This document provides an overview of a webinar on nanotechnology and nanosafety. The webinar will include presentations on what nanoparticles are, different types of nanoparticles, health and safety issues with nanoparticles, methods for evaluating and controlling exposures, and developing nanosafety programs. It lists the presenters and provides an agenda that will cover nanoparticles basics, types, hazards, controls, and programs with a question and answer session. Environmental and occupational exposure assessment methods for nanoparticles are discussed.
Green nanotechnology & its application in biomedical researchRunjhunDutta
This presentation gives detailed description of Green Nanotechnology including its principles & significance. Illustrated with examples for its application in various biomedical research fields.
Different types of methods can be used for the preparation of Magnetic Nanoparticles, their advantages and disadvantages and applications of the materials in various fields are given in the presentation
Green nanotechnology & its application in biomedical researchRunjhunDutta
This presentation gives detailed description of Green Nanotechnology including its principles & significance. Illustrated with examples for its application in various biomedical research fields.
Different types of methods can be used for the preparation of Magnetic Nanoparticles, their advantages and disadvantages and applications of the materials in various fields are given in the presentation
A part of nanotechnology. Nanosensors is very hot topic for research. As nanosensor has immense applications in the fields like medical, analysis, research etc. Nanosensor recude the cost and also the time require for analysis.
know more about nanomaterials and its apllication in future as well as current situation, and what wil we reserch on basis of nanomaterials and carbon structure and its aplication in such futuriastic manner.
Presenting a topic based on introduction to nanoscience and nanotechnology.
what is nano?
certain nomenclature like nanotechnology, nanoscience, nanomaterial, nanoscale, nanometer and so on.
surface to volume ratio and quantum effect related concepts.
future applications.
https://www.linkedin.com/in/preeti-choudhary-266414182/
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If any query then contact:
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Thanking-You
Preeti Choudhary
Biological method for the preparation of nanoparticles(Sheersho)Sheersha Pramanik 🇮🇳
I have described about the biological processes(other than physical,chemical) for the preparation of Nanoparticles.
do like comment share if you like it.
Introduction to nanoparticles and bionanomaterialsShreyaBhatt23
what is a nanoparticle, why small is good,nanoscale effect, how to make nanostructures,top down and bottom up approachs,
methods of making nanomaterials,chemical methods od making nanomaterial,bionanomaterials,
A part of nanotechnology. Nanosensors is very hot topic for research. As nanosensor has immense applications in the fields like medical, analysis, research etc. Nanosensor recude the cost and also the time require for analysis.
know more about nanomaterials and its apllication in future as well as current situation, and what wil we reserch on basis of nanomaterials and carbon structure and its aplication in such futuriastic manner.
Presenting a topic based on introduction to nanoscience and nanotechnology.
what is nano?
certain nomenclature like nanotechnology, nanoscience, nanomaterial, nanoscale, nanometer and so on.
surface to volume ratio and quantum effect related concepts.
future applications.
https://www.linkedin.com/in/preeti-choudhary-266414182/
https://www.instagram.com/chaudharypreeti1997/
https://www.facebook.com/profile.php?id=100013419194533
https://twitter.com/preetic27018281
Please like, share, comment and follow.
stay connected
If any query then contact:
chaudharypreeti1997@gmail.com
Thanking-You
Preeti Choudhary
Biological method for the preparation of nanoparticles(Sheersho)Sheersha Pramanik 🇮🇳
I have described about the biological processes(other than physical,chemical) for the preparation of Nanoparticles.
do like comment share if you like it.
Introduction to nanoparticles and bionanomaterialsShreyaBhatt23
what is a nanoparticle, why small is good,nanoscale effect, how to make nanostructures,top down and bottom up approachs,
methods of making nanomaterials,chemical methods od making nanomaterial,bionanomaterials,
Revolution of Nanotechnology:
Theory and Application
2016
Dr. nat.Sci. Ahmed Abdel-Megeed
Ph.D Germany, Hamburg University
Associate Professor, Plant Protection Dept.
Faculty of ِِِAgriculture- Alexandria University
Alexandria, Egypt
P.O. BOX 21531
Homepage: http://faculty.ksu.edu.sa/75164/default.aspx
Introduction
History
Types of Nanomaterials
Properties of Nanomaterials
Synthesis and processing of Nanomaterials
Advance nanomaterials
Fullerenes
Carbon nanotubes
Nanowires
Polymer nanostructures
Quantum dots
How to Prepare for and Respond to a Confirmed COVID-19 Case at Your Lab or Ma...Triumvirate Environmental
As essential businesses continue to operate, it’s crucial to consider how to handle a confirmed COVID-19 case in the workplace. Despite safety precautions to avoid the spread, one of your employees may get sick – do you know what to do? The COVID-19 pandemic has drastically altered how we work and operate. Take a proactive approach to safely keep your business operational in the event of a confirmed COVID-19 case by developing sound disinfection policies and procedures.
