Pharmacognosy is "the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources".
Sources of crude drugs (natural)
Drugs obtained from Plants, Animals, Marine, Microorganism, Mineral and from Biotechnology (plant tissue culture) are covered in the presentation
Pharmacognosy is "the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources".
Sources of crude drugs (natural)
Drugs obtained from Plants, Animals, Marine, Microorganism, Mineral and from Biotechnology (plant tissue culture) are covered in the presentation
Crude drugs are plant, animal or their parts which after collection are subjected only to drying or making them into transverse/ longitudinal slices pieces or peeling them in some cases. They exist in natural form.
Crude drugs may be derived from various natural sources like Plants, Animals, Minerals, Marine and Micro-organisms etc
Unit II Introduction to secondary metabolite
Steroids, Cardiac Glycosides & Triterpenoids:
Liquorice, Dioscorea, Digitalis
For video lecture suscribe youtube channel snehal chakorkar.
Sources of drug for Undergraduate MBBS studentsSarju Zilate
--> Drugs are obtained from 8 major sources
.Plant sources
.Animal sources
.Mineral/ Earth sources
.Microbiological sources
.Synthetic sources
.Semi synthetic sources
.Human sources
.Genetically engineered
Almost all parts of the plants are used i.e. leaves, flowers, fruits, seeds, roots, bark and stem.
Leaves
Digitoxin and Digoxin
Hyoscine
Nicotine
Atropine
Oil of Eucalyptus
Animal source
Heparin - Leech
Pepsin - stomach of cow
Human source
HCG - Pregnant women
Urokinase - human kidney cell
Cultivation,Collection, Processing and Storage of crude drugsJegan Nadar
Thus PPT covers Cultivation,Collection, Processing and Storage of crude drugs. This ppt includes different methods of propagation, pest and pest control management, growth regulators, polyploidy, hybridization, collection of crude drugs and storage of crude drugs.
In this ppt we study about sources of drugs which are obtained naturally mostly from plants and animals and various sources like minerals and other sources.
pharmacognosy of crude drugs.
Crude drugs are plant, animal or their parts which after collection are subjected only to drying or making them into transverse/ longitudinal slices pieces or peeling them in some cases. They exist in natural form.
Crude drugs may be derived from various natural sources like Plants, Animals, Minerals, Marine and Micro-organisms etc
Unit II Introduction to secondary metabolite
Steroids, Cardiac Glycosides & Triterpenoids:
Liquorice, Dioscorea, Digitalis
For video lecture suscribe youtube channel snehal chakorkar.
Sources of drug for Undergraduate MBBS studentsSarju Zilate
--> Drugs are obtained from 8 major sources
.Plant sources
.Animal sources
.Mineral/ Earth sources
.Microbiological sources
.Synthetic sources
.Semi synthetic sources
.Human sources
.Genetically engineered
Almost all parts of the plants are used i.e. leaves, flowers, fruits, seeds, roots, bark and stem.
Leaves
Digitoxin and Digoxin
Hyoscine
Nicotine
Atropine
Oil of Eucalyptus
Animal source
Heparin - Leech
Pepsin - stomach of cow
Human source
HCG - Pregnant women
Urokinase - human kidney cell
Cultivation,Collection, Processing and Storage of crude drugsJegan Nadar
Thus PPT covers Cultivation,Collection, Processing and Storage of crude drugs. This ppt includes different methods of propagation, pest and pest control management, growth regulators, polyploidy, hybridization, collection of crude drugs and storage of crude drugs.
In this ppt we study about sources of drugs which are obtained naturally mostly from plants and animals and various sources like minerals and other sources.
pharmacognosy of crude drugs.
Sources of Drugs: Drugs are substances that are used or intended to be used in the diagnosis, prevention, treatment or cure of diseases. In early times, these substances were derived from natural sources, of which plants took up the major share. With the introduction of technology, most drugs today are manufactured synthetically in the laboratory. The major sources of drugs can be grouped into the following
Exploring the Nature and Sources of Drugs: A Comprehensive Overviewpandeygsu
This presentation delves into the fascinating world of pharmaceuticals, exploring the diverse nature of drugs and their sources. From natural compounds to synthetic creations, we'll uncover the origins of these crucial medications and their impact on healthcare.
