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Y O G A R E V I E W B Y
D R A N J A N A P
F I N A L Y E A R P G
R & B D E PA RT M E N T
G O V T. AY U RV E D A C O L L E G E , T R I P U N I T H U R A , K E R A L A
SMRITISAGARA RASA
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Contents
 Introduction
 Ingredients
 Properties
 Indications
 Dose
 Mode of action
 Conclusion
 References
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INTRODUCTION
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 Smritisagara rasa – increasing smriti.
 Mentioned in several rasasastra classics in apasmara
prakarana.
 Contains arsenic compounds, kajjali and tamra
bhasma.
 Processed in medhya smrtivardhaka plants.
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₹ 155 for 50 tab ₹ 58 for 40 tab ₹ 142 for 80 tab
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Mentioned in Apasmara prakarana
 Ayurveda sara sangraha
 Ayurveda aushadha gunadharma shastra
 Brhat yoga tarangini
 Nighantu ratnakara
 Rasa Koumudi
 Rasatantra sara evum Siddhaprayogsangraha
 Rasayana sangraha
 Rasayoga sagara
 Ratnakara oushadhayoga
 Yogaratnakara
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 Rasa gandhaka taalaanam
sashilaa taapyabhaasvataam |
Shudhanam murcchitaanamcha
choorne bhaavyam vachasrtai:||
Ekavimshatidhaa paschaat
braahmiivaraa tathaiva cha |
Katabhiibeejatailena bhaavayet ekavaarakam ||
Smritisaagara naamaa ayam raso apasmara nashana: |
Sarpishaa mashamaatro ayam bhukto
hanyaadapasmarasmritim ||
(Rasayoga sagara)
INGREDIENTS
 Shuddha parada
 Shuddha gandhaka
 Shuddha haritala
 Shuddha manashila
 (Swarnamakshika bhasma???)- not mentioned in some
text books
 Tamra bhasma
 BHAVANA – : Vacha- Acorus calamus.(21 times)
Brahmi swarasa-Bacopa monnieri(21 times)
Jyotishmati taila-Celastrus paniculata( 1 time)
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 Haritala karmas - Lekhana , jantughna , Romasatana , nadi
daurbalya , dipana, pachana , anulomana , sothahara , raktha
shodaka, tvachya , jwaraghna .
 Till date Tamra Bhasma have been tested for its anti ulcerogenic,
anti oxidant, anti hyperlipidemic activities. Its toxicity studies
have also been carried from time to time in which it has proved to
be safe at the therapeutic drug dose level.
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 Manashila
 Rasa: Katu, Tikta
 Guna: Snigdha, Ushna, Guru
 Virya : Ushna
 Karma: Lekhana, Kapha Hara
 Prabhava:Visha Nashaka
 Rasayana action– gandhaka, manashila
Properties and Action of BHAVANA DRAVYA
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BRAHMI VACHA JYOTISHMATI or
MALKANGINI
Laghu, tikta,
kashaya, madhura,
sheeta
Katu, tikta, tikshna,
ushna
Katu, tikta, tikshna,
ushna
Action
Medhya,
Kaphapittashamaka,
smritivardhaka
Medhya,
Kaphavatashamaka,
samjnasthapana,
akshepashamana.
Medhya,
Balya, Kaphagna.
Dose
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 1 Masha once or twice a day (classical)
 125 mg once or twice a day
 250 – 500 mg also seen.
Anupana
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 Ghrta (as medhya, smritivardhaka)
 Madhu
 ksheera
 Vacha choorna
 Sarpagandha choorna
 Pravala pishti etc..
Indications
 More kaphahara
 Smritisagara rasa- J.S. Tripathi and Singh 1994 in
Residual schizophrenia.
 Other psychotic disorders
 Epilepsy
 Insomnia
 Neuropathy
 Mastishka dourbalya -Rajata bhasma 1 ratti, pravala
pishti 1 ratti, Smritisagar rasa 1 ratti and brahmi juice.
