The document discusses goldenseal (Hydrastis canadensis), a perennial herb used medicinally. It describes goldenseal's botanical origin, chemical constituents including berberine, uses such as treating infections and promoting healing, side effects like hypoglycemia, contraindications like pregnancy, and drug interactions with cyclosporine and liver-metabolized medications. Goldenseal is used as an anti-fungal, anti-catarrhal, and anti-diabetic, but its use is often recommended for short-term treatment only.

1. HYDRASTISCANADENSIS

2. INTRODUCTION
GOLDENSEAL ,ALSO CALLED ORANGEROOT OR YELLOW ,PUCCOON, IS A
PERENNIAL HERB.

3. BOTANICAL ORIGIN : HYDRASATIS CANADENSIS
FAMILY: RANUNCULACEAE
LOCAL NAMES: GOLDENSEAL , ORANGEROOT
PART USED: ROOTS AND RHIZOMES
CHEMICAL CLASS: ALKALOIDS

4. CHEMICAL CONSTITUENTS
• BERBERINE
• CANADINE
• HYDRASTINE

5. SOLUBILITY
• IN WATER (SOLUBLE SLOWLY)
• IN ORGANIC SOLVENT (INSOLUBLE IN ETHER)

6. BIOAVAILABLITY
• DOSES RANGE FROM 500 TO 2000 MG OF THE DRIED EXTRACT, 1 ML LIQUID
EXTRACT, OR 2 TO 4 ML, TINCTURE. IT IS OFTEN RECOMMENDED FOR SHORT-
TERM USE TO HELP TREAT INFECTIONS AND PROMOTE HEALING.

7. USES
• MASKING ILLEGAL DRUGS IN URINE TESTS.
• ANTI FUNGAL
• ANTICATARRHAL
• ANTI-DIABETIC

8. SIDE EFFECTS
• HYPOGLYCEMIA
• MUCOSAL IRRITATION

9. CONTRAINDICATIONS
• CONTRAINDICATED IN PREGNANCY

10. DRUG INTERACTION
• CYCLOSPORINE INTERACTS WITH GOLDENSEAL.
• MEDICATIONS CHANGED BY THE LIVER INTERACTS WITH GOLDENSEAL.

11. REFRENCES
• HTTP://WWW.WEBMD.COM/VITAMINS-SUPPLEMENTS/INGREDIENTMONO-943-
GOLDENSEAL.ASPX?ACTIVEINGREDIENTID=943&ACTIVEINGREDIENTNAME=GO
LDENSEAL
• HTTP://MEDICINALPLANTS.US/CATEGORY/GOLDENSEAL
• HTTP://WWW.NCBI.NLM.NIH.GOV/ PMC1868501
• HTTP://WWW.AGR.GC.CA/ › ENG › MEDICINAL-CROPS
• HTTP://ABCHOMEOPATHY.COM/ › R.PHP ›