Radiopharmaceuticals are radioactive compounds used for diagnostic and therapeutic purposes in fields like medicine, research, and sterilization. They are used as tracers to study organ function, detect diseases like cancer, and deliver radiation therapy. Proper handling and storage of radiopharmaceuticals is important due to their radioactive nature.
PTC: Pharmacy and Therapeutics committeeSHIVANEE VYAS
The pharmacy and therapeutics committee is a policy framing and recommending body to the medical staff and the administration of the hospital on matters related to the therapeutic use of drugs.
PTC: Pharmacy and Therapeutics committeeSHIVANEE VYAS
The pharmacy and therapeutics committee is a policy framing and recommending body to the medical staff and the administration of the hospital on matters related to the therapeutic use of drugs.
The number of chemicals, poisonous household products and medicines on the Indian market it is increasing day by day which can frequently increases the risk of misuse of these products and leads to Greater incidence of intentional and unintentional poisoning.
Radiopharmaceuticals are the radioactive substances or radioactive drugs for diagnostic or therapeutic interventions.
Radiopharmaceuticals are composed of 2 parts: Radionuclide + Pharmaceutical
Radiopharmacy/Radionuclide laboratory is a controlled area & access will be restricted.
Only properly trained staff should be allowed to work in radionuclide laboratory.
Protective equipments should be used to reduce staff dose.
Patient counseling is a process wherein pharmacist implements face-to-face interaction with the patient to provide information, orally or in written form, on directions of use & advice on side effects to help them to use their medications appropriately
Patient Counseling is defined as providing medication information Orally or in written form to the patients or their representatives on directions of use, on side effects, precautions, storage, diet, life style modifications.
Radioactivity, Alpha radiation, Beta radiation, Gamma radiation, Types of radiation, properties of alpha, beta and gamma radiations, Half-life of radioactive substances, Methods to measure radioactivity, Radioactive isotopes, Isotopes of Hydrogen, Isotopes of Carbon, Sodium Iodide -131, Medicinal uses of Sodium Iodide - 131, Storage of radioactive substances, Precautions in the handling of Radioactive substances, Applications of Radiopharmaceuticals
The Drugs and Cosmetics Act, 1940 is an Act of the Parliament of India which regulates the import, manufacture and distribution of drugs in India. The primary objective of the act is to ensure that the drugs and cosmetics sold in India are safe, effective and conform to state quality standards.
A brief intoducation on Radiopharmaceutical including types of radiation, isotopes, manufacturing, Quality control , and equipments for measurement of radioactivity and Application of radiopharmaceuticals.
COMMUNITY PHARMACY AND MANAGEMENT – CHAPTER -1................... (1).pptSumit Tiwari
A community pharmacy, often referred to as retail pharmacy or retail drug outlets, is places where medicines are stored and dispensed, supplied or sold
Radio pharmacuticals are the compounds and substances that emits radiation and which are used in the pharmacy are called as radiopharmaceuticals.
The process of emitting radiation by the radioactive isotopes is called as RADIOACTIVITY.
Egs:uranium-238 isotope
cobalit-60
gallium etc.
Health education is a process that informs, motivates and helps people to adopt and maintain healthy practices and lifestyles, advocates environmental changes as needed to facilitate this goal and conducts professional training and research to the same end.
The number of chemicals, poisonous household products and medicines on the Indian market it is increasing day by day which can frequently increases the risk of misuse of these products and leads to Greater incidence of intentional and unintentional poisoning.
Radiopharmaceuticals are the radioactive substances or radioactive drugs for diagnostic or therapeutic interventions.
Radiopharmaceuticals are composed of 2 parts: Radionuclide + Pharmaceutical
Radiopharmacy/Radionuclide laboratory is a controlled area & access will be restricted.
Only properly trained staff should be allowed to work in radionuclide laboratory.
Protective equipments should be used to reduce staff dose.
