Global estimates indicate that the prevalence of glaucoma is 3.54% worldwide, and the number of people affected is projected to increase from 64.3 million in 2013 to 111.8 million in 2040. Glaucoma is the leading cause of irreversible blindness, with open-angle glaucoma affecting an estimated 4.5 million people and angle-closure glaucoma affecting 3.9 million people globally. Pseudoexfoliation syndrome is the most common cause of secondary open-angle glaucoma worldwide and is characterized by the deposition of pseudoexfoliative material in various structures of the anterior eye segment.
Congenital Glaucoma is one of the most common causes of irreversible childhood blindness. This presentation covers this topic in detail that can aid physicians in effective patient care.
PS: The slides in the preview look skewed, download the presentation to view the font used in Office 2012 and upwards.
A surgical procedure featuring a partial thickness scleral flap that creates a fistula between AC and subconjunctival space for filtration of aqueous and creation of conjunctival bleb in an effort to lower IOP
This presentation describes the nature of amniotic membrane grafts, Indications, and limitations with presentation of two cases of corneal perforations treated with it as a self experience
Congenital Glaucoma is one of the most common causes of irreversible childhood blindness. This presentation covers this topic in detail that can aid physicians in effective patient care.
PS: The slides in the preview look skewed, download the presentation to view the font used in Office 2012 and upwards.
A surgical procedure featuring a partial thickness scleral flap that creates a fistula between AC and subconjunctival space for filtration of aqueous and creation of conjunctival bleb in an effort to lower IOP
This presentation describes the nature of amniotic membrane grafts, Indications, and limitations with presentation of two cases of corneal perforations treated with it as a self experience
A case of intermittent exotropia by Krishna BanjadeKrishna Banjade
Intermittent exotropia is the most common type of strabismus in India, also known as "Intermittent divergent squint."
This PPT gives us the clear idea about different types of intermittent exotropia and the importance of patch test to differentiate basic X(T) from pseudodivergence X(T)
Crouzon syndrome is the most common syndrome in the craniosynostosis group. Crouzon syndrome accounts for about 4.8 of all cases. It usually has autosomal dominant inheritance with full penetrance and variable expressiveness from subtle to severe forms and is caused by maxillary hypoplasia with craniosynostosis, proptosis, and relative mandibular protrusion. be characterized. Mutations in the fibroblast growth factor receptor 2 gene have been implicated in the development of this rare genetic disorder. Our work reports the diagnosis of this rare syndrome in young patients based on clinical and radiological features. Prompt and timely treatment of the syndrome has allowed this patient to lead a normal life despite the syndrome. Dr. Kala Barathi. S | Mr. Azrudheen. B "Crouzon Syndrome: A Case Report" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-1 , February 2023, URL: https://www.ijtsrd.com/papers/ijtsrd53851.pdf Paper URL: https://www.ijtsrd.com/medicine/nursing/53851/crouzon-syndrome-a-case-report/dr-kala-barathi-s
TUBEROUS SCLEROSIS
Cutaneous Features
Neurological Features
Retinal Features
Systemic Features
NEUROFIBROMATOSIS
Cutaneous Features of Neurofibromatosis Type 1
Systemic Features of Neurofibromatosis Type 1
Neurological Features in Neurofibromatosis Type 1
Clinical Features of Neurofibromatosis Type 2
STURGE-WEBER SYNDROME
Cutaneous Features
Ocular Features
Neurological Features
Diagnostic Studies
Treatment
VON HIPPEL-LINDAU SYNDROME
Neurological Features
Ocular Features
Systemic Features
Molecular Genetics
Treatment
HEREDITARY HEMORRHAGIC TELANGIECTASIA
Neurological Features
Treatment
HYPOMELANOSIS OF ITO
Cutaneous Features
Neurological Features
Systemic Features
INCONTINENTIA PIGMENTI
Cutaneous Features
Neurological Features
Genetics
ATAXIA-TELANGIECTASIA
Cutaneous Features
Neurological Features
Immunodeficiency and Cancer Risk
Laboratory Diagnosis
EPIDERMAL NEVUS SYNDROME
Cutaneous Features
Neurological Features
Other Features
Neuroimaging
NEUROCUTANEOUS MELANOSIS
Cutaneous Features
Neurological Features
Laboratory Findings
Neuroimaging
EHLERS-DANLOS SYNDROME
Neurovascular Features
CEREBROTENDINOUS XANTHOMATOSIS
Neurological Features
Xanthomas
Other Clinical Features
Treatment
PROGRESSIVE FACIAL HEMIATROPHY
Clinical Features
KINKY HAIR SYNDROME (MENKES DISEASE)