Pharmacology Experiment based Questions With Answer KeysA M O L D E O R E
MSBTE Pharmacology Practical Exam for Diploma in pharmacy students in Maharashtra.
Experimental pharmacology for D. Pharmacy Students
Pharmacology Experiment based Questions
PCI New Syllabus ER2020
Course Code: 20056
Antidepressants are a class of medication used to treat major depressive disorder, anxiety disorders, chronic pain conditions and to help manage addictions. Common side-effects of antidepressants include dry mouth, weight gain, dizziness, headaches, sexual dysfunction, and emotional blunting
Anatomy and physiology are two of the most basic terms and areas of study in the life sciences. Anatomy refers to the internal and external structures of the body and their physical relationships, whereas physiology refers to the study of the functions of those structures.
Animal cells are typical of the eukaryotic cell, enclosed by a plasma membrane and containing a membrane-bound nucleus and organelles. Unlike the eukaryotic cells of plants and fungi, animal cells do not have a cell wall. This feature was lost in the distant past by the single-celled organisms that gave rise to the kingdom Animalia. Most cells, both animal and plant, range in size between 1 and 100 micrometers and are thus visible only with the aid of a microscope.
All living organisms are made of cells and cellular products. The cell is the smallest structural, functional, and biological unit of all living organisms. It can capable of biosynthesis, replication and energy transformation. All cellular organelles carry out specific functions that are necessary for the normal functioning of the cell. Animal cells work together and function interdependently. Human cells vary in size, shape, and function. Most animal cells are so small they can only be seen with the aid of a microscope. Based on function, there are more than 200 different kinds of animal cells that help each system contribute to the homeostasis of the entire body. Despite their many differences, human cells have several similar structural features: a cell membrane, a nucleus, and cytoplasm and cell organelles.
The term “opiate” refers only to substances with morphine-like activity that are structurally related to morphine. Opioids are sometimes referred to as “narcotic analgesics” and opioid receptor antagonists as “narcotic antagonists”
Sympatholytic drugs (Adrenergic blockers) bind to the adrenergic receptors and prevent the action of adrenergic drugs.
These are drugs which block the actions of sympathetic division or catecholamines (adrenaline and noradrenaline).
They are competitive antagonists at both α and β adrenergic receptors.
Your sympathetic nervous system is best known for its role in responding to dangerous or stressful situations.
In these situations, your sympathetic nervous system activates to speed up your heart rate, deliver more blood to areas of your body that need more oxygen or other responses to help your get out of danger.
Its nerve fibers arise from the thoracic and lumbar regions of the spinal cord.
The autonomic ganglia are the synapses between preganglionic and postganglionic neurons. The postganglionic axons then go to the visceral effectors.
Acetylcholine is a neurotransmitter releases in the preganglionic nerve endings and Noradrenaline at postganglionic nerve endings.
The drugs which mimic the action sympathetic division are called sympathomimetics.
They show similar actions as that of catecholamines.
Sympathomimetic
They act by either by directly interacting with adrenergic receptors (alpha or beta) or stimulation of the adrenergic nerve endings.
The digestive system is made up of the gastrointestinal tract—also called the GI tract or digestive tract—and the liver, pancreas, and gallbladder. ... The hollow organs that make up the GI tract are the mouth, esophagus, stomach, small intestine, large intestine, and anus.
Hemostasis or haemostasis is a process to prevent and stop bleeding, meaning to keep blood within a damaged blood vessel (the opposite of hemostasis is hemorrhage). It is the first stage of wound healing. This involves coagulation, blood changing from a liquid to a gel.
Aminocaproates.
Antifibrinolytic Agents.
Estrogens, Conjugated (USP)
Hemostatics.
Tranexamic Acid.
