This document discusses radiopharmaceuticals, which are radioactive substances used for diagnostic or therapeutic medical purposes. It covers their production, safety precautions when handling them, storage requirements, and applications. Radiopharmaceuticals are produced using machines like cyclotrons and nuclear reactors and strict good manufacturing practices must be followed. They are safely used for diagnostic tests and cancer treatments but precautions are needed when working with radioactive materials.
A brief intoducation on Radiopharmaceutical including types of radiation, isotopes, manufacturing, Quality control , and equipments for measurement of radioactivity and Application of radiopharmaceuticals.
A brief intoducation on Radiopharmaceutical including types of radiation, isotopes, manufacturing, Quality control , and equipments for measurement of radioactivity and Application of radiopharmaceuticals.
Radio pharmacuticals are the compounds and substances that emits radiation and which are used in the pharmacy are called as radiopharmaceuticals.
The process of emitting radiation by the radioactive isotopes is called as RADIOACTIVITY.
Egs:uranium-238 isotope
cobalit-60
gallium etc.
Radioactivity, Alpha radiation, Beta radiation, Gamma radiation, Types of radiation, properties of alpha, beta and gamma radiations, Half-life of radioactive substances, Methods to measure radioactivity, Radioactive isotopes, Isotopes of Hydrogen, Isotopes of Carbon, Sodium Iodide -131, Medicinal uses of Sodium Iodide - 131, Storage of radioactive substances, Precautions in the handling of Radioactive substances, Applications of Radiopharmaceuticals
it is GTU based syllabus chapter and all the points are covered like... handling of prescription , etc... very helpful for pharmacy students...and its in easy language..
Impurities in pharmaceutical substancesShaliniBarad
Impurities definition
Sources of impurities
Effect/ type of impurities
Limit test definition
Limit test Importance,
Principle & procedure of Limit test for iron, chloride, sulphate, arsenic & heavy metals.
Radio pharmacuticals are the compounds and substances that emits radiation and which are used in the pharmacy are called as radiopharmaceuticals.
The process of emitting radiation by the radioactive isotopes is called as RADIOACTIVITY.
Egs:uranium-238 isotope
cobalit-60
gallium etc.
Radioactivity, Alpha radiation, Beta radiation, Gamma radiation, Types of radiation, properties of alpha, beta and gamma radiations, Half-life of radioactive substances, Methods to measure radioactivity, Radioactive isotopes, Isotopes of Hydrogen, Isotopes of Carbon, Sodium Iodide -131, Medicinal uses of Sodium Iodide - 131, Storage of radioactive substances, Precautions in the handling of Radioactive substances, Applications of Radiopharmaceuticals
it is GTU based syllabus chapter and all the points are covered like... handling of prescription , etc... very helpful for pharmacy students...and its in easy language..
Impurities in pharmaceutical substancesShaliniBarad
Impurities definition
Sources of impurities
Effect/ type of impurities
Limit test definition
Limit test Importance,
Principle & procedure of Limit test for iron, chloride, sulphate, arsenic & heavy metals.
Phụ lục 3 tiêu chuẩn GMP EU về sản xuất thuốc phóng xạ bao gồm:
1. Hệ thống chất lượng.
2. Nhân sự trong nhà máy thuốc phóng xạ.
3. Nhà xưởng, trang thiết bị nhà máy thuốc phóng xạ.
4. Hệ thống phụ trợ nhà máy thuốc phóng xạ.
5. Công nghệ sản xuất.
6. Hệ thống giám sát, quản lý môi trường sản xuất và quá trình vận hành.
7. Kiểm soát chất lượng thành phẩm đầu ra
They are radioactive substances or radioactive medications for diagnostic & therapeutic intervention
Radiopharmaceutical are medicinal formulations containing radioisotopes which are safe for organization in people for analysis or for treatment
Usually radiopharmaceuticals contain at least 2major components;
Radionuclide that provides the desired radiation characteristics &
Chemical compound with structural or chemical properties that determine the physiological behavior of radiopharmaceutical
Radiopharmaceuticals are the radioactive substances or radioactive drugs for diagnostic or therapeutic interventions.
Radiopharmaceuticals are composed of 2 parts: Radionuclide + Pharmaceutical
Radiopharmacy/Radionuclide laboratory is a controlled area & access will be restricted.