Patient counseling is a process wherein pharmacist implements face-to-face interaction with the patient to provide information, orally or in written form, on directions of use & advice on side effects to help them to use their medications appropriately
Patient Counseling is defined as providing medication information Orally or in written form to the patients or their representatives on directions of use, on side effects, precautions, storage, diet, life style modifications.
Radioactivity, Alpha radiation, Beta radiation, Gamma radiation, Types of radiation, properties of alpha, beta and gamma radiations, Half-life of radioactive substances, Methods to measure radioactivity, Radioactive isotopes, Isotopes of Hydrogen, Isotopes of Carbon, Sodium Iodide -131, Medicinal uses of Sodium Iodide - 131, Storage of radioactive substances, Precautions in the handling of Radioactive substances, Applications of Radiopharmaceuticals
The Drugs and Cosmetics Act, 1940 is an Act of the Parliament of India which regulates the import, manufacture and distribution of drugs in India. The primary objective of the act is to ensure that the drugs and cosmetics sold in India are safe, effective and conform to state quality standards.
A brief intoducation on Radiopharmaceutical including types of radiation, isotopes, manufacturing, Quality control , and equipments for measurement of radioactivity and Application of radiopharmaceuticals.
COMMUNITY PHARMACY AND MANAGEMENT – CHAPTER -1................... (1).pptSumit Tiwari
A community pharmacy, often referred to as retail pharmacy or retail drug outlets, is places where medicines are stored and dispensed, supplied or sold
Radio pharmacuticals are the compounds and substances that emits radiation and which are used in the pharmacy are called as radiopharmaceuticals.
The process of emitting radiation by the radioactive isotopes is called as RADIOACTIVITY.
Egs:uranium-238 isotope
cobalit-60
gallium etc.
Health education is a process that informs, motivates and helps people to adopt and maintain healthy practices and lifestyles, advocates environmental changes as needed to facilitate this goal and conducts professional training and research to the same end.
Prussian Blue An Radioactive De Corporation Agentijtsrd
During the past few years, Science and Technology has extended to a large extent. They are mainly used in the field of medicine, diagnosis and treatment of the various diseases. Radioisotopes are extensively used in the field of medicine, treatment and diagnosis. But Apart from it, their major use is in the field of diagnosis. When a Human or a Living Being comes in contact with the radiations which are exerted by the radioactive elements or comes in contact with the any of the radioactive elements then it got incorporated in its body cells, tissues or organs. So, as to remove them we extensively used the de corporation technique, which works on the phenomenon of adsorption. The agents we preferably used in the de corporation are known as de corporating agents. There are mainly two categories in which we have divided these decoporating agents they are External de corporating agents and Internal de corporating agents. External de corporating agents are mainly used to remove radioactive elements from the external body surfaces like skin and the mucous membrane and on the other side Internal de corporating agents remove the radioactive elements from the Internal body parts, they are further classified as GI absorbers, Mobilizing agent, Blocking agent, Diluting and Chelating agents. Prussian Blue is one of the most commonly used Internal de corporating agent, it mainly performs their action by the absorption of the radioactive elements in the GIT, so they are also known as the GI absorbers. In US market it is marketed as 5oomg hard gelatin capsule which contains PB granules and marketed by the Brand name of Radio gardase. There are different nuclear disasters which we faced during the last some years like the Fukushima Nuclear Disaster, Chernobyl Nuclear Disaster, etc. Hence, we concluded that we need De contaminating agents, so as to remove the radioactivity from the body. Hardeep Singh Bambra | Mohd Mazhar ""Prussian Blue- An Radioactive De-Corporation Agent"" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23960.pdf
Paper URL: https://www.ijtsrd.com/medicine/other/23960/prussian-blue--an-radioactive-de-corporation-agent/hardeep-singh-bambra
More than one hundred radio-isotopes have been used to assist in a w.pdfaquacosmossystems
More than one hundred radio-isotopes have been used to assist in a wide variety of diagnostic
tests and treatment protocols. The use of radio-isotopes is convenient because they can emit
gamma radiation, have a short half-life, and are eliminated from the body shortly after the
completion of the diagnostic test or treatment. Radiodiagnostic protocols include:
1. Radioactive tracers are added to the blood stream to enable us to monitor the movement of
biochemical components in the human body.