ISO auditing leads to improved company EHS culture, consistency, and team focus. When organizations conform to these ISO standards and obtain third-party ISO certification, it authenticates that they utilize standardized management systems to continuously improve Occupational Health and Safety and Environmental performance.
Does your organization need an industrial hygiene program? Are you looking to create a program but don’t know where to start? Industrial hygiene allows you to anticipate, evaluate and control environmental factors that impact people’s health. Critical to environmental health and safety, an industrial hygiene program is important not only for regulatory compliance but also to maintain your public relations and reputation.
The deadlines for Tier II Reports, Biennial Reports, and OSHA 300 Logs are all fast approaching. Are you prepared to file all your necessary reports in time? It is important to take the time to carefully review your facility to determine your requirements for these regulatory reports.
Cannabis growers, cultivators, and distributors face unique compliance challenges when navigating federal and state regulations, managing hazardous and non-hazardous waste streams, and ensuring your facility runs safely and compliantly. This webinar will help early-stage and fast-growing cannabis companies understand the state and federal regulatory environment, obtain permits and licenses, and build environmental, health, and safety (EH&S) programs. Whether your cannabis organization is new to the compliance world or has some safety programs in place, this webinar will provide guidance on how to reach operational excellence.
The Key Elements of Building an OSHA-Compliant Workplace from the Ground UpTriumvirate Environmental
OSHA violations are expensive and time consuming to resolve. It is significantly cheaper and easier to create an OSHA-compliant workplace from the start. Ensuring OSHA compliance requires a complete understanding of the OSHA requirements and a complete assessment of your current workplace. In this webinar, our expert will walk you through the key steps to creating an OSHA-compliant workplace.
In September, OSHA released its latest “Top 10” list of most frequently cited workplace violations. Hear our expert analyze the most common OSHA violations and the overall state of EHS regulatory compliance in 2019.
2019 Healthcare Accreditation Regulatory Updates: How Do the New Regulations ...Triumvirate Environmental
Recently there have been regulatory updates that affect healthcare facilities including standards that apply to hospital accreditation. The Joint Commission applies standards that pertain to federal Medicare and Medicaid reimbursement. Has your facility adapted to comply with the current and updated standards? Hear our expert provide a comprehensive look at the “Environment of Care” and see how to better adapt your facility to ensure the health and safety of hospital staff, patients, and visitors.
Oil spills present real public health and environmental concerns. In response to these concerns, the EPA created rules around SPCC. The EPA’s SPCC rules are meant to prevent oil discharge from entering navigable waters and/or adjoining shorelines.
There have been many recent changes to the DEA and EPA regulations regarding pharmaceutical waste management. Is your organization compliant with the current rules? Here is a comprehensive look at the disposal and onsite waste management regulations for controlled substances.
Measuring the Success of Your EHS Program: Are You Tracking These Key Perform...Triumvirate Environmental
You have taken the first step and implemented an EHS program in your workplace, but how do you know if the program is working? Do you fall short on meeting department and corporate goals? Do you know which metrics you should be tracking to ensure the success of your EHS program?
There are over 90 biotechnology and pharmaceutical laboratories located within the Cambridge city limits. With such a high concentration of labs, the city has stringent regulations to contain exposure risks and ensure that the community is safe. In this session, the Department of Public Health will discuss lab safety in the city. Join us to gain a more comprehensive understanding of Massachusetts and Cambridge regulations to ensure you are running a safe and compliant lab.
Why Audit? What Is the Difference Between Regulatory Auditing and ISO 14001 o...Triumvirate Environmental
We hear about the importance of conducting audits of your facilities. They allow us to be prepared for when the regulators show up. However, have you ever considered obtaining an ISO certification? The two standards that focus solely on EH&S are the ISO 14001 Environmental Management Standard or the ISO 45001 Occupations Health and Safety Standard. This session will cover the importance of auditing, what the ISO standards entail, and how they may actually help you with compliance and to show your end users that you care about your employees' health and safety and the environment.
Managing Medical or Biological Waste in Massachusetts - Guidance for GeneratorsTriumvirate Environmental
Medical or Biological Waste, a.k.a., Regulated Medical Waste, is regulated by the Massachusetts Department of Public Health. DPH has adopted management requirements codified under 105 CMR 480 that affect those who generate such wastes. Individuals impacted by these rules would be employees who are responsible for the medical/bio waste management program and those who manage the waste onsite (e.g., internal transport, storage, onsite treatment, and other handling).
