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By:
Dr.Lavanya.S.A
II yr PG Scholar
Dept of RS & BK
T.G.A.M.C
Bellary
Under the guidance of:
Dr.M.S.Doddamani
HOD & Professor
PG Dept of RS & BK
T.G.A.M.C
Bellary
Abuse of nature’s law upsets the human system and ends up in
disease like arbuda, granthi etc. It is again the nature , the foremost
physician who brings the cure. Ayurvedic system of medicine was well
founded on the basic principles of nature and its elements. No disease is
manifested without involvement of tridosha is the basic ideology of
ayurveda and one can control the vitiation of tridosha with the help of
herbal/ herbo-mineral compound.
Rasoushadhi’s are considered to be the most potent
formulations administered in smaller dosage forms. One such rasoushadhi
is ROUDRA RASA, which is mentioned in classics for the treatment of
Arbuda
अगाधमाांसोच्छ्रयमत्यगाधमर्बुदां इति ।
दोष सांमूच्छ््ुन in
गात्र प्रदेश
Leads to
माांस प्रदूषण
चिरवृद्चध
अपाक
चिर,वृत्त,
महान्ि शोफअर्बुद
Based on dosha Based on saadhyasaadhyata Based on sthana
Saadhya Asaadhya
Vataja Vataja Raktaja Vartmarbuda
Pittaja Pittaja Marmajanita Karnarbuda
Kaphaja Kaphaja Adhyarbuda Talu-arbuda
Raktaja Medaja Mamsarbuda Shiro-arbuda
Medaja Srotraarbuda Galarbuda
Mamsaja Jalarbuda Nasarbuda
Talu-arbuda Raktarbuda
Galarbuda Jalarbuda
Mukharbuda
shonitarbuda
Mamsarbuda
According to Su.Ni(11/14,18-19)
CHIKITSA
SHALYA
CHIKITSA
OUSHADHI
CHIKITSA
ANUSHASTRA
CHIKITSA
STHANIKA SARVADEHIKA AGNIKARMA RAKTAMOKSHANA KSHARA
CHIKITSA
It is a formulation told under Arbudadikara. There are 6 references
which are as follows available for this preparation.
Bhaishajya Ratnavali
Rasaratna samucchaya
Rasendra Chinatmani
Rasamruta
Bharata Bhaishajya Ratnakara
Basavarajiyam
Sl
no
INGREDIENT QUANTITY FORM CHEMICAL/
BOTANICAL/
SCIENTIFIC NAME
1. Parada 1 part Shuddha Hydrargium
2. Gandhaka 1 part Shuddha Sulphur
3. Nagavalli Patra Q.S Swarasa Piper betel
4. Meghanada
Panchanga
Q.S Kwatha Amaranthus spinosus
5. Punarnava
Panchanga
Q.S Swarasa Boerhavia diffusa
6. Gomutra Q.S Liquid Bos tauraus
7. Pippali phala Q.S Kwatha Piper longum
METHOD OF PREPARATION
• Shuddha Parada and Shuddha Gandhaka is taken and kajjali is
prepared until the siddhi lakshanas are obtained.
Bhavana of kajjali is done with the following media for one time
each for 4 yama kala.
Nagavalli patra swarasa Meghanada Panchanga
Kwatha
Punarnava panchanga
kwatha
Gomutra Pippali Phala
Kashaya
Thereafter chakrikas are prepared and put inside sharava. After
sandhibandhana it is subjected for 1 laghu puta.
Dose: 125 mg Anupana : Madhu
Indication: Arbuda
 In majority of the references the ingredients are the same, only In
Basavarajiyam, Bala is told as an additional drug for bhavana, all
other ingredients are same.
 In parishishta of Rasa yoga sagara, there is a preparation in the
name of Roudra rasa indicated for Sannipataja Jwara.
Pharmacological Properties:
Rasa : Shad Rasa
Guna : Snigdha, Sara
Veerya : Ushna
Vipaka : Madhura
Karma : Yoga Vahi, Rasayana, Vrishya, Balya, Vayastambhana, Pustikarak,
Deepana, Agni Vardhaka, Deha Sidhikara, Loha Sidhikara, Krimighna.
Dosha Prabhava : Tridoshagna
Vyadhi Prabhava : Vata Roga, Valipalitha, Jara Roga, Sarva Akshiroga, Krimi, Kusta,
Sarva roga
Pharmacological
Properties
• Rasa : Katu, Madhura,
• Veerya : Ushna
• Guna : Laghu, Snigda
• Doshgnatha : Kapha vatahara
• Dose : 1-8 Ratti
• Anupana : Milk ,water
Properties
Rasa : Katu, Tikta
Guna : Laghu, Ruksha, Tikshna,
Vishada.
