Rotavirus is a non-enveloped RNA virus with a characteristic wheel-like appearance that causes gastroenteritis in humans. It is transmitted through the fecal-oral route and causes watery diarrhea, vomiting, and dehydration for 3-8 days, primarily in infants and children under 5 years old. Diagnosis involves PCR or antigen detection assays on stool samples. Treatment focuses on oral rehydration and prevention involves routine vaccination with RotaTeq or Rotarix.
Adenoviridae is a group of medium sized, non-enveloped, double stranded DNA viruses that replicate and produce disease in the eye and in the respiratory, gastrointestinal and urinary tracts;
Adenoviridae is a group of medium sized, non-enveloped, double stranded DNA viruses that replicate and produce disease in the eye and in the respiratory, gastrointestinal and urinary tracts;
Rotavirus RV is a disease that is extremely spreadable in children whose age ranges between 3'5 years. Rotavirus vaccination RVV is an effective method for combating the diarrhoea disease as rotavirus is the leading cause of diarrhoea worldwide. For fulfilling the aim of reducing the burden of RV caused in children under 5 years for diarrhoea mortality. World Health Organization WHO recommends introducing RVVs worldwide. Globally three RVVs are licensed for local use two monovalent vaccines Rotarix, and Rotavac and a pentavalent vaccine RotaTeq. Safety and efficacy of these vaccines have been proved, however, they require cold chain storage at or below 2oto 8oC before use. In this article, a detailed profile of Rotarix vaccine is being emphasized. Rotavirus Vaccines are in high demand for introduction by many low income countries, but limitations such as price, poor supply and insufficient cold chain capacity at distant delivery points, have restricted their introduction. A. A Bhosale | Dr. V. U Barge "Illustrative Review on Rotavirus Vaccines" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29552.pdfPaper URL: https://www.ijtsrd.com/biological-science/biotechnology/29552/illustrative-review-on-rotavirus-vaccines/a-a-bhosale
Rotavirus is a contagious virus that can cause gastroenteritis (inflammation of the stomach and intestines). Symptoms include severe watery diarrhea, often with vomiting, fever, and abdominal pain. Infants and young children are most likely to get rotavirus disease.
Prevalence of Rota Virus Detection by Reverse TranscriptasePolymerase Chain R...IOSRJPBS
The present study was conducted for the period from 1/6/2016 to 20/1/2017 in Baquba city. The study aimed to detection of rotavirus in stool specimens of children fewer than five age and also explore the effects of certain demographic factors on the detection rates by revers transcriptase- polymerase chain reaction. The study included 49 patients with acute diarrhea, 32 were male and 17 were female. The age range was two months to 5 years. Demographic information on the patients regarding age, sex, residence, type of feeding and source of drinking water were collected from their parents. Stool specimens were collected from each patients and. Detection of rotavirus in stool specimens was done by conventional reverse transcriptase polymerase chain reaction (RT-PCR). The results of present study showed that the overall infection rate by rotavirus among patients with acute diarrhea by RT-PCR tests was 93.88%. The highest infection rate was recorded among those >10-≤15 months of age. None of the results showed significantly difference between female and male, PCR (88% vs 96.87%). Likewise, there was insignificantly difference between urban and rural residence, PCR (95.65% vs 92.30%). The results revealed insignificantly higher infection rate among patients (those below 2 years) feed mixing (91.66%) and bottled (100%) compared to that breast feeding (77.77%) by RT-PCR. The rotavirus infection rate was insignificantly higher among patients consuming municipal water for drinking (97.22%) compared to those consuming bottled water (84.61%) by the RT-PCR. The study concluded that rotavirus was detected in high rates among children less than 5 years old with acute diarrhea in Baquba city, particularly those less than 2 year old.
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2. Virus
➔ Rotavirus has a characteristic wheel-like appearance when viewed by an electron
microscope
➔ The name rotavirus is derived from the Latin word rota, meaning “wheel.”
