This document summarizes different types and causes of ptosis presented by Nazneen Nasir. It discusses acquired ptosis which can be neurogenic, myogenic, aponeurotic, or mechanical. Congenital ptosis and pseudo ptosis are also mentioned. Examination techniques for ptosis including margin-reflex distance, palpebral fissure height, and levator function are outlined. Surgical correction methods such as Müllerectomy, levator resection, and brow suspension are briefly described for different types and severities of ptosis.
you will get knowledge about the ptosis, its different types, its examination, its measurement, its treatment in detail.
different eyelid muscles such as LPS, Orbicularis oculi and frontalis are also explained.
you will get knowledge about the ptosis, its different types, its examination, its measurement, its treatment in detail.
different eyelid muscles such as LPS, Orbicularis oculi and frontalis are also explained.
Ptosis is known as the drooping of the upper eyelid, and the patient usually presents with the complaint of the defect in vision and cosmesis. It can be congenital or acquired, or it can be neurogenic, myogenic, aponeurotic, mechanical, or traumatic in origin.
Congenital third ( oculomotor )nerve palsyVinitkumar MJ
Ask about pregnancy & birth history due to the association with birth trauma & perinatal complications.
Inquire whether the patient is meeting their developmental milestones or if they are exhibiting any other neurologic signs or symptoms. Although additional focal neurologic abnormalities or generalized delays in development have been described in these patients, their presence may increase concerns of other neurologic etiologies.
Determine whether they have signs of oculomotor synkinesis, such as asking the parents if they notice eye or eyelid movement during feeding.
Question if they have any family history of strabismus.
Heritability may suggest other forms of strabismus with known genetic associations.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
8. myopathy of the levator muscle itself,
or by impairment of transmission of impulses
at the neuromuscular junction
(neuromyopathic).
Acquired myogenic ptosis occurs in
:myasthenia gravis, myotonic dystrophy and
progressive external ophthalmoplegia
9.
10. Aponeurotic or involutional ptosis is caused
by a defect in the levator aponeurosis
11. Mechanical ptosis is caused by the
gravitational effect of a mass or by scarring
12. A false impression of ptosis
• Lack of support of the lids by the globe may be due to an
orbital volume deficit associated with an artificial eye,
microphthalmos, phthisis bulbi or enophthalmos.
• Contralateral lid retraction, which is detected by comparing the
levels of the upper lids, remembering that the margin of the
upper lid normally covers the superior 2 mm of the cornea
• Ipsilateral hypotropia causes pseudoptosis because the upper lid
follows the globe downwards It disappears when the hypotropic
eye assumes fixation on covering the normal eye.
• Brow ptosis due to excessive skin on the brow, or seventh
nerve palsy, which is diagnosed by manually elevating the
eyebrow
• Dermatochalasis. Overhanging skin on the upper lids may be
mistaken for ptosis, but may also cause mechanical ptosis.
13.
14. The age at onset of ptosis and its duration will usually
distinguish congenital from acquired cases.
If the history is ambiguous, old photographs may be helpful.
It is also important to enquire about symptoms of possible
underlying systemic disease, such as associated;
Diplopia
variability of ptosis during the day
excessive fatigue
15. Margin–reflex distance
Palpebral fissure height
Levator function (upper lid excursion)
Upper lid crease
Pretarsal show
16. Margin–reflex distance is the distance between the upper lid
margin and the corneal reflection of a pen torch held by the
examiner on which the patient fixates
the normal measurement is 4–5 mm.
17. distance between the upper and lower lid margins, measured
in the pupillary plan
The upper lid margin normally rests about 2 mm below the
upper limbus and the lower 1 mm above the lower limbus.
This measurement is shorter in males (7–10 mm) than in
females (8–12 mm)
Ptosis may be graded as mild (up to 2 mm), moderate (3 mm)
and severe (4 mm or more).
18. measured by placing a thumb firmly against the patient’s
brow to negate the action of the frontalis muscle, with the
eyes in downgaze.
The patient then looks up as far as possible and the amount
of excursion is measured with a rule
Levator function is graded as normal (15 mm or more), good
(12–14 mm), fair (5–11 mm) and poor (4 mm or less).
19.
20. distance between the lid margin and the skin
fold with the eyes in the primary position.
21. The pupils: examined to exclude Horner syndrome
and a subtle pupil-involving third nerve palsy
Increased innervation may flow to the levator
muscle of a unilateral ptosis, particularly in
upgaze.
Fatigability is tested by asking the patient to look
up without blinking for 30–60 seconds
Ocular motility defects, particularly of the superior
rectus, must be evaluated in patients with
congenital ptosis.
22. Jaw-winking can be identified by asking the
patient to chew and move the jaws from side
to side
23. tested by manually holding the lids open, asking the patient
to try to shut the eyes and observing upward and outward
rotation of the globe. A weak Bell phenomenon carries a
variable risk of postoperative exposure keratopathy,
particularly following large levator resections or suspension
procedures
24. should be inspected – a poor volume or unstable film may be
worsened by ptosis surgery and should be addressed
preoperatively as far as possible.
25. About 5% of all cases of congenital ptosis are
associated with the Marcus Gunn jaw-winking
phenomenon.
majority are unilateral.
a branch of the mandibular division of the
fifth cranial nerve is misdirected to the
levator muscle.
26. Retraction of the ptotic lid in conjunction with
stimulation of the ipsilateral pterygoid
muscles by chewing, sucking, opening the
mouth
contralateral jaw movement.
Less common stimuli to winking include jaw
protrusion, smiling, swallowing and clenching
of teeth.
Jaw-winking does not improve with age
although patients may learn to mask it.
27. Surgery should be considered if jaw-winking or
ptosis represents a significant functional or cosmetic
problem.
• Mild cases with reasonable levator function of 5 mm
or better, and little synkinetic movement may be
treated with unilateral levator advancement
• Moderate cases. Unilateral levator disinsertion can be
performed to address the synkinetic winking
component, with ipsilateral brow (frontalis)
suspension so that lid elevation is due solely to
frontalis muscle elevation.
• Bilateral surgery. Bilateral levator disinsertion with
bilateral brow suspension may be carried out to
produce a symmetrical result.
28. Mechanical ptosis is the result of impaired
mobility of the upper lid. It may be caused by
dermatochalasis, large tumours such as
neurofibromas ,heavy scar tissue, severe
oedema and anterior orbital lesion.
29. This involves excision of Müller muscle and overlying
conjunctiva with reattachment of the resected edges
The maximal elevation achievable is 2–3 mm, so it is used in
cases of mild ptosis with good (at least 10 mm) levator
function, which includes most cases of Horner syndrome and
mild congenital ptosis.
30. In this technique the levator complex is shortened through
either an anterior – skin– or posterior – conjunctival –
approach. Indications include ptosis of any cause, provided
residual levator function is at least 5 mm.
The extent of resection is determined by the severity of the
ptosis and the amount of levator function.
31. Brow (frontalis) suspension is used for severe
ptosis (>4 mm) with very poor levator
function