pose serious problems to the Anesthesiologist.
In Er, health care providers are confronted to spine injury, where wrong manipulations and positions, may provoke irreversible impacts. Here are some hints to meet the challenge
Arterial Hypertension is a devastating illness, against which we better get ready to control it - Patient and family awareness needs more effort from providers. A companion is Respiratory Distress to recognize and manage in ER
Patient focus is a fundamental principle at health care,
Targeting the safety of the patient, once realized by the health care givers, they will certainly perform with a better outcome
Among the health care givers, the nursing team would certainly being aware of the qualifications and responsibilities of a head nurse,
on the road to health care quality improvement
Health care givers, led by a medical director,
would get awareness to enhance a better performance, when aware of a medical director qualifications and responsibilities
The how of a design, for health care quality improvement, made simple, would help constructing bridges for and effectively acceptable template for a better performance.
Quality Management Health Plan is a roadmap to apply standards of health care quality improvement for health care providers. An individualized one is to be taken into consideration, cause quality isn't a fit-for-all dress, despite of having similar objectives
هذه هى سلسلة من المحاضرات للتوعية الصحية لأجل العناية بأفضل مما يمكن لإنسان أن يحصل عليه - الصحة الجيدة - وأرجو منكم أن ننشر الخير سويا عبر الاصدقاء والعائلات والجيران وحتى الاطفال - فهذا واجب لمجتمعاتنا العربية فى زمن نحتاج فيه للوحدة والتكاتف والاعتدال والايجابية
هذه هى سلسلة من المحاضرات للتوعية الصحية لأجل العناية بأفضل مما يمكن لإنسان أن يحصل عليه - الصحة الجيدة - وأرجو منكم أن ننشر الخير سويا عبر الاصدقاء والعائلات والجيران وحتى الاطفال - فهذا واجب لمجتمعاتنا العربية فى زمن نحتاج فيه للوحدة والتكاتف والاعتدال والايجابية
هذه هى سلسلة من المحاضرات للتوعية الصحية لأجل العناية بأفضل مما يمكن لإنسان أن يحصل عليه - الصحة الجيدة - وأرجو منكم أن ننشر الخير سويا عبر الاصدقاء والعائلات والجيران وحتى الاطفال - فهذا واجب لمجتمعاتنا العربية فى زمن نحتاج فيه للوحدة والتكاتف والاعتدال والايجابية
هذه هى سلسلة من المحاضرات للتوعية الصحية لأجل العناية بأفضل مما يمكن لإنسان أن يحصل عليه - الصحة الجيدة - وأرجو منكم أن ننشر الخير سويا عبر الاصدقاء والعائلات والجيران وحتى الاطفال - فهذا واجب لمجتمعاتنا العربية فى زمن نحتاج فيه للوحدة والتكاتف والاعتدال والايجابية
هذه هى سلسلة من المحاضرات للتوعية الصحية لأجل العناية بأفضل مما يمكن لإنسان أن يحصل عليه - الصحة الجيدة - وأرجو منكم أن ننشر الخير سويا عبر الاصدقاء والعائلات والجيران وحتى الاطفال - فهذا واجب لمجتمعاتنا العربية فى زمن نحتاج فيه للوحدة والتكاتف والاعتدال والايجابية
هذه هى سلسلة من المحاضرات للتوعية الصحية لأجل العناية بأفضل مما يمكن لإنسان أن يحصل عليه - الصحة الجيدة - وأرجو منكم أن ننشر الخير سويا عبر الاصدقاء والعائلات والجيران وحتى الاطفال - فهذا واجب لمجتمعاتنا العربية فى زمن نحتاج فيه للوحدة والتكاتف والاعتدال والايجابية
هذه هى سلسلة من المحاضرات للتوعية الصحية لأجل العناية بأفضل مما يمكن لإنسان أن يحصل عليه - الصحة الجيدة - وأرجو منكم أن ننشر الخير سويا عبر الاصدقاء والعائلات والجيران وحتى الاطفال - فهذا واجب لمجتمعاتنا العربية فى زمن نحتاج فيه للوحدة والتكاتف والاعتدال والايجابية
هذه هى سلسلة من المحاضرات للتوعية الصحية لأجل العناية بأفضل مما يمكن لإنسان أن يحصل عليه - الصحة الجيدة - وأرجو منكم أن ننشر الخير سويا عبر الاصدقاء والعائلات والجيران وحتى الاطفال - فهذا واجب لمجتمعاتنا العربية فى زمن نحتاج فيه للوحدة والتكاتف والاعتدال والايجابية
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Colonic and anorectal physiology with surgical implications
Er heat stroke-hemorrhage
1. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
HEAT STROKEHEAT STROKE
HEMORRHAGEHEMORRHAGE
2. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
HEAT STROKEHEAT STROKE
3. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
DEFINITIONDEFINITION
Heat stroke is an acute medical emergencyHeat stroke is an acute medical emergency
caused by failure of the heat-regulating mechanismscaused by failure of the heat-regulating mechanisms
of the body.of the body.
