lowest heart rate
lowest mean arterial pressure
estimated blood loss
A score built from these 3 predictors has proved strongly predictive of the risk of major postoperative complications and death in general and vascular surgery
This document discusses various types of chest injuries including blunt injuries, penetrating injuries, crush injuries, and inhalation burns. It covers the mechanisms, clinical features, investigations, and management of different chest traumas. Specific injuries discussed in more detail include tension pneumothorax, open pneumothorax, cardiac tamponade, and massive hemothorax which require immediate intervention due to their life-threatening nature. The document emphasizes the importance of airway management, oxygenation, and treatment of associated injuries in chest trauma patients.
This document provides information on perioperative management of patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). It discusses physiological changes during HIPEC including increased heart rate and venous pressure, decreased tissue oxygenation, and coagulopathy. It outlines selection criteria for CRS/HIPEC and important preoperative assessments. Intraoperatively, there are massive fluid shifts, blood loss, electrolyte imbalances, and temperature regulation challenges. Postoperatively, complications can include hypovolemia, bowel issues, bleeding, and infections. Close monitoring of fluids, hemodynamics, coagulation, nutrition, and other parameters is important for critical care management after CRS/H
This document discusses fetal surgery techniques and criteria. It outlines various prenatal interventions that can be performed including transplacental treatments, needle-based procedures, fetoscopic surgeries, and open repairs. Fetal surgery is performed to treat conditions where prenatal diagnosis is possible, the natural history is known, and there are no effective postnatal treatments. Interventions are done in specialized centers according to strict protocols and ethics approval. Examples of conditions treated include spina bifida, twin-twin transfusion syndrome (TTTS), and lower urinary tract obstruction (LUTO). The document presents data from trials demonstrating improved outcomes for fetal surgery compared to postnatal care for conditions like myelomeningocele (MMC).
This document discusses mitral stenosis in pregnancy. It begins by introducing mitral stenosis and its prevalence as a cause of maternal death in India. It then discusses the physiological cardiovascular changes that occur during pregnancy, labor, and the postpartum period. Several sections describe the pathophysiology of mitral stenosis and how it impacts hemodynamics during pregnancy. The document outlines methods for diagnosing and grading the severity of mitral stenosis, as well as predicting mortality and morbidity risks. General management approaches are discussed including medical, surgical, and obstetrical options. The goals of anesthetic management during delivery are provided. In summary, this document provides an overview of mitral stenosis in pregnancy, including its effects, diagnostic evaluation, severity grading
Artificial intelligence in anesthesiology by dr tushar chokshi dr tushar chokshi
The document provides an overview of current and future applications of artificial intelligence (AI) in the field of anesthesiology. It discusses how AI is currently used for tasks like pre-anesthesia checkups, operating room monitoring and control, and teleanesthesia. It predicts that in the future, AI will allow anesthesiologists to control operating room devices and monitors using voice commands. AI may also help automate some cognitive tasks but dexterous tasks will still require human anesthesiologists. While AI can reduce some errors, it is unlikely to fully replace anesthesiologists as complex clinical decision making will still need human judgment.
the
head
of
the
bed
to
30
degrees.
The document discusses anesthesia considerations for trauma patients. It notes that trauma is a leading cause of death worldwide and anesthesiologists are involved in trauma care from the emergency department through the operating room and intensive care unit. Anesthesia for trauma patients differs from routine cases as they often present off-hours, with limited information, multiple injuries requiring complex procedures. The document outlines priorities for trauma care including the ABCDE approach, indications for intubation, approaches to intubation, and prophylaxis against aspiration given trauma patients' risk of full stomachs.
This document discusses various types of chest injuries including blunt injuries, penetrating injuries, crush injuries, and inhalation burns. It covers the mechanisms, clinical features, investigations, and management of different chest traumas. Specific injuries discussed in more detail include tension pneumothorax, open pneumothorax, cardiac tamponade, and massive hemothorax which require immediate intervention due to their life-threatening nature. The document emphasizes the importance of airway management, oxygenation, and treatment of associated injuries in chest trauma patients.
This document provides information on perioperative management of patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). It discusses physiological changes during HIPEC including increased heart rate and venous pressure, decreased tissue oxygenation, and coagulopathy. It outlines selection criteria for CRS/HIPEC and important preoperative assessments. Intraoperatively, there are massive fluid shifts, blood loss, electrolyte imbalances, and temperature regulation challenges. Postoperatively, complications can include hypovolemia, bowel issues, bleeding, and infections. Close monitoring of fluids, hemodynamics, coagulation, nutrition, and other parameters is important for critical care management after CRS/H
This document discusses fetal surgery techniques and criteria. It outlines various prenatal interventions that can be performed including transplacental treatments, needle-based procedures, fetoscopic surgeries, and open repairs. Fetal surgery is performed to treat conditions where prenatal diagnosis is possible, the natural history is known, and there are no effective postnatal treatments. Interventions are done in specialized centers according to strict protocols and ethics approval. Examples of conditions treated include spina bifida, twin-twin transfusion syndrome (TTTS), and lower urinary tract obstruction (LUTO). The document presents data from trials demonstrating improved outcomes for fetal surgery compared to postnatal care for conditions like myelomeningocele (MMC).
This document discusses mitral stenosis in pregnancy. It begins by introducing mitral stenosis and its prevalence as a cause of maternal death in India. It then discusses the physiological cardiovascular changes that occur during pregnancy, labor, and the postpartum period. Several sections describe the pathophysiology of mitral stenosis and how it impacts hemodynamics during pregnancy. The document outlines methods for diagnosing and grading the severity of mitral stenosis, as well as predicting mortality and morbidity risks. General management approaches are discussed including medical, surgical, and obstetrical options. The goals of anesthetic management during delivery are provided. In summary, this document provides an overview of mitral stenosis in pregnancy, including its effects, diagnostic evaluation, severity grading
Artificial intelligence in anesthesiology by dr tushar chokshi dr tushar chokshi
The document provides an overview of current and future applications of artificial intelligence (AI) in the field of anesthesiology. It discusses how AI is currently used for tasks like pre-anesthesia checkups, operating room monitoring and control, and teleanesthesia. It predicts that in the future, AI will allow anesthesiologists to control operating room devices and monitors using voice commands. AI may also help automate some cognitive tasks but dexterous tasks will still require human anesthesiologists. While AI can reduce some errors, it is unlikely to fully replace anesthesiologists as complex clinical decision making will still need human judgment.
the
head
of
the
bed
to
30
degrees.