Recently the National Safety Council collaborated with three Campbell Institute members to understand the role fatigue plays in their operations at selected locations. Research participants took part in a two-part survey consisting of an operational needs assessment and an employee survey.
Does your organization run internal audits regularly? Prepare for a regulator to come knocking at your door by catching areas of non-compliance before the inspector can. Internal audits allow you to identify gaps in your existing EHS programs and improve processes before an official inspection, so you can be confident in your audit-readiness.
Despite well-defined requirements, procedures, and targets, many organizations still struggle with delivering well-defined, exceptional EHS compliance programs. A strong external partnership can reposition your EHS compliance program and drive strong operational and financial outcomes. But once you decide to establish an EHS partnership, how do you ensure you are getting the most out of it?
Chemical inventory management is often a confusing and labor-intensive exercise. This webinar sheds light on how to build, operationalize, and improve a chemical inventory program. We will dissect the many nuances of a chemical inventory, and offer innovative, service-based solutions to help you successfully manage your chemical inventory program.
OSHA Compliance: Ensuring Laboratory & Manufacturing Safety at Your WorksiteTriumvirate Environmental
Are you prepared for your next OSHA audit? Ensuring OSHA compliance requires a complete understanding of the OSHA requirements and a complete assessment of your current workplace. In this session, Rick will walk you through the key steps to building a compliant EHS program at your worksite and the key performance indicators needed to measure EHS progress.
Does your facility have a fully compliant environmental program? Are you prepared for your next EPA audit? In this session, you will receive a comprehensive overview of the EPA and the components needed to create a compliant environmental program for your workplace. We will cover environmental compliance in both laboratory and manufacturing settings.
Hybrid optimization of pumped hydro system and solar- Engr. Abdul-Azeez.pdffxintegritypublishin
Advancements in technology unveil a myriad of electrical and electronic breakthroughs geared towards efficiently harnessing limited resources to meet human energy demands. The optimization of hybrid solar PV panels and pumped hydro energy supply systems plays a pivotal role in utilizing natural resources effectively. This initiative not only benefits humanity but also fosters environmental sustainability. The study investigated the design optimization of these hybrid systems, focusing on understanding solar radiation patterns, identifying geographical influences on solar radiation, formulating a mathematical model for system optimization, and determining the optimal configuration of PV panels and pumped hydro storage. Through a comparative analysis approach and eight weeks of data collection, the study addressed key research questions related to solar radiation patterns and optimal system design. The findings highlighted regions with heightened solar radiation levels, showcasing substantial potential for power generation and emphasizing the system's efficiency. Optimizing system design significantly boosted power generation, promoted renewable energy utilization, and enhanced energy storage capacity. The study underscored the benefits of optimizing hybrid solar PV panels and pumped hydro energy supply systems for sustainable energy usage. Optimizing the design of solar PV panels and pumped hydro energy supply systems as examined across diverse climatic conditions in a developing country, not only enhances power generation but also improves the integration of renewable energy sources and boosts energy storage capacities, particularly beneficial for less economically prosperous regions. Additionally, the study provides valuable insights for advancing energy research in economically viable areas. Recommendations included conducting site-specific assessments, utilizing advanced modeling tools, implementing regular maintenance protocols, and enhancing communication among system components.
Explore the innovative world of trenchless pipe repair with our comprehensive guide, "The Benefits and Techniques of Trenchless Pipe Repair." This document delves into the modern methods of repairing underground pipes without the need for extensive excavation, highlighting the numerous advantages and the latest techniques used in the industry.
Learn about the cost savings, reduced environmental impact, and minimal disruption associated with trenchless technology. Discover detailed explanations of popular techniques such as pipe bursting, cured-in-place pipe (CIPP) lining, and directional drilling. Understand how these methods can be applied to various types of infrastructure, from residential plumbing to large-scale municipal systems.
Ideal for homeowners, contractors, engineers, and anyone interested in modern plumbing solutions, this guide provides valuable insights into why trenchless pipe repair is becoming the preferred choice for pipe rehabilitation. Stay informed about the latest advancements and best practices in the field.
Overview of the fundamental roles in Hydropower generation and the components involved in wider Electrical Engineering.
This paper presents the design and construction of hydroelectric dams from the hydrologist’s survey of the valley before construction, all aspects and involved disciplines, fluid dynamics, structural engineering, generation and mains frequency regulation to the very transmission of power through the network in the United Kingdom.