Only properly trained staff should be allowed to work in radionuclide laboratory.
Protective equipments should be used to reduce staff dose.
Radiopharmaceutical is a key component involved in the field of nuclear medicine. It serves various purposes diagnostically and also serves with different diagnostic applications. Radioactive agents are employed in nuclear field for demonstration of high and exact localized radioactive effect in a particular target tissue. In recent years various amount of radionuclides and radiopharmaceuticals are utilized for treating cancer and other complex disease like neuroendocrine disorder. This review focuses on the manufacturing, quality control tests and diagnostic applications of radiopharmaceuticals. K. R. Satav | T. P. Shangrapawar | Dr. Ashok Bhosale "Illustrative Review on Radiopharmaceuticals" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29762.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/29762/illustrative-review-on-radiopharmaceuticals/k-r-satav
Nuclear medicine uses radiation to provide information about the functioning of a person's
specific organs, or to treat disease. In most cases, the information is used by physicians to make a
quick diagnosis of the patient's illness. What is Radiopharmaceuticals? How Radionuclides are produced?
It has been concluded that the management of radiation accidents is a very challenging process and that nuclear medicine physicians have to be well organized in.
Dear B.Sc MIT Students,
Attached is an essential document featuring comprehensive Questions & Answers for Nuclear medicine 3 marks questions and answers. We encourage you to utilize this resource to deepen your understanding and excel in your studies. Wishing you all the success in your academic endeavors and future careers.
Best regards,
UNIT V
Mucoadhesive Delivery Systems:
Mechanism of bioadhesion, mucoadhesive materials, formulation and evaluation of Buccal and Nasal drug delivery systems.
I. INTRODUCTION
II. DEFINITIONS
III. TYPES OF DRUG MASTER FILES
IV. SUBMISSIONS TO DRUG MASTER FILES
V. AUTHORIZATION TO REFER TO A DRUG MASTER FILE
VI. PROCESSING AND REVIEWING POLICIES
VII. HOLDER OBLIGATIONS
IX. CLOSURE OF A DRUG MASTER FILE.
Introduction to Dissolution equipment's, Calibration of dissolution apparatus, Dissolution procedure development and validation, Dissolution method development for generic drug products.
Introduction and classification, anatomy of skin and factors affecting absorption, Formulation ,preparation, packaging, labeling and storage of ointments, Formulation, preparation, packaging, labeling and storage of jellies, creams, pastes.
Semisolid dosage forms: Definitions, classification, mechanisms and factors influencing dermal penetration of drugs. Preparation of ointments, pastes, creams and gels. Excipients used in semi solid dosage forms. Evaluation of semi solid dosages forms
Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of flocculated and deflocculated suspensions. Emulsions and theories of emulsification, microemulsion and multiple emulsions; Stability of emulsions, preservation of emulsions, rheological properties of emulsions.
Historical background and development of profession of pharmacy: History of profession of Pharmacy in India in relation to pharmacy education, industry and organization, Pharmacy as a career, Pharmacopoeias: Introduction to IP, BP, USP and Extra Pharmacopoeia.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Telegram: bmksupplier
signal: +85264872720
threema: TUD4A6YC
You can contact me on Telegram or Threema
Communicate promptly and reply
Free of customs clearance, Double Clearance 100% pass delivery to USA, Canada, Spain, Germany, Netherland, Poland, Italy, Sweden, UK, Czech Republic, Australia, Mexico, Russia, Ukraine, Kazakhstan.Door to door service
Hot Selling Organic intermediates
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdf
Radiopharmaceuticals
1. RADIO PHARMACEUTICALS
Production control
Safety precautions
Applications
Storage.
Presented by:
K. ARSHAD AHMED KHAN
M.Pharm, (Ph.D)
Department of Pharmaceutics,
Raghavendra Institute of Pharmaceutical
Education and Research [RIPER]
Anantapur.
1
2. DEFINITION:
Radiopharmaceuticals are the radioactive
substances or radioactive drugs for diagnostic or
therapeutic interventions.
or
Radiopharmaceuticals are medicinal formulations
containing radioisotopes which are safe for
administration in humans for diagnosis or for
therapy.
2
3. COMPOSITION:
• A radioactive isotope that can be injected safely
into the body, and
• A carrier molecule which delivers the isotope to
the area to be treated or examined.