People at risk are elderly and very young people,People at risk are elderly and very young people,
those unable to care for themselvesthose unable to care for themselves
and those with chronic andand those with chronic and
debilitating diseases anddebilitating diseases and
those taking medications.those taking medications.
4. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
OBJECTIVEOBJECTIVE
1.1. To reduce high temperature as quickly as possible.To reduce high temperature as quickly as possible.
2.2. To monitor fluid losses and weight loss.To monitor fluid losses and weight loss.
5. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
POLICYPOLICY
1.1. Heat stroke causes thermal injuryHeat stroke causes thermal injury
at the cellular level,at the cellular level,
resulting in damage to the heart,resulting in damage to the heart,
liver, kidney and blood coagulation.liver, kidney and blood coagulation.
6. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
2.1 Exposure to elevated temperature2.1 Exposure to elevated temperature
2.1 Exercise during extreme heat2.1 Exercise during extreme heat
2.3 Profound CNS dysfunction (manifested by confusion,2.3 Profound CNS dysfunction (manifested by confusion,
delirium, bizarre behavior, coma)delirium, bizarre behavior, coma)
2.4 Hot, dry skin2.4 Hot, dry skin
2.5 Tachypnea, hypotension and tachycardia2.5 Tachypnea, hypotension and tachycardia
7. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
3.3. The patient is monitored carefully for vital signsThe patient is monitored carefully for vital signs
and ECG and level of responsiveness.and ECG and level of responsiveness.
4.4. Oxygen is administered and patient may requireOxygen is administered and patient may require
endotracheal intubation and mechanical ventilation.endotracheal intubation and mechanical ventilation.
5.5. Intravenous infusion is initiated as prescribed andIntravenous infusion is initiated as prescribed and
administered carefully becauseadministered carefully because
of dangers of myocardial injuryof dangers of myocardial injury
from high body temperature and poor renal function.from high body temperature and poor renal function.
8. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
6.6. Urine output is measured frequentlyUrine output is measured frequently
because tubular necrosis is a complicationbecause tubular necrosis is a complication
of heat stroke.of heat stroke.
7.7. Blood specimens are obtained for investigations.Blood specimens are obtained for investigations.
8.8. Dialysis maybe done for renal failure.Dialysis maybe done for renal failure.
9. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
MATERIALS & EQUIPMENTMATERIALS & EQUIPMENT
1.1. Cool sheets and towelsCool sheets and towels
2.2. Ice and cool waterIce and cool water
3.3. Cooling blanketsCooling blankets
4.4. Iced saline lavage ofIced saline lavage of
stomach or colonstomach or colon
5.5. ThermometerThermometer
6.6. OxygenOxygen
7.7. I.V. fluids as prescribedI.V. fluids as prescribed
10. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
PROCEDUREPROCEDURE RATIONALERATIONALE
1. Assess the patient for:1. Assess the patient for:
1.11.1 Elevated temperatureElevated temperature
1.21.2 Confusion, delirium, bizarre behaviorConfusion, delirium, bizarre behavior
1.31.3 Hot, dry skinHot, dry skin
.
11. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
1.41.4 Tachypnea, hypotension,Tachypnea, hypotension,
tachycardia.tachycardia.
1. To properly assess and1. To properly assess and
provide measures forprovide measures for
emergency treatmenemergency treatment.
12. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
2. After removing patient's clothes, start2. After removing patient's clothes, start
2. To reduce temperature2. To reduce temperature
cooling measurescooling measures as rapidly asas rapidly as
possible.possible.
Cool sheets and towelsCool sheets and towels
Apply ice packs to neck, groin, axillaApply ice packs to neck, groin, axilla
Iced saline lavage of stomach or colon.Iced saline lavage of stomach or colon.
Immerse patient in cold water.Immerse patient in cold water.
13. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
HEMORRHAGE
14. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
DEFINITIONDEFINITION
It is a loss of more than 500ml. ofIt is a loss of more than 500ml. of
blood, or 30% of estimated totalblood, or 30% of estimated total
volume of blood - which maybevolume of blood - which maybe
internal or external.internal or external.
15. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
OBJECTIVEOBJECTIVE
1.1. To control bleeding.To control bleeding.
2.2. To maintain an adequately circulating bloodTo maintain an adequately circulating blood
volume for tissue oxygenation.volume for tissue oxygenation.
3.3. To prevent shock.To prevent shock.
16. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
POLICY
1. Blood transfusion must be initiated immediately.
2. Intravenous fluid replacement is started as ordered.
17. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
3.3. Vital signs are taken and monitored frequently.Vital signs are taken and monitored frequently.
4.4. The patient is maintained in a supine position andThe patient is maintained in a supine position and
monitored closely until hemodynamic circulatorymonitored closely until hemodynamic circulatory
parameters are stable.parameters are stable.
18. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
CBC, blood chemistry, PT, PTT.CBC, blood chemistry, PT, PTT.
Blood grouping, cross- matching.Blood grouping, cross- matching.
Blood gas determination.Blood gas determination.
7.7. Most bleeding can be stopped by applying directMost bleeding can be stopped by applying direct
pressure or a firm pressure dressing.pressure or a firm pressure dressing.
19. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
8.8. A tourniquet is applied as a last resort whenA tourniquet is applied as a last resort when
external hemorrhage cannot be controlled.external hemorrhage cannot be controlled.
20. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
MATERIALS &MATERIALS &
EQUIPMENTEQUIPMENT
1.1. OxygenOxygen
2.2. PressurePressure
dressingdressing
3.3. SuctionSuction
machinemachine
4.4. Blood andBlood and
blood productsblood products
5.5. IntravenousIntravenous
fluidsfluids
21. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
6.6. Blood containers forBlood containers for
blood samplesblood samples
7.7. Medications areMedications are
orderedordered
8.8. SphygmomanometerSphygmomanometer
and stethoscopeand stethoscope
9.9. TourniquetTourniquet
10.10. Large-boreLarge-bore
intravenous cannulaintravenous cannula
22. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
PROCEDURE & RATIONALEPROCEDURE & RATIONALE
1.1. Assess the patient for the following symptoms.Assess the patient for the following symptoms.
1.1. Patients with hemorrhage are at risk for cardiac arrestPatients with hemorrhage are at risk for cardiac arrest
caused by hypovolemia with secondary anoxia.caused by hypovolemia with secondary anoxia.
23. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
1.11.1 Cool, moist skin (resulting from poor peripheralCool, moist skin (resulting from poor peripheral
perfusion).perfusion).
1.21.2 Falling blood pressure.Falling blood pressure.
1.31.3 Increased heart rate.Increased heart rate.
24. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
1.41.4 Delayed capillary refill.Delayed capillary refill.
1.51.5 Decreasing urine volume.Decreasing urine volume.
2.2. Initiate fluid replacement as ordered.Initiate fluid replacement as ordered. 2.2. A loss ofA loss of
circulating blood leads to a fluid volume deficit andcirculating blood leads to a fluid volume deficit and
decreased cardiac output.decreased cardiac output.
25. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
3.3. Obtain blood samples for analysis, blood groupingObtain blood samples for analysis, blood grouping
and cross-matching.and cross-matching.
3.3. For blood replacement due to massive blood loss.For blood replacement due to massive blood loss.
4.4. Perform rapid assessment of hemorrhage:Perform rapid assessment of hemorrhage:.
26. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
DISCUSSIONDISCUSSION
27. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
28. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A
29. S ilv e r C r e s c e n t D is p e n s a r y – K h o b a r - K S A