Mixed crop-livestock systems in developing countries are crucial for supporting millions of poor people and producing a significant portion of livestock and crop commodities, addressing food needs while balancing environmental and social equity. The future of these systems relies on understanding multiple factors, including intensification, market relationships, and the role of smallholders, particularly in transitioning to more market-oriented approaches. Strategies for improving efficiency, productivity, and market access must be integrated with supportive policies, technological innovations, and a focus on sustainable practices.