This document discusses critical care for obstetric patients. It begins with an introduction and epidemiology section noting that while the proportion of obstetric patients in ICUs is low, the most common reasons for admission are postpartum hemorrhage and hypertensive disorders. It then covers obstetric critical care, basic principles for obstetric emergencies, transfer to critical care settings, the role of obstetricians, resuscitative hysterotomy, and supportive care. It provides recommendations including prioritizing maternal stabilization, consulting obstetricians, and not withholding necessary treatments due to fetal concerns. The document aims to guide management of critically ill obstetric patients.
Pregnant patients are admitted in ICU with a number of pregnancy related problems. Some of them are really life threatening. Identification and prompt action is the key to save lives.
Pregnant patients are admitted in ICU with a number of pregnancy related problems. Some of them are really life threatening. Identification and prompt action is the key to save lives.
Maternal collapse by dr alka mukherjee &; dr apurva mukherjeealka mukherjee
Not all maternal deaths are preceded by an identifiable collapse, and not all maternal collapses result in death. Maternal collapse occurs any time during pregnancy, up to 42 days following delivery and is an acute event involving cardiorespiratory systems and/or brain, resulting in impaired consciousness or death.1
Maternal deaths are generally quantified as a maternal mortality ratio (MMR), expressed as the number of maternal deaths per 100,000 women giving birth. It includes deaths that occur due to complications of the pregnancy (direct deaths), and those resulting from worsening of other disease processes due to the pregnancy (indirect deaths). Deaths that occur from causes completely unrelated to pregnancy or birth are termed When faced with an acute maternal collapse, it is helpful to think of potential causes as falling into five categories, or the 5 Hs for simplicity:4
Head including eclampsia, stroke, epilepsy, vasovagal
Heart including myocardial infarction, arrhythmia, cardiomyopathy, thoracic aortic dissection
Hypoxia including pulmonary embolus, pulmonary oedema, anaphylaxis, asthma
Haemorrhage including abruption, uterine atony, genital tract trauma, uterine rupture, uterine inversion, ruptured aortic aneurysm
wHole body and Hazards amniotic fluid embolus, hypoglycaemia, trauma, anaesthetic complications, drug reactions (illicit or prescribed), sepsis
The likelihood of any one of these being causative will obviously depend somewhat on the timing of the collapse – early or late pregnancy, intrapartum, immediately postpartum, remotely postpartum.
Maternal cardiac arrest represents a small subset of women affected by maternal collapse. The incidence is approximately 1 in 30,000 ongoing pregnancies, with a high likelihood of death for both the mother and the fetus. The vast majority of us will never need to attend a maternal cardiac arrest, and doing so is uniquely stressful. For these reasons, it is important to have a framework in mind of how to deal with a maternal cardiac arrest, and to have practised the response to this situation.
incidental deaths, and are not included in calculation of the MMR.
• Several other risk factors for maternal death are recognised. These include:
• Maternal age 35 and older
• Obesity
• Lower socioeconomic status
• Pre-existing mental health issues, substance use and domestic violence, all of which may be exacerbated by pregnancy and the puerperium
• Medical co-morbidities, particularly asthma, autoimmune diseases, inflammatory and atopic disorders, haematological disorders, essential hypertension, infections and musculoskeletal disorders
One of the important developments in improving identification of a pregnant or postnatal patient at risk of collapse during hospital admission has been the development of maternity-specific Early Warning Charts.
Maternal Near Miss Operational GuidelinesRajesh Ludam
Maternal Near Miss guidelines is designed for the program managers at different levels of public health system.to provide quality services and identify the best practices.
In settings with limited access to health care, misoprostol is an important intervention that could reduce maternal deaths both directly and through the more cost-effective use of health services. Misoprostol is, however, a powerful drug that needs to be used with care. Evidence-based information about the safest regimens should be widely disseminated so as to prevent its inappropriate use
Maternal collapse by dr alka mukherjee &; dr apurva mukherjeealka mukherjee
Not all maternal deaths are preceded by an identifiable collapse, and not all maternal collapses result in death. Maternal collapse occurs any time during pregnancy, up to 42 days following delivery and is an acute event involving cardiorespiratory systems and/or brain, resulting in impaired consciousness or death.1
Maternal deaths are generally quantified as a maternal mortality ratio (MMR), expressed as the number of maternal deaths per 100,000 women giving birth. It includes deaths that occur due to complications of the pregnancy (direct deaths), and those resulting from worsening of other disease processes due to the pregnancy (indirect deaths). Deaths that occur from causes completely unrelated to pregnancy or birth are termed When faced with an acute maternal collapse, it is helpful to think of potential causes as falling into five categories, or the 5 Hs for simplicity:4
Head including eclampsia, stroke, epilepsy, vasovagal
Heart including myocardial infarction, arrhythmia, cardiomyopathy, thoracic aortic dissection
Hypoxia including pulmonary embolus, pulmonary oedema, anaphylaxis, asthma
Haemorrhage including abruption, uterine atony, genital tract trauma, uterine rupture, uterine inversion, ruptured aortic aneurysm
wHole body and Hazards amniotic fluid embolus, hypoglycaemia, trauma, anaesthetic complications, drug reactions (illicit or prescribed), sepsis
The likelihood of any one of these being causative will obviously depend somewhat on the timing of the collapse – early or late pregnancy, intrapartum, immediately postpartum, remotely postpartum.
