controlled drug delivery system to avoid problems regarding conventional drug delivery system.Predetermined rate controlled drug delivery system.Drug release follow zero order kinetics.Reduction in dose and frequency of dosing .reduction in fluctuation
pH-activated and Enzyme-activated drug delivery systemSakshiSharma250807
As per the syllabus of M.Pharma (1st sem.) I have presented the topic pH-activated and Enzyme-activated. This comes under rate-controlled drug delivery system under the subject Drug delivery system. Best wishes from Sakshi Sharma
pH-activated and Enzyme-activated drug delivery systemSakshiSharma250807
As per the syllabus of M.Pharma (1st sem.) I have presented the topic pH-activated and Enzyme-activated. This comes under rate-controlled drug delivery system under the subject Drug delivery system. Best wishes from Sakshi Sharma
rate control drug delivery system machenism Nirmal Maurya
rate control drug delivery system
including all machenism with figures
Prepared by
NIRMAL MORYA
M.Pharma
Mob +91 7060346038
BBAU Lucknow
A Central University
Barriers to Protein and peptide drug delivery system JaskiranKaur72
Protein and peptide DDS are novel systems of drug delivery.
The successful delivery of peptide and protein-based pharmaceuticals is primarily determined by its ability to cross the various barriers presented to it in the biological milieu. Various barriers encountered are-
1 Physiological Barrier
2 Intestinal Epithelial barriers
3 Capillary Endothelial Barrier
4 Blood-Brain barrier (BBB)
Description about a type of activation modulated drug delivery system, which a type of control drug delivery system.
Also, give a detailed description about each subclassification.
CrDDS is one which delivers the drug at a predetermined rate, for locally or systematically, for a prolong period of time.
rate control drug delivery system machenism Nirmal Maurya
rate control drug delivery system
including all machenism with figures
Prepared by
NIRMAL MORYA
M.Pharma
Mob +91 7060346038
BBAU Lucknow
A Central University
Barriers to Protein and peptide drug delivery system JaskiranKaur72
Protein and peptide DDS are novel systems of drug delivery.
The successful delivery of peptide and protein-based pharmaceuticals is primarily determined by its ability to cross the various barriers presented to it in the biological milieu. Various barriers encountered are-
1 Physiological Barrier
2 Intestinal Epithelial barriers
3 Capillary Endothelial Barrier
4 Blood-Brain barrier (BBB)
Description about a type of activation modulated drug delivery system, which a type of control drug delivery system.
Also, give a detailed description about each subclassification.
CrDDS is one which delivers the drug at a predetermined rate, for locally or systematically, for a prolong period of time.
Introduction, Definitions, Advantages and Disadvantages, Selection of drug candidates for designing controlled drug release systems and rationale biological and medical rationale
Introduction to CR/SR preparations, concept of controlled release formulation, challenges of CR drug delivery system, advantages and disadvantages, Factors influencing the design and performance of CR products (physiochemical properties: molecular size and diffusivity, aqueous solubility, ionization constant, partition coefficient, stability, pharmacokinetic and pharmacodynamic considerations: release rate and dose, Biological factors: Absorption, distribution, metabolism and elimination half life, therapeutic index, duration of action.
Kinetics of drug release from CRDS: Zero order, first order, Hixson-Crowell Release Model, Higuchi Release Model and Korsmeyer-Peppas Release Model
Oral controlled release systems: Dissolution controlled release (Matrix and encapsulated dissolution), diffusion controlled release (Reservoir and matrix system), dissolution and diffusion controlled release, Osmotically controlled release, pH independent formulations, Ion exchange resins.
Evaluation of CR formulations: Quality control methods( Identity, purity, strength, stability of the dosage form and drug in the dosage form, disintegration and dissolution, dosage form appearance, bioavailability of the drug from dosage form
Could PDC Be A New Direction For Targeted Therapy After ADC.pdfDoriaFang
Peptide-drug conjugates (PDCs) are the next generation of targeted therapeutics after ADCs, and their core advantages are enhanced cell permeability and improved drug selectivity.
Similar to Rate controlled drug delivery system (20)
General information on antiperspirant and deodorant which is part of syllabus of final year B.pharmacy in cosmetic science
Definations of antiperspirant and deodorant are included in these presentation
Types of antiperspirant and deodorant in details are explained in this presentation
Detailed mechanism of actives present in antiperspirant are explained in these presentation
Detailed mechanism of actives present in deodorant are included in these presentation
Examples in details are given in these presentation
Mechanism of each example are given in these presentation
These presentation is useful for all b.pharmacy final year and also diploma in pharmacy students.
Antiperspirant and deodorant are used to masking the odor of body produced due to sweat and sebum secretion and hence it is very important point in pharmacy and it has high value in the pharmacy and medicine ,medical technology stream also
Packaging and working of each part of packaging material is also important in antiperspirant and deodorant
Rate controlled drug delivery system achieved by using some polymers and predetermined release of drug from reservoir. CRDDS Avoids problems regarding conventional drug delivery
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
For Better Surat #ℂall #Girl Service ❤85270-49040❤ Surat #ℂall #Girls
Rate controlled drug delivery system
1. RATE CONTROLLED DRUG DELIVERY
SYSTEM
Presented by-
Miss Khade S.B
M.Pharm-1 [pharmaceutics department]
RCP , Kasegaon
10/09/2019 1Rate controlled DDS
2. Content-
Introduction
Needs of rate controlled DDS
Advantages
Disadvantages
Classification
Mechanism CDDS
Activation modulated drug delivery system
Effect of system parameters on controlled DDS
Applications of Rate controlled DDS
10/09/2019 2Rate controlled DDS
3. Introduction
“The term controlled release may be defined as a
technique or approach by which the drug is
delivered at predetermined rate , for locally or
systemically for a specified period of time”
controlled delivery of drug or protein and
bioactive agent can be achieved by incorporating
them either in dissolved or dispersed form in
polymer.
