This document summarizes information about PolyomaVirus. It notes that PolyomaVirus has a non-enveloped, naked icosahedral capsid around 45nm in diameter that contains a closed circular double-stranded DNA genome. It encodes for viral capsid proteins VP1, VP2, and VP3. Examples given are JC virus which can cause progressive multifocal leukoencephalopathy in immunocompromised individuals, and BK virus which can cause renal disease in transplant patients. Transmission is via respiratory fluids or urine and infection may be asymptomatic or cause fever, with diagnosis via PCR or blood/urine tests. There is no effective treatment without toxicity, only supportive care or immunosuppress

1. Represented by:
Kainat Zafar
13-131-02
Erum Haider
13-131-03

2. PolyomaVirus

3. PolyomaVirus
 Poly= multiple & oma= tumor
 Family: Polyomaviridae
(formally grouped with papillomaviruses)
 Non-Enveloped, Naked Capsid.
 Icosahedral shape.
 Capsid: about 45nm in diameter

4. PolyomaVirus
 Closed, Circular, dsDNA genome
 Complexed with cellular histones.
 Encodes proteins/genes:
 VP1(Viral protein 1), VP2, VP3---form viral capsid
 Polyomavirus replicates in nucleus of host, host
dependent-specific

5. PolyomaVirus
Examples:
1-JC virus (JCV)
 Causes progressive multifocal leukoencephalopathy (PML)
 Progressive demage or inflamation of white matter of brain
at multiple locations.
 Harmless except in cases of weakend immune system in AIDS
2-BK virus (BKV)
 Latent until immunosuppression occurs.
 Causes renal diseases in kidney transplanted patients

6. PolyomaVirus
Virus Symptoms &
Transmission
Infection/
Disease
Diagnosis Treatment
BK Transmission:
Respiratory
fluid or urine
Renal disease in AIDS
paients
Respiratory infection
Fever
PCR
Blood or
urine test
No effective
drugs without
toxicity.
Supportive
JC Transmission:
Respiratory
Infect respiratory system,
kidneys or brain
PML (progressive
leukoencephalopathy) in
AIDS & transplant
patients.
As given
above
Supportive
Potent
imunosuppere
nt drugs

7. Reference
 http//.www.polyomaviridaewiki.com
 From Medical Microbiology
 http://www.google.com
 KAPLAN Medical USMLE Step 1.Immunology &
Microbiology.