The document summarizes new additions and guidelines in neonatal resuscitation based on recent evidence. Key points include: recommending delayed cord clamping for term and preterm infants; maintaining normothermia between 36.5-37.5°C; using low oxygen (21-30%) for resuscitating preterm infants under 35 weeks; considering CPAP initially over intubation for respiratory distress in preterm infants; and structuring educational programs to teach resuscitation every 6 months for better performance and confidence.
About 10% of all newborn require some assistance to begin breathing after birth, and 1% require extensive resuscitation efforts. Newborn resuscitation cannot always be anticipated in time to transfer the mother before delivery to a facility with specialized neonatal support. Therefore, every hospital with a delivery suite should have an organized, skilled resuscitation team and appropriate equipments available.
Presentation on NRP (Neonatal Resuscitation Program)Moninder Kaur
NRP is neonatal resuscitation program. Approximately 10% of newborns require some assistance to begin breathing at birth. Less than 1% require extensive resuscitative measures. Although the majority of newly born infants do not require intervention to make the transition from intrauterine to extra-uterine life, because of the large total number of births, a sizable number will require some degree of resuscitation.
Pneumothorax is one of the most common air leak syndromes that occurs more frequently in the neonatal period than in any other period of life and is a life-threatening condition associated with a high incidence of morbidity and mortality.
Presented by Dr. Rupom
About 10% of all newborn require some assistance to begin breathing after birth, and 1% require extensive resuscitation efforts. Newborn resuscitation cannot always be anticipated in time to transfer the mother before delivery to a facility with specialized neonatal support. Therefore, every hospital with a delivery suite should have an organized, skilled resuscitation team and appropriate equipments available.
Presentation on NRP (Neonatal Resuscitation Program)Moninder Kaur
NRP is neonatal resuscitation program. Approximately 10% of newborns require some assistance to begin breathing at birth. Less than 1% require extensive resuscitative measures. Although the majority of newly born infants do not require intervention to make the transition from intrauterine to extra-uterine life, because of the large total number of births, a sizable number will require some degree of resuscitation.
Pneumothorax is one of the most common air leak syndromes that occurs more frequently in the neonatal period than in any other period of life and is a life-threatening condition associated with a high incidence of morbidity and mortality.
Presented by Dr. Rupom
How to resuscitate, management in meconium aspirated baby, thin and thick meconium, ratio of ventilation and perfusion in new born, latest change in guidelines for resuscitation
Neonatal resuscitation also known as newborn resuscitation is an emergency procedure focused on supporting the approximately 10% of newborn children who do not readily begin breathing, putting them at risk of irreversible organ injury and death.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
2. • Introduction
• Preparation /Anticipation
• Initial assessment
• Whom to resuscitate
• Steps of resuscitation
• New additions
• Conclusion
3. Introduction
• Approximately 10% of newborn's require some
assistance.
• Less than 1% require extensive resuscitation
measures
Because of the large total number of births, a significant number
will require some degree of resuscitation
4. Anticipate the risk
• Assessment of perinatal risk factors
• Assemble the appropriate personnel
• Organize access to supplies and check equipment
• Effective teamwork and communication
5. Initial Assessment?
• Assess the answers to the following 3 questions:
• Term gestation?
• Good tone?
• Breathing or crying
6. Whom to resuscitate?
• If the answer to any of these assessment questions is
“NO”
• A. Initial steps of stabilization
• B. Ventilate and oxygenate (HR/Breathing)
• C. Initiate chest compressions (HR < 60)
• D. Administer epinephrine and/or volume
7. Approximately 60 seconds (“the Golden Minute”) are allotted for
completing
initial steps, revaluating and beginning ventilation if required
8. New Entries
Umbilical cord management
DCC : less IVH, higher BP, blood volume, less need for
transfusion after birth, and less NEC
No evidence of decreased mortality or
decreased incidence of severe IVH
slightly increased level of bilirubin associated with more
need for phototherapy
9. New Entries
Consensus:
• DCC > 30 seconds is reasonable for both T/PT infants
who do not require resuscitation at birth
• No routine use of cord milking for infants < 29 weeks
of gestation outside of a research setting
10. New Entries
Temperature regulation
• Admission temperature strong predictor of mortality
at all gestational ages.