The document discusses anesthesia considerations for trauma patients. It notes that trauma is a leading cause of death worldwide and anesthesiologists are involved in trauma care from the emergency department through the operating room and intensive care unit. Anesthesia for trauma patients differs from routine cases as they often present off-hours, with limited information, multiple injuries requiring complex procedures. The document outlines priorities for trauma care including the ABCDE approach, indications for intubation, approaches to intubation, and prophylaxis against aspiration given trauma patients' risk of full stomachs.
The document discusses Enhanced Recovery After Surgery (ERAS) protocols. It describes how ERAS aims to reduce surgical stress on patients through multimodal perioperative care, facilitating early recovery. This includes optimizations in pre-, intra-, and postoperative care such as shortened fasting times, carbohydrate loading, minimized fluid administration, and early mobilization. The document provides examples of procedures that can be done as day surgeries and details the key elements of ERAS protocols.
This document discusses pregnancy and surgery, specifically addressing whether they can safely mix. It notes that around 0.75-2% of pregnancies involve surgery. The most common surgeries are appendectomy, cholecystectomy, adnexal disease procedures, and trauma procedures. It reviews important physiologic changes in pregnancy and rates of complications from surgery. It discusses fetal hazards, principles of teratology, and implications for anesthetizing pregnant patients. It provides FDA categories and reviews effects of specific anesthetic agents. The document emphasizes using minimal effective doses of historically safe drugs and avoiding maternal hypotension, hypoxia, and hypercarbia.
its sometime difficult to decide in urgent clinical scenarios - Trauma,active bleeding, surgery: What ; when ; how and why to transfuse? answering some of these queries here is my presentation especially made for PG students (will help in answer writing)
This document discusses static and dynamic indices used for hemodynamic monitoring. Static indices like CVP and PAOP are poor predictors of fluid responsiveness. Only about 50% of critically ill patients are fluid responsive. Dynamic indices that measure the response of cardiac output to fluid challenges or changes in preload are better predictors. The passive leg raise test is a non-invasive dynamic index that can reliably assess fluid responsiveness. Dynamic monitoring allows for goal-directed fluid therapy to optimize cardiac preload while avoiding over-resuscitation.
Prenatal surgery, also known as fetal surgery, involves performing surgery on a fetus while still in the womb. It can treat certain birth defects to prevent or lessen health issues. Fetal surgery has advanced from open fetal procedures to minimally invasive techniques using fetoscopy or fetal image-guided interventions. Conditions commonly treated include congenital diaphragmatic hernia, lower urinary tract obstructions, cystic adenomatoid malformation, and twin-twin transfusion syndrome. Fetal surgery requires a multidisciplinary team and careful patient selection due to risks of preterm birth and other maternal-fetal complications. Outcomes are continually improving as the field further develops new techniques and treatments.
This document discusses classification and pathophysiology of traumatic brain injury (TBI). It defines TBI and provides epidemiological data on incidence and causes. It describes several classification systems that categorize TBI based on mechanism, location, severity and other factors. It then explains the primary and secondary pathophysiological changes that occur following TBI, including disruption of autoregulation, increased intracranial pressure, blood-brain barrier breakdown, cellular metabolic changes, free radical production and more. Potential therapeutic strategies are also briefly mentioned.
Diagnostic evaluation of the infertile femaleAsaad Hashim
This document provides an overview of the diagnostic evaluation process for an infertile female. It discusses the typical causes of female infertility, including ovulatory disorders, endometriosis, pelvic adhesions, and tubal blockage. The evaluation involves assessing the reproductive axis through history, physical exam, tests of ovarian reserve, ovulation, tubal patency, and detection of uterine or peritoneal abnormalities. Common tests include hormonal assays, ultrasound, hysterosalpingography, laparoscopy, and semen analysis of the male partner. The goal is to identify any treatable causes of infertility and guide treatment decisions.
This document discusses various methods for estimating blood loss and determining when blood transfusions are needed. It notes that visual inspection and clinical estimates typically underreport blood loss by 30-40%. Other estimation methods include changes in vital signs, urine output, weighing blood-soaked materials, and using the hemodilution or percentage method to calculate allowable blood loss based on patient condition and initial hematocrit. Training programs are recommended to help clinicians more accurately estimate blood loss amounts.
Due to stretching forces placed on individual nerve cells
Pathology distributed throughout brain
Types
Concussion
Diffuse Axonal Injury (Moderate to Severe)
1) Visual inspection and clinical estimation of blood loss is typically inaccurate, with blood loss often being underestimated by 30-50%.
2) Critical blood loss occurs over 2000cc, but blood loss is almost always underestimated by the time a patient shows signs of hypotension and shock.
3) Methods to more accurately assess blood loss include weighing blood soaked materials, measuring changes in hematocrit levels using formulas to calculate actual blood loss, and transfusing blood unit by unit while reevaluating the patient's condition between each unit.
Vaginal and intramuscular progesterone are both effective for luteal phase support in IVF, but vaginal administration is preferred. Several studies found comparable pregnancy and live birth rates between vaginal and intramuscular progesterone. Vaginal progesterone increases endometrial tissue levels while intramuscular progesterone results in higher serum levels. However, vaginal administration has better patient compliance and fewer side effects than intramuscular injections.
This document discusses various methods of labor analgesia. It begins by outlining the objectives and introducing the stages of labor and physiology of pain. It then summarizes non-pharmacological methods like psychoprophylaxis and TENS. Various pharmacological methods are discussed including inhalational analgesia, systemic opioids, and regional techniques like epidural analgesia, combined spinal epidural, and walking epidural. Epidural analgesia is described as the gold standard, and optimal epidural regimens, administration techniques, and monitoring are outlined.
This document provides an overview of several ICU scoring systems used to evaluate severity of illness and predict outcomes in critically ill patients. It describes the components and scoring of systems such as APACHE, SAPS, SOFA, MODS, and LODS. APACHE uses physiological variables and chronic health factors to calculate mortality risk. SAPS and SAPS II similarly assess physiology but also include age and admission type. SOFA evaluates degree of organ dysfunction in six organ systems. MODS and LODS also score dysfunction across multiple organ systems based on laboratory and clinical findings.
1) Chest injuries account for 20-25% of all trauma deaths and are a leading cause of death worldwide. Life-threatening conditions include tension pneumothorax, open pneumothorax, massive hemothorax, flail chest, and cardiac tamponade.
2) Tension pneumothorax requires immediate needle decompression without waiting for imaging if suspected clinically. Open pneumothorax is managed with an occlusive dressing.