➔ Rotaviruses are non-enveloped, possess a triple-layered capsid, and have a
segmented RNA genome.
3. Transmission electron micrograph of intact
rotavirus particles. This digitally colorized
image reveals structure of rotavirus virions
(viral particles).
4. Antigenic structure
➔ Rotaviruses are 70-nm nonenveloped RNA viruses in the family Reoviridae
➔ The viral nucleocapsid is composed of 3 concentric shells that enclose 11 segments of double-
stranded RNA.
➔ The outermost layer contains two structural viral proteins (VP): VP4, the protease-cleaved protein (P
protein) and VP7, the glycoprotein (G protein).
➔ These two proteins define the serotype of the virus and are considered critical to vaccine development
because they are targets for neutralizing antibodies that are believed to be important for protection.
5. Typing system
➔ Because the two gene segments that encode these proteins can segregate independently, a
typing system consisting of both P and G types has been developed.
➔ Although characterizing G serotypes by traditional methods is straightforward, using these
methods for determining P serotypes is more difficult. Consequently, molecular methods are
used almost exclusively to define genetically distinct P genotypes by nucleotide sequencing.
➔ These genotypes correlate well with known serotypes, but they are designated in brackets
(e.g., P[8]) to distinguish them from P serotypes determined by antigenic analyses.
6. Serogroups
➔ Rotaviruses are classified into 7 different serogroups (A–G), on the basis of the antigenic
specificity of the capsid proteins in the virus, as well as on the basis of the pattern of the
electrophoretic mobility of the 11 RNA segments of the viral genome.
➔ Of the 7 rotavirus serogroups, only groups A–C are known to infect humans, and
group A rotaviruses are viruses that cause severe, life-threatening disease in children
worldwide.
7. Clinical Features
➔ Rotavirus disease is characterized by vomiting and watery diarrhea for three to
eight days.
➔ Fever and abdominal pain also are common.
➔ Additional symptoms include loss of appetite and dehydration.
Symptoms of dehydration include
● decreased urination
● dry mouth and throat
● feeling dizzy when standing up
● crying with few or no tears and
● unusual sleepiness or fussiness.
8. ➔ The incubation period for rotavirus disease is approximately two days.
➔ Children may develop rotavirus disease more than once because neither
vaccine nor natural infection provide full immunity from future infections.
➔ A child’s first infection with rotavirus tends to cause the most severe symptoms.
9. Epidemiology
➔ The primary mode of transmission is the fecal-oral route, usually through direct contact
between people.
➔ Because the virus is stable in the environment, transmission also can occur through
ingestion of contaminated water or food and contact with contaminated surfaces or objects.
➔ In the United States and other countries with a temperate climate, the disease has a winter
and spring seasonal pattern, with annual epidemics occurring from January through June.
➔ The highest rates of illness occur among infants and children age 5 and under. Adults
can get rotavirus, though disease tends to be milder.
10. Diagnosis
➔ Nucleic acid detection PCR assays (for rotavirus alone or in multipathogen panels)
➔ Antigen-detection immunoassays on stool specimens to rapidly detect rotavirus.
➔ Characterization of strains by nucleic acid sequencing by laboratories engaged in surveillance
testing or research.
11. Treatment
➔ For people with healthy immune systems, rotavirus disease is self-limited, lasting only
a few days.
➔ Treatment is nonspecific and consists primarily of oral rehydration therapy to prevent
dehydration.
12. Vaccination
The CDC recommends routine vaccination of infants with either of the two available vaccines:
➔ RotaTeq® (RV5, Pentavalent Human-Bovine Reassortant Rotavirus Vaccine) licensed in
2006, is given in three doses at ages 2 months, 4 months, and 6 months.
➔ Rotarix® (RV1, monovalent human rotavirus vaccine) licensed in 2008, is given in two doses
at ages 2 months and 4 months