• Hypothermia increases risk of IVH, respiratory issues,
hypoglycaemia and late-onset sepsis
predictor of outcomes as well as a quality indicator
11. New Entries
Consensus
• Maintain temperature between 36.5-37.5°C
• Plastic wrap, radiant warmer, thermal mattress, warm
humidified gases and increased room temperature
• Hyperthermia (>38.0°C) should be avoided
• Rapid or slow cooling both acceptable
12. New Entries
Maintaining normothermia in resource-limited
settings
• Clean food-grade plastic bag up to the level of the
neck and swaddle
them after drying
• Kangaroo mother care
14. New Entries
Meconium Stained Amniotic Fluid
• Deterioration of pulmonary compliance, oxygenation and
cerebral blood flow velocity accompany tracheal suction
Non vigorous baby: Routine intubation for tracheal suction not
suggested
15. New Entries
Assessment of Heart Rate
• Increasing heart rate is most sensitive indicator of a
successful response to each intervention
• Underestimation of the newborn’s heart rate by
auscultation, palpation and pulse oximetry
• 3-lead ECG displayed a reliable heart rate faster
than pulse oximetry
17. New Entries
Administration of oxygen in Preterm
• Resuscitation of PT newborn's (<35) with high oxygen (65%) showed
no improvement in survival to hospital discharge
Resuscitate preterm < 35 weeks with low oxygen (21-30%)
and titrate to achieve preductal oxygen saturation
18. New Entries
Positive Pressure Ventilation/PEEP
• PEEP :supplementary oxygen required to achieve target oxygen saturation may be
slightly less when using PEEP.
5 cm H2O PEEP when PPV is administered to preterm newborn's
PPV delivered effectively with a flow-inflating bag, self-inflating bag or T-piece
resuscitator
19. New Entries
• Use of respiratory mechanics monitors have been reported
to prevent excessive pressures and tidal volumes
• Exhaled CO2 monitors may help assess that actual gas
exchange is occurring during face-mask PPV attempts.
Effectiveness, particularly in changing important outcomes,
has not been established
20. New Entries
LMA recommended during resuscitation > 34 weeks when tracheal
intubation is unsuccessful or is not feasible
21. New Entries
• CPAP decreases rate of intubation, duration of MV with potential benefit of
reduction of death and/or BPD without significant increase in air leak or
severe IVH.
spontaneously breathing PT infants with respiratory distress may be
supported with CPAP initially rather than routine intubation for
administering PPV
22. New Entries
Chest compression
100% Oxygen whenever chest compressions are provided
Supplementary oxygen concentration should be weaned as soon
as the HR recovers
23. • In asystolic /bradycardic neonates no routine use of
any single feedback device (ETCO2 monitors/pulse
oximeters) for detection of return of spontaneous
circulation
• Usefulness has not been well established
24. New Entries
Induced Therapeutic Hypothermia (Resource Limited setting)
TH may be considered and offered under clearly defined
protocols similar to those used in published clinical
trials and in facilities with the capabilities for
multidisciplinary care and longitudinal follow-up
25. New Entries
Withholding Resuscitation
• < 25 weeks, consider accuracy of gestational age assignment,
presence/absence of chorioamnionitis and the level of care
• Useful data for antenatal counselling provides outcome
figures for infants alive at the onset of labor, not only for
those born alive or admitted to a neonatal intensive care unit
26. Structure of educational programs to teach neonatal resuscitation
• Advantages in psychomotor performance, knowledge and confidence
when focused training occurred every 6 months or more
frequently.
Neonatal resuscitation task training should occur more frequently
than the current 2-year interval