3
5. BASICS
Nuclide:
This is a particular nuclear species characterized by
its atomic number (No. of protons) and mass
number (No. of protons + neutrons). 6C12 , 11Na23
Isotopes:
These are nuclides with same atomic number and
different mass number.
Hydrogen has 3 isotopes --- 1H1, 1H2, 1H3.
Carbon has 5 isotopes ------6C10, 6C11, 6C12, 6C13, 6C14.
5
6. • ISOTOPES MAY BE STABLE OR UNSTABLE.
• The nucleus is unstable if the number of
neutrons is less or greater than the number of
protons.
• If they are unstable, they under go radioactive
decay or disintegration and are known as
radioactive isotopes/ radioactive nuclides.
Radioactivity:
The property of unstable nuclides of emitting
radiation by spontaneous transformation of nuclei
into other nuclides is called radioactivity.
•Radioactive isotopes emit radiations or rays like
α, β, γ rays. 6
16. Radiopharmaceuticals production occurs in machines like
1. Cyclotron (low energy, high energy)
2. Nuclear reactors
3. Hot cells. 4. Radionuclide generator
1. CYCLOTRON:
• Used for acceleration of particles to produce
radioisotopes.
• The early use of cyclotron in radiopharmaceuticals field
was for the production of long lived radioisotopes that
can be used to prepare tracers for diagnostic imaging.
• For this, medium to high energy (20-70 MeV) cyclotrons
with high beam currents were needed.
• Isotopes such as thallium-201, iodine-123 and indium-
111 were prepared for use with single photon emission
computed tomography (SPECT). 16
17. • With the advent of positron emission tomography (PET),
there has been a surge in the production of low energy
cyclotrons (9-19 MeV) exclusively for the production of
short lived PET radionuclides.
Ex: fluorine-18, carbon-11, nitrogen-13 and oxygen-15.
• The majority of the cyclotrons (~350) worldwide are now
used for the preparation of fluorine-18 for making
radiolabelled glucose for medical imaging.
13 MeV cyclotron in
operation in Chosun
University, Republic of
Korea.
17
18. 2. Nuclear reactors:
These have ability to prepare larger quantities of
radioisotopes.
3. Hot cells:
These used for radioisotopes/radiopharmaceuticals
production.
They should be compatible with the requirements for both
radiological and pharmaceutical safety.
FUTURE:
The need for rapid, remote and reliable synthesis of PET
radiopharmaceuticals has led to the introduction of
microprocessor controlled automated synthesis modules.
18
21. • Radiopharmaceuticals production involves handling of
large quantities of radioactive substances and chemical
processing.
• Aspects which need to be addressed in production of
radiopharmaceuticals, are
1. Management of radioisotope production,
2. Import,
3. Operation and maintenance of processing facilities,
4. Complying with the codes of cGMP,
5. Ensuring effective QA & QC systems,
6. Registration of the products with national/regional
health authorities and
7. Radioactive material transport etc.
21
22. Radiopharmaceuticals production is still on a relatively
small scale and implementing the CGMP guidelines and it
involves taking care of several aspects
1. Proper selection and in service training of qualified personnel.
2. Drawing out of in house specifications for raw materials.
3. Generating test and storage standards.
4. Drawing out a manual of standardized procedures of safe
handling and step by step processing ,testing and waste disposal.
5. Availability of qualified equipment.
6. Assignment of responsibilities in writing.
7. Applying validated processes and analytical methods.
8. Facilities for minimizing of surface and airborne contamination.
9. Periodic inspection of protective devices for wear and tear and
performance.
10. Establishment of well understood emergency procedures.
11. Proper documentation system is required by law.
22
23. Production of radio pharmaceuticals is therefore a bit more
complex than normal pharmaceuticals. Good Radiation
Practices (GRPs) and Good Manufacturing Practices (GMPs)
should be strictly followed during manufacturing and
dispensing operations.
1. Strict personnel hygiene.
2. Avoidance of risk methodology.
3. Operations only in the recommended zones of hot Lab.
4. Proper techniques of distance and shielding.
5. Isolated storage , refrigeration of radionuclides and
labelled compounds.
6. Trial run using dummy or inactive source.
7. Adequate washing facilities including showers.
8. Proper in service training of qualified personnel.
23
24. 9. Drawing out a manual of standardized procedures of safe
handling and step by step processing , testing and waste
disposal of radio active compounds.