 Smriti sagara rasa is a traditional medhya rasayana.
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Researches….
 Choudhuri 2001; J.S. Tripathi and Singh 1994.
In open trials, other Ayurvedic polyherbal formulas have
shown promise in the treatment of schizophrenia. Smritisagara
rasa and Unmada gaja kesari are two complex polyherbomineral
rasayanas with reported efficacy in improving the negative
symptoms of residual-phase schizophrenia {residual or recovery
phase implies atleast 1 year period where symptoms like
hallucinations are minimal}
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 Ajit Narayan KS, et.al. pharmaceutico-analytical study
of haratala bhasma and its anticonvulsant effect on
albino rats (an experimental study). Taranath Govt.
Ayurvedic Medical College, Bellary, RGUHS,
Bengaluru. 2006. [MD Thesis]
- Haratala bhasma is having a definite demonstrable
anticonvulsant action as ascribed by experimental study
conducted on Albino rats (In vivo method)
 The plant Bacopa monnieri is reported to contain steroidal
saponin, alkaloid and glycosides etc.
 Bacoside is an active constituent in Smritisagar rasa. Bacoside A3
the main triterpenoid saponins is now regarded as responsible for
the characteristic neuropharmacological effects of the B. monnieri.
 The Bacoside A (Bacoside A3 and A2) is a saponin from B.
monnieri and reported to have antiepileptic, anticancer,
hepatoprotective, memory enhancing and antidepressant activities.
[Rastogi S, Pal R, Kulshreshtha DK. Bacoside A3-a triterpenoid
saponin from Bacopa monnieri. Phytochemistry. 1994;36:133-137]
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 Smritisagara Rasa is already tested for its genotoxic
potential by maximum single dose 2000 mg assessed
through micronucleus (MN) assay and Comet assay.
 Amongst Ayurvedic compound medicines Brahmi Vati,
Medhya Vati, Smritisagar ras etc. can be used to treat
various mental disorders.
[Psychiatry Update Psychopharmacology
Kamal N Kalita, Angshuman Kalita.Bhabani Offset &
Imaging Systems Pvt. Ltd, 2019]
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 Sutaria Bharati, Gurdipsingh and Bheem Sen Bahera,
Role of Smritisagara Rasa, Brahmighrita Nasya and
Rasayana Compounds in the Management of Epilepsy
(Apasmara). Journal of Ayurveda Physicians and
Surgeons. 2017 (October) Volume 4(4)
 The regimen consists administration of 333 mg of Smriti
Sagara Rasa along with 2 g of Vachadi Churna three times
a day orally along with intake of multiple drugs.
 Group of 12 patients of epilepsy were treated with Smriti-
Sagara Rasa along with multiple Rasayana drugs.
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Continued..
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 The therapy provided significant relief in the cardinal
symptoms ranging from 65% to 100% in
unconsciousness, falling down, convulsions, eye
distortion, foaming from mouth and teeth locking as
well as in the general symptoms, post ictal symptoms.
 The therapy reduced the duration of the fit by 86.4%
and frequency of the epileptic attacks by 66.1%. It also
significantly increased the immediate memory span and
reduced the mental fatigue.
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 Vacha, Brahmi and Jyotishmati all are medhya ,
seeta veerya and helpful in mental slowness and
depression, acts as brain tonic slowing the
degenerative changes in the brain.
-Deepak Ekka et.al. Effect of Rajat Bhasma with
SmritisagaraRasa in Parkinson
8/18/2020
21 Toxicity due to many herbomineral formulations including
Smritisagara rasa in a 11 year old girl who took 8 different
medicines once a day at different times for 6 months for
epilepsy. [Khandpur et al. Chronic arsenic toxicity from
Ayurvedic medicines]
 After 6 months of this therapy, she noticed generalized
hyperpigmentation with thickening of the palms and soles, and,
after 18 months, she developed acute abdominal distension and
vomiting.