3) Flail chest involves fractures of 3 or more ribs in two places, leading to paradoxical chest wall movement and impaired ventilation. Massive hemothorax involves over 1.5L of blood drained by chest tube or more than 200cc/hour
Pharmacological agents in obs and placental transfer of drugs krishna dhakal
This presentation discusses pharmacological agents used in obstetrics and their placental transfer. It begins by reviewing the basic mechanisms of placental drug transfer and factors that affect maternal to fetal drug transfer. It then reviews various anesthetic agents and other drugs used in obstetrics, including their placental transfer properties and anesthetic implications. The presentation concludes by reviewing oxytocics that stimulate uterine contraction.
Massive transfusion protocols aim to standardize the resuscitation of patients experiencing severe bleeding through the early administration of blood products. The key aspects of such protocols discussed in the document include:
- Definitions of massive transfusion as the replacement of over 50% of total blood volume within 3-4 hours or transfusion of over 10 units of packed red blood cells within 24 hours.
- Common clinical conditions requiring massive transfusion include severe trauma, ruptured aortic aneurysms, and obstetric or surgical complications.
- Current concepts favor permissive hypotension and minimal crystalloid resuscitation to control bleeding before aggressively restoring blood pressure and volume.
- Blood products administered according to protocols include packed red blood
This document discusses critical care for obstetric patients. It begins with an introduction and epidemiology section noting that while the proportion of obstetric patients in ICUs is low, the most common reasons for admission are postpartum hemorrhage and hypertensive disorders. It then covers obstetric critical care, basic principles for obstetric emergencies, transfer to critical care settings, the role of obstetricians, resuscitative hysterotomy, and supportive care. It provides recommendations including prioritizing maternal stabilization, consulting obstetricians, and not withholding necessary treatments due to fetal concerns. The document aims to guide management of critically ill obstetric patients.
1. Proper patient positioning is important to provide optimal surgical exposure, maintain physiologic safety, and prevent injuries.
2. Various positions like supine, lateral, lithotomy and prone were discussed along with their physiologic effects and pressure points.
3. Prolonged pressure on nerves from improper positioning can lead to neuropathies. Regular assessment of pressure points and changing position is recommended to prevent injuries.
Advances in the field of labour analgesia have tread a long journey from the days of ether and chloroform in 1847 to the present day practice of comprehensive programme of labour pain management using evidence-based medicine. Newer advances include introduction of newer techniques like combined spinal epidurals, low-dose epidurals facilitating ambulation, pharmacological advances like introduction of remifentanil for patient-controlled intravenous analgesia, introduction of newer local anaesthetics and adjuvants like ropivacaine, levobupivacaine, sufentanil, clonidine and neostigmine, use of inhalational agents like sevoflourane for patient-controlled inhalational analgesia using special vaporizers, all have revolutionized the practice of pain management in labouring parturients.
Massive obstetric haemorrhage is a leading cause of maternal mortality. It can occur without warning at any stage of pregnancy or childbirth. Early recognition and treatment is essential to prevent severe blood loss. A multidisciplinary team approach is needed to resuscitate the mother and determine the source of bleeding to apply appropriate medical or surgical interventions.
The document discusses different types of injections including intravenous, intramuscular, subcutaneous and intradermal injections. It defines injections, lists the rights of medication administration, and outlines the general preparation, equipment, sites, and procedures for various injections. The purpose is to educate students on properly administering different injections and ensuring medication safety.
Journal club on Correlation of APGAR Score with Asphyxial Hepatic Injury and ...Shubhra Paul
This study evaluated the correlation between APGAR scores and hepatic injury/mortality in newborns in India. Researchers measured liver enzyme levels in 70 asphyxiated newborns and 30 controls on days 1, 3, and 10. Asphyxiated newborns had significantly higher liver enzyme levels than controls, especially those with severe asphyxia (APGAR 0-3). Mortality and deranged liver functions were significantly correlated with lower APGAR scores. The study found APGAR is a useful indicator for predicting hepatic injury and mortality in asphyxiated newborns.
The document discusses Enhanced Recovery After Surgery (ERAS) protocols. It describes how ERAS aims to reduce surgical stress on patients through multimodal perioperative care, facilitating early recovery. This includes optimizations in pre-, intra-, and postoperative care such as shortened fasting times, carbohydrate loading, minimized fluid administration, and early mobilization. The document provides examples of procedures that can be done as day surgeries and details the key elements of ERAS protocols.
This document discusses pregnancy and surgery, specifically addressing whether they can safely mix. It notes that around 0.75-2% of pregnancies involve surgery. The most common surgeries are appendectomy, cholecystectomy, adnexal disease procedures, and trauma procedures. It reviews important physiologic changes in pregnancy and rates of complications from surgery. It discusses fetal hazards, principles of teratology, and implications for anesthetizing pregnant patients. It provides FDA categories and reviews effects of specific anesthetic agents. The document emphasizes using minimal effective doses of historically safe drugs and avoiding maternal hypotension, hypoxia, and hypercarbia.
its sometime difficult to decide in urgent clinical scenarios - Trauma,active bleeding, surgery: What ; when ; how and why to transfuse? answering some of these queries here is my presentation especially made for PG students (will help in answer writing)
This document discusses static and dynamic indices used for hemodynamic monitoring. Static indices like CVP and PAOP are poor predictors of fluid responsiveness. Only about 50% of critically ill patients are fluid responsive. Dynamic indices that measure the response of cardiac output to fluid challenges or changes in preload are better predictors. The passive leg raise test is a non-invasive dynamic index that can reliably assess fluid responsiveness. Dynamic monitoring allows for goal-directed fluid therapy to optimize cardiac preload while avoiding over-resuscitation.
Prenatal surgery, also known as fetal surgery, involves performing surgery on a fetus while still in the womb. It can treat certain birth defects to prevent or lessen health issues. Fetal surgery has advanced from open fetal procedures to minimally invasive techniques using fetoscopy or fetal image-guided interventions. Conditions commonly treated include congenital diaphragmatic hernia, lower urinary tract obstructions, cystic adenomatoid malformation, and twin-twin transfusion syndrome. Fetal surgery requires a multidisciplinary team and careful patient selection due to risks of preterm birth and other maternal-fetal complications. Outcomes are continually improving as the field further develops new techniques and treatments.
This document discusses classification and pathophysiology of traumatic brain injury (TBI). It defines TBI and provides epidemiological data on incidence and causes. It describes several classification systems that categorize TBI based on mechanism, location, severity and other factors. It then explains the primary and secondary pathophysiological changes that occur following TBI, including disruption of autoregulation, increased intracranial pressure, blood-brain barrier breakdown, cellular metabolic changes, free radical production and more. Potential therapeutic strategies are also briefly mentioned.