Follow “ZERO ORDER DRUG RELEASE”
Rapidly attained required plasma concentration
and maintained for the entire period of treatment.
10/09/2019 3Rate controlled DDS
4. Needs of rate controlled DDS
Less fluctuation in drug blood level
Frequency reduction in dosing
Improving patient convenience and compliances
Increased safety margin of the high potency drug
Reduction in total health care cost
Suitable DDS for drug having “ short biological half
life” 10/09/2019 4Rate controlled DDS
5. Disadvantages
Dose dumping
Decreased systemic availability in comparision to
immediate release conventional dosage form
Poor in vivo- in vitro correlation
Possibility of dose dumping
Difficult to optimize the accurate dose and dosing
interval
Patient variability affects release rate i.e GI emptying
rate, fasting or non fasting condition
10/09/2019 5Rate controlled DDS
6. Controlled Release system[Mechanism]
Controlled
release system
Dissolution
controlled
Diffusion
controlled
Chemically
controlled
Ion –
exchange
resin Hydrogel
Water
penetration
controlled
Diffusion
and
dissolution
Matrix
Encapsulation
Matrix
Reservoir
Reservoir
and
monolithic
Osmotic
pressure
controlled
system
10/09/2019 6Rate controlled DDS
7. Classification
Based on their technical sophistication
1. Rate preprogrammed drug delivery system
2. Activation modulated drug delivery system
3. Feedback regulated drug delivery system
4. Site targeting drug delivery system
10/09/2019 7Rate controlled DDS
8. RATE PREPROGRAMMED DDS
Polymer membrane permeation controlled DDS
Release of drug controlled by-
partition coefficient of drug
Diffusivity of drug molecule
Thickness of rate controlling membrane
e.g. progestasert
Polymer matrix diffusion controlled DDS
Release of drug controlled by-
Loading dose
Polymer solubility
Drug diffusivity in polymer matrix
e.g. Nitro- Dur
10/09/2019 8Rate controlled DDS
9. Micro reservoir partition CDDS
Release controlled by-
Partition coefficient
Diffusivity of drug
Solubility of drug
e.g. Syncro-mate-c ,Nitrodisc
10/09/2019 9Rate controlled DDS
10. Activation modulated DDS
“The release of drug molecule from the DDS is
activated by some physical, chemical or biochemical
process or energy supplied externally”
Based on nature of energy used –
1.By physical means
Osmotic activated DDS e.g. Alzet osmotic
pump
Hydrodynamic pressure activated DDS
Mechanically activated DDS
Magnetically activated DDS
Sonophoresis activated DDS
Iontophoresis activated DDS
Hydration activated DDS 10/09/2019 10Rate controlled DDS
11. 2.Chemical means
pH activated DDS e.g. Salts of citric acid ,
cellulose derivatives
Ion activated DDS
Hydrolysis activated DDS
3.Biochemical means
Enzyme activated DDS
Biochemical activated DDS
10/09/2019 11Rate controlled DDS
12. Feedback activated DDS
“Rate of drug release is controlled by concentration triggering
agent”
Classified as-
Bioerosion regulated DDS e.g. Hydrocortisone
Bioresponsive DDS e.g. Glucose triggered insulin
Self regulating DDS e.g. Glycosylated insulin
10/09/2019 12Rate controlled DDS
13. Effect of system parameters-
Physiological properties
Polymer solubility
solution solubility
Partition coefficient
Polymer diffusivity
Solution diffusivity
Thickness of polymer diffusional path
Thickness of hydrodynamic diffusional layer
Molecular size [400 Dalton] ,Drug pKa
Drug stability , Protein binding
Biological factors-Absorption ,Half life[2-3hrs]
Dose size, Therapeutic and Absorption window,
patient physiology
10/09/2019 13Rate controlled DDS
14. Applications of CDDS
Adsorbent of toxin
As Antacids
As Bile Acid binding agent
In treatment of Liver diseases
In Renal insufficiency
In Ophthalmology for glaucoma
Therapeutic application
1.Cholestyramine –Reduction of elevated serum
cholesterol level in patients with hypercholesterolemia
2. Sod. Polystrene –Sulphonic cation exchange resin
used in treatment of renal failure
10/09/2019 14Rate controlled DDS
15. 10/09/2019 Rate controlled DDS 15
Conclusion
A suitably deliberate controlled release drug delivery
system can be significant progress towards solving problems
regarding the targeting of the drug a particular organ or
tissue and controlling the rate of drug delivery to the target
site . Controlled release stuff provide an advantage over
conventional quality from by optimizing bio- pharmaceutics
pharmacokinetics and pharmacodynamics properties of
medicinal product
With improved understanding of controlled release
mechanism and improved development of technologies, it
may possible to design an appropriate method for efficient
drug delivery system at particular site