 Analysis showed 248 mg/L arsenic concentration per
tablet(Unjha pharmacy) which was far above the normal limits.
 The safe amount of arsenic that can be handled by the human
body per day is estimated to be 12μg. The normal serum arsenic
level is < 60 μg/L.
 The source of arsenic in these medicines may be intentional,
incidental, or originating from raw plant materials.
Mode of action
 Vata shamaka, kapha shamaka
 Teekshna, ushna, vyavayi, yogavahi properties
 Seeta veerya
 Madhura vipaka
 Akshepaghna, balya(strengthens sensory neurons),
kaphaghna, samjnasthapaka, smritivardhaka.
 Srotoshodhana- clears kapha.
 Chala guna of vata gets controlled in Parkinson’s
disease(may be excessive motor functions).
 Medhya action of bhavana dravyas.
 Rasayana
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Conclusion
 Analyzing different Rasa formulations of Ayurveda
Smriti-Sagara Rasa is used as a nervine stimulant,
alterative and brain tonic.
 Used in epilepsy, mania and weakness of memory.
 Proper anupana should be selected.
 Never ‘over the counter’ drug.
 Routine inspection for any toxic effects and intake of
other medicines is to be interrogated.
 Each and every ingredient in the formulation has
its own specific role in the body.
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References
1. A review article on the use of Rajata bhasma in the management of
various diseases Dr. Pritika Devi and Dr. Keshav Rana. www.wjpr.net
Vol 8, Issue 6, 2019.
2. Complementary and Alternative Treatments in Mental Health Care by
James Lake M.D.David Spiegel M.D, American Psychiatric Publishing,
Inc, 2007.
3. Deepak Ekka et.al. Effect of Rajat Bhasma with SmritisagaraRasa in
Parkinson. Journal of Ayurveda and Integrated Medical Scieneces, July-
Aug 2017
4. Pathak Rajneesh, Sharma Arti, Patel Dhananjay V. Epilepsy (Apasmar)
& Role Of Ayurveda in its Management, International Journal of
Applied Ayurved Research. Volume II Issue 5 Jan-Feb 2016 .
5. Tripathi JS, Singh RH: Clinical evaluation of Smriti sagar rasa in cases
of residual schizophrenia. Journal of Research in Ayurveda and Siddha
15:8–16, 1994
8/18/2020
24
6. Mathew J, Paul J, Nandhu MS, Paulose CS. Bacopa monnieri and Bacoside-A
for ameliorating epilepsy associated behavioral deficits. Fitoterapia. 2010;
81:315-322.
7. A. Mishra et al. HPLC analysis and standardization of Brahmi vati e An
Ayurvedic poly-herbal formulation / Journal of Young Pharmacists(2013) 77-
82.
8. Prakash NS, Sundaram R, Mitra SK. In vitro and in vivo anticancer activity of
Bacoside A3 from whole plant of Bacopa monnieri (Linn). Am J Pharmacol
Toxicol. 2011;6:11-19.
9. Janani P, Sivakumari K, Parthasarathy C. Hepatoprotective activity of bacoside
A against N-nitrosodiethylamine-induced liver toxicity in adult rats. Cell Biol
Toxicol. 2009;25:425-434.
10. Singh HK, Rastogi RP, Srimal RC, Dhawan BN. Effect of bacoside A and B
in avoidance responses in rat. Phytother Res. 1988;2:70-75.
8/18/2020
25
11. Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effect of a
standardized Bacopa monnieri extract on cognitive performance, anxiety and
depression in the elderly: a randomized, double blind, placebo controlled trail.
J Altern Complement Med. 2008;14:707-713.
12. Vardhini NV, Sathya TN, Murthy PB. Assessment of genotoxic potential of
herbo-mineral preparations- Bhasmas. Curr Sci 2010;99:1096-100.
13. Sathya TN, Balakrishna Murthy P, Vardhini NV. Genotoxicity evaluation of
certain bhasmas using micronucleus and comet assays. Internet J Altern Med
2009;7:1.