Diagnostic evaluation of the infertile femaleAsaad Hashim
This document provides an overview of the diagnostic evaluation process for an infertile female. It discusses the typical causes of female infertility, including ovulatory disorders, endometriosis, pelvic adhesions, and tubal blockage. The evaluation involves assessing the reproductive axis through history, physical exam, tests of ovarian reserve, ovulation, tubal patency, and detection of uterine or peritoneal abnormalities. Common tests include hormonal assays, ultrasound, hysterosalpingography, laparoscopy, and semen analysis of the male partner. The goal is to identify any treatable causes of infertility and guide treatment decisions.
This document discusses various methods for estimating blood loss and determining when blood transfusions are needed. It notes that visual inspection and clinical estimates typically underreport blood loss by 30-40%. Other estimation methods include changes in vital signs, urine output, weighing blood-soaked materials, and using the hemodilution or percentage method to calculate allowable blood loss based on patient condition and initial hematocrit. Training programs are recommended to help clinicians more accurately estimate blood loss amounts.
Due to stretching forces placed on individual nerve cells
Pathology distributed throughout brain
Types
Concussion
Diffuse Axonal Injury (Moderate to Severe)
1) Visual inspection and clinical estimation of blood loss is typically inaccurate, with blood loss often being underestimated by 30-50%.
2) Critical blood loss occurs over 2000cc, but blood loss is almost always underestimated by the time a patient shows signs of hypotension and shock.
3) Methods to more accurately assess blood loss include weighing blood soaked materials, measuring changes in hematocrit levels using formulas to calculate actual blood loss, and transfusing blood unit by unit while reevaluating the patient's condition between each unit.
Vaginal and intramuscular progesterone are both effective for luteal phase support in IVF, but vaginal administration is preferred. Several studies found comparable pregnancy and live birth rates between vaginal and intramuscular progesterone. Vaginal progesterone increases endometrial tissue levels while intramuscular progesterone results in higher serum levels. However, vaginal administration has better patient compliance and fewer side effects than intramuscular injections.
This document discusses various methods of labor analgesia. It begins by outlining the objectives and introducing the stages of labor and physiology of pain. It then summarizes non-pharmacological methods like psychoprophylaxis and TENS. Various pharmacological methods are discussed including inhalational analgesia, systemic opioids, and regional techniques like epidural analgesia, combined spinal epidural, and walking epidural. Epidural analgesia is described as the gold standard, and optimal epidural regimens, administration techniques, and monitoring are outlined.
This document provides an overview of several ICU scoring systems used to evaluate severity of illness and predict outcomes in critically ill patients. It describes the components and scoring of systems such as APACHE, SAPS, SOFA, MODS, and LODS. APACHE uses physiological variables and chronic health factors to calculate mortality risk. SAPS and SAPS II similarly assess physiology but also include age and admission type. SOFA evaluates degree of organ dysfunction in six organ systems. MODS and LODS also score dysfunction across multiple organ systems based on laboratory and clinical findings.
1) Chest injuries account for 20-25% of all trauma deaths and are a leading cause of death worldwide. Life-threatening conditions include tension pneumothorax, open pneumothorax, massive hemothorax, flail chest, and cardiac tamponade.
2) Tension pneumothorax requires immediate needle decompression without waiting for imaging if suspected clinically. Open pneumothorax is managed with an occlusive dressing.
3) Flail chest involves fractures of 3 or more ribs in two places, leading to paradoxical chest wall movement and impaired ventilation. Massive hemothorax involves over 1.5L of blood drained by chest tube or more than 200cc/hour
Pharmacological agents in obs and placental transfer of drugs krishna dhakal
This presentation discusses pharmacological agents used in obstetrics and their placental transfer. It begins by reviewing the basic mechanisms of placental drug transfer and factors that affect maternal to fetal drug transfer. It then reviews various anesthetic agents and other drugs used in obstetrics, including their placental transfer properties and anesthetic implications. The presentation concludes by reviewing oxytocics that stimulate uterine contraction.
Massive transfusion protocols aim to standardize the resuscitation of patients experiencing severe bleeding through the early administration of blood products. The key aspects of such protocols discussed in the document include:
- Definitions of massive transfusion as the replacement of over 50% of total blood volume within 3-4 hours or transfusion of over 10 units of packed red blood cells within 24 hours.
- Common clinical conditions requiring massive transfusion include severe trauma, ruptured aortic aneurysms, and obstetric or surgical complications.
- Current concepts favor permissive hypotension and minimal crystalloid resuscitation to control bleeding before aggressively restoring blood pressure and volume.
- Blood products administered according to protocols include packed red blood
This document discusses critical care for obstetric patients. It begins with an introduction and epidemiology section noting that while the proportion of obstetric patients in ICUs is low, the most common reasons for admission are postpartum hemorrhage and hypertensive disorders. It then covers obstetric critical care, basic principles for obstetric emergencies, transfer to critical care settings, the role of obstetricians, resuscitative hysterotomy, and supportive care. It provides recommendations including prioritizing maternal stabilization, consulting obstetricians, and not withholding necessary treatments due to fetal concerns. The document aims to guide management of critically ill obstetric patients.
1. Proper patient positioning is important to provide optimal surgical exposure, maintain physiologic safety, and prevent injuries.
2. Various positions like supine, lateral, lithotomy and prone were discussed along with their physiologic effects and pressure points.
3. Prolonged pressure on nerves from improper positioning can lead to neuropathies. Regular assessment of pressure points and changing position is recommended to prevent injuries.
Advances in the field of labour analgesia have tread a long journey from the days of ether and chloroform in 1847 to the present day practice of comprehensive programme of labour pain management using evidence-based medicine. Newer advances include introduction of newer techniques like combined spinal epidurals, low-dose epidurals facilitating ambulation, pharmacological advances like introduction of remifentanil for patient-controlled intravenous analgesia, introduction of newer local anaesthetics and adjuvants like ropivacaine, levobupivacaine, sufentanil, clonidine and neostigmine, use of inhalational agents like sevoflourane for patient-controlled inhalational analgesia using special vaporizers, all have revolutionized the practice of pain management in labouring parturients.
Massive obstetric haemorrhage is a leading cause of maternal mortality. It can occur without warning at any stage of pregnancy or childbirth. Early recognition and treatment is essential to prevent severe blood loss. A multidisciplinary team approach is needed to resuscitate the mother and determine the source of bleeding to apply appropriate medical or surgical interventions.
The document discusses different types of injections including intravenous, intramuscular, subcutaneous and intradermal injections. It defines injections, lists the rights of medication administration, and outlines the general preparation, equipment, sites, and procedures for various injections. The purpose is to educate students on properly administering different injections and ensuring medication safety.