Aprotinin.
Deamino Arginine Vasopressin
Sulfonamides (sulphonamides) are a group of man-made (synthetic) medicines that contain the sulfonamide chemical group. They may also be called sulfa drugs. Many people use the term sulfonamide imprecisely to refer only to antibiotics that have a sulfonamide functional group in their chemical structure.
The endocrine system is a messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. In vertebrates, the hypothalamus is the neural control center for all endocrine systems.
Anticoagulants are used to treat and prevent blood clots that may occur in your blood vessels. Blood clots can block blood vessels (an artery or a vein). A blocked artery stops blood and oxygen from getting to a part of your body (for example, to a part of the heart, brain or lungs).
A tissue is a group of similar cells that are specialized for a particular function.
The four basic fundamental types of body tissues are
1. Epithelial tissue
2. Connective tissue
3. Muscular tissue
4. Nervous tissue
Each type of tissue is characterized by specific functions. These tissues contribute to the overall health and maintenance of the body. These tissues combine to form organs. The various organs make up the systems of the body that allow us to function and survive in our complex world. Histology is the science that deals with the study of tissues.
In biology, the tissue is a cellular organizational level between cells and a complete organ. A tissue is an ensemble of similar cells and their extracellular matrix from the same origin that together carry out a specific function. Organs are then formed by the functional grouping together of multiple tissues.
The English word "tissue" derives from the French word "tissue", meaning that something that is "woven", from the verb tisse, "to weave".
Career scope and opportunities
Pharmacy is the health profession that links the health sciences with the chemical sciences, and it is charged with ensuring the safe and effective use of medication. The scope of pharmacy practice includes compounding and dispensing medications, and it also related to more modern services like patient care, including clinical services, reviewing medications for safety and efficacy, and providing drug information.
The demand for pharma graduates is high in sectors like - healthcare, research, manufacturing, medical marketing, pharmacovigilance etc. As a pharma graduate, you can take up job roles like - drugs inspector, drugs controller, hospital pharmacist etc.
Ever hear the term "bronchial asthma" and wonder what it means? When people talk about bronchial asthma, they are really talking about asthma, a chronic inflammatory disease of the airways that causes periodic "attacks" of coughing, wheezing, shortness of breath, and chest tightness.
According to the CDC, more than 25 million Americans, including 6.8 million children under age 18, suffer with asthma today.
Allergies are strongly linked to asthma and to other respiratory diseases such as chronic sinusitis, middle ear infections, and nasal polyps. Most interestingly, a recent analysis of people with asthma showed that those who had both allergies and asthma were much more likely to have nighttime awakening due to asthma, miss work because of asthma, and require more powerful medications to control their symptoms.
Asthma is associated with mast cells, eosinophils, and T lymphocytes. Mast cells are the allergy-causing cells that release chemicals like histamine. Histamine is the substance that causes nasal stuffiness and dripping in a cold or hay fever, constriction of airways in asthma, and itchy areas in a skin allergy. Eosinophils are a type of white blood cell associated with allergic disease. T lymphocytes are also white blood cells associated with allergy and inflammation.
These cells, along with other inflammatory cells, are involved in the development of airway inflammation in asthma that contributes to the airway hyperresponsiveness, airflow limitation, respiratory symptoms, and chronic disease. In certain individuals, the inflammation results in the feelings of chest tightness and breathlessness that's felt often at night (nocturnal asthma) or in the early morning hours. Others only feel symptoms when they exercise (called exercise-induced asthma). Because of the inflammation, the airway hyperresponsiveness occurs as a result of specific triggers.
These are substances produced by a wide variety of cells in the body, having strong biological activity. Autacoids generally act locally at the site of synthesis and release. So they have also been called ‘local hormones’. They have short duration of action. They usually exert their action at the site of inflammation, lesion and injury.
The autacoids also differ from circulating hormones in that they are produced by many tissues rather than in specific endocrine glands.
The classical autacoids are— Ex.