Author: Robbie Edward Sayers
Collaborators and co editors: Charlie Sims and Connor Healey.
(C) 2024 Robbie E. Sayers
About
Indigenized remote control interface card suitable for MAFI system CCR equipment. Compatible for IDM8000 CCR. Backplane mounted serial and TCP/Ethernet communication module for CCR remote access. IDM 8000 CCR remote control on serial and TCP protocol.
• Remote control: Parallel or serial interface.
• Compatible with MAFI CCR system.
• Compatible with IDM8000 CCR.
• Compatible with Backplane mount serial communication.
• Compatible with commercial and Defence aviation CCR system.
• Remote control system for accessing CCR and allied system over serial or TCP.
• Indigenized local Support/presence in India.
• Easy in configuration using DIP switches.
Technical Specifications
Indigenized remote control interface card suitable for MAFI system CCR equipment. Compatible for IDM8000 CCR. Backplane mounted serial and TCP/Ethernet communication module for CCR remote access. IDM 8000 CCR remote control on serial and TCP protocol.
Key Features
Indigenized remote control interface card suitable for MAFI system CCR equipment. Compatible for IDM8000 CCR. Backplane mounted serial and TCP/Ethernet communication module for CCR remote access. IDM 8000 CCR remote control on serial and TCP protocol.
• Remote control: Parallel or serial interface
• Compatible with MAFI CCR system
• Copatiable with IDM8000 CCR
• Compatible with Backplane mount serial communication.
• Compatible with commercial and Defence aviation CCR system.
• Remote control system for accessing CCR and allied system over serial or TCP.
• Indigenized local Support/presence in India.
Application
• Remote control: Parallel or serial interface.
• Compatible with MAFI CCR system.
• Compatible with IDM8000 CCR.
• Compatible with Backplane mount serial communication.
• Compatible with commercial and Defence aviation CCR system.
• Remote control system for accessing CCR and allied system over serial or TCP.
• Indigenized local Support/presence in India.
• Easy in configuration using DIP switches.
Cosmetic shop management system project report.pdfKamal Acharya
Buying new cosmetic products is difficult. It can even be scary for those who have sensitive skin and are prone to skin trouble. The information needed to alleviate this problem is on the back of each product, but it's thought to interpret those ingredient lists unless you have a background in chemistry.
Instead of buying and hoping for the best, we can use data science to help us predict which products may be good fits for us. It includes various function programs to do the above mentioned tasks.
Data file handling has been effectively used in the program.
The automated cosmetic shop management system should deal with the automation of general workflow and administration process of the shop. The main processes of the system focus on customer's request where the system is able to search the most appropriate products and deliver it to the customers. It should help the employees to quickly identify the list of cosmetic product that have reached the minimum quantity and also keep a track of expired date for each cosmetic product. It should help the employees to find the rack number in which the product is placed.It is also Faster and more efficient way.
Water scarcity is the lack of fresh water resources to meet the standard water demand. There are two type of water scarcity. One is physical. The other is economic water scarcity.
3. During this
Webinar
All lines will be muted – please communicate
via the questions tab in your webinar panel.
There will be a Q&A session at the end of the
presentation – submit your question(s)
anytime throughout the webinar.
The webinar recording and slides will be sent
to you tomorrow.
7. What are They?
• The ASTM Committee on Nanotechnology defines a
nanoparticle as a particle with lengths in two or three
dimensions between 1 and 100 nanometers (nm)
• Nanoparticles might be composed of many different base
materials and may take on different shapes including:
spheres, rods, discs, cubes, tubes, globular or amorphous
• Nano-particles or -materials used in the laboratory are likely
to be in the form of a powder, a suspension, or a solid matrix
• Nanomaterials properties can differ from those of the same
materials with micron- or mm-scale dimensions
8. Industry Overview
Noninvasive molecular imaging
Therapeutic delivery
http://mritnt.com/education-centre/common-uses/mri-of-the-brain/
Freiberg, S and Zhu, X. Int. J. Pharmaceutics. (2004) 282, 1–18
Industries:
• Biotechnology
• Pharmaceuticals
• Cosmetics
• Diagnostics
• Sensors
• Electronics
• Pigments
• Ceramics
• Textiles
• Water Purification
Fields of Research:
• Chemistry
• Physics
• Biology
• Biomedical Engineering
• Chemical Engineering
• Electrical Engineering
• Mechanical Engineering
• Drug Delivery
• Tissue Engineering
• Medical Imaging
Biomedical Engineering Applications
9. • Nanopowders are solid powders of nanoparticles, often containing micron-sized
agglomerates
• These agglomerates can be dispersed by mechanical agitation (ultrasonics, milling,
homogenization)
• Resulting nanoparticle dispersions are suspensions of nanoparticles in water or
organic solvents
Nanopowders and Dispersions
Quantum DotsCarbon Nanotubes Gold Nanorods
10. • High surface-to-volume ratio and surface area
• Aspect ratio
• Surface charge (+, -, or neutral)
• Size of 1<x<100 nm in 2- or 3-D
• Shape (spherical, rod, cubic, tubular, amorphous)
• Porosity (solid, matrix, hydrogel, porous, hollow)
