Presented by Shirley Tarawali at the Expert dialogue: The future of sustainable agriculture. Let’s think about… livestock, German Federal Ministry for Economic Cooperation and Development (BMZ), 28 June 2022
Livestock marketing and supply chain management of livestock products ILRI
Presented by Steven J. Staal as a keynote address at the 74th Annual Conference of the Indian Society of Agricultural Economics, Maharashtra, India, 18-20 December 2014
Priority areas of livestock sector for strengthening food and nutrition secur...ILRI
Presented by Tek B. Gurung and Bimal K. Nirmal at the Workshop on transforming livelihoods in South Asia through sustainable livestock research and development, Kathmandu, Nepal, 13-14 November 2018
Livestock Master Plan (LMP): Roadmaps for the Ethiopia Growth and Transformat...ILRI
Presented by Barry Shapiro at the Rural Economic Development and Food Security Sector Working Group Broader Platform meeting, Addis Ababa, Ethiopia, 2 July 2015
Livestock marketing and supply chain management of livestock products ILRI
Presented by Steven J. Staal as a keynote address at the 74th Annual Conference of the Indian Society of Agricultural Economics, Maharashtra, India, 18-20 December 2014
Priority areas of livestock sector for strengthening food and nutrition secur...ILRI
Presented by Tek B. Gurung and Bimal K. Nirmal at the Workshop on transforming livelihoods in South Asia through sustainable livestock research and development, Kathmandu, Nepal, 13-14 November 2018
Livestock Master Plan (LMP): Roadmaps for the Ethiopia Growth and Transformat...ILRI
Presented by Barry Shapiro at the Rural Economic Development and Food Security Sector Working Group Broader Platform meeting, Addis Ababa, Ethiopia, 2 July 2015
This slides contains information on precision feeding in dairy cattle and requirement of energy, protein, fat, minerals and vitamins of a dairy cattle during lactation. Precision feeding protects reproductive health and milk production while reducing the nutrient loss in manure.
Only 25-35% of the N in feed goes into milk, with the rest excreted in feces and urine.
Dairy diets often have 120-160% of the P and that the excess is excreted in the manure.
Cost of feed can be reduced.
Precision feeding helps to improve water quality
Improving the efficiency of use of feed N.
Reduce SARA condition.
Controlled-release urea in dairy cattle feed.
Straw treatment-Ammoniation.
Reducing Enteric Methane Losses from Ruminant Livestock.
Phase feeding in dairy cattle.
Feeding bypass fat in early lactation.
Use of chelated minerals in dairy animals.
Nutraceuticals in dairy animal precision feeding.
10. Use of area specific mineral mixture to precise dairy animal nutrition.
11. TMR in precision nutrition.
12. Manipulation of dietary CAD.
Five distinct feeding phases can be defined to attain optimum production, reproduction and health of dairy cows:
Early lactation—0 to 70 days (peak milk production) after calving (postpartum).
Peak DM intake—70 to 140 days (declining milk production) postpartum.
Mid and late lactation—140 to 305 days (declining milk production) postpartum.
Dry period—60 days before the next lactation.
Transition or close-up period—14 days before to parturition.
Feed top quality forage.
Make sure the diet contains adequate amounts of CP, DIP and UIP.
Increase grain intake at a constant rate after calving.
Consider adding fat (0.4-0.6 kg/cow/day) to diets.
Allow constant access to feed.
Minimize stress conditions.
Limit urea to 80-160g/day.
Buffers, such as Na bicarbonate alone or in combination with Mg oxide (rumen pH)
In Transition period
Increase grain feeding, so cows are consuming 4.5-6 kg grain/day at calving (1% of B.wt)
Increase protein in the ration to between 14 - 15 % of the ration DM
Limit fat in the ration to 0.1kg. High fat feeding will depress DM intake.
Maintain 2.5-4kg of long hay in the ration to stimulate rumination.
Feed a low-Ca ration (< 0.20%, reduce Ca intake to 14 to 18 g/d)
Also, feed a diet with a negative dietary electrolyte balance (-10 to -15meq/100 g DM) may alleviate milk fever problems
Niacin (to control ketosis) and/or anionic salts (to help prevent milk fever) should be included in the ration during this period.
"Use of feed additives generated through fermentation technologies for livest...ExternalEvents
"Use of feed additives generated through fermentation
technologies for livestock feed " presentation by "Cavaba Srinivas Prasad, National Institute of Animal Nutrition and Physiology, Bengaluru, India"
The Livestock Sector in India: Progress and Challenges by Vijay Sardana, Poultry Federation of India.
Presented at the ReSAKSS-Asia - MIID conference "Evolving Agrifood Systems in Asia: Achieving food and nutrition security by 2030" on Oct 30-31, 2019 in Yangon, Myanmar.
Presentation by Mario Herrero, Philip Thornton and Iain Wright to Workshop on climate change vulnerability and adaptation in the livestock sector, Kathmandu, Nepal, 28-29 October 2010.
Nexus between One Health, nutrition and food safetyILRI
Presentation by Hung Nguyen-Viet, Fred Unger, Dang Xuan Sinh, Paula Dominguez-Salas and Delia Grace at the Asia-Pacific regional symposium on sustainable food systems for healthy diets and improved nutrition, Bangkok, Thailand, 10–11 November 2017.
Presented by Muhammad Farooq Tareen at the Workshop on transforming livelihoods in South Asia through sustainable livestock research and development, Kathmandu, Nepal, 13-14 November 2018
This slides contains information on precision feeding in dairy cattle and requirement of energy, protein, fat, minerals and vitamins of a dairy cattle during lactation. Precision feeding protects reproductive health and milk production while reducing the nutrient loss in manure.
Only 25-35% of the N in feed goes into milk, with the rest excreted in feces and urine.
Dairy diets often have 120-160% of the P and that the excess is excreted in the manure.
Cost of feed can be reduced.
Precision feeding helps to improve water quality
Improving the efficiency of use of feed N.
Reduce SARA condition.
Controlled-release urea in dairy cattle feed.
Straw treatment-Ammoniation.
Reducing Enteric Methane Losses from Ruminant Livestock.
Phase feeding in dairy cattle.
Feeding bypass fat in early lactation.
Use of chelated minerals in dairy animals.
Nutraceuticals in dairy animal precision feeding.
10. Use of area specific mineral mixture to precise dairy animal nutrition.
11. TMR in precision nutrition.
12. Manipulation of dietary CAD.
Five distinct feeding phases can be defined to attain optimum production, reproduction and health of dairy cows:
Early lactation—0 to 70 days (peak milk production) after calving (postpartum).
Peak DM intake—70 to 140 days (declining milk production) postpartum.
Mid and late lactation—140 to 305 days (declining milk production) postpartum.
Dry period—60 days before the next lactation.
Transition or close-up period—14 days before to parturition.
Feed top quality forage.
Make sure the diet contains adequate amounts of CP, DIP and UIP.
Increase grain intake at a constant rate after calving.
Consider adding fat (0.4-0.6 kg/cow/day) to diets.
Allow constant access to feed.
Minimize stress conditions.
Limit urea to 80-160g/day.
Buffers, such as Na bicarbonate alone or in combination with Mg oxide (rumen pH)
In Transition period
Increase grain feeding, so cows are consuming 4.5-6 kg grain/day at calving (1% of B.wt)
Increase protein in the ration to between 14 - 15 % of the ration DM
Limit fat in the ration to 0.1kg. High fat feeding will depress DM intake.
Maintain 2.5-4kg of long hay in the ration to stimulate rumination.
Feed a low-Ca ration (< 0.20%, reduce Ca intake to 14 to 18 g/d)
Also, feed a diet with a negative dietary electrolyte balance (-10 to -15meq/100 g DM) may alleviate milk fever problems
Niacin (to control ketosis) and/or anionic salts (to help prevent milk fever) should be included in the ration during this period.
"Use of feed additives generated through fermentation technologies for livest...ExternalEvents
"Use of feed additives generated through fermentation
technologies for livestock feed " presentation by "Cavaba Srinivas Prasad, National Institute of Animal Nutrition and Physiology, Bengaluru, India"
The Livestock Sector in India: Progress and Challenges by Vijay Sardana, Poultry Federation of India.
Presented at the ReSAKSS-Asia - MIID conference "Evolving Agrifood Systems in Asia: Achieving food and nutrition security by 2030" on Oct 30-31, 2019 in Yangon, Myanmar.
Presentation by Mario Herrero, Philip Thornton and Iain Wright to Workshop on climate change vulnerability and adaptation in the livestock sector, Kathmandu, Nepal, 28-29 October 2010.
Nexus between One Health, nutrition and food safetyILRI
Presentation by Hung Nguyen-Viet, Fred Unger, Dang Xuan Sinh, Paula Dominguez-Salas and Delia Grace at the Asia-Pacific regional symposium on sustainable food systems for healthy diets and improved nutrition, Bangkok, Thailand, 10–11 November 2017.
Presented by Muhammad Farooq Tareen at the Workshop on transforming livelihoods in South Asia through sustainable livestock research and development, Kathmandu, Nepal, 13-14 November 2018
Transforming livestock farming: Key elements for medium scale enterprisesILRI
Presented by Jimmy Smith, at the 9th International conference on appropriate technology Workshop: appropriate technology for medium-scale farmers, Virtual, 23 November 2020
Livestock research contributions to the SDGs—Starting with the End in Mind: R...ILRI
Presented by Jimmy Smith, ILRI Director General, at the Centre for Tropical Livestock Genetics and Health 2017 Annual Meeting, Edinburgh, 26–29 September 2017
Mixed crop-livestock systems: Indispensable means to achieving global food an...ILRI
Presented by Jimmy Smith at the ADSA (American Dairy Science Association)-ASAS (American Society of Animal Science)-CSAS (Canadian Society of Animal Science) Joint Annual Meeting on Linking Animal Science and Animal Agriculture: Meeting the global demands of 2050, Kansas City, Missouri, 20–24 July 2014
Livestock and food security: An ILRI perspectiveILRI
A series of presentations by ILRI scientists (Thomas Randolph, Hikuepi Katjiuongua, Timothy Robinson, Isabelle Baltenweck, Alessandra Galie, Alan Duncan, Nils Teufel, Mats Lannerstad, Bernard Bett, Johanna Lindahl, Eric Fèvre, Silvia Alonso and Delia Grace) at a seminar on "Sustainable Agricultural Development for Food Security and Nutrition, including the role of Livestock" for the Committee on World Food Security High Level Panel of Experts on food security and nutrition (HLPE), Nairobi, Kenya, 8 May 2015.
Integrated crop livestock systems:A key to sustainable intensification in Af...ILRI
Presented by Shirley Tarawali, Alan Duncan, Peter Thorne, Diego Valbuena, Katrien Descheemaeker, Sabine Homann-KeeTui at the 22nd International Grassland Congress, Sydney, Australia, 15−19 September 2013
How can Animal Biotechnology contribute to Agenda 2063, ST&I Strategy for Afr...ILRI
Presented by Christian K. Tiambo, Jimmy Smith, Okeyo Mwai and Steve Kemp at the Animal Biotechnology: The Next Frontier Stakeholders Sensitization and Awareness Workshop on Animal Biotechnology Applications and Regulatory Perspectives, Naivasha, Kenya, 22-24 March 2021
Pathways for sustainable development of mixed crop-livestock systems in devel...ILRI
Presented by Shirley Tarawali, Mario Herrero, Katrien Descheemaeker, Elaine Grings and Michael Blümmel at the Workshop on the Assessment for sustainable development of animal production systems, 3 November 2011.
Similar to The future of sustainable livestock systems in low- and middle-income countries (20)
Small ruminant keepers’ knowledge, attitudes and practices towards peste des ...ILRI
Presentation by Guy Ilboudo, Abel Sènabgè Biguezoton, Cheick Abou Kounta Sidibé, Modou Moustapha Lo, Zoë Campbell and Michel Dione at the 6th Peste des Petits Ruminants Global Research and Expertise Networks (PPR-GREN) annual meeting, Bengaluru, India, 28–30 November 2023.
Small ruminant keepers’ knowledge, attitudes and practices towards peste des ...ILRI
Poster by Guy Ilboudo, Abel Sènabgè Biguezoton, Cheick Abou Kounta Sidibé, Modou Moustapha Lo, Zoë Campbell and Michel Dione presented at the 6th Peste des Petits Ruminants Global Research and Expertise Networks (PPR-GREN) annual meeting, Bengaluru, India, 29 November 2023.
A training, certification and marketing scheme for informal dairy vendors in ...ILRI
Presentation by Silvia Alonso, Jef L. Leroy, Emmanuel Muunda, Moira Donahue Angel, Emily Kilonzi, Giordano Palloni, Gideon Kiarie, Paula Dominguez-Salas and Delia Grace at the Micronutrient Forum 6th Global Conference, The Hague, Netherlands, 16 October 2023.
Milk safety and child nutrition impacts of the MoreMilk training, certificati...ILRI
Poster by Silvia Alonso, Emmanuel Muunda, Moira Donahue Angel, Emily Kilonzi, Giordano Palloni, Gideon Kiarie, Paula Dominguez-Salas, Delia Grace and Jef L. Leroy presented at the Micronutrient Forum 6th Global Conference, The Hague, Netherlands, 16 October 2023.
Food safety research in low- and middle-income countriesILRI
Presentation by Hung Nguyen-Viet at the first technical meeting to launch the Food Safety Working Group under the One Health Partnership framework, Hanoi, Vietnam, 28 September 2023
Presentation by Hung Nguyen-Viet at the first technical meeting to launch the Food Safety Working Group under the One Health Partnership framework, Hanoi, Vietnam, 28 September 2023
Reservoirs of pathogenic Leptospira species in UgandaILRI
Presentation by Lordrick Alinaitwe, Martin Wainaina, Salome Dürr, Clovice Kankya, Velma Kivali, James Bugeza, Martin Richter, Kristina Roesel, Annie Cook and Anne Mayer-Scholl at the University of Bern Graduate School for Cellular and Biomedical Sciences Symposium, Bern, Switzerland, 29 June 2023.
Assessing meat microbiological safety and associated handling practices in bu...ILRI
Presentation by Patricia Koech, Winnie Ogutu, Linnet Ochieng, Delia Grace, George Gitao, Lily Bebora, Max Korir, Florence Mutua and Arshnee Moodley at the 8th All Africa Conference on Animal Agriculture, Gaborone, Botswana, 26–29 September 2023.
Ecological factors associated with abundance and distribution of mosquito vec...ILRI
Poster by Max Korir, Joel Lutomiah and Bernard Bett presented the 8th All Africa Conference on Animal Agriculture, Gaborone, Botswana, 26–29 September 2023.
Practices and drivers of antibiotic use in Kenyan smallholder dairy farmsILRI
Poster by Lydiah Kisoo, Dishon M. Muloi, Walter Oguta, Daisy Ronoh, Lynn Kirwa, James Akoko, Eric Fèvre, Arshnee Moodley and Lillian Wambua presented at Tropentag 2023, Berlin, Germany, 20–22 September 2023.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
The future of sustainable livestock systems in low- and middle-income countries
1. Better lives through livestock
The future of sustainable livestock systems
in low- and middle-income countries
Expert dialogue: The future of sustainable agriculture. Let’s think about… livestock
German Federal Ministry for Economic Cooperation and Development (BMZ)
28 June 2022
Shirley Tarawali
Assistant Director General, International Livestock Research Institute
Chair, Global Agenda for Sustainable Livestock
With inputs from: Mireille Ferrari, Susan MacMillan, Annabel Slater, Cynthia
Mugo, David Aronson, Polly Ericksen, Alessandra Galiè
2. 2
Key messages
Thinking about livestock
01
02
03
Status quo is
not an option
Be aware of trade-offs; avoid unintended
consequences; there are multiple pathways
towards sustainable livestock outcomes
In our quest for solutions, we must
not over-simplify complexity
… But change is an opportunity
… Or complicate simplicity
… Dichotomous
debates are not
helpful
3. 3
Transforming Food, Land, and
Water Systems in a Climate Crisis
Livestock and CGIAR impact areas
Nutrition, health and food security: Animal source foods remain
essential for proper nutrition and long-term health for most people in lower-
and middle-income countries; and must be SAFE
Poverty reduction, livelihoods and jobs: Livestock are
fundamental for the livelihoods of almost one in five people on the planet
and in virtually every country on earth, for national economic growth
Gender equality, youth and social inclusion: The
transformation of women’s livelihoods is impacted by livestock; the
transformation of livestock food systems is impacted by women
Climate adaptation and mitigation: A sustainable
livestock sector presents many very big opportunities to adapt
to climate change and lower GHG emissions
Environmental health and biodiversity: Livestock
enterprises are integral to the planet’s future environmental
health and for supporting biodiversity
5. 5
Demand for food
will keep growing
Projections based on IMPACT
model, Dolapo Enahoro (ILRI)
• Demand for milk, meat, eggs is
increasing fastest in LMICs
driven by population, rising
incomes and urbanization
• Not based on significant over-
consumption in LMICs
(attention: ‘double burden’)
• 70% of livestock-derived foods
consumed in LMICs are sourced
in informal markets
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200.00
Milk
0.00
40.00
80.00
120.00
160.00
200.00
Fruits & Vegetables
Percentage changes in
demand 2010 to 2030
Especially in LMICs
6. 6
Farms of less than 20 hectares provide:
Nearly 50% of the world’s livestock and cereals,
and close to 70% of the livestock and cereals in
emerging and developing economies
Share of total livestock-
derived foods produced
by small farms in 2010
• 1.7 billion people derive some
livelihood from livestock; over half a
billion depend on livestock
• Livestock are fundamental to many
economies; provide income, jobs, and
supporting risk mitigation
• Livestock are the basis for farm
sustainability, integrated livestock-
food farms make food crop farming
even possible for many in the Global
South – circular bioeconomy in action!