2. Iodine 131, a beta emitter, is used for the treatment of overactive thyroids and also for
detecting internal hemorrhages.
3. Diagnostic techniques:
Diagnostic techniques in nuclear medicine use radioactive tracers which emit gamma rays from
within the body. These tracers are generally short-lived isotopes linked to chemical compounds
which permit specific physiological processes to be scrutinized. They can be given by injection,
inhalation, or orally.
An instrument called a gamma camera produces an image of the distribution of radioactivity in
an organ and by using this in conjunction with a computer, the functioning of the organ can be
closely monitored.
4. In Positron Emission Tomography (PET) scan, which is \"a more precise and sophisticated
technique\" for detecting cancerous growth in the human body:
A positron-emitting radionuclide is introduced, usually by injection, and accumulates in the
target tissue. As it decays it emits a positron, which promptly combines with a nearby electron
resulting in the simultaneous emission of two identifiable gamma rays in opposite directions.
These are detected by a PET camera and give very precise indication of their origin. PET\'s most
important clinical role is in oncology, with fluorine-18 as the tracer, since it has proven to be the
most accurate non-invasive method of detecting and evaluating most cancers. It is also well used
in cardiac and brain imaging.
Major therapeutic uses of radio-isotopes are:
1. Cobalt 60, an intense gamma emitter is often used in cancer therapy through direct irradiation.
2. Phosphorous 32, another beta emitter is often injected intravenously for treatment of leukemia.
3. Plutonium 238, an alpha emitter is used as a long lasting low level power source for
pacemakers to regulate heart action.
4. Caesium 137, encased in a biologically inert material container, is inserted into body cavities
like cervix or rectum to treat cancers in these regions effectively. Intense gamma radiation from
the radioisotope kills cancer cells locally, while the beta emissions are shielded by the container
walls.
5. Gold 198 or Iridium 192 wires can be inserted as implant for treatment of cancer in the tongue.
The list seems endless. A more detailed account can be obtained in the reference link given here.
The future of radiotherapy is probably the tagging of a monoclonal antibody for a specific cell
followed by the injection of the radioactive complex into the blood. The monoclonal antibodies
then bind.
what is radio active isotopes
uses of various fields in tracers
disadvantages of tracers
what are radioactive tracers
application in research fields in tracers
application in agriculture fields
Radiopharmaceutical is a key component involved in the field of nuclear medicine. It serves various purposes diagnostically and also serves with different diagnostic applications. Radioactive agents are employed in nuclear field for demonstration of high and exact localized radioactive effect in a particular target tissue. In recent years various amount of radionuclides and radiopharmaceuticals are utilized for treating cancer and other complex disease like neuroendocrine disorder. This review focuses on the manufacturing, quality control tests and diagnostic applications of radiopharmaceuticals. K. R. Satav | T. P. Shangrapawar | Dr. Ashok Bhosale "Illustrative Review on Radiopharmaceuticals" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29762.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/29762/illustrative-review-on-radiopharmaceuticals/k-r-satav
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2. Measurement of radioactivity,
study of radio isotopes –
Sodium iodide 131,
Storage conditions,
precautions &
Pharmaceutical application of radioactive substance .
3. Radiopharmaceuticals are used in various branches
like,
1) Diagnostic applications (Radioactive tracers)
2) Radiotherapy (Radioisotopes in Therapy)
3) Sterilization(Pharmaceuticals and surgical instruments)
4) Research. (Biological and medicinal studies by use of
radioactive isotopes as tracers)
5) Analytical Applications.