Journal club on Correlation of APGAR Score with Asphyxial Hepatic Injury and ...Shubhra Paul
This study evaluated the correlation between APGAR scores and hepatic injury/mortality in newborns in India. Researchers measured liver enzyme levels in 70 asphyxiated newborns and 30 controls on days 1, 3, and 10. Asphyxiated newborns had significantly higher liver enzyme levels than controls, especially those with severe asphyxia (APGAR 0-3). Mortality and deranged liver functions were significantly correlated with lower APGAR scores. The study found APGAR is a useful indicator for predicting hepatic injury and mortality in asphyxiated newborns.
Birth asphyxia occurs when there is an interruption in oxygen delivery to the fetus during delivery, causing hypoxia and hypercapnia. It can be assessed using the APGAR score, where a score below 7 at 1 minute indicates asphyxia. Risk factors include maternal diabetes, hypertension, infection, and prolonged labor. Effects may include central nervous system injuries, cardiovascular and respiratory issues, and hypoglycemia. Resuscitation involves providing ventilation and oxygen while monitoring heart rate, with chest compressions and epinephrine as needed. Prognosis depends on factors like APGAR score and time without respiration. Hypoxic-ischemic encephalopathy may result in neonatal death or long-term disabilities like cerebral p
Birth asphyxia, with Tanzania perspectiveJoseph Kimaro
Birth asphyxia occurs when the fetus is deprived of oxygen during or shortly after birth. It can cause complications including hypoxic ischemic encephalopathy, cerebral palsy, seizures, and death. Risk factors include prematurity, maternal infection, hypertension, and complications during labor or delivery that interrupt oxygen delivery to the fetus. Treatment involves resuscitation, monitoring for complications, controlling seizures, and in some cases therapeutic hypothermia. Preventing birth asphyxia requires close fetal monitoring and careful management of at-risk deliveries.
This document provides an overview of pediatric medication administration for nurses. It discusses:
- The physiological differences between children and adults that impact medication administration.
- Guidelines for administering different types of medications orally and via other routes such as intravenous, ophthalmic, otic, inhalation, and rectal.
- Specific considerations for administering certain high risk medications like cyclosporine and digoxin.
- The steps involved in preparing and administering intravenous medications correctly including checking medications, preparing different drug formulations, setting up IV lines, and documenting properly.
- Potential complications of IV therapy and the importance of following policies and procedures to ensure safe medication administration for pediatric patients.
This document provides definitions and information about various topics in pathology of the newborn. It discusses basic definitions of terms like abortion, delivery, and fetal maturity. It also describes the Apgar score system used to evaluate newborns and outcomes associated with different scores. Causes of prenatal and neonatal death are explained. Immaturity of organs in preterm infants and various types of lung pathology affecting newborns are also outlined.
This document discusses oral administration of medications. It provides information on drug definitions, prescription orders, generic and trade names, legal aspects, routes of administration, parts of a medication order, and the procedure for administering oral medications. It also discusses nursing process considerations like assessment, diagnoses, planning, implementation, and evaluation related to medication administration. Key steps in the procedure include preparing medications, identifying the patient, explaining the purpose and effects, administering with fluids, recording administration, and monitoring the patient.
The document summarizes new additions and guidelines in neonatal resuscitation based on recent evidence. Key points include: recommending delayed cord clamping for term and preterm infants; maintaining normothermia between 36.5-37.5°C; using low oxygen (21-30%) for resuscitating preterm infants under 35 weeks; considering CPAP initially over intubation for respiratory distress in preterm infants; and structuring educational programs to teach resuscitation every 6 months for better performance and confidence.
This document provides recommendations from the 2015 Neonatal Resuscitation Guidelines on various topics relating to neonatal resuscitation. It discusses recommendations regarding umbilical cord management, maintaining normal temperature, warming hypothermic newborns, administration of oxygen, positive pressure ventilation, and other aspects of resuscitation. The recommendations are based on levels of evidence and aim to optimize resuscitation practices for improved newborn outcomes.
Newborn screening involves a head-to-toe physical examination of a newborn to check for any abnormalities, as well as biochemical screening tests and special screenings to check for conditions like retinopathy of prematurity, hearing issues, and heart defects. The physical exam includes measurements, assessment of vital signs, and examination of features from head to toe to check growth and development. Biochemical screening checks for inborn errors of metabolism, while special screenings aim to identify conditions that require early intervention.
This document provides information about medication administration by nurses. It discusses key responsibilities of nurses including having thorough knowledge of the medications being administered, ensuring the right patient, drug, dose, route, time and frequency. It covers drug classifications, effects, interactions and incompatibilities. The document also reviews the nursing process for safe administration including assessment, diagnosis, planning intervention and evaluation. Different routes of medication administration such as oral, parenteral, topical and inhalation are explained.
The document provides guidance on newborn examination including:
- Classifying newborns by birth weight, gestational age, and weight percentiles.
- Assessing vital signs, growth measurements, gestational age, and examining different body systems.
- Recognizing normal findings as well as common problems in newborns such as jaundice, rashes, and congenital abnormalities.
This document discusses birth asphyxia, including its definition, causes, pathophysiology, clinical manifestations, assessment, effects, classification, management, investigations and prognosis. Some key points:
- Birth asphyxia is defined as reduction of oxygen delivery and accumulation of carbon dioxide around birth, leading to respiratory failure in newborns. It is assessed using Apgar scores and fetal monitoring.
- Causes include maternal, delivery and fetal factors that interfere with maternal-fetal circulation such as prematurity, cord problems and placental issues.
- Effects depend on severity and can involve multiple organs, particularly the brain, heart and lungs. Management focuses on stabilizing vital functions and preventing further injury through temperature control
1) The document discusses the role of cardiac resynchronization therapy (CRT) in treating chronic heart failure based on results from clinical trials.
2) Landmark trials like CARE-HF, MADIT-CRT and REVERSE showed that CRT reduces mortality and hospitalization in patients with heart failure symptoms.
3) Later trials also found benefits of CRT in mildly symptomatic patients with reduced left ventricular function and wide QRS duration, including decreased heart failure events and increased left ventricular ejection fraction, though effects on quality of life and exercise capacity were less clear.
This study analyzed 12-lead electrocardiograms from 90 patients with inferior myocardial infarction to determine the influence of the measurement point of ST segment elevation on algorithms for localizing the culprit artery. ST elevation was measured at the J-point and 80 ms after the J-point, and three algorithms were applied to each measurement. The area under the curve was significantly better for two algorithms when measuring at the J-point compared to 80 ms. Agreement between the J-point and 80 ms measurements was suboptimal for all three algorithms. The results suggest that the point used to measure ST segment elevation can significantly impact the performance of algorithms to identify the responsible artery.
