Drugs are obtained from six major sources: plant sources, animal sources, mineral/earth sources, microbiological sources, semi-synthetic sources, and recombinant DNA technology. Plant sources provide many older drugs and include poppy flowers, tobacco leaves, and ipecacuanha roots. Animal sources such as sheep thyroid and cod liver are used. Mineral sources include metals like iron and non-metals like iodine. Microbiological sources provide antibiotics from fungi and bacteria. Semi-synthetic drugs are modified from natural sources, while synthetic drugs have altered chemical structures. Recombinant DNA technology produces drugs by inserting genes into bacterial cultures.