14. Suryawanshi C.S. Study of Insomnia according to Trisutra.
15. Binu Alappat A, Kamdev Das, Arun Kumar Das, Roshy Joseph C. Ayurvedic
review of Haratala (Arsenic trisulphide – As2 S3) and its therapeutic
importance. Int J Res Altern Med. 2015;2(1):1-10.
8/18/2020
26
THANK YOU
8/18/202027

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SMRITISAGARA RASA- YOGA REVIEW

  • 1. Y O G A R E V I E W B Y D R A N J A N A P F I N A L Y E A R P G R & B D E PA RT M E N T G O V T. AY U RV E D A C O L L E G E , T R I P U N I T H U R A , K E R A L A SMRITISAGARA RASA 8/18/2020 1
  • 2. Contents  Introduction  Ingredients  Properties  Indications  Dose  Mode of action  Conclusion  References 8/18/2020 2
  • 3. INTRODUCTION 8/18/2020 3  Smritisagara rasa – increasing smriti.  Mentioned in several rasasastra classics in apasmara prakarana.  Contains arsenic compounds, kajjali and tamra bhasma.  Processed in medhya smrtivardhaka plants.
  • 4. 8/18/2020 4 ₹ 155 for 50 tab ₹ 58 for 40 tab ₹ 142 for 80 tab
  • 5. 8/18/2020 5 Mentioned in Apasmara prakarana  Ayurveda sara sangraha  Ayurveda aushadha gunadharma shastra  Brhat yoga tarangini  Nighantu ratnakara  Rasa Koumudi  Rasatantra sara evum Siddhaprayogsangraha  Rasayana sangraha  Rasayoga sagara  Ratnakara oushadhayoga  Yogaratnakara
  • 6. 8/18/2020 6  Rasa gandhaka taalaanam sashilaa taapyabhaasvataam | Shudhanam murcchitaanamcha choorne bhaavyam vachasrtai:|| Ekavimshatidhaa paschaat braahmiivaraa tathaiva cha | Katabhiibeejatailena bhaavayet ekavaarakam || Smritisaagara naamaa ayam raso apasmara nashana: | Sarpishaa mashamaatro ayam bhukto hanyaadapasmarasmritim || (Rasayoga sagara)
  • 7. INGREDIENTS  Shuddha parada  Shuddha gandhaka  Shuddha haritala  Shuddha manashila  (Swarnamakshika bhasma???)- not mentioned in some text books  Tamra bhasma  BHAVANA – : Vacha- Acorus calamus.(21 times) Brahmi swarasa-Bacopa monnieri(21 times) Jyotishmati taila-Celastrus paniculata( 1 time) 8/18/2020 7
  • 8. 8/18/2020 8  Haritala karmas - Lekhana , jantughna , Romasatana , nadi daurbalya , dipana, pachana , anulomana , sothahara , raktha shodaka, tvachya , jwaraghna .  Till date Tamra Bhasma have been tested for its anti ulcerogenic, anti oxidant, anti hyperlipidemic activities. Its toxicity studies have also been carried from time to time in which it has proved to be safe at the therapeutic drug dose level.
  • 9. 8/18/2020 9  Manashila  Rasa: Katu, Tikta  Guna: Snigdha, Ushna, Guru  Virya : Ushna  Karma: Lekhana, Kapha Hara  Prabhava:Visha Nashaka  Rasayana action– gandhaka, manashila
  • 10. Properties and Action of BHAVANA DRAVYA 8/18/2020 10 BRAHMI VACHA JYOTISHMATI or MALKANGINI Laghu, tikta, kashaya, madhura, sheeta Katu, tikta, tikshna, ushna Katu, tikta, tikshna, ushna Action Medhya, Kaphapittashamaka, smritivardhaka Medhya, Kaphavatashamaka, samjnasthapana, akshepashamana. Medhya, Balya, Kaphagna.
  • 11. Dose 8/18/2020 11  1 Masha once or twice a day (classical)  125 mg once or twice a day  250 – 500 mg also seen.