Applications of radiopharmaceuticals in pharmacy:
4. 1. Phosphorus 32: Used for diagnosis of cancer.
2. Chromium51: Used for diagnosis of red cell survival &
volume.
it is also Used to estimate GI blood losses through stool or
urine.
3. Co 57, 58 used measurement of absorption of vit. B12
Diagnosis of Pernicious anemia.
4.Iodine131:Determination of Thyroid function
.
Diagnostic applications
5. Radioactive tracers find use in medicine for diagnostic
purposes.
1. Labelled cyanocobalamine finds use for measuring the
glomerular filtration rate.
2. Ferric citrate injection finds use for the diagnosis of
haematological disorders.
3. Colloidal gold injection is used diagnostically to study blood
circulation in liver.
4. Sodium iodide injection finds use in diagnosis of proper
functioning of thyroid gland.
5. Sodium iodohippurate injection finds use in the study of
renal function.
6. Sodium rose Bengal injection finds use as diagnostic agent
to test liver function.
6. The therapeutically used radioisotopes have been found to
depend mainly on their ability to ionize atoms.
The energy measurement involved in radiation and resulting in
ionization may be expressed in millions of electron volts called
MeV.
The strength of alpha, beta and gamma rays in expressed in MeV.
All radiations bring about ionization of atoms in their paths.
The radiation of short wavelength (gamma rays) is having high
penetrating power than long wavelength (beta rays).
The greater the MeV of the rays, the more destructive it
becomes to the surrounding tissues.
RADIOPHARMACEUTICALS CAN DESTROY MALFUNCTIONING
CELLS.
This method of therapy is called radiotherapy. It can be used for
both benign and malignant cancers.
Radiotherapy
7. Some radioisotope are have ability to destroy
the disease without destroying healthy tissues.
a)Iodine 131: Used in the treatment of
hyperthyroidism
b) Used in the treatment of thyroid cancer.
C)Cobalt 60: Used in treatment of cancer involving cervix,
vagina, uterus, bladder, mouth, tongue and lips.
d)Phosphorus 32: Used in treatment of various types of
cancer in polycythaemia (erythrocytosis) & Leukemia.
Radiotherapy
8. Examples:
Gold (198 Au) treatment of abdominal and pleural effusions associated with
malignant tumours. It is given in the form of colloidal gold suspension.
Gold (198 Au) treatment of carcinoma of uterus and urinary bladder.
Cobalt labelled cyanocobalamine (vitamin B12) is used in diagnosis of
pernicious anaemia.
Sodium iodide preparation finds use in treatment of thyroid disorders.
Calcium is used to study bone structure and in carcinoma of bone.
Strontium 90 is used in diagnosis of superficial carcinomas.
Radioisotopes may be used internally or externally.
If the radioisotope are used externally or used as implants in sealed capsule in a
tissue, the dose could be terminated by removal or sources.
If they are given internally, as unsealed sources, the dose cannot be stopped by
the removal of the source.
The total dose in therapeutic applications may be calculated on the basis of
effective half life of the isotope, concentration of the isotope and the type and
energy of the radiation emitted.
9. Used for sterilization of Pharmaceuticals in their final
packed containers, thermolabile drugs
Hormones, Vitamins, Antibiotics, Surgical dressings,
Disposable syringes.
No heat or chemical gets involved.
Examples: Cobalt 60: Used for the sterilization of
disposable syringes, catheters and surgical dressings
and surgical instruments in hospitals.
Sterilization
10. Used in biochemical reactions,
may be used for detection of mechanism of
reactions.
Ex: Iodine 131,
Sodium 24,
Phosphorus 32.
5)Analytical: Plays major role when dealing with
dilute solutions.
Research
11.
12. Calcium (Ca-44 and Ca-45) radioactive calcium used to study bone structure
and in treatment of carcinoma of bone.
Strontium -90 Used in the radiotherapy of superficial carcinomas.
Cyanocobalamine (Co-57) Used in the diagnosis of pernicious anaemia.