• Biodegradable vs. non-biodegradable
• Surface functionality that gives rise to charge
• Amine, carboxyl, hydroxyl, thiol, acetyl, sulfonyl, PEG
• Coupling of surface ligands and molecules
Properties of
Nanoparticles
13. Kolhar P., et al. PNAS (2013) 110 (26), 10753-10758.
Ragheb RRT., et al. Magn Reson Med (2013) 70, 1748-1760.
PLGA NPs
Polystyrene NPs
Biodegradable
Non-biodegradable
-Is it a polymeric nanoparticle?
-If so, is it biodegradable?
-If so, what are the degradation products?
-If so, is it non-biodegradable?
-Are the polymeric components
FDA-approved?
Polymeric
Nanoparticles
14. http://www.cytodiagnostics.com
http://nanocomposix.com/technology/gold Demortiere A., et al. Nanoscale. (2011) 3, 225-232.
http://www.sigmaaldrich.com/
Gold NPsIron Oxide NPs Silica-coated Au
core-shell NPs
Cd-Se Q-dots
-Is it a metallic nanoparticle or nanocrystal?
-If so, is it comprised of a noble metal?
-If so, is it a metal oxide nanoparticle?
-If so, is it a core-shell nanoparticle?
-If so, what comprises the core and the shell?
-If so, is it a quantum dot?
-If so, what comprises the quantum dot?
Metallic
Nanoparticles
15. http://www.alibaba.com
Nandiyanto ABD., et al. Microporous and Mesoporous Materials (2009) 120, 447-453.
Trofimova EY., et al. Nanotechnology (2013) 24, 155601-611.
Silica NPsExamples of Ceramic
Nanoparticles or Nanopowders
Type Morphology
Silica Spherical
Silicon carbide Cubic, hexagonal
Silicon nitride (α) Cubic, spherical
Silicon nitride (β) Rod-like
Titanium dioxide Spherical
Aluminum oxide Spherical
Scale bar is 1 𝜇m
Ceramic Nanoparticles
17. Bitounis D., et al. ISRN Pharm (2012) doi:10.5402/2012/738432.
-Is it a vesicular nanoparticle?
-If so, is it a liposomal
nanoparticle?
-If so, is it comprised of
natural or synthetic
lipids?
-If so, is it a polymersomal
nanoparticle?
-If so, what block
copolymer are used?
-Is it a micellar nanoparticle?
-If so, what surfactants or
amphiphilic polymers are
used?
Vesicular/Micellar
Nanoparticles
18. Macromolecular
Nanoparticles
https://macrocyclics.com
Tomalia DA, et al. Tetrahedron 59 (2003) 3799–3813
Svenson S and Tomalia DA. Adv Drug Deliv Rev 57 (2005) 2106– 2129
Dendritic
Macrocyclic chelator
-Is it a dendritic polymer-based nanoparticle?
-e.g. PAMAM, PEI, PEG, or polyester-
based dendrimers or dendrons
-Is it a macrocyclic or acyclic metal chelator?
-e.g. DTPA, DOTA, NOTA
-If so, what metal is chelated?
20. How are the Nanoparticles being Prepared?
-Are the surfaces being functionalized?
-Are the surfaces going to incorporate
poly(ethylene glycol)?
-Are the nanoparticles going to encapsulate
therapeutics?
-Small-molecule drugs
-Genetic materials
-Proteins or peptides
-Are the nanoparticles going to encapsulate
fluorescent dye molecules?
-Via nanoprecipitation?
-Via nano-emulsification?
-Via electro-spinning?
-Via electro-spraying?
-Via extrusion?
-Via self-assembly?
-Via chemical cross-link?
-Via chemical synthetic methods?
-Via chemical vapor deposition (CVD)?
-Via catalytic growth?
-Via incomplete combustion?
-Via mechanical milling or grinding?
21. Characterization of Nanoparticle Physico-
chemical Properties
What are the nanoparticles size distribution and how is this characterized?
-5nm < x <200 nm?
