This document provides an overview of safe handling practices for nanomaterials. It defines engineered nanoparticles as particles less than 100nm designed and manufactured. Examples given include carbon nanotubes and quantum dots. The document notes that due to their small size, nanoparticles can more easily enter the body and cross barriers like the blood-brain barrier, posing unknown health risks. It recommends approaches like controlling exposures through ventilation, containment, and personal protective equipment. The key challenges are the lack of toxicity data and standardized exposure methods for nanomaterials.