The document discusses structural biology related to neurodegeneration, particularly focusing on intrinsically disordered proteins (IDPs) and their roles in processes such as protein folding and assembly. It highlights the concept of liquid-phase transition relevant to myelin membrane assembly and references key studies that explore the phase transition and amyloid-like assembly of myelin basic protein. The research emphasizes the significance of IDPs in dementia and the mechanisms that modulate their functions.

1. 1DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC
Structural Biology in
Neurodegeneration
Markus Zweckstetter
DZNE-Göttingen &
University of Göttingen &
Max Planck Institute for Biophysical Chemistry

2. 2DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC

3. 3DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC
Intrinsically Disordered Proteins
ordered
molten globule disordered

4. 4DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC
IDPs
entropic chains recognition
transient binding permanent binding
display sites chaperones effectorsassemblers scavengers
sites of post-
translational
modifications
assist folding
modulate the
activity of a
partner molecule
assemble
complexes
store small
ligands
Formation of
membrane-less
compartments

5. 5DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC
Liquid-phase transition for myelin membrane
assembly
Aggarwal et al., PLoS Biol 2013 Libich et al.,
Biophys J 2008
Mika Simons

6. 6DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC
Phase transition of myelin basic protein
Aggarwal et al., PLoS Biol 2013

7. 7DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC
Amyloid-like assembly of myelin basic protein
Aggarwal et al.,
PLoS Biol 2013