Maternal cardiac arrest represents a small subset of women affected by maternal collapse. The incidence is approximately 1 in 30,000 ongoing pregnancies, with a high likelihood of death for both the mother and the fetus. The vast majority of us will never need to attend a maternal cardiac arrest, and doing so is uniquely stressful. For these reasons, it is important to have a framework in mind of how to deal with a maternal cardiac arrest, and to have practised the response to this situation.
incidental deaths, and are not included in calculation of the MMR.
• Several other risk factors for maternal death are recognised. These include:
• Maternal age 35 and older
• Obesity
• Lower socioeconomic status
• Pre-existing mental health issues, substance use and domestic violence, all of which may be exacerbated by pregnancy and the puerperium
• Medical co-morbidities, particularly asthma, autoimmune diseases, inflammatory and atopic disorders, haematological disorders, essential hypertension, infections and musculoskeletal disorders
One of the important developments in improving identification of a pregnant or postnatal patient at risk of collapse during hospital admission has been the development of maternity-specific Early Warning Charts.
Maternal Near Miss Operational GuidelinesRajesh Ludam
Maternal Near Miss guidelines is designed for the program managers at different levels of public health system.to provide quality services and identify the best practices.
In settings with limited access to health care, misoprostol is an important intervention that could reduce maternal deaths both directly and through the more cost-effective use of health services. Misoprostol is, however, a powerful drug that needs to be used with care. Evidence-based information about the safest regimens should be widely disseminated so as to prevent its inappropriate use
Malaria in pregnancy is an obstetric, social and medical problem requiring multidisciplinary and multidimensional solution. Pregnant women constitute the main adult risk group for malaria and 80% of deaths due to malaria in Africa occur in pregnant women and children below 5 years. Malaria and pregnancy are mutually aggravating conditions. The physiological changes of pregnancy and the pathological changes due to malaria have a synergistic effect on the course of each other, thus making the life difficult for the mother, the child and the treating physician. P. falciparum malaria can run a turbulent and dramatic course in pregnant women. The non- immune, primi-gravidae are usually the most affected. In pregnant women the morbidity due to malaria includes anemia, fever illness, hypoglycemia, cerebral malaria, pulmonary edema, puerperal sepsis and mortality can occur from severe malaria and haemorrhage. The problems in the new born include low birth weight, prematurity, malaria illness and mortality.
Malaria in pregnancy is a major cause of maternal morbidity worldwide and leads to poor birth outcomes. Pregnant women are more prone to complications of malaria infection than non-gravid women. Pregnant women are more susceptible than the general population to malaria: they are more likely to become infected, suffer a recurrence, develop severe complications and to die from the disease.
The role of a Nurse in the prevention and care of malaria in pregnancy starts in the ante natal clinic. Ante natal care is a critical service delivery point through which control /prevention of malaria in pregnancy takes place. The four (4) key Nursing roles in malaria interventions that are delivered through the ANC are;
1. Focused Antenatal Care & Health Education.
II. Early diagnosis &treatment of symptomatic women.
III. Intermittent preventive treatment (IPT).
IV. Regular& appropriate use of long lasting insecticide treated nets
(LLINs).SSS
Others are --
Evidence-based, goal-directed actions
Individualized, woman-centered care
Early detection and treatment of problems and complications
Prevention of complications and disease
Quality vs. quantity of visits
Care by skilled Nurses and health promotion
Birth preparedness & complication readiness
- List the goals of good antenatal care.
- Diagnose pregnancy.
- Know what history should be taken and examination done at the first visit.
- Determine the duration of pregnancy.
- List and assess the results of the side-room and screening tests needed at the first visit.
- Identify low-, intermediate- and high-risk pregnancies.
- Plan and provide antenatal care that is problem orientated.