Histamine, Serotonin
Prostaglandins, Leukotriene, Heparin, Endothelins
Bradykinin, Angiotensin, Eicosanoids
Interleukins, TNFα (tissue necrosis factor),
Platelet activating factor
The cell is the smallest structural, functional, and biological unit of all living organisms. It can capable of biosynthesis, replication and energy transformation.
ANATOMY
Anatomy is the study of the structure or morphology of the body and the physical relationship between body parts.
PHYSIOLOGY
Physiology is the study of the functions of body parts, what they do, and how they do it.
Within the body, there are different levels of structural organization and complexity.
Parasympatholytics are the drugs that block or inhibit the actions of acetylcholine at postganglionic nerve endings and cholinergic receptors. They are also referred to as anticholinergics or cholinergic blocking agents or antispasmodics.
Anticholinergic drugs include atropine and related drugs- atropine is the prototype. Atropine is obtained from the plant Atropa belladonna. Atropine and scopolamine (hyoscine) are the belladonna alkaloids. They compete with acetylcholine for muscarinic receptors and block this receptors-they are muscarinic antagonists.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
Sources of drug (easy notes of pharmacology)
1. SOURCES OF DRUGS
Prof. Amol B. Deore
Department of Pharmacology
MVP’s Institute of Pharmaceutical Sciences, Nashik
2. SOURCES OF DRUGS
Drugs are obtained from six major sources:
Plant sources
Animal sources
Mineral/ Earth sources
Synthetic sources
Microbiological sources
Recombinant DNA technology
3. Plant Sources
• Plant source is the oldest source of
drugs.
• Most of the drugs in ancient times
were derived from plants.
• Almost all parts of the plants are
used
• i.e. leaves, stem, bark, fruits and
roots.
12. hormonal replacement
source Drug Indication
Cattle Pancreas Insulin Diabetes type-1
Sheep thyroid thyroxine hypothyroidism
Urine of pregnant
women
human chorionic
gonadotropin (hCG)
infertility
13. Animal source
source Drug Indication
Pancreas Insulin Diabetes type-1
Sheep thyroid atropine hypothyroidism
Urine of pregnant
women
human chorionic
gonadotropin (hCG)
Infertility
Cod liver vitamin A and D Vitamin deficiency
Blood of animals vaccines Infectious disease
14. Mineral Sources
• Minerals are inorganic crystal
substances that are found
naturally on earth (or in the soil).
• Patients lacking an adequate level
of these materials may take
specific mineral based drugs to
raise the level of minerals.
16. Metallic and Non-metallic sources:
Drug Indication
Iron iron deficiency anemia
Mercurial salts Syphilis
Zinc wounds and in eczema
Iodine antiseptic
Gold salts rheumatoid arthritis.
17. Synthetic Sources
• A synthetic drug is produced using chemical synthesis, which
rearranges chemical derivatives to form a new compound.
19. Microbiological Sources
• Antibiotics are the chemical substances produces by a microorganism,
which on high dilution can inhibit the growth and/or multiplication, or
kill another microorganism.
Antibiotics
20. Microbiological Sources
Bacterial source Drug
Actinobacteria Streptomycin
Streptomycis and
Micromonosporas
Aminoglycosides like
gentamicin and tobramycin
Penicillium notatum Penicillins
21. Recombinant DNA technology
• Recombinant DNA technology involves cleavage of DNA by enzyme
restriction endonucleases.
• The desired gene is coupled to rapidly replicating DNA (viral, bacterial
or plasmid).
• The new genetic combination is inserted into the bacterial cultures
which allow production of large amount of genetic material.
22.
23. Recombinant DNA technology
For example-
human insulin,
tissue plasminogen activator,
hematopoietic growth factors like erythropoietin
Advantages
Huge amounts of drugs can be produced.
Drug can be obtained in pure form.
It is less antigenic.
24. Assignment
1. Enlist sources of drugs.
2. Name any five plant sources of drugs
3. Name any five mineral drugs with therapeutic uses
4. Name any five synthetic drugs with therapeutic uses.