-Is the size measured by dry powder radius? (e.g. SEM, TEM)
-Is the size measured by hydrodynamic radius? (e.g. DLS, SEC)
What is the geometric shape of
the nanoparticle?
-Amorphous?
-Spherical?
-Rods?
-Cubes?
-Tubular?
What is the aspect ratio
of the nanoparticle?
What is the surface charge and character?
-Is it positive, negative or neutral?
-Is it hydrophilic or hydrophobic?
-Is it lipophilic or lipophobic?
-What is the surface functionality giving
rise to the surface charge?
-amine
-carboxyl
-hydroxyl
-sulfonyl
-acetyl
-PEGylation
What is the surface area of
the nanoparticle?
22. How are the Nanoparticles Handled?
-Is the material handled as a dry nanopowder?
-Are the balances located in a chemical fume hood or biosafety cabinet?
-Is there any transferring of dry nanopowders?
-Where is this performed?
-Is the material handled as a nano-emulsion, -suspension, or -dispersion?
-Are the solutions transferred? Or aliquotted?
-Where is this performed?
-Are the solutions lyophilized?
-Are appropriate engineering controls available and utilized to enable safe handling?
-biosafety cabinets
-laminar flow hoods
-downdraft tables
-chemical fume hoods
-glove boxes
-ESD mats and devices
25. • We know very little about exposures during
common lab and industry processes
• Transferring and weighing NM
• Mixing and pouring NM
• Sonicating dispersions
• Cleaning of equipment and glassware
• Cleaning of surfaces
• The types of functionalized NM are vast
and so little have been studied
Health, Safety and Environmental Issues
Mesotheliomas have been produced in mice with MWCNTs that
are fibers with long aspect ratios (Takagi 2008, Poland 2008)
Multi-walled carbon nanotube penetrating the pleura of the lung.
Courtesy of Robert Mercer, and Diane Schwegler- Berry, NIOSH
26. • The molecular structure of nanoparticles and the relatively greater
surface area give these particles different chemical reactivities than
for larger structures made from the same elements or molecules
• Nanoparticles present a unique challenge from an occupational
health perspective as there is a limited amount of toxicological
data currently available for review
• What does “FDA approved materials” mean?
• Currently, agencies charged with providing safety guidelines,
including NIOSH, the NIH and the EPA, advocate caution in
research, with a view toward minimizing or eliminating
exposures to nanoparticles
Health, Safety and
Environmental Issues
27. Occupational Standards are Emerging
NIOSH recommended exposure limit (REL)
• 2.4 mg/m3 for pigmentary titanium dioxide (TiO2)
• 0.3 mg/m3 for ultrafine TiO2.
• (NIOSH has also concluded that ultrafine TiO2 is a potential
occupational carcinogen)
• 1 ug/m3 for carbon nanotubes or carbon nanofibers
• Based on limit of detection
• Draft CIB 10 μg/m3 (8-hour TWA) for silver nanomaterials
OTHER
• Manufacturer OEL’s and Control Banding
28. NIOSH chose mass-based REL over
counting with electron microscopy
Animal toxicology studies are
mass-based
Counting protocols haven’t
been developed, although
ASTM has a committee
working on it
29. • Harvesting (Scraping material out of reactor)
– Small -inside fume hood
– Large - reactor in housing
• Bagging
• Packaging
• Mixing
• Weighing
• Nanocomposite machining
• Maintenance, filter change-outs
Common Processes
30. Laboratory research
• Limited data exists for research work
• At research scale, Tsai et al. (2008)
found that the handling of dry powders
consisting of nano-sized particles inside
laboratory fume hoods can result in a
significant release of airborne
nanoparticles from the fume hood into
the laboratory environment and the
researcher’s breathing zone
Common Processes
32. Exposure Pathways
• Inhalation. Respiratory absorption of airborne nanoparticles may occur through
the mucosal lining of the trachea or bronchioles, or the alveolus of the lungs.
Certain nanoparticles appear to penetrate deep into the lungs and may
translocate to other organs or pass through the blood-brain barrier Thus,
whenever possible, nanoparticles are to be handled in a form that is not easily
made airborne, such as in solution or on a substrate.
• Dermal absorption. In some cases nanoparticles have been shown to migrate
through skin and be circulated in the body. If the particle is carcinogenic or
allergenic, even tiny quantities may be biologically significant. Skin contact can
occur during the handling of liquid suspensions of nanoparticles or dry powders.
Skin absorption is much less likely for solid bound or matrixed nanomaterials.
• Ingestion. As with any material, ingestion can occur if good hygiene practices
are not followed. Once ingested, some types of nanoparticles might be absorbed
and transported within the body by the circulatory system.