IRJET - Comparative Study of Cardiovascular Disease Detection AlgorithmsIRJET Journal
The document compares four algorithms - K-Nearest Neighbors, Support Vector Machine, Decision Tree, and Random Forest - for cardiovascular disease detection using data mining techniques. It summarizes previous studies that have used these algorithms on cardiovascular disease data and evaluated their performance. The document concludes that K-Nearest Neighbors, Support Vector Machine, Decision Tree, or Random Forest algorithms could be used for cardiovascular disease detection, and that the best algorithm depends on the specific dataset and type of disease being diagnosed.
Heart Disease Prediction Using Machine Learning TechniquesIRJET Journal
This document describes a study that used five machine learning algorithms to predict heart disease: Random Forest classification, Support Vector Machine, AdaBoost Classifier, Logistic Regression, and Decision Tree Classifier. The algorithms were tested on a dataset of 270 patients described by 14 attributes. Random Forest classification achieved the highest test accuracy of 85.22%, compared to accuracies ranging from 67.43% to 81.23% for the other algorithms. Therefore, the study concludes that Random Forest classification is the best performing algorithm for predicting heart disease based on this dataset and analysis.
This study aimed to determine if preoperative hematological parameters and risk factors could predict in-hospital mortality for patients undergoing surgery to repair Type A aortic dissection. The study reviewed data from 78 patients who underwent deep hypothermic circulatory arrest surgery. Only preoperative creatinine levels were higher in patients who died. Total circulatory arrest time and cross-clamp time during surgery were found to be factors affecting mortality, with times over 44.5 minutes and 71 minutes respectively predicting higher risk of death. The study concluded that hematological biomarkers alone may be insufficient for estimating mortality risk, and intraoperative factors like longer circulatory arrest and clamp times impact outcomes for Type A aortic dissection surgery.
IRJET- Study of Hypocalcemic Cardiac Disorder by Analyzing the Features o...IRJET Journal
This document presents a study that analyzes ECG signals using discrete wavelet transform (DWT) to detect hypocalcemia, a condition caused by low calcium levels. The proposed methodology involves denoising the ECG signal, detecting peaks (Q, R, S) using DWT, calculating time intervals, and using statistical measures like mean square error, root mean square deviation, and percentage deviation to distinguish between healthy and hypocalcemic patients. The results of applying this methodology to ECG signals from a database are discussed.
This document summarizes a seminar on health technology assessment and economic evaluation. It discusses key concepts like incremental cost-effectiveness ratio (ICER) and quality-adjusted life years (QALYs). It also summarizes a past study on the cost-effectiveness of treating hypertension at worksites versus regular care. The study found that the worksite program had an ICER of $5.63/mmHg reduction in blood pressure, which was more cost-effective than the regular care ICER of $32.51/mmHg. Sensitivity analysis supported these findings.
IRJET- A Survey on ECG Signals Classification for Early Detection of Cardiova...IRJET Journal
This document summarizes a research paper that proposes a new methodology for the automated classification of cardiovascular diseases using electrocardiogram (ECG) signals. The methodology involves extracting nonlinear features from ECG signals after applying a five-level discrete wavelet transform. Only a reduced number of features are considered to increase efficiency. Feature ranking is performed using ANOVA and Relief methods to select important features for classification. The proposed system aims to classify ECG segments into normal, hypertrophic cardiomyopathy, dilated cardiomyopathy, and myocardial infarction classes with higher accuracy compared to existing methods.
Espessamento medio intimal carótidal trialsJorge Garcia
Carotid intima-media thickness (CIMT) is a measure of subclinical atherosclerosis that can be assessed noninvasively using ultrasound. CIMT has been shown to be related to traditional cardiovascular risk factors and predicts future cardiovascular events. Several studies have found that therapies which slow the progression of CIMT, such as statins, antihypertensives, and lifestyle changes, can reduce cardiovascular risk. However, CIMT is an imperfect surrogate and definitive outcomes trials are still needed to determine the clinical impact of therapies that affect CIMT progression.
This study compared outcomes for patients in the intensive care unit (ICU) who received contrast echocardiography (cTTE) versus non-contrast echocardiography (nTTE). cTTE patients had a significantly lower risk of death during hospitalization compared to nTTE patients. There was no significant difference in length of stay, ICU length of stay, total hospitalization cost, or cost of cardiac function tests between the two groups. However, cTTE patients required significantly fewer additional cardiac function tests after echocardiography compared to nTTE patients.
A prospective study was conducted at a critical care department and post-anesthesia care unit of a university teaching hospital in Barcelona, Spain. The study recruited 707 patients with invasive BP and finger PPG waves over a period of 26 months. Exclusion criteria were presence of major arrhythmia, immediate death condition and disturbances in the arterial or PPG curve morphology. For each patient we automatically recorded the systolic blood pressure (SBP), mean arterial pressure (MAP), diastolic blood pressure (DBP) and PPG curve for 30 minutes. The PPG signal was further processed to obtain a set of features that were used to construct a Deep Belief Network with Gaussian Restricted Boltzmann Machine (DBN-RBM). The available dataset was split into three subsets (Training, Validation and Testing). The training and validation datasets included 85% of data and the testing dataset included 15% of the available data. The regression error was assessed through a Bland-Altman analysis and the AAMI standard. The mean prediction error were -2.98+-19.35 mmHg for SBP, -3.38+-10.35 mmHg for MAP and 3.65+-8.69 mmHg for DBP.
The results obtained are promising for the assessment of MAP and DBP with DBN-RBM. Further research and clinical validation are needed to bring this technology to standard medical practice.
1. Successful PCI of chronic total occlusions (CTO) is associated with improved symptoms, increased exercise capacity, reduced need for CABG, and survival benefit compared to failed CTO PCI based on observational studies.
2. Randomized trials are still needed to provide high-level evidence on the benefits of CTO PCI given limitations of observational data though several large randomized trials are underway.
3. Expert operators can now achieve high success rates of over 90% for CTO PCI with low complication rates even for complex CTOs, using bilateral injections, IVUS, retrograde approaches and specialized guidewires and catheters.
Blood Transfusion success rate prediction using Artificial IntelligenceIRJET Journal
This document discusses using machine learning models to predict whether patients will require an intraoperative blood transfusion during mitral valve surgery. Specifically, it examines using the XGBoost and gradient boost techniques to predict transfusion success rates. It finds that XGBoost achieves an accuracy of about 93% for predicting transfusions, compared to 90% for gradient boost, making XGBoost the better performing model. The document concludes that machine learning can successfully predict transfusion needs with an accuracy of 93% using XGBoost.
Right Anterior Thoracotomy Minimally Invasive Aortic Valve Replacement vs. Co...semualkaira
This research aims to compare intraoperative
and postoperative outcomes of Right Anterior Thoracotomy minimally invasive aortic valve replacement (RAT-MIAVR) surgery
with conventional aortic valve replacement (C-AVR) surgery and
analyze the results.
Right Anterior Thoracotomy Minimally Invasive Aortic Valve Replacement vs. Co...semualkaira
This research aims to compare intraoperative
and postoperative outcomes of Right Anterior Thoracotomy minimally invasive aortic valve replacement (RAT-MIAVR) surgery
with conventional aortic valve replacement (C-AVR) surgery and
analyze the results.
Right Anterior Thoracotomy Minimally Invasive Aortic Valve Replacement vs. Co...semualkaira
This research aims to compare intraoperative
and postoperative outcomes of Right Anterior Thoracotomy minimally invasive aortic valve replacement (RAT-MIAVR) surgery
with conventional aortic valve replacement (C-AVR) surgery and
analyze the results
This document provides a summary of clinical evidence supporting the use of PiCCO Technology. It discusses review articles that have explained the basic principles of PiCCO. It also summarizes studies showing PiCCO is cost-effective by reducing complications and costs. Validation studies demonstrate PiCCO parameters for cardiac output and lung water are accurate compared to established methods. Recommended clinical application areas discussed include septic shock, acute respiratory distress syndrome, cardiogenic shock, and pediatrics. The document also summarizes clinical significance and outcomes studies related to PiCCO.
Tranexamic acid in hip hemiarthroplasty Conrad Lee
This study examined whether administering tranexamic acid (TXA) before hip hemiarthroplasty surgery reduces postoperative blood transfusions. The study reviewed 271 patient records, with 84 patients receiving TXA and 187 not receiving it. Patients receiving TXA saw a lower drop in postoperative hemoglobin levels and lower transfusion rates. Specifically, the TXA group saw a 26% transfusion rate compared to 42% in the non-TXA group. The study concluded that TXA reduces postoperative blood loss and transfusions in hip hemiarthroplasty patients, and is a safe and cost-effective intervention.
Conscious sedation for dentistry requires processes, facilities, equipment, and personnel similar to MAC anesthesia in an operating room to ensure patient safety. The author has extensive experience in anesthesia and publishes in peer-reviewed journals on topics like conscious sedation, monitoring, and risk assessment for noncardiac surgery. Guidelines from organizations like the ASA provide standards for preoperative assessment, monitoring during conscious sedation, and post-operative care to maintain patient safety and appropriate levels of sedation.
Nora e reversal colorato slideshare; NaPoli i SIA 2016Claudio Melloni
This document discusses complications that can occur during MRI, endoscopy, and dental procedures when sedation or anesthesia is used. It provides data on adverse events and deaths from studies in the United States and United Kingdom. Risk factors discussed include the type of sedation used, the age of the patient, and procedures occurring outside of an operating room. The need for proper patient monitoring during non-operating room anesthesia is emphasized.
Importanza anestesista in oftalmologia 2013/IMportance of the anesthesiologis...Claudio Melloni
This document discusses the role of anesthesiologists in ophthalmic surgery, with a focus on day/office surgery. It outlines the safety services anesthesiologists provide, including screening patients, administering and monitoring anesthesia, preventing and treating complications, and safe discharge. It also discusses value-added services like developing policies, purchasing equipment, and providing drug formulary advice. Specific responsibilities in the operating room and ways anesthesiologists can improve efficiency are covered. The document also discusses monitoring, equipment, training, and standards required for day surgery anesthesia care.
Corso sul cisatracurium per glaxo 2007 ottobreClaudio Melloni
This study examined the incidence of postoperative weakness in patients who received either cisatracurium or rocuronium as muscle relaxants during surgery. The drugs were administered and antagonized using a strict protocol based on tactile train-of-four (TOF) counts rather than quantitative neuromuscular monitoring. Results showed no significant differences between the two drugs. At 10 minutes post-antagonism, mean TOF ratios were above 0.7. By 15 minutes, only one patient in each group had a TOF ratio below 0.7. No patients arrived in the post-anesthesia care unit with weakness. The study concludes that tactile TOF assessment can safely guide administration and reversal of these muscle relax
Valut az rischio anest sia napoli dic 2008;italian + bibliografyClaudio Melloni
evaluation of operative risk for non cardiac surgery ;for anesthesia and surgery.Cardiac conditions,including heart failure ,use of betablockers,stains.Diabetes risk,including difficult intubation.Thromboembolic risk,
The document describes a study that aimed to develop and validate a concise screening tool called the STOP questionnaire for detecting obstructive sleep apnea (OSA) in surgical patients. The STOP questionnaire consists of 4 yes/no questions related to snoring, daytime tiredness, observed breathing stops during sleep, and high blood pressure. The study found the STOP questionnaire had a sensitivity of 65.6-79.5% for detecting different severities of OSA compared to polysomnography. Incorporating additional risk factors into the STOP-Bang model increased the sensitivity to over 83%. The study validated the STOP questionnaire as an easy-to-use screening tool for OSA in surgical patients.
A new dantrolene formulation for the treatment of Malignant hyperthermia(MH).Receptors,pharmacokinetics,dosages,preparation of dantrolene,practical tips,advantages.
Raccomandazioni per la valutazione preoperatoria malattie remaliiClaudio Melloni
The document describes a study that developed an Acute Kidney Injury (AKI) risk index for patients undergoing general surgery. The study used data from over 75,000 patients to identify 11 independent preoperative predictors of AKI. These predictors were used to create a risk index with a high predictive capability (c statistic of 0.80). Patients who experienced AKI had an eightfold increase in 30-day mortality. The risk index can help identify patients at risk of AKI so preventative measures or closer monitoring can be taken.
Raccomandazioni per la val preop in chirurgia non cardiaca;pazienti diabetici Claudio Melloni
This document provides guidelines for preoperative evaluation of adult patients undergoing non-cardiac surgery, with an emphasis on respiratory diseases. It discusses risk factors for postoperative pneumonia and respiratory failure, including patient characteristics like age, functional status, smoking history; and type of surgery. Spirometry and chest X-rays are assessed, with evidence suggesting they have limited value in predicting postoperative pulmonary complications for individual patients. Risk indices are presented that stratify patients into categories of increasing probability of developing postoperative pneumonia or respiratory failure based on their risk factor profile.