Cutaneous Features
Other Clinical Features
Neurological Features
Neuroimaging
Genetic Studies
Diagnosis and Treatment
XERODERMA PIGMENTOSUM
Complementation Groups
Related Syndromes
Cutaneous and Ocular Features
Treatment
OTHER NEUROLOGICAL CONDITIONS WITH CUTANEOUS
MANIFESTATIONS
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
2. Estimated, the global prevalence of glaucoma
to be 3.54%
◦ The number of people with glaucoma worldwide
(aged 40-80 years) will increase from 64.3 million
in 2013 to 111.8 million in 2040
1st leading cause of irreversible blindness
◦ 4.5 million people open-angle glaucoma
◦ 3.9 million people angle-closure glaucoma
These numbers are set to rise to 5.9 and 5.3 million,
respectively, by 2020
Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040
Tham, Yih-Chung et al. ;Ophthalmology , Volume 121 , Issue 11 , 2081 - 2090
3. True
◦ True exfoliation or lamellar delamination of the lens
capsule
Pseudo
◦ Deposition of a protein-like material within the
anterior segment of the eye
Whitish-gray protein
Lens
Iris
Ciliary epithelium
Corneal endothelium
Trabecular meshwork
4. Pseudoexfoliation
syndrome
Pseudoexfoliative
glaucoma
• Presence of typical
pseudoexfoliation material
on the anterior lens capsule
in one or both eyes
• A normal optic disk
appearance and visual field
testing (Humphrey 30-2 SITA
standard test)
• IOP < 21 mm Hg
• Pseudoexfoliative material
on the anterior lens capsule
• Typical glaucomatous
cupping and visual field loss
in one or both eyes
• IOP > 21 mm Hg
Serpil Yazgan et al; (2015) Corneal Biomechanical Comparison of Pseudoexfoliation Syndrome, Pseudoexfoliative
Glaucoma and Healthy Subjects, Current Eye Research, 40:5, 470-475
5. Pseudoexfoliation syndrome (PXS) is a systemic
condition with eye manifestations.
◦ Deposits on various structures of the anterior segment.
The nature of this material is mostly fibrillar with fibers made
up of microfibrils and coated with amorphous material.
Fibrils is diverse and includes
basement membrane components
enzymes involved in extracellular matrix maintenance.
Pseudoexfoliation is the most common cause of
secondary open-angle glaucoma worldwide.
Pseudoexfoliative Glaucoma, PXG
6. Late onset condition with prevalence that
increases markedly with age
Generally more prevalent in women than in
men
In Japan the incidence of PXS increased with
age from 0.7% in ages 50 to 60 years to 7.3%
in ages over 80 years.
Ritch R: Exfoliation syndrome: clinical findings and occurrence in patients with occludable angles.
Trans Am Ophthalmol Soc. 1994, 92: 845-944
7. Evidence suggests a strong genetic
component to this condition.
PXS has been strongly associated with single
nucleotide polymorphisms (SNPs) of the lysyl
oxidase-like 1 (LOXL1) gene on chromosome
15q24.1
Elhawy E et. al.;Pseudoexfoliation syndrome, a systemic disorder with ocular manifestations. Human
Genomics 2012 6:22
8. Non-genetic factors correlated with
exfoliation syndrome
◦ exposure to ultraviolet radiation
◦ immunological or virus involvement
◦ transmission through keratoplasty
◦ nutrition – selenium, caffeine etc
9. PXM fibrils contain components of the elastic
fiber and basement membrane system
It is likely that PXM accumulation is a result of
a combination of both excessive synthesis
and insufficient degradation.
Elhawy E et. al.;Pseudoexfoliation syndrome, a systemic disorder with ocular manifestations. Human
Genomics 2012 6:22
11. Increased out flow resistance at TM
◦ Blockage by PXM
The side of accumulation and pathological alteration
occurs at juxtacanalicular tissue beneath inner wall of
Schlemm`s canal
Site of greatest resistance
Thickened through gradual deposition of PXM
Gradual build up of PXM at juxtacanalicular
tissue correlates with IOP level
◦ Development of Glaucomatous Optic Nerve damage
12. The age of the patient
Asymmetry and possible unilateral
13. Deposits on the anterior capsule, in a manner
resembling a target
Small white fibrillar deposits on the anterior
capsule or on the pupil margin
14. Pigmentation beyond the expected level
Peripupillary atrophy
Asymmetry in the signs
Poorly dilating pupils
16. PXM was identified in the wall of greater
vessels
Found in the heart, lung, liver, kidney, gall
bladder and cerebral meninges
Association with specific diseases
◦ TIA
◦ HPT
◦ MCI
◦ Stroke
◦ Alzheimer`s
◦ Hearing loss
17. IOP reduction
◦ Same as POAG treatment
LASER
◦ Laser trabeculoplasty delay the use of medical
therapy
Surgical Approach
◦ Trabeculectomy has comparable to those in POAG
Surgical complication more common
Pre op high IOP predispose
Choroidal hemorrhage or effusion
Weakened zonules-> lens movement / subluxation
Hyphaema