• Injection. Exposure by accidental injection (skin puncture) is also a potential
route of exposure, especially when working with animals or needles.
35. Worker Exposure
• One important point to consider in workplaces exposure
is that most exposures to nanomaterials are in the form
of aggregates and agglomerates.
• In those cases size measured by e.g. impactors or
mobility analyzers can not reveal the agglomeration state
and thus to which degree an agglomerate can break up
into many smaller units in the lung fluid.
• Thus results of such measurements cannot be directly
related to risk if particle number is a relevant measure of
this risk
37. Evaluation
• Strategies are being developed by a number of researchers
• Non-mass based metrics such as particle surface area or
particle number may be a reasonable approach.
• Evaluation should consider:
- ID emission sources
- Background and area monitoring
- Air concentration by direct reading instruments
- Measurement of air velocity patterns
38. Occupational Exposure
Assessments
• Aerosol mass concentration is a standard measure
• Use a filter-based personal sampler comprising
some form of inertial particle pre-selector.
• However, conventional pump-based filter sampling
is NOT the best solution for exposure assessment
for an aerosol of nanostructured particles.
Background Levels
• To assess occupational exposure to nanomaterials, it is
important to know background particles that include those
particles that penetrate from outdoors to indoors and those
that are suspended by background activities in the production
facility like combustion engines, heating units or cleaners.
• The particle number size distribution and the particle number
concentration are useful parameters for identifying sources of
particles
39. Occupational Exposure
Measurements
• Mass concentration, which is the parameter considered in
this form of sampling, is not well-suited to the toxicity
assessment of inhaled nanoparticles.
• Toxicity studies show that particle toxicity increases as
they become smaller
• None of the existing instruments used for monitoring
give specific information about particle concentration
below 1 μm aerodynamic diameter
40. Cascade impactor
• The cascade impactor is an example of a
traditional aerosol sampling method, which
provides the aerosol mass distribution for the
aerosol with respect to the aerodynamic
diameter of the collected particles.
• The last, smallest diameter stage only allows
nanoaerosols to be collected on a filter.
• The cut-off diameter of their last stage is more
than 250 nanometers
What’s an IH to Do?
Available Monitoring tools and Limitations
41. Tapered Element Oscillating Microbalance (TEOM)
Available IH Tools and Limitations
• Performs the measurement of the mass of a sampled
aerosol in a single operation
• The TEOM enables the measurement of aerosol
mass concentration ranging from μg/m3 to g/m3.
• Particles are collected on a glass tube-mounted filter,
the system being oscillated at a vibration frequency f.
• The variation in oscillation frequency is observed
when the aerosol is collected. This variation is
directly proportional to the mass of particles
deposited on the filter.
• Used for EPA air quality work
Model 1405-F Single Flow TEOM
42. Scanning Mobility Particle Sizer (SMPS)
TSI Scanning Mobility Particle
Sizer Spectrometer
• This instrument measures the particle number size
distribution. It is composed of a Differential Mobility
Analyser (DMA) which is coupled in series with a
Condensation Particle Counter (CPC).
• Size range of 2 nm to 1 micron
• An electric field is created and the airborne particles
drift according to their electrical mobility. Particle
size is then calculated from the mobility distribution.
• Particles must be neutralized at the DMA inlet using
radioactive sources (Kr85, Am241) to reach a state
of charge equilibrium. Transport could be an issue.
Available IH Tools and Limitations
43. Electrical Low Pressure Impactor (ELPI)
Dekati® ELPI™
Electrical Low Pressure Impactor (77 lbs)
• Sampled particles are charged
electrically by corona effect at the
instrument inlet and neutralize their
charge by depositing themselves at the
collection stage corresponding to their
aerodynamic diameter.
• The current measured at each stage
enables the determination of the
particle number concentration
• Particle size to 10 microns
Available IH Tools and Limitations
44. Condensation Particle Counter (CPC) or
Condensation Nuclei Counter (CNC)
TSI Nano Water-based
Condensation Particle Counter
3788 (18 lbs)
• This instrument measures the particles’ numerical
concentration in air sampled by laser optical detection.
• Optical reading restricted to particles with diameters
less than 100 nm requires their artificial growth for
detection purposes.
• To achieve this, sampled particles are used as alcohol
or water vapour condensation nuclei.
• This particle growth operation then enables the
detection of nanoparticles as small as three nm in
diameter in the case of the most sensitive instruments.