- List what specific complications to look for at 28, 34 and 41 weeks.
- Provide health information during antenatal visits.
- Manage pregnant women with HIV infection.
FAST HUGS BID principle followed for care of critically ill patients, as checklist is a simple strategy which is used for identifying and checking the significant aspects in the general care of ICU patients.
Intensive Care Management of Severe Pre-eclampsia and EclampsiaApollo Hospitals
Pregnancy induced hypertension is a common medical complication of pregnancy and is a significant contribution to maternal and perinatal morbidity and mortality. Early diagnosis, increased patient awareness and appropriate medical intervention, especially intensive care management of severe preeclampsia and eclampsia have led to marked fall in mortality in this group of patients. In this review article, the pathophysiology, effect on different organ systems, choice of drugs (anticonvulsants and antihpertensives), support of a critically ill patient in the intensive care, monitoring, anaesthetic considerations and management of the neonate are discussed.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
2. Introduction
Epidemiology
OBSTETRIC CRITICAL CARE
BASIC PRINCIPLES FOR OBSTETRIC
EMERGENCIES
Transfer to critical care setting
Role of the Obstetrician–Gynecologist
Resuscitative hysterotomy
SUPPORTIVE CARE
Recommendations and Conclusions
Items to be discussed
3. ICU receives obstetric patients with medical &
surgical emergencies as well as specific obstetric
complications
Proportion of obstetric patients in most ICUs is low
Relative inexperience in management & team-work
between ICU team & obstetrician.
Introduction
4. Approximately (0.7–13.5) obstetric patients per
1,000 deliveries are admitted to ICU
Most common indications are postpartum
hemorrhage and hypertensive disorders
Most of these (63–92%) are postpartum
admissions
not require major lifesaving interventions but rather
more intensive monitoring than can be provided
on antepartum or postpartum units
Epidemiology
5. median length of stay was 2.0 days for women
admitted antepartum and 1.1 day for those
admitted postpartum
The maternal death rate after ICU admission
differs significantly between high- and low-income
countries (median 3.3% versus 14.0%, respectively,
P=.002)
Epidemiology
9. Clinically unstable ( hypotensive or hypoxemic)
At high risk of deterioration
Need specialized ICU care such as mechanical ventilation
Laboratory work
• arterial blood gas
• serum lactate
The Quick Sequential Organ Failure Assessment can also be
used to stratify risk in patients who have infection
Patients require
• level 2 care (monitoring and simple interventions)
• level 3 care (major organ support)
Factors contribute to the decision to
move a pregnant patient to ICU
11. Physiological changes in pregnancy modify:
• Presentation of the problem
• Normal physiological variables
• Response to treatment
Both mother & fetus are affected by the pathology
& subsequent treatment.
Mother’s welfare always takes precedence over
fetal concerns
Fetal survival dependent on optimal management
12.
13.
14.
15.
16.
17. If a pregnancy is complicated by a critical illness or
condition, the woman should be cared for at a
hospital with obstetric services, an adult ICU,
advanced neonatal care services, and appropriate
hospital services such as a blood bank.
It is important not to discourage ICU admission;
rather, encouraged to use critical care services when
appropriate
21. Pre-transport evaluation of the woman and her
fetus must be performed, and maternal status must be
stabilized before transport
when transport is unsafe or impossible, or when imminent
delivery is anticipated, arrangements can be made for
postpartum rather than antepartum maternal transport
If there is a high probability that intubation and mechanical
ventilation will be needed during transport, it should be
accomplished before departure
Transfer Between Hospitals
22. During transport :
• continuous cardiac rhythm and pulse oximetry monitoring
• regular assessment of vital signs
• Venous access must be established before transport
• Left uterine displacement should be routine
obstetrician–gynecologists at the receiving hospital give an
opinion about medical interventions before arrival, or
prepare for interventions needed
Transfer Between Hospitals
23. communication between the obstetrician–gynecologist and
critical care services is crucial. In some cases (eg, planned
cesarean hysterectomy
possible to request an ICU bed in advance (planned)
involve critical care staff early in the transfer process
During transport, the team must be able to assess BP, heart
rate, and oxygenation status.
For a critically ill patient , the team also should have a
cardiac monitor with defibrillator, airway management
equipment, oxygen, and basic resuscitation medications.
At least two health care professionals should accompany the
patient during transport
Transfer Within the Hospital
24. obstetrician–gynecologist’s role will depend on:
• patient status (antepartum or postpartum)
• ICU model and type
According to ICU model , his role is
• open model >>>>>> 1ry physician
• closed model >>>>>> only to be consulted
• semi-open model >>>>>> MDT
patient care decisions made collaboratively multidisciplinary
care team.