This document summarizes guidelines for preoperative evaluation of adult patients undergoing non-cardiac surgery, with an emphasis on respiratory diseases. It identifies several risk factors for postoperative pneumonia, including age over 60, dependent functional status, weight loss, COPD, and surgery type. A risk index for predicting postoperative respiratory failure is also described, which includes patient factors like albumin level, BUN, functional status, and COPD, as well as surgery type. The document discusses strategies for reducing postoperative pulmonary complications, such as various lung expansion techniques.
This document discusses the development and validation of a multifactorial risk index to predict the risk of postoperative pneumonia in patients undergoing major noncardiac surgery. It describes defining postoperative pneumonia as new radiographic lung findings accompanied by changes in sputum, a positive blood culture, or isolation of a pathogen from respiratory samples. Risk factors identified for the index included age, functional status, weight loss, COPD, anesthesia type, impaired sensorium, steroid use, smoking, and medical history. The risk index stratified patients into five classes from lowest to highest risk of developing postoperative pneumonia.
Obesity and sleep apnea are associated with several health risks. Screening tools can help identify patients at high risk for obstructive sleep apnea (OSA) so they can be properly treated before surgery to prevent postoperative complications. Studies have shown that untreated OSA is linked to increased risks of pulmonary issues like pneumonia and respiratory distress after surgery. The STOP questionnaire is a validated screening tool that uses 4 simple questions about snoring, tiredness, breathing pauses witnessed by others, and blood pressure to help identify patients likely to have undiagnosed OSA.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
2. Surgical Apgar Score
Regenbogen, Scott E. MD, MPH *+; Lancaster, R Todd MD *+; Lipsitz, Stuart R. ScD ++; Greenberg, Caprice
C. MD, MPH ++; Hutter, Matthew M. MD, MPH +; Gawande, Atul A. MD, MPH *++ Does the Surgical Apgar
Score Measure Intraoperative Performance? Annals of Surgery. 248(2):320-328, August 2008.
• lowest heart rate
• lowest mean arterial pressure
• estimated blood loss
• A score built from these 3 predictors has proved
strongly predictive of the risk of major postoperative
complications and death in general and vascular surgery.
• The score was thus developed using these 3 variables, and their beta coefficients
were used to weight the points allocated to each variable in a 10-point score (
Table 1).
3. Regenbogen, Scott E. MD, MPH *+; Lancaster, R Todd MD *+; Lipsitz, Stuart R. ScD ++;
Greenberg, Caprice C. MD, MPH ++; Hutter, Matthew M. MD, MPH +; Gawande, Atul
A. MD, MPH *++ Does the Surgical Apgar Score Measure Intraoperative Performance?
Annals of Surgery. 248(2):320-328, August 2008.
4.
5. Regenbogen, Scott E. MD, MPH *+; Lancaster, R Todd MD *+; Lipsitz, Stuart R. ScD ++;
Greenberg, Caprice C. MD, MPH ++; Hutter, Matthew M. MD, MPH +; Gawande, Atul
A. MD, MPH *++ Does the Surgical Apgar Score Measure Intraoperative Performance?
Annals of Surgery. 248(2):320-328, August 2008.
6. Regenbogen, Scott E. MD, MPH *+; Lancaster, R Todd MD *+; Lipsitz, Stuart R. ScD ++;
Greenberg, Caprice C. MD, MPH ++; Hutter, Matthew M. MD, MPH +; Gawande, Atul
A. MD, MPH *++ Does the Surgical Apgar Score Measure Intraoperative Performance?
Annals of Surgery. 248(2):320-328, August 2008.
7. Regenbogen, Scott E. MD, MPH *+; Lancaster, R Todd MD *+; Lipsitz, Stuart R. ScD ++;
Greenberg, Caprice C. MD, MPH ++; Hutter, Matthew M. MD, MPH +; Gawande, Atul
A. MD, MPH *++ Does the Surgical Apgar Score Measure Intraoperative Performance?
Annals of Surgery. 248(2):320-328, August 2008.
8. Frequenza delle complicanze a seconda del Surgical Apgar
Score
Regenbogen, Scott E. MD, MPH *+; Lancaster, R Todd MD *+; Lipsitz, Stuart R. ScD ++; Greenberg, Caprice C.
MD, MPH ++; Hutter, Matthew M. MD, MPH +; Gawande, Atul A. MD, MPH *++ Does the Surgical Apgar
Score Measure Intraoperative Performance? Annals of Surgery. 248(2):320-328, August 2008.
%
9. Regenbogen, Scott E. MD, MPH *+; Lancaster, R Todd MD *+; Lipsitz, Stuart R. ScD ++;
Greenberg, Caprice C. MD, MPH ++; Hutter, Matthew M. MD, MPH +; Gawande, Atul
A. MD, MPH *++ Does the Surgical Apgar Score Measure Intraoperative Performance?
Annals of Surgery. 248(2):320-328, August 2008.
• We find that even after detailed adjustment for comorbidity
• and procedure-specific risk factors, the amount of
• blood loss, lowest heart rate, and lowest blood pressure were
• still important predictors of the risk of a major complication.
• The Surgical Apgar Score, therefore, conveyed useful prognostic
• information, either in isolation or in combination with
• assessments of the risks that patients brought to the operating
• room. It also may provide an immediate assessment of how
• well or poorly the operation has gone for a patient. In this
• cohort, surgical teams could cut a patient’s risk-adjusted
• odds of major complications nearly in half with a score of
• 9 –10, or conversely, nearly triple the risk-adjusted odds
• with scores 4.
• This finding, that intraoperative blood loss, heart rate,
• and blood pressure are critical predictors of postoperative
• risk, is consistent with a variety of previous observations.
10. Regenbogen, Scott E. MD, MPH *+; Lancaster, R Todd MD *+; Lipsitz, Stuart R. ScD ++;
Greenberg, Caprice C. MD, MPH ++; Hutter, Matthew M. MD, MPH +; Gawande, Atul
A. MD, MPH *++ Does the Surgical Apgar Score Measure Intraoperative Performance?
Annals of Surgery. 248(2):320-328, August 2008.
• In summary, we have found that a simple clinimetric
• surgical outcome score can provide both clinical surgeons
• and surgical safety researchers with useful and important
• information. The Surgical Apgar Score integrates components
• of patient susceptibility, procedure complexity, and
• operative performance, providing a measure of immediate
• postoperative condition and prognostication beyond standard
• risk-adjustment. As a decision-support tool, the score can
• inform postoperative prognostication, communication, and
• triage, regardless of the sophistication of preoperative risk
• stratification available. Finally, as a simple intraoperative
• outcome measure and safety improvement metric, it may
• prove useful as an indicator of surgical performance