Available IH Tools and Limitations
45. Nanoparticle Surface Aerosol Monitor (NSAM)
TSI AeroTrak Nanoparticle
Aerosol Monitor 9000 (16 lbs)
• This instrument measures the surface
concentration of an aerosol that would be
deposited either in the tracheobronchial or
alveolar section of the airway.
• Sampled aerosol particles are charged by a
corona effect-induced ion diffusion at their
surface. The number of charges carried by a
particle is related to its surface area. Particles
charged in this way are then collected on a filter,
which current conduction, measured against time,
allows to determine the surface concentration.
• This is a full measurement, but it does not
provide the particle size distribution of the
collected particles.
Available IH Tools and Limitations
47. Basic Safety Guidelines for Handling
Engineered Nanoparticles
The current practices for
working with engineered
nanoparticles safely are
essentially the same as
one would use when
working with any
research chemical of
unknown toxicity…
48. If handling materials outside of a fume hood, biosafety cabinet or glovebox,
workers should wear protective equipment, including:
• Latex or nitrile gloves when handling nanoparticle powders and
nanoparticles in suspension (glove changes should be performed
frequently); Outer gloves should always be removed inside the hood or
under the influence of local exhaust ventilation and placed into a sealed
bag. This will prevent the particles from becoming airborne.
• Chemical splash goggles when working with nanomaterials in
suspension or dry powdered form.
• Lab coats should be laundered on a periodic basis. Do not take lab coats
home for laundering.
• Respirators (N95, N100, P100, half-face or full-face with P100 cartridges)
Basic Safety Guidelines
49. • When purchasing commercially available nanoscale materials, be sure to obtain
the Safety Data Sheet (SDS) and to review the information in the SDS with all
persons who will be working with the material. Note, however, that given the lack of
extensive data on nanoparticles, the information on an SDS may be more
descriptive of the properties of the bulk material.
• Nanoparticle solutions may be handled on the lab bench once placed in
solution.
• Transport of nanomaterials should employ a sealed secondary containment device.
• Work surfaces should be wet-wiped regularly – daily is recommended. Because
many engineered nanoparticles are not visible to the naked eye, surface
contamination may not be obvious. The cleaning solution should be compatible
with the vehicle in which the nanoparticles are suspended.
Basic Safety Guidelines for
Handling Engineered Nanoparticles
50. Managing Spills and Wastes
• All spills involving nanoparticles should be treated like a hazardous material spill
and cleaned up immediately.
• Wastes are classified and managed as the parent material(s).
• Solid wastes, where possible, should be converted to liquid wastes and
managed appropriately.
• The person cleaning up should wear double nitrile gloves and either vacuum up
the area with a HEPA filtered vacuum or wet wipe the area with towels, or
combination of the two.
• For spills that might result in airborne nanoparticles, proper respiratory protection
should be worn, such as a respirator with NIOSH-approved filters that are rated
as P-100 (HEPA).
• Do not brush or sweep spilled/dried nanoparticles.
51. Research Nano Safety Programs Vary Greatly
From one page handouts…
University Nanoparticle Safety
…to detailed SOPs
NIOSH Nanoparticle Safety
52. Common Plan Elements
Identification and Registration of EHS
Engineering Controls
• Chemical fume hood or biosafety cabinet w/ HEPA
filtration
• Glove boxes
• Laminar flow hoods
• ESD controls
Administrative/Work Practice Controls
• SOPs based on risk assessment
• ALARA principle
PPE
• Eyes, Hands, Body
• Respirators (N-95, P100)
Emergency and Waste Management procedures
• Eye wash/Shower
• Routine and Upset
Boron nanotube harvest
53. Hierarchy of Controls
Source: osha.gov
Hierarchy of Controls
• Select the highest
level that is feasible.
• If elimination or
substitution can’t be
used, a combination
of controls and PPE is
typically the most
effective control
measure.
56. Thank You For Attending!
Call Us!
1-888-834-9697
www.triumvirate.com
Contact:
Mark Liffers:
mliffers@triumvirate.com
Practice Director, EHS Consulting
Triumvirate Environmental
Jason Criscione:
jason@jmcriscioneconsulting.com
Owner & Managing Director
JM Criscione Consulting LLC
Request a Free Consultation:
http://info.triumvirate.com/nano-safety-program-consultation
57. NIOSH References
Current Strategies for Engineering Controls in Nanomaterial
Production and Downstream Handling Processes, DHHS
(NIOSH) Publication No. 2014-102
Occupational Exposure to Carbon Nanotubes and
Nanofibers, DHHS (NIOSH) Publication No. 2013-145
Filling the Knowledge Gaps for Safe Nanotechnology in the
Workplace, DHHS (NIOSH) Publication No. 2013-101