  • 12. Anupana 8/18/2020 12  Ghrta (as medhya, smritivardhaka)  Madhu  ksheera  Vacha choorna  Sarpagandha choorna  Pravala pishti etc..
  • 13. Indications  More kaphahara  Smritisagara rasa- J.S. Tripathi and Singh 1994 in Residual schizophrenia.  Other psychotic disorders  Epilepsy  Insomnia  Neuropathy  Mastishka dourbalya -Rajata bhasma 1 ratti, pravala pishti 1 ratti, Smritisagar rasa 1 ratti and brahmi juice.  Smriti sagara rasa is a traditional medhya rasayana. 8/18/2020 13
  • 14. Researches….  Choudhuri 2001; J.S. Tripathi and Singh 1994. In open trials, other Ayurvedic polyherbal formulas have shown promise in the treatment of schizophrenia. Smritisagara rasa and Unmada gaja kesari are two complex polyherbomineral rasayanas with reported efficacy in improving the negative symptoms of residual-phase schizophrenia {residual or recovery phase implies atleast 1 year period where symptoms like hallucinations are minimal} 8/18/2020 14
  • 15. 8/18/2020 15  Ajit Narayan KS, et.al. pharmaceutico-analytical study of haratala bhasma and its anticonvulsant effect on albino rats (an experimental study). Taranath Govt. Ayurvedic Medical College, Bellary, RGUHS, Bengaluru. 2006. [MD Thesis] - Haratala bhasma is having a definite demonstrable anticonvulsant action as ascribed by experimental study conducted on Albino rats (In vivo method)
  • 16.  The plant Bacopa monnieri is reported to contain steroidal saponin, alkaloid and glycosides etc.  Bacoside is an active constituent in Smritisagar rasa. Bacoside A3 the main triterpenoid saponins is now regarded as responsible for the characteristic neuropharmacological effects of the B. monnieri.  The Bacoside A (Bacoside A3 and A2) is a saponin from B. monnieri and reported to have antiepileptic, anticancer, hepatoprotective, memory enhancing and antidepressant activities. [Rastogi S, Pal R, Kulshreshtha DK. Bacoside A3-a triterpenoid saponin from Bacopa monnieri. Phytochemistry. 1994;36:133-137] 8/18/2020 16
  • 17.  Smritisagara Rasa is already tested for its genotoxic potential by maximum single dose 2000 mg assessed through micronucleus (MN) assay and Comet assay.  Amongst Ayurvedic compound medicines Brahmi Vati, Medhya Vati, Smritisagar ras etc. can be used to treat various mental disorders. [Psychiatry Update Psychopharmacology Kamal N Kalita, Angshuman Kalita.Bhabani Offset & Imaging Systems Pvt. Ltd, 2019] 8/18/2020 17
  • 18.  Sutaria Bharati, Gurdipsingh and Bheem Sen Bahera, Role of Smritisagara Rasa, Brahmighrita Nasya and Rasayana Compounds in the Management of Epilepsy (Apasmara). Journal of Ayurveda Physicians and Surgeons. 2017 (October) Volume 4(4)  The regimen consists administration of 333 mg of Smriti Sagara Rasa along with 2 g of Vachadi Churna three times a day orally along with intake of multiple drugs.  Group of 12 patients of epilepsy were treated with Smriti- Sagara Rasa along with multiple Rasayana drugs. 8/18/2020 18
  • 19. Continued.. 8/18/2020 19  The therapy provided significant relief in the cardinal symptoms ranging from 65% to 100% in unconsciousness, falling down, convulsions, eye distortion, foaming from mouth and teeth locking as well as in the general symptoms, post ictal symptoms.  The therapy reduced the duration of the fit by 86.4% and frequency of the epileptic attacks by 66.1%. It also significantly increased the immediate memory span and reduced the mental fatigue.
