Silybum marianum, commonly known as milk thistle, contains chemical constituents such as silibinin, silychristin, silydianin, and tocopherols. It has various uses including as an antioxidant, anti-inflammatory, hepatoprotective agent, and for treating depression. Its mechanism of action involves inhibiting inflammatory processes, protecting the liver from toxins, and preventing blood clots. Potential side effects include increased bile flow and mild loose stools. It can interact with various drugs and should be avoided in pregnancy, breastfeeding, and for those with certain medical conditions.