This document discusses primary immunodeficiencies, which are a group of genetically determined disorders characterized by impaired immune response. It defines several types of primary immunodeficiencies including SCID, XLA, DiGeorge syndrome, Ataxia-teleangectesia, Wiskott-Aldrich syndrome, and CGD. For each, it describes the genetic cause, characteristic infections, clinical features, and available therapies. The document provides an overview of primary immunodeficiencies for educational purposes.
Immunological Disorders can be classified into 3 distinct categories.They are Hypersensitivity, Autoimmunity and Immunodeficiency.Here in this presentation we talk about Immunodeficiency disorders.Get more on our blog : http://dentistryandmedicine.blogspot.com/
Secondary Immunodeficiency
By Dr. Usama Ragab Youssif
Reference: Included in Slides
Include causes of secondary immunodeficiency including AIDS and other viral infections
Immunological Disorders can be classified into 3 distinct categories.They are Hypersensitivity, Autoimmunity and Immunodeficiency.Here in this presentation we talk about Immunodeficiency disorders.Get more on our blog : http://dentistryandmedicine.blogspot.com/
Secondary Immunodeficiency
By Dr. Usama Ragab Youssif
Reference: Included in Slides
Include causes of secondary immunodeficiency including AIDS and other viral infections
IMMUNE RESPONSE TO TUMORS-Humoral immunity
-Cellular Immunity- Failure of Host Defenses
- Evasion of Immune Responses by Tumors
- Cancer Immunosurveillance vs Immunoediting- Immunotherapy
Introduction, causes and symptoms, Mechanism and treatment are been explained about this deadly disease SCID where production of T and B cells is affected.
Prenatal Testing, deteksi kelainan bawaan sejak dalam kandunganHendrik Sutopo
Pengenalan mengenai prenatal diagnosis.
Memberikan gambaran sekilas mengenai cara-cara untuk mengetahui kelainan bawaan sejak janin dalam kandungan.
lebih ditujukan untuk kalangan medis.
Non Invasive Prenatal Testing (NIPT)
IMMUNE RESPONSE TO TUMORS-Humoral immunity
-Cellular Immunity- Failure of Host Defenses
- Evasion of Immune Responses by Tumors
- Cancer Immunosurveillance vs Immunoediting- Immunotherapy
Introduction, causes and symptoms, Mechanism and treatment are been explained about this deadly disease SCID where production of T and B cells is affected.
Prenatal Testing, deteksi kelainan bawaan sejak dalam kandunganHendrik Sutopo
Pengenalan mengenai prenatal diagnosis.
Memberikan gambaran sekilas mengenai cara-cara untuk mengetahui kelainan bawaan sejak janin dalam kandungan.
lebih ditujukan untuk kalangan medis.
Non Invasive Prenatal Testing (NIPT)
Planning is making current decisions in the light of their future effects.
Health planning is a process culminating in decisions regarding the future provisions of health facilities and services to meet health needs of the community.
Immunodeficiency is a state in which the body is incapable of of protecting it from foreign pathogens. It is classified into two categories primary - which can be inherited and secondary - which is caused due to life style factors, drugs, nutrition. Treatments include - antibiotics- to suppress the symptoms , stem transplantation- done to introduce the deficient immune cells. There are many diseases associated with immunodeficiency.
Primary Immunodeficiencies
SEVERE COMBINED IMMUNODEFICIENCY (SCID)
Different causes for SCID
WISKOTT-ALDRICH SYNDROME (WAS)
INTERFERON-GAMMA–RECEPTOR DEFECT
X-LINKED AGAMMAGLOBULINEMIA
X-LINKED HYPER-IgM SYNDROME
COMMON VARIABLE IMMUNODEFICIENCY (CVI)
HYPER-IgE SYNDROME (JOB SYNDROME)
ATAXIA TELANGIECTASIA
Immune Disorders Involving The Thymus
Immunodeficiencies Of The Myeloid Lineage Affect Innate Immunity
Complement Defects Result in Immunodeficiency or Immune-Complex Disease
AIDS and Other Acquired or Secondary Immunodeficiencies
Natural history of disease is a very important concept in Community Medicine. I had prepared this presentation in a very short duration for my class presentaton. There is not a lot of text in the presentation but there is a really good collection of images.
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
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Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
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3. Immunodeficiency
• Immune system’s ability to fight infectious
diseases is completely absent or
compromised.
• Types:
Primary Immunodeficiency
Secondary Immunodeficiency
4. Immunodeficiency
• Cause for Immunodeficiency:
Human Immune system:
Very specific
Dependent on memory of cells and
lymphocytes that recognise foreign antigen
and infected cells respectively.
• Any alterations in these functions
Immunodeficiency.
5. Classification
•Most are genetically
determined
•Less common
•May arise as complications
of cancers, infestations,
malnutrition, or side effects
of immunosuppression,
Irradiation and
chemotherapy.
•More common
Primary
Immunodeficiency
Secondary
Immunodeficiency
6. Primary Immunodeficiencies
• A group of disorders characterized by an
impaired ability to produce normal immune
response.
• Cause: mutations in genes involved in the
development and function of immune organs,
cells, and molecules.
• Genetically determined.
• Usually diseases of infancy & childhood.
7. Primary Immunodeficiency
• Most important feature:
• High Incidence in Males: Why ?
• 6 X-linked ID’s have been
described:
5 - Affect
Lymphocytes
1- Affect
Phagocyte
8.
9. Table 1. Characteristic infections of the primary immunodeficiencies
component primary pathogen primary site clinical example
T-cells
intracellular, bacteria
viruses, protozoa, fungi,
non-specific SCID, DiGeorge
B-cells
pneumococcus,
streptococcus,
haemophilus
lung, skin, CNS
IgG, IgM deficiency
IgG, IgM deficiency
enteric bacteria and
viruses
GI, nasal, eye IgA deficiency
phagocytes
Staphylococcal,
Klebsiella
Pseudomonas,
lung, skin,
regional lymph
node
Chronic
granulomatous
disease (CGD)
complement
neisseria, Haemophilus,
pneumococcus,
streptococcus
CNS
lung
skin
C3, Factors I and H,
late C omponents
10. Severe Combined
Immunodeficiency(SCID)
• Synonyms: Glanzzman-Rinker syndrome,
Bubble Boy Disease, Thymic Alymphoplasia
• Genetic disorder characterised by absence of
T-lymphocytes.
• Impairment of both cellular & humoral
response
• Specific defects in antigen presentation &
functional immune molecules.
12. SCID-Types
• Main Types:
Autosomal recessive (-ve T & B cells)
X-linked recessive(+ve B cells)
• Other important types:
Nezelof Syndrome
SCID associated with ADA & PNP deficiency.
13. Features of SCID
• Absent tonsils
• Small or absent lymph nodes
• Absent thymic shadow
• Lymphopenias
• Decreased Number of T cells
• Severe agammaglobulinemia (Swiss type of
agammaglobulinemia)
• No IG’s usually present
16. Bruton’s X-linked Agammaglobuinemia
• Primarily B-cell defect
• Boys-more affected
• Severe reduction in γ-globulins
• IG’s, circulating and marrow B-cells.
• Probable cause: Molecular defect at
Xq22.Mutation of bruton tyrosine kinase.
• Therapy: IV IG’s.
17. DiGeorge’s syndrome
• Also called thymic hypoplasia
• Congenital disorder
• Abnormalities in structure derived from 3rd
and 4th pharyngeal pouches
• Predominantly T cell defect
• Charactersitics: Neonatal tetany(absence of
parathyroid)
• Therapy: Thymic transplants
18. • Cleft palate
• Antimongoloid eyes
• Short philtrum with
fish-mouth appearance ,
• Micrognathia
• Low set pixie-like ears
• Short palpebral fissures
Facial features of children with DiGeorge syndrome
26. Chronic Granulomatous Disease
• Incidence:1:10,00,000
• Defect: Inability of phagocytes to produce
superoxide ineffective reduction of O2.
• Failure to express respiratory burst associated
with phagocytosis.
• Central necrosis and granulomatoid response
in lung, liver, bone , skin and lymph nodes.
• Presence of numerous pigmented
macrophages.