Veerya : Ushna
Vipaka : Katu
Karma : Shothahara, Kaphagna,
Poushtika, Jwaraghna etc..
Doshagnata : Kaphavatashamaka
Rogaghnata : Shotha, kasa, shwasa,
swarbheda, vibandha etc..
Actions Proved
Aqueous leaf extract exhibit
strong anti-proliferative activity
towards human naso-pharangeal
epidermoid carcinoma
Chlorogenic acid target and kills
myeloid and lymphoid cancer cells
Induce programmed cell death in
human cancer cells.
Rasa : Madhura,tikta,kashaya
Guna : Laghu,Rooksha
Veerya : Ushna
Vipaka : Madhura
Karma : Shothahara, Lekhana
Deepana, Anulomana,
Rasayana, Vishaghna,
Mootrajanana etc..
Doshagnata : Tridoshshamaka
Properties
Actions proved
Inhibits
Human NK Cell
cytotoxicity in
vitro
Enhances NK
cell Activity
Ethanolic extracts of roots
Rasa : Katu
Guna : Laghu,Sheeta,Rooksha
Veerya : Sheeta
Vipaka : Katu
Karma : Ruchya, Deepana,
Vishaharaka
Doshagnata : Kaphapittajit
Properties Actions proved
Antitumor
effects in EAC
Bearing mice
Increase
antibody
production
Ethanol
Extract
of leaves
Rasa : Katu
Guna : Laghu,Snigdha,tikshna
Veerya : Anushna sheeta
Vipaka : Madhura
Karma : Raktotkleshaka,
Deepana, Rasayana
Doshagnata : Kaphavatahara.
Properties Actions proved
Inhibit
growth of
tumor
induced DLA
Cells
Increase
lifespan of
mice bearing
ascites tumor
induced by
ELA
Properties Actions proved
Reduce
apoptosis in
lymphocytes
Repair the
damaged
DNA
Rasa : Katu, Tikta, Kashaya,
Guna : Ushna, Kshaara, Teekshna.
Veerya : Ushna
Vipaka : Katu
Doshagnata: Kaphavatahara
Rogaghnata: Shoola, Gulma, Aanaha,
Kandu, Akshiroga, Kilasa,
Mukharoga, Atisara
• Tridosha causes arbuda with
dominance of kapha and vata. Parada
is tridoshghna and gandhaka is kapha
vataghna.
• Katu tikta rasa of bhavana dravyas act
as rochana, deepana,pachana and
stimulates both Jatharagni and
Dhatvagni. Thus, acts as ama pachaka
and prevent the formation of ama.
• Srotas blocked by kapha and ama are
cleared up by the help of sroto
shodhana karma of the ingredients.
Actions proved
Cytotoxic against KB cells
Apoptotic action
• Ushna veerya of the drugs help in srotoshodhana by doing lekhana
karma.
• Vishaghna and krimighna action of gandhaka and rakta shodhana
karma of parada helps in purification of blood and work as antibiotic
and antiseptic.
• Due to laghu puta compound become sukshma, laghu and help in
reaching the site through its action at the main site of khavaigunya.
• The main lakshana of arbuda is shopha, Shopha mainly develops
because of kapha and medas. The bhavana dravyas are mainly
kaphahara and are of kashaya rasa which does lekhana karma.
• Madhu is given as anupana where in it is one of the best sleshmahara
dravya.
• Alpo hi matra vipulogunshcha……..
explains about the small quantity of the drug and great efficacy of rasa
dravyas.
• As the ingredients are easily available and the method of preparation is
easier, Roudra rasa is cost effective.
• Arbuda requires tridoshahara and rasayana chikitsa. Thus, roudra rasa
becomes the drug of choice in the treatment of cancer.
REFERNCES
1. Dr.Ambikadata Shastri,(1995) Sushruta samhita( Purvardha). Ayurveda Tatwa Snadipaika Hindi
vyakhya, 9th edition,Varanasi, Chaukambha Sanskrit Sansthan, Nidanasthana,P270 .
2. Shri Govindadas (2002), Bhaisajya Ratnavalli, Chapter 44, shloka no 59-60, edited by Kaviraj
Shri Ambikadatta shastri and by Shri Rajeswaradatta shastri (2002), Chaukambha Sanskrita
Samsthana, Varanasi, p 583.
3. Vaidya Pandit hariprapannafji (2005) Rasa Yoga Sagara, Chaukamba, chapter 3, shloka no 25-
26, Krishnadas academy, Varanasi, vol 2, p 619
4. Sri Gopala Krishna (2003) Rasendra Sara Sangraha, Chapter 3, shloka no 1-2, Dr. A.D. Satpute,
Chaukamba, Krishnadas academy, Varanasi, p 576.