10. Facilities of minimizing radiation levels , removal of
surface and air borne contaminants.
11. Calibration and maintenance of instruments for
radioactivity measurements.
12. Provision of appropriate personnel monitoring and
protective devices.
13. Periodic inspection of protective devices for wear and
tear and performance.
14. Establishment of well understood emergency
procedures.
15. Proper documentation system is required by law.
24
25. • Radiation Safety is a term applied to concepts
requirements, technologies and operations related to
protection of people against the harmful effects of
ionizing radiation.
Safe Handling of Radio Isotopes :
1. GRP needs to be strictly followed for operations with
unrelated sources to reduce the chances of getting
unwanted and avoidable radiation exposure.
2. It is necessary to mark the area in which the radio
active work is carried out and it should be monitored
regularly at periodic intervals.
SAFETY PRECAUTIONS
25
26. 3. Unnecessary movements of persons or materials should
be avoided in the hot laboratory or radiopharmacy.
4. All the radiation workers must wear suitable protective
clothing and radiation monitoring devices, Surgical
gloves is necessary.
5. When not in use, the radionuclides must be kept in
sealed containers.
6. The area should be surveyed regularly for both
contamination and exposure hazards.
7. Work areas should be covered with a plastic, glass or
stainless.
8. Tray with absorbent paper should be use to catch any
spills and to prevent the spread of contamination.
26
27. 9. Do not pipette by mouth.
10. Wash hands thoroughly.
11. Radioactive materials should never be touched with
hand but handled with forceps or suitable instrument.
12. Do not eat, drink and smoke in areas where unsealed
radionuclides are stored.
13. The radiation survey meter should be used to ensure
safety of worker and public.
14. Survey an wipe test suggested action levels are
For unrestricted area 0.25 mR/hr. (milli Roentgens)
For restricted area 20 mR/hr.
27
28. Are radiopharmaceuticals safe?
• Absolutely. Like any medicine.
• The quantity of the pharmaceutical part of the
radiopharmaceutical is very small, generally 1/10th of a
millionth of an ounce.
• The risk of a reaction is 2-3 incidents per 1,00,000
injections, over 50% of which are rashes.
• Tell your doctor, if you have ever had any unusual or
allergic reaction to radiopharmaceutical products.
• These are not recommended for use during pregnancy
to avoid exposing the fetus to radiation.
• It may be necessary for you to stop breast-feeding for
some time after receiving it.
• Very low amount is used for children in diagnosis.
28
29. STORAGE
1. Because of the short life of the radiopharmaceuticals
the nuclear pharmacist will order the drug directly from
manufacturer usually through over night delivery.
2. In addition knowledge of shipping time / delivery
schedules and radio active decay associated loss should
be calculated while ordering radio pharmaceuticals.
3. Isotope storage areas should be as per the rules, there
should be separate labs for the manipulation and
preparation of radio pharmaceutical dosage and
another for calibration of doses, treatment room must
also be different
29
30. 4. Store in an airtight, suitable labeled containers shielded
by lead bricks to protect personnel from exposure to
primary or secondary emissions and that complies with
national and international regulations concerning the
storage of radioactive substances.
5. During storage, containers may darken due to
irradiation. Such darkening does not necessarily involve
deterioration of the preparations.
6. Radiopharmaceuticals intended for parental use should
be stored in such a manner so that pharmaceutical
purity of the product is maintained.
30
31. APPLICATIONS
Radioisotopes and radiopharmaceuticals are widely used
in many branches of medicine and surgery.
1. Diagnostic applications
2. Radiotherapy
3. Sterilization techniques.
4. Research applications
Radioiodine (iodine-131) was first introduced in 1946 for
the treatment of thyroid cancer & hyperthyroidism
31
32. 1.Diagnostic applications:
Radiation for diagnostic purpose must have sufficient
energy to pass through tissues from inside the body to
detecting device.
Phosphorous – 32 (15P32):
This is used as sodium phosphate for diagnosis of malignant
neoplasamas affecting eye, brain & skin.
Chrominium – 51 (24Cr51):
Chrominium – 51 as sodium chromate sterile solution is
used to label RBC to measure their survival, volume &
gastrointestinal blood losses.
