This document summarizes information about programmed cell death (PCD) in plants. It discusses how PCD is essential for plant development and defense. There are two main classes of plant PCD - developmental and defensive. Developmental PCD regulates cell division and organ development, while defensive PCD helps destroy infected cells and activate systemic resistance. PCD is controlled by genetically regulated proteases like metacaspases and vacuolar processing enzymes. Hypersensitive response is a form of defensive PCD that rapidly kills cells at infection sites. Necrosis differs from PCD in that it is an unregulated form of cell death caused by injury rather than an active suicide process.
Programmed cell death (PCD) is an important physiological process in plants that involves the selective elimination of unwanted tissues through controlled cell destruction. There are two main types of PCD in plants - autolytic PCD, which involves rapid cytoplasm clearance after vacuole rupture, and non-autolytic PCD where death occurs prior to vacuole rupture. PCD plays essential roles in plant development and defense. The purpose of developmental PCD is to regulate cell division and shape tissues and organs. Defensive PCD helps control invading microbes. Biochemical changes involved in PCD regulation include the action of various proteases and the vacuole. PCD occurs in many developmental processes including reproduction, seed and root development, and senescence.
Systemic acquired resistance (SAR) is a whole-plant immune response that is activated upon localized infection by a pathogen. It provides long-lasting, broad-spectrum resistance against secondary infections. SAR involves the production of mobile signaling molecules like methyl salicylate, azelaic acid, and glycerol-3-phosphate in infected tissues that activate defenses in distant, uninfected tissues. This results in increased expression of pathogenesis-related proteins and other defenses. The NPR1 protein is a master regulator of the SAR response.
The document discusses meristematic tissues and apical meristems in plants. It summarizes that the shoot apical meristem (SAM) and root apical meristem (RAM) contain stem cells and are responsible for postembryonic growth. The SAM contains four distinct cell groups and is maintained by genes like SHOOT MERISTEMLESS, WUSCHEL, and CLAVATA1/3. The RAM contains a quiescent center and produces root cells. Key genes that regulate SAM and RAM development include MONOPTEROS and HOBBIT.
The document discusses systemic acquired resistance (SAR), which confers long-lasting protection against a broad spectrum of pathogens. SAR is induced by initial infection and involves the signaling molecule salicylic acid, leading to accumulation of pathogenesis-related proteins throughout the plant. Key regulators of SAR include NPR1, which is required for SAR, and salicylic acid, which is involved in transmitting the defense signal systemically.
The document discusses abiotic stress responses in plants, with a focus on drought stress. It defines abiotic stress and describes different types of drought stress and plant responses. It discusses the genetic basