Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease that can affect many different organs in the body. It is more common in women, especially African American women of childbearing age. The cause is largely unknown but genetic and environmental factors are believed to play a role. Diagnosis is based on clinical criteria including symptoms like arthritis, rashes, and involvement of organs like the kidneys or brain. Treatment involves managing symptoms with medications like NSAIDs, steroids, and immunosuppressants. Prognosis is generally good if major organ dysfunction can be prevented or treated, though risks like infection and lymphoma remain. Early diagnosis and management are important to optimize outcomes for patients with SLE.
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease. The immune system attacks the body’s cell and tissue, resulting in inflammation and tissue damage. SLE can affect any part of the body, but most often harms the heart, joints, skin, lungs, blood vessels, liver, kidney and nervous system.
Over 40 different genes predispose to SLE.
Characterized by remission and exacerbation.
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease. The immune system attacks the body’s cell and tissue, resulting in inflammation and tissue damage. SLE can affect any part of the body, but most often harms the heart, joints, skin, lungs, blood vessels, liver, kidney and nervous system.
Over 40 different genes predispose to SLE.
Characterized by remission and exacerbation.
SLE still an enigma where both patient and health care professionals are blind and do more harm than saving the patient. Hope in future anything can be done to save the patient from the grip of lupus,
this research is made by a dental student (me) under supervision of our oral medicine specialist dr. muhassad almudhafer and this research is collected from several articles hope u like it
this my email if u would like to contact me - mnmmnz4503.mm@gmail.com
Recent advances in diagnosis & management of SLEShadab Ahmad
Systemic lupus erythematosus (SLE) is an autoimmune disease in which organs and cells undergo damage mediated by tissue binding autoantibodies and immune complexes.
90 % of patients at diagnosis are women of childbearing age groups.
Highest prevalence is in black women and lowest is in white men.
SLE still an enigma where both patient and health care professionals are blind and do more harm than saving the patient. Hope in future anything can be done to save the patient from the grip of lupus,
this research is made by a dental student (me) under supervision of our oral medicine specialist dr. muhassad almudhafer and this research is collected from several articles hope u like it
this my email if u would like to contact me - mnmmnz4503.mm@gmail.com
Recent advances in diagnosis & management of SLEShadab Ahmad
Systemic lupus erythematosus (SLE) is an autoimmune disease in which organs and cells undergo damage mediated by tissue binding autoantibodies and immune complexes.
90 % of patients at diagnosis are women of childbearing age groups.
Highest prevalence is in black women and lowest is in white men.
Systemic Lupus erythematous , is world wide health problem
Here we talk about criteria for diagnosis investigation , Management and complication
With some scenarios to about disease and complication
Rheumatology MCQs Practice questions with explanationDr. Almas A
Topic: Rheumatology
Exam type: MCQs Practice questions
Q. A 26-year-old female presented to ER with dry cough and shortness of breath and often complains of chest pain. Chest x-ray shows bilateral hilar lymphadenopathy. Which of the following will indicate that the patient suffers from sarcoidosis?
Q: A 50-year-old female presents to ER with dyspnea on exertion and orthopnea, red painful eyes. She complains of chronic dull pain in the gluteal region for the last 5 years and stiffness in the lower back that wakes her up in the morning. X-ray spine reveals squaring of vertebrae with bone spur formation. On MRI sacroiliitis is seen. Which of the following is the most likely diagnosis?
Q: A 60-year-old female presents in OPD with knee joint stiffness in the morning and increases with activity and decreases on rest. She also complains about a crackling noise on joint movement. X-ray shows narrowing of the joint space and osteophytes. Which of the following treatments is recommended in this patient?
Q: A 70-year-old female presented to ER with swelling of knee joint and severe pain. Arthrocentesis revealed rhomboid-shaped crystals that stained deeply blue with H&E stain, and show weak positive birefringence on light microscopy. X-ray reveals chondrocalcinosis. Which of the following statements is true?
Q: A 40-year-old female comes to OPD with dry eyes and dyspareunia for the last 6 months. She also complains of cough and fatigue with joint pains. On examination, her parotid gland was enlarged and laboratory tests revealed anti-Ro antibodies are positive. Which of the following tests is recommended to this patient?
Dr Richard Schloeffel - Chronic Fatigue Syndrome Diagnosis and TreatmentPeer Support Network
Emerge Australia seminar 13 September 2014.
Dr Richard Schloeffel graduated in 1978 from NSW Uni with post -graduate training in isolated rural general practice. He worked in country practices for thirteen years and spent five years working in the developing world, including Papua New Guinea, China, India, Bali and Eastern Europe. For the last twenty years He has been the principal at ‘Pymble Grove Health Centre’ where he has been treating and specializing in complex and chronic disorders with an integrative team of practitioners.
This broad experience has been invaluable in developing the diagnosis and treatment of chronic disorders and the ability to look beyond the existing paradigms to a deeper and more profound understanding of complex disease, particularly Chronic Fatigue Syndrome, Borreliosis and its co-infections and Auto Immune Disease.
Dr Schloeffel has treated over three and a half thousand patients with Chronic Fatigue Syndrome and related disorders, refining diagnosis and appropriate investigations and management protocols. He has lectured widely on CFS and is currently undertaking research at Sydney University into Australian Lyme Disease.
The term ‘lupus’ (Latin for ‘wolf’) was first used during the Middle Ages to describe erosive skin lesions evocative of a ‘wolf’s bite’.
Lupus is an autoimmune disease, which means that the body's natural defense system (immune system) attacks its own tissues instead of attacking foreign substances like bacteria and viruses. This causes inflammation which can causes swelling, pain, and tissue damage throughout the body.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. OUTLINE
• Introduction and Definition
• Epidemiology
• Pathogenesis
• Aetiology
• Pathology
• Clinical features and Diagnosis
• Investigations
• Treatment
• Course and Prognosis
• Conclusion
3. Introduction
• ‘Lupus’ in Latin means wolf. This term was used in
the middle ages to describe erosive skin lesions
evocative of a wolf’s bite.
• In 1846, Viennese Physician, Ferdinand Von
Hebra introduced the term ‘butterfly rash’ and was
the first to use the name Lupus erythematosus.
• Many other physicians have since discovered and
named various conditions associated with the
disease.
4. Definition
• SLE is an inflammatory, multisystem disorder with
arthralgia and rashes as the commonest clinical
features and cerebral/renal disease as the most
serious problem.
5. Epidemiology
• Prevalence rates in the USA is about 10-400 per
100000.
• Common in African-American women
• Disease is 9 times more common in women than
in men
• Peak age is between 20 and 40 years (women in
their fertile years).
6. Pathogenesis
• 1. Ineffective Phagocytosis of apoptotic cells.
• 2. Breakdown in tolerance ( B cells and T cells
destroy self cells).
• There is therefore sustained production of auto
antibodies and immune complexes that bind
tissues.
• There is complement activation and release of
cytokines, vasoactive peptides, destructive
enzymes and development of chronic
inflammation, causing tissue damage.
7. Aetiology
• Cause is largely unknown. A number of
predisposing factors have however been
implicated;
1. Heredity: Higher concordance rates among
monozygotics (25%), than dizygotics (3%). First
degree relatives have a 3% chance of developing
disease.
2. Genetics: Associations with HLA genes-
HLADRB1, HLA A1, B8 and DR3.
8. 3. Homozygous deficiencies of complement genes-
c1q, c2 or c4.
4. Sex hormone status- commoner in pre-
menopausal women, women who use oestrogen
containing oral contraceptives or women on
hormone replacement therapies.
5. Klinefelter syndrome(XXY), TREX-1, STAT4
CTLA4.
9. • 6.UV light
• 7. EBV infection
• 8. Tobacco smoking
• 9. Drugs- Hydralazine, procainamide, isoniazid,
penicillamine; here, the CNS and Kidneys are
usually not affected.
10. Autoantibodies present in SLE:
1. ANA 6. Anti-phospholipid
2. Anti dsDNA 7. Anti-RNP
3. Anti sm 8. Anti-histone
4. Anti-Ro 9.Anti c1q
5. Anti-La 10. Anti-ribosomal P
11. Pathology
• Biopsies of skin and kidneys reveal igG antibodies
and complement deposition with influx of T
lymphocytes and neutrophils.
12. Clinical features
1. General features: Fever, severe fatigue, weight
loss.
2. Joints and Muscle symptoms: In more than
90% of patients.
-Symmetrical small joint arthralgia ( hands,
wrists) and Knees and sometimes arthritis.
-Myalgia
13. 3. Mucocutaneous Manifestations:
-Butterfly rash
-Photosensitivity
-Discoid rash
-Vasculitic lesions in finger tips,around the nailfolds,
purpura and urticaria.
Livedo reticularis
14. - Palmar and plantar rashes
- Scarring alopecia
- Oral and nasal ulcerations
4. Lungs: - Recurrent pleurisy
-Pleural effusions
-Pneumonitis
-Atelectasis
-Restrictive lung disease in few cases
18. 11. Ocular: - Sicca
- Episcleritis
- Conjuctivitis
- Retinal vasculitis
- Optic neuritis
* Keep in mind the effects of glucocorticoid treatment
19. 12. Lupus and Pregnancy: Recurrent abortions in
those with the antiphospholipid antibody.
-Congenital heart block esp. with anti Ro.
-Teratogenic potential of warfarin and
cyclophosphamide.
- Preterm birth risk associated with high dose
steroids.
25. • 4 or more of the above, well documented, and
present at any time in a patient’s history is
required to make a diagnosis.
• The diagnosis is based on characteristic clinical
findings and the presence of autoantibodies.
• When a diagnosis is made, it is important to
establish the severity and potential reversibility of
symptoms and to establish the possible
consequences of various therapeutic
interventions.
26. Investigations
1. FBC, ESR and CRP
2. Urinalysis
3. BUE+Cr
4. Autoantibodies
5. C3, C4
6. Renal biopsy
7. ***CT scan head if need be to rule out other CNS
causes.
28. Severity Assessment
1. SLEDAI score: Asseses the presence of a mild or
moderate and Severe flares.
2. SLICC/ACR Damage Index for SLE.
29. Management
• There is no cure.
1. General measures: -Discuss with patient the
disfiguring effects of cutaneous and the debility
associated with fatigue.
- Avoid UV/sunlight exposure
- Reduce cardiovascular risk factors
30. Symptomatic treatment
1. Athralgia, arthritis fever – NSAIDs bearing in mind
renal function.
If severe, low dose steroids by mouth and
hydroxychloroquine.
2. Cutaneous lesions- mild potency steroids for face,
mid to high potency for other areas, consider sunscreens;
Low dose oral steroids, hydroxychloroquine can be used.
31. 3. Serositis- Moderate dose steroids, Azathioprine or
mycophenolate.
4. Renal problems-
Class I, II- Low dose steroids
Class III,IV- these are the active stages and require
aggressive management to allow remission.
-Induction with high dose steroids and cyclophosphamide
-Maintenance with Azathioprine or Mycophenolate
32. Class V- ACEI, Steroids, consider other DMARDs
Class VI- Dialysis or Transplantation
5. CNS problems- Require induction and
maintenance medications as in Renal problems.
33. 6. Haematological problems-
Severe haemolytic anaemia is treated initially with
high dose IV Methylprednisolone 1g/day for 3 days.
Severe thrombocytopaenia may also require IV
methylprednisolone.
34. Course and Prognosis
• Prognosis is good in the absence of major organ
dysfunction.
• There is a long term risk of Lymphoma.
35. Conclusion
• SLE diagnosis at an early stage is crucial to
ensuring favourable prognosis.
• There is no exact cure, symptoms can however be
managed.
• Refer early for rheumatological consult.
• Educate patients on the various possible
complications of the disease and its treatment,
and especially pregnant women on the possible
effects on pregnancy.