polyoma virus

1. Represented by:
Kainat Zafar
13-131-02
Erum Haider
13-131-03

2. PolyomaVirus

3. PolyomaVirus
 Poly= multiple & oma= tumor
 Family: Polyomaviridae
(formally grouped with papillomaviruses)
 Non-Enveloped, Naked Capsid.
 Icosahedral shape.
 Capsid: about 45nm in diameter

4. PolyomaVirus
 Closed, Circular, dsDNA genome
 Complexed with cellular histones.
 Encodes proteins/genes:
 VP1(Viral protein 1), VP2, VP3---form viral capsid
 Polyomavirus replicates in nucleus of host, host
dependent-specific

5. PolyomaVirus
Examples:
1-JC virus (JCV)
 Causes progressive multifocal leukoencephalopathy (PML)
 Progressive demage or inflamation of white matter of brain
at multiple locations.
 Harmless except in cases of weakend immune system in AIDS
2-BK virus (BKV)
 Latent until immunosuppression occurs.
 Causes renal diseases in kidney transplanted patients

6. PolyomaVirus
Virus Symptoms &
Transmission
Infection/
Disease
Diagnosis Treatment
BK Transmission:
Respiratory
fluid or urine
Renal disease in AIDS
paients
Respiratory infection
Fever
PCR
Blood or
urine test
No effective
drugs without
toxicity.
Supportive
JC Transmission:
Respiratory
Infect respiratory system,
kidneys or brain
PML (progressive
leukoencephalopathy) in
AIDS & transplant
patients.
As given
above
Supportive
Potent
imunosuppere
nt drugs

7. Reference
 http//.www.polyomaviridaewiki.com
 From Medical Microbiology
 http://www.google.com
 KAPLAN Medical USMLE Step 1.Immunology &
Microbiology.