5. Acharya Dhundhuk Nath (2006), Rasendra Chintamani, chapter 9, shloka no 1-2, Prof. Siddhi
nandan mishra, Chaukamba Orientalia, Varanasi, p 342.
6. Acharya Shalinath (2003), Rasa Manjari, chapter 6, shloka 320-321, Prof. Siddhi Nandan
Mishra, Chaukamba Orientalia, Varanasi, second edition, p 127.
7. Shri Nagindas Chaganlal Shah (1999) Bharat Bhaisajya Ratnakara, Vaidya Gopinatha
bhishagratna, B.jain.publications, New Delhi, p 455 (6161).
8. Basavarajiyam (1999), Basavarajavirautam, Imprint Delhi, Chaukamba Samskritapratistha,
Varanasi, p 326.
9.Dhanwantari with shikki kandiyam (1979), commentary by kavungal neelkandapilla
chapter 80, reddiyar press,thiruvanthapuram, 4th edition, p 138.
10.Acharya Sri Madhava (2000), Ayurveda Prakasha chapter 2 shloka no 83, Shri Gulrajsharma
mishra and Pandit Shiva Sharma, Hindi commentary, Chaukambha bharat academy,
Varanasi, p 277.
11.Acharya Vagbhata (2003), RRS English translation chapter 1, shloka no 89, Dr. A.D. Satpute,
Chaukamba Sanskrit pratisthan, Delhi, 3rd edition, p 16.
12.Acharya Vagbhata (2003), RRS English translation, chapter 1, shloka no 34, Dr. A.D. Satpute,
Chaukamba Sanskrit ,pratisthan, Delhi, Chapter 1, 2nd edition p 8.
13. Fathilah1 A. R., Sujata R., Norhanom A. W. and Adenan M. I.Antiproliferative activit of
aqueous extract of Piper betle L. and Psidium guajava L. on KB and HeLa cell lines,
Journal of Medicinal Plants Research 2010.Vol. 4 (11), pp. 987-990.
14. Samuel Joshua L., Vipin Chandra Pal, K. L. Senthil Kumar, Ram Kumar Sahu, Amit Roy,
Antitumour activity of the ethanol extract of Amaranthus spinosus leaves against EAC bearing
Swiss albino mice, 2010: Scholars Research Library .Der Pharmacia Lettre2(2): 10-15.
15. Mehrotra S, Singh V.K, Agrawal SS, Maurya R. Srimal R.C:Anti lymphoproliferative Activity of
Ethanolic Extract of Boerhaavia diffusa Roots.2002. Exp. Mol.Patho1
72(3):236-42.
16. Mehrotra, S. Mishra, K. P Maurya, R. Srimal R. C. and Singh V.K Immunomodulatory activities
of Punarnavine, an alkaloid from Boerhaavia diffusa 2002. International
Immunopharmacology.Vol. (2)987-996.
17. Sunila ES, Kuttan G, Immunomodulatory and anti tumor activity of Piper longum Linn. and
piperine. 2004:J.Ethanopharmacol.90 (2-3):339-46.

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Anticancer Properties of Roudra Rasa

  • 1. By: Dr.Lavanya.S.A II yr PG Scholar Dept of RS & BK T.G.A.M.C Bellary Under the guidance of: Dr.M.S.Doddamani HOD & Professor PG Dept of RS & BK T.G.A.M.C Bellary
  • 2. Abuse of nature’s law upsets the human system and ends up in disease like arbuda, granthi etc. It is again the nature , the foremost physician who brings the cure. Ayurvedic system of medicine was well founded on the basic principles of nature and its elements. No disease is manifested without involvement of tridosha is the basic ideology of ayurveda and one can control the vitiation of tridosha with the help of herbal/ herbo-mineral compound. Rasoushadhi’s are considered to be the most potent formulations administered in smaller dosage forms. One such rasoushadhi is ROUDRA RASA, which is mentioned in classics for the treatment of Arbuda
  • 4.