Cobalt – 57 (27Co57) & Cobalt – 58 (27Co58):
These are labeled with Cynacobalamine (Vit- B12)
preparations for measurement of absorption, diagnosis of
pernicious anemia and other malabsorption syndromes.32
33. Technetium-99m:
1. Technetium-99m is the most widely used radioisotope in
diagnostic nuclear medicine, over 80% of the nearly 25
million diagnostic studies carried out annually.
2. Technetium-99m has a half-life of 6 hours and it is
daughter product of the long lived molybdenum-99 (a
half-life of 66 hours).
3. Technetium 99m has short half life of 6 hours , which
allows administration of higher amounts for faster and
clearer images while exposing the patient to a low
radiation dose. it offers an abundance of gamma
photons for imaging.
4. Technetium- 99m complexes, are used for imaging the
thyroid, liver, bone, kidneys etc.
33
34. New Technetium-99m complexes , are used as agents for
imaging the blood flow (perfusion) in the muscular
tissue of the heart (myocardium) and the brain.
1. In future, specific roles of technetium-
99m radiopharmaceuticals for imaging in
oncology may include the lymphatic
system, development of new blood
vessels and monitoring gene therapy.
Technetium-99m complexes USES
99mTc-Exametazime Cerebral perfusion radio
labeling
99mTc-Macro aggregated albumin Pulmonary perfusion
99mTc-Methylene diphophonate Detect bone metastasis associated
with cancer.
99mTc-Medronate Bone imaging
99mTc-Per technetate Imaging of thyroid salivary
glands
99mTc-Sulfur colloid Imaging of reticuloendothelial
cells
34
35. 2. Radio Therapy:
Radio isotopes are used for therapeutic action.
The Principle of radiotherapy is to destroy diseased tissues with out
destroying healthy tissues.
β- radiations have sufficient penetration so used to treat surface
lesions on eyes.
γ- radiations have high penetrating power, used to treat deep seated
tumors.
Iodine-131 (53I131) & Iodine-123 (53I123):
These are used in study of thyroid function, in treatment of
thyrotoxicosis & thyroid carcinoma.
Yttrium – 90 (39Y90):
This is used as colloid al suspension of Yttrium silicate in treatment of
arthritic conditions of joints.
Phosphorus – 32 (15P32):
Sodium phosphate is used in treatment of polycythaemia by I.V
injection. 35
36. Radiopharmaceuticals for bone pain palliation:
• Persons suffering from breast, lung and prostate cancer develop
metastasis in bones in the advanced stage of their diseases.
• Therapeutic radiopharmaceuticals containing radionuclides such
as strontium-89, samarium-153 and rhenium-186/188 are used
for effective palliation of pain from skeletal metastases.
• The IAEA has initiated a programme for the development and
clinical application of lutetium-177 based radiopharmaceuticals
for bone pain palliation.
Radiopharmaceuticals for primary cancer treatment:
• Radiolabelled peptides as molecular vectors are being developed
for targeted therapy.
• Peptide molecules when labelled with therapeutic radionuclides,
have the potential to destroy receptor-expressing tumours, an
approach referred to as Peptide Receptor Radionuclide Therapy
(PRRT).
• Yttrium-90 and lutetium-177 are frequently used. 36
37. Radiopharmaceuticals for radiosynoviorthesis:
• Radiosynoviorthesis or radiosynovectomy is a technique
wherein a radiopharmaceutical is delivered into the affected
synovial compartment (the interior of joints that is lubricated
by fluid) of patients suffering from joint pain, as in the case of
rheumatoid arthritis.
• Phosphorus-32, yttrium-90, samarium-153, holmium-166,
erbium-169, lutetium-177, rhenium-186, etc. and some of
them used in treatment of joint pain, are registered for
human use.
37
38. 3. Sterilization techniques:
Radio isotopes are employed in radiation sterilization of
heat liable drugs like hormones, vitamins, antibiotics and
surgical dressings, disposable syringes etc.,
Cobalt – 60 (27Co60):
This is used as radiation source for sterilization by
γ- irradiation of disposable syringes, catheters and surgical
dressings.
4. Research applications:
Radioisotopes are used in biochemical research for
determination of mechanism of reaction, locus of action.
Iodine – 131:
Sodium iodohippuric is used in determination of effective
renal plasma flow.
38