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Tammie Benzinger, MD, PhD
Imaging the blood brain barrier
Imaging the blood brain barrier
• Blood brain barrier breakdown
– Stroke
– Brain tumors
– Multiple sclerosis
– Aging
– Alz...
Imaging the blood brain barrier
• Computed tomography (CT)
– Dynamic perfusion, iodinated contrast
• Magnetic resonance im...
Imaging the blood brain barrier
• Positron emission tomography (PET)
– FDG
– O15
– Amyloid tracers
Divergent or convergent pathologies?
• Hippocampal sclerosis?
• AD
– Amyloid & tau imaging
– CSF measures
• Other dementia...
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Alzforum Benzinger

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Leaky Blood-Brain Barrier a Harbinger of Alzheimer s Disease - presentation made at Alzforum's live webinar of February 17, 2015. See details at: http://www.alzforum.org/webinars/leaky-blood-brain-barrier-harbinger-alzheimers

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Alzforum Benzinger

  1. 1. Tammie Benzinger, MD, PhD Imaging the blood brain barrier
  2. 2. Imaging the blood brain barrier • Blood brain barrier breakdown – Stroke – Brain tumors – Multiple sclerosis – Aging – Alzheimer’s disease
  3. 3. Imaging the blood brain barrier • Computed tomography (CT) – Dynamic perfusion, iodinated contrast • Magnetic resonance imaging (MRI) – Arterial spin labelling (ASL) – Gadolinium-based • Dynamic contrast enhancement (DCE) • Dynamic susceptibility contrast (DSC)
  4. 4. Imaging the blood brain barrier • Positron emission tomography (PET) – FDG – O15 – Amyloid tracers
  5. 5. Divergent or convergent pathologies? • Hippocampal sclerosis? • AD – Amyloid & tau imaging – CSF measures • Other dementias? • Breakthrough technology – can be streamlined for clinical trials and patients in the future

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