  • 5. दोष सांमूच्छ््ुन in गात्र प्रदेश Leads to माांस प्रदूषण चिरवृद्चध अपाक चिर,वृत्त, महान्ि शोफअर्बुद
  • 6. Based on dosha Based on saadhyasaadhyata Based on sthana Saadhya Asaadhya Vataja Vataja Raktaja Vartmarbuda Pittaja Pittaja Marmajanita Karnarbuda Kaphaja Kaphaja Adhyarbuda Talu-arbuda Raktaja Medaja Mamsarbuda Shiro-arbuda Medaja Srotraarbuda Galarbuda Mamsaja Jalarbuda Nasarbuda Talu-arbuda Raktarbuda Galarbuda Jalarbuda Mukharbuda shonitarbuda Mamsarbuda According to Su.Ni(11/14,18-19)
  • 8. It is a formulation told under Arbudadikara. There are 6 references which are as follows available for this preparation. Bhaishajya Ratnavali Rasaratna samucchaya Rasendra Chinatmani Rasamruta Bharata Bhaishajya Ratnakara Basavarajiyam
  • 9. Sl no INGREDIENT QUANTITY FORM CHEMICAL/ BOTANICAL/ SCIENTIFIC NAME 1. Parada 1 part Shuddha Hydrargium 2. Gandhaka 1 part Shuddha Sulphur 3. Nagavalli Patra Q.S Swarasa Piper betel 4. Meghanada Panchanga Q.S Kwatha Amaranthus spinosus 5. Punarnava Panchanga Q.S Swarasa Boerhavia diffusa 6. Gomutra Q.S Liquid Bos tauraus 7. Pippali phala Q.S Kwatha Piper longum
  • 10. METHOD OF PREPARATION • Shuddha Parada and Shuddha Gandhaka is taken and kajjali is prepared until the siddhi lakshanas are obtained.
  • 11. Bhavana of kajjali is done with the following media for one time each for 4 yama kala. Nagavalli patra swarasa Meghanada Panchanga Kwatha Punarnava panchanga kwatha Gomutra Pippali Phala Kashaya
  • 12. Thereafter chakrikas are prepared and put inside sharava. After sandhibandhana it is subjected for 1 laghu puta.
  • 13. Dose: 125 mg Anupana : Madhu Indication: Arbuda
  • 14.  In majority of the references the ingredients are the same, only In Basavarajiyam, Bala is told as an additional drug for bhavana, all other ingredients are same.  In parishishta of Rasa yoga sagara, there is a preparation in the name of Roudra rasa indicated for Sannipataja Jwara.
  • 15. Pharmacological Properties: Rasa : Shad Rasa Guna : Snigdha, Sara Veerya : Ushna Vipaka : Madhura Karma : Yoga Vahi, Rasayana, Vrishya, Balya, Vayastambhana, Pustikarak, Deepana, Agni Vardhaka, Deha Sidhikara, Loha Sidhikara, Krimighna. Dosha Prabhava : Tridoshagna Vyadhi Prabhava : Vata Roga, Valipalitha, Jara Roga, Sarva Akshiroga, Krimi, Kusta, Sarva roga
  • 16. Pharmacological Properties • Rasa : Katu, Madhura, • Veerya : Ushna • Guna : Laghu, Snigda • Doshgnatha : Kapha vatahara • Dose : 1-8 Ratti • Anupana : Milk ,water
  • 17. Properties Rasa : Katu, Tikta Guna : Laghu, Ruksha, Tikshna, Vishada. Veerya : Ushna Vipaka : Katu Karma : Shothahara, Kaphagna, Poushtika, Jwaraghna etc.. Doshagnata : Kaphavatashamaka Rogaghnata : Shotha, kasa, shwasa, swarbheda, vibandha etc.. Actions Proved Aqueous leaf extract exhibit strong anti-proliferative activity towards human naso-pharangeal epidermoid carcinoma Chlorogenic acid target and kills myeloid and lymphoid cancer cells Induce programmed cell death in human cancer cells.