  • 20. 8/18/2020 20  Vacha, Brahmi and Jyotishmati all are medhya , seeta veerya and helpful in mental slowness and depression, acts as brain tonic slowing the degenerative changes in the brain. -Deepak Ekka et.al. Effect of Rajat Bhasma with SmritisagaraRasa in Parkinson
  • 21. 8/18/2020 21 Toxicity due to many herbomineral formulations including Smritisagara rasa in a 11 year old girl who took 8 different medicines once a day at different times for 6 months for epilepsy. [Khandpur et al. Chronic arsenic toxicity from Ayurvedic medicines]  After 6 months of this therapy, she noticed generalized hyperpigmentation with thickening of the palms and soles, and, after 18 months, she developed acute abdominal distension and vomiting.  Analysis showed 248 mg/L arsenic concentration per tablet(Unjha pharmacy) which was far above the normal limits.  The safe amount of arsenic that can be handled by the human body per day is estimated to be 12μg. The normal serum arsenic level is < 60 μg/L.  The source of arsenic in these medicines may be intentional, incidental, or originating from raw plant materials.
  • 22. Mode of action  Vata shamaka, kapha shamaka  Teekshna, ushna, vyavayi, yogavahi properties  Seeta veerya  Madhura vipaka  Akshepaghna, balya(strengthens sensory neurons), kaphaghna, samjnasthapaka, smritivardhaka.  Srotoshodhana- clears kapha.  Chala guna of vata gets controlled in Parkinson’s disease(may be excessive motor functions).  Medhya action of bhavana dravyas.  Rasayana 8/18/2020 22
  • 23. Conclusion  Analyzing different Rasa formulations of Ayurveda Smriti-Sagara Rasa is used as a nervine stimulant, alterative and brain tonic.  Used in epilepsy, mania and weakness of memory.  Proper anupana should be selected.  Never ‘over the counter’ drug.  Routine inspection for any toxic effects and intake of other medicines is to be interrogated.  Each and every ingredient in the formulation has its own specific role in the body. 8/18/2020 23
  • 24. References 1. A review article on the use of Rajata bhasma in the management of various diseases Dr. Pritika Devi and Dr. Keshav Rana. www.wjpr.net Vol 8, Issue 6, 2019. 2. Complementary and Alternative Treatments in Mental Health Care by James Lake M.D.David Spiegel M.D, American Psychiatric Publishing, Inc, 2007. 3. Deepak Ekka et.al. Effect of Rajat Bhasma with SmritisagaraRasa in Parkinson. Journal of Ayurveda and Integrated Medical Scieneces, July- Aug 2017 4. Pathak Rajneesh, Sharma Arti, Patel Dhananjay V. Epilepsy (Apasmar) & Role Of Ayurveda in its Management, International Journal of Applied Ayurved Research. Volume II Issue 5 Jan-Feb 2016 . 5. Tripathi JS, Singh RH: Clinical evaluation of Smriti sagar rasa in cases of residual schizophrenia. Journal of Research in Ayurveda and Siddha 15:8–16, 1994 8/18/2020 24
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  • 26. 11. Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effect of a standardized Bacopa monnieri extract on cognitive performance, anxiety and depression in the elderly: a randomized, double blind, placebo controlled trail. J Altern Complement Med. 2008;14:707-713. 12. Vardhini NV, Sathya TN, Murthy PB. Assessment of genotoxic potential of herbo-mineral preparations- Bhasmas. Curr Sci 2010;99:1096-100. 13. Sathya TN, Balakrishna Murthy P, Vardhini NV. Genotoxicity evaluation of certain bhasmas using micronucleus and comet assays. Internet J Altern Med 2009;7:1. 14. Suryawanshi C.S. Study of Insomnia according to Trisutra. 15. Binu Alappat A, Kamdev Das, Arun Kumar Das, Roshy Joseph C. Ayurvedic review of Haratala (Arsenic trisulphide – As2 S3) and its therapeutic importance. Int J Res Altern Med. 2015;2(1):1-10. 8/18/2020 26