The document discusses the One Health approach implemented through the COHESA project, which aims to enhance research and innovation ecosystems for health across humans, animals, and environments in Eastern and Southern Africa from 2022 to 2025. It outlines objectives, work packages, and governance structures, with a specific focus on Rwanda's One Health policy framework and its operational challenges. The project emphasizes the importance of inter-sectoral collaboration and capacity building to address health issues related to zoonotic diseases.