Calcium -47 It is having half life of 4.7 days. It is used in
calcium absorption studies.
Cyanocobalamine
(Co-60 Solution
USP)
Used to study absorption and deposition of
vitamin B12 in normal individuals.
Gold (Au-198) solution Finds use in estimation of reticuloendothelial
activity.
Iron (Fe-59) Finds use in research studies about utilization
and absorption of Iron salts.
13. Labeling ,handling and storage of
radiopharmaceuticals
Name of Radioisotope.
Ex.I131
Strength in Microcurie or Milicurie per mililitre
at given time and date RADIOACTIVE..Indicates
Warning.
Name And Percentage of any bactericide added.
if not the statement must be there that the
product (INJECTION) does not contain any
bactericide.
Expiry date and name of manufacturer.
14. Radioactive Materials
Must Never Be Touch
With Hand But
Smoking ,Eating & drinking
Activities Should Not Be
Carried Out In The
Laboratory
Protective Clothing Or
Shielding Must Be Used
While Handling The
Radioactive Material
Handled By Means Of
Forceps Or Suitable
Instruments.
15. Radioactive Materials
Should Be Kept In
Suitable Labeled
Containers Shielded
By Lead Bricks And
Preferably In
Remote Area.
Storage
16.
17. Used as a diagnostic aid for studying the functioning of the
thyroid gland.
Used in scanning the thyroid for determining the size, position
and possible tumour location.
Used in the treatment of severe cardiac disease (Sodium
iodide I-131), which reduces work load on heart.
Radioactive iodine in thyroid carcinoma (cancer): The
isotope is used most frequently after the surgical removal
of cancer to treat any residual tumour tissues.
Uses of Sodium iodide I-131
18. Iron 59 is a beta and gamma emitting isotope.
Used in diagnosis to study the iron metabolism and to study
the red blood cell formation.
The preparation is administered orally for studying the
absorption of iron from GIT.
Administered I.V to study incorporation of iron in
formation of red blood cells.
Used to study the formation and destruction of spleen, liver
etc. from outside the body.
Iron59
19. Def: These are chemical compounds which have
ability to absorb X rays and block the passage
it through tissues.
➢Used for describing the body structures of the
particular part in the form of image.
➢X rays are capable of passing through most
soft tissues, but bones, cartilages and teeth's
are capable of blocking the passage of X rays.
Xrays are electromagnetic radiations and
interact with electrostatic field of electrons of
an atom.
Radiopaque (Contrast Media):
20. Radiopaques are administered like Barium sulphate
and Iodine for diagnosis of diseases in soft tissues
which shows image of that organ.
They do Not have Pharmacodynamic effect in the
body.
21. Chem. Form.: BaSO4 Mol. Wt.: 233.39
Synonyms: Barii sulfas, Barium meal.
Properties:
➢It is fine, heavy, white, odourless, tasteless, bulky powder,
free from gritty particles.
➢Practically insoluble in water & organic solvents.
➢Very slightly soluble in acids, alkalies & many salt
solutions.
➢Soluble in conc. Sulphuric acid with the
formation of bisulphate salt.
BaSO4+ H2SO4 Ba(HSO4)2
Barium sulphate
22. ➢Used as a radiopaque CONTRAST MEDIA for the X Ray
examination of various organs.
➢It is administered in the form of suspension. It is insoluble
salt is not absorbed.
➢Roentgenographic or Fluoroscopic.
➢in the diagnosis of structural and motility of Interior part
of the alimentary canal, from the mouth to the
duodenum .
23. Precautions:
▪ Barium sulphate may be used
cautiously in elderly patients.
▪ Once absorbed in blood can produced
Cardiac arrest.
Storage: Store in well closed containers.
Dosage forms:
• Suspension:
• Single dose powder.
•Single disposable, prefilled cups as enema kit.
Dose: 1) 60-450 gm (Oral). 2)150-750gm (Rectal).