  • 18. Rasa : Madhura,tikta,kashaya Guna : Laghu,Rooksha Veerya : Ushna Vipaka : Madhura Karma : Shothahara, Lekhana Deepana, Anulomana, Rasayana, Vishaghna, Mootrajanana etc.. Doshagnata : Tridoshshamaka Properties Actions proved Inhibits Human NK Cell cytotoxicity in vitro Enhances NK cell Activity Ethanolic extracts of roots
  • 19. Rasa : Katu Guna : Laghu,Sheeta,Rooksha Veerya : Sheeta Vipaka : Katu Karma : Ruchya, Deepana, Vishaharaka Doshagnata : Kaphapittajit Properties Actions proved Antitumor effects in EAC Bearing mice Increase antibody production Ethanol Extract of leaves
  • 20. Rasa : Katu Guna : Laghu,Snigdha,tikshna Veerya : Anushna sheeta Vipaka : Madhura Karma : Raktotkleshaka, Deepana, Rasayana Doshagnata : Kaphavatahara. Properties Actions proved Inhibit growth of tumor induced DLA Cells Increase lifespan of mice bearing ascites tumor induced by ELA
  • 21. Properties Actions proved Reduce apoptosis in lymphocytes Repair the damaged DNA Rasa : Katu, Tikta, Kashaya, Guna : Ushna, Kshaara, Teekshna. Veerya : Ushna Vipaka : Katu Doshagnata: Kaphavatahara Rogaghnata: Shoola, Gulma, Aanaha, Kandu, Akshiroga, Kilasa, Mukharoga, Atisara
  • 22. • Tridosha causes arbuda with dominance of kapha and vata. Parada is tridoshghna and gandhaka is kapha vataghna. • Katu tikta rasa of bhavana dravyas act as rochana, deepana,pachana and stimulates both Jatharagni and Dhatvagni. Thus, acts as ama pachaka and prevent the formation of ama. • Srotas blocked by kapha and ama are cleared up by the help of sroto shodhana karma of the ingredients. Actions proved Cytotoxic against KB cells Apoptotic action
  • 23. • Ushna veerya of the drugs help in srotoshodhana by doing lekhana karma. • Vishaghna and krimighna action of gandhaka and rakta shodhana karma of parada helps in purification of blood and work as antibiotic and antiseptic. • Due to laghu puta compound become sukshma, laghu and help in reaching the site through its action at the main site of khavaigunya. • The main lakshana of arbuda is shopha, Shopha mainly develops because of kapha and medas. The bhavana dravyas are mainly kaphahara and are of kashaya rasa which does lekhana karma. • Madhu is given as anupana where in it is one of the best sleshmahara dravya.
  • 24. • Alpo hi matra vipulogunshcha…….. explains about the small quantity of the drug and great efficacy of rasa dravyas. • As the ingredients are easily available and the method of preparation is easier, Roudra rasa is cost effective. • Arbuda requires tridoshahara and rasayana chikitsa. Thus, roudra rasa becomes the drug of choice in the treatment of cancer.
  • 25. REFERNCES 1. Dr.Ambikadata Shastri,(1995) Sushruta samhita( Purvardha). Ayurveda Tatwa Snadipaika Hindi vyakhya, 9th edition,Varanasi, Chaukambha Sanskrit Sansthan, Nidanasthana,P270 . 2. Shri Govindadas (2002), Bhaisajya Ratnavalli, Chapter 44, shloka no 59-60, edited by Kaviraj Shri Ambikadatta shastri and by Shri Rajeswaradatta shastri (2002), Chaukambha Sanskrita Samsthana, Varanasi, p 583. 3. Vaidya Pandit hariprapannafji (2005) Rasa Yoga Sagara, Chaukamba, chapter 3, shloka no 25- 26, Krishnadas academy, Varanasi, vol 2, p 619 4. Sri Gopala Krishna (2003) Rasendra Sara Sangraha, Chapter 3, shloka no 1-2, Dr. A.D. Satpute, Chaukamba, Krishnadas academy, Varanasi, p 576. 5. Acharya Dhundhuk Nath (2006), Rasendra Chintamani, chapter 9, shloka no 1-2, Prof. Siddhi nandan mishra, Chaukamba Orientalia, Varanasi, p 342. 6. Acharya Shalinath (2003), Rasa Manjari, chapter 6, shloka 320-321, Prof. Siddhi Nandan Mishra, Chaukamba Orientalia, Varanasi, second edition, p 127.
  • 26. 7. Shri Nagindas Chaganlal Shah (1999) Bharat Bhaisajya Ratnakara, Vaidya Gopinatha bhishagratna, B.jain.publications, New Delhi, p 455 (6161). 8. Basavarajiyam (1999), Basavarajavirautam, Imprint Delhi, Chaukamba Samskritapratistha, Varanasi, p 326. 9.Dhanwantari with shikki kandiyam (1979), commentary by kavungal neelkandapilla chapter 80, reddiyar press,thiruvanthapuram, 4th edition, p 138. 10.Acharya Sri Madhava (2000), Ayurveda Prakasha chapter 2 shloka no 83, Shri Gulrajsharma mishra and Pandit Shiva Sharma, Hindi commentary, Chaukambha bharat academy, Varanasi, p 277. 11.Acharya Vagbhata (2003), RRS English translation chapter 1, shloka no 89, Dr. A.D. Satpute, Chaukamba Sanskrit pratisthan, Delhi, 3rd edition, p 16. 12.Acharya Vagbhata (2003), RRS English translation, chapter 1, shloka no 34, Dr. A.D. Satpute, Chaukamba Sanskrit ,pratisthan, Delhi, Chapter 1, 2nd edition p 8.
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