Decisions also should involve the patient, her family, or both.
Role of the Obstetrician–Gynecologist
25. weighing the risks and benefits of interventions such as
medication administration and diagnostic Imaging
fetal monitoring
delivery planning when indicated.
Daily rounds, frequent communication with the ICU team
rapid response to calls for consultation are all important
evaluation of vaginal or surgical site bleeding
obstetric sources of infection,
therapies (such as magnesium for eclampsia prophylaxis),
surgical issues, such as re-exploration of the abdomen or
reclosure of abdominal and perineal or vaginal incisions.
Role of the Obstetrician–Gynecologist
Regardless of the type of ICU
26. The underpinning principles are that the woman’s interests
are paramount, and optimal fetal status is generally
predicated on optimizing the maternal condition as much as
possible.
Medical interventions and diagnostic imaging may be
modified to an extent but when indicated for maternal
health should not be withheld purely for fetal concerns.
It is important not to discourage ICU admission; rather,
encouraged to use critical care services when appropriate
Role of the Obstetrician–Gynecologist
Regardless of the type of ICU
27. Maternal stabilization is the first priority
Once woman is stable, determine GA to plan of care,
immediate decision-making.
Drugs that cross the placenta may have fetal effects
Known adverse effects on the woman and the fetus must
be carefully monitored, and risk–benefit ratios assessed
Neither necessary medications nor diagnostic imaging
should be withheld from a pregnant woman because of
fetal concerns.
Special considerations in care of a pregnant
woman in a critical care setting
28. Administration of steroids for fetal benefit
Indicated delivery should not be delayed for
administration of steroids in the late preterm period
Fetal monitoring
In postpartum period, obstetricians should evaluate
vaginal or surgical site bleeding, therapies, surgical issues
Provision of lactation support and a breast pump may
also be considered when feasible.
special considerations in care of a pregnant
woman in a critical care setting
32. Mechanical ventilation
Sedation
Vasopressors
hemodynamic monitoring
SUPPORTIVE CARE
Defined as interventions that sustain life and prevent
complications, but do not treat the cause of the critical
illness
33. Normal physiology, pregnancy maintain respiratory
alkalosis (PaCO2 32 mmHg and arterial pH 7.4 to
7.47) due to respiratory stimulation by progesterone
Mechanical ventilation is similar for pregnant and non-
pregnant women
The major pregnancy-specific considerations are related
PaCO2. Target PaCO2 should be 30 to 32 mmHg
PaCO2 values <30 mmHg or >40 mmHg to be avoided
A reasonable goal is a maternal PaO2 above 65 mmHg
Mechanical ventilation
34. Intubation and mechanical ventilation are undertaken
when hypoxemia is profound and cannot be corrected by
noninvasive means, or when ventilation is failing
Airway management in pregnancy can be challenging
Increased airway edema and increased breast size make
positioning and direct laryngeal visualization more
difficult.
The risk of failed intubation in obstetrics is eight times
higher than in the general population
Once the decision to intubate is made, the patient should
be preoxygenated and suction should be available; the
most qualified personavailable should intubate.
A plan for failed intubation must be made ahead of time,
Mechanical Ventilation
35. Interventions other than vasopressors should be used
initially to manage hypotension, including the IV fluids
and left lateral decubitus position.
If Hypotension persists initiate vasopressor, since
sustained hypotension decreases uterine blood flow.
For pregnant women, suggest norepinephrine as the
initial agent, rather than ephedrine, epinephrine or
dopamine (Grade 2C).
If refractory shock , suggest the use of phenylephrine
rather than ephedrine (Grade 2C)
Vasopressors
36. Most drugs used for analgesia, sedation, and paralysis
cross the placenta >>>>>> Possible adverse effects
Consultation with an obstetrician and a pharmacist
A neonatologist should be present at delivery because
may respiratory depression in the newborn
Analgesia: Any opioid is acceptable. However, NSAIDs
should be avoided during late pregnancy
Sedation:
* Midazolam is superior to lorazepam
* Propofol classified as a pregnancy category B agent.
Neuromuscular blocker: Cisatracurium may be
preferable as a first line agent
Sedation
37. All patients should undergo conventional ICU
monitoring.
Invasive hemodynamic monitoring especially when
hypoxemic respiratory failure (pulmonary edema)
accompanied by hypotension and/or renal failure.
Using a central venous catheter to measure the
central venous pressure, rather than a pulmonary
artery catheter
Arterial catheter if BP is labile or frequent ABG needed
Hemodynamic monitoring