Livestock are integral to ‘circular
bioeconomy’ which is the basis for
most livestock production in LMICs
Smallholder farmers
currently provide most of the
meat, milk and eggs AND
staple cereals in LMICs
Did you know...
7. 7
• Contribution of livestock emissions
to GHGs must be mitigated,
especially as demand for meat,
milk and eggs increases
• Adaptation measures needed:
climate change already impacting
livestock, placing increasing
pressure on livelihoods and food
supply
• Also, livestock offer adaptation
opportunities to climate change!
Manure applied to soils
Enteric fermentation
Manure left on pasture
Manure management
Burning – savanna
Synthetic fertilizer
Rice cultivation
Crop residues
Cultivation organic soils
Burning – crop residue
Global agricultural greenhouse
gas emission sources
FAO, Tubiello et al. 2014
Approx 65% of agricultural emissions
are related to livestock production
Livestock mitigation
and adaptation
strategies are critical
8. 8
• Rangeland management,
especially by often-marginalized
pastoral communities, provides
multiple ecosystem services
(biodiversity, c-sequestration)
• Water used for livestock
production in LMICs is almost
entirely green water (=water that
would have anyway fallen on the
land)
Well managed livestock
systems can provide
important ecosystem
services
Source: Rangelands Atlas, 2021
10. 10
However,
• Meat, milk and eggs are
essential dietary elements
especially for most vulnerable
• For least wealthy populations, a
little more–not less–livestock-
derived foods would contribute
to significant positive nutritional
outcomes
Stop consuming animal
products for the benefit
of your health
MESSAGE
Sources: Data from FAO, IFAD, UNICEF, WFP and WHO, “The State of Food Security and Nutrition in the World
2018: Building Climate Resilience for Food Security and Nutrition”, 2018.; Development Initiatives Poverty
Research Ltd, Global Nutrition Report 2017: Nourishing the SDGs, 2017.
11. 11
However,
• For over 500 million small scale
livestock dependent households
in LMICs, a ‘just transition’
includes improving the livelihood
opportunities from animal
agriculture
• For women, in HICs, engagement
in livestock enterprises is an
option; in LMICs it’s a necessity
Transition away from
animal production
MESSAGE
In LMICs…
Women’s empowerment leads to healthier people, animals and
environment. Livestock Pathways to 2030: One Health Brief 7. ILRI, 2021.
12. 12
Annual estimates from: https://www.fao.org/gleam/results/en/
However,
• LMIC emissions (amounts and
sources) vastly different from
HIC: in aggregate and specifically
• There are big opportunities for
mitigation of GHG emissions in
LMICs as part of sustainable
livestock food systems
transformation
Stop consuming
animal foods to save
the environment
MESSAGE
14. 14
Challenges
- Positive transition of today’s
small-scale farms and pastoral
systems in LMICs:
- More milk, meat and eggs
- Without causing environmental
harm, food safety or disease
hazards
- Addressing equality, equity for all
- Climate change will lead to new
pressures and unknowns
- Failure to nuance messaging
about livestock could jeopardize
millions of livelihoods and impact
on multiple development
challenges
16. 16
• Bundling technological solutions
(and bringing many new ones) for
greater productivity with reduced
environmental footprint,
improved animal welfare
• Local supply chains must be
professionalized, supported by
enabling policies
Transformation of
livestock-based food
systems to meet
demand must also
incorporate positive
transitions for the
environment,
livelihoods, equity…..
Technologies and
practices for sustainable
productivity
- Animal and herd
health
- Feeds and forages
- Genetics and
breeding
Livestock derived foods
as part of diverse diets
- Diet choices
- Food safety
Gender equity and
social inclusion
- Accommodative and
transformative
approaches
Competitive and
inclusive livestock value
chains
Co-design, co-
development of context
specific innovation
packages
Evidence,
decision
and
scaling
Sustainable Animal Productivity for Livelihoods, Nutrition
and Gender inclusion (SAPLING)
17. 17
One Health
Foodborne illnesses cost LMICs
up to USD 110 bln annually!
Did you know...
PANDEMIC
PREVENTION
Surveillance, detection
and response at the
animal level
FOOD SAFETY
Opportunities to provide
enabling regulatory
environments, training, simple
technologies and incentives to
adopt food safety practices
ANTI-MICROBIAL
RESISTANCE
Develop integrated
approaches to understand the
opportunities for mitigation
without jeopardizing
livelihoods and production
RESPONSE
THROUGH…
Institutional coordination
and action at every level
for animal, human and
environment health
Integral to improving food and nutrition security
BMZ investment in ILRI One Health:
Euro 22 million (2019 to 2025)
18. 18
• Chicken business offers a rare and good income earning opportunity for
young women
• Reaching remote women with a ‘poultry package including marketing’ is
effective
• Addressing gender norms about women in chicken business at various levels
(household, community, business, customers and trainings) is necessary for
the women to benefit from poultry business
• More systematic evidence is needed on impact of Gender Transformative
Approaches and their potential for Gender Transformative Change.
Intentional incorporation of opportunities for women
Chicken business in Ethiopia and Tanzania
19. 19
• Accurate emission metrics to
assess interventions and access
climate finance
• Big opportunity to improve
productivity and reduce emissions
per unit of product without
switching to industrial production
Measure and mitigate
GHG emissions in
context
Intensive: 50.6 kg /head/yr
Semi-intensive: 28.3 kg/head/yr
Industrial systems: 60-160 kg/head/year
(depending on animal size and DM intake)
Sub-Saharan Africa Tier 1: 42kg/head/yr
(female cattle)
New IPCC Tier 2 emission factors for smallholders’ cows in Kenya
Dairy system characterization and emissions
German investment in Program for Climate
Smart Livestock Euro 6.5 million
20. 20
• In spite of the uncertainty in climate
science, livestock producers, traders,
processers, and retailers need to adapt
to future climate change
• Example: Index-based livestock
insurance:
• An innovation to provide better risk
protection
• Viable alternative to humanitarian
relief
• Helps to prevent vulnerable
populations from losing too many
livestock
• Potential to crowd-in investment
and asset accumulation
Livestock and climate
adaptation (with
mitigation co-benefits)
Those who purchased
insurance:
- 36% drop in distress
sales of livestock
- 25% reduced
likelihood of having to
eat significantly
smaller meals
- 33% reduction in
dependence on food
aid
Satellite imagery
used to assess
forage availability
21. 21
• Integrated options for sustainable
rangeland management
• Incentives and opportunities for
environmental stewardship
Sustainable rangeland
management
22. The Global Agenda for Sustainable Livestock
Vision: By 2030 sustainable, inclusive, resilient and diverse livestock systems across the world contribute
significantly to Sustainable Development Goals (SDGs) of the UN Agenda 2030 and are integral to
sustainable food systems
o A unique, multi-stakeholder partnership operating
in an open, consensual manner
o Brings together diverse livestock stakeholders
• 120 member organizations, 000s of stakeholders, all
dimensions of the livestock sector
• From backyard one cow operation, pastoral/range-
based systems, through emerging new businesses,
to large scale commercial enterprises; producers,
processors, covering every region of the world
• All stakeholder typologies: governments, private
sector, NGO, research, investors, civil society and
multilateral organizations
Evidence and practice
change
Dialogue
Policy change
23. 23
…..efficient, low-carbon, sustainable livestock production that
supports rather than harms the environment…..
…..inclusive, fair, equitable livestock systems……
…..affordable, accessible, balanced, nutritious diets that include
the choice of healthy livestock-derived foods
…..healthy animals, safe food, healthy people….
…..every opportunity for every citizen and every nation to benefit
fully from multiple livelihood and economic dimensions from
sustainable livestock systems…..
….. a healthy planet, with rich biodiversity and sustainable water
use…..
Multiple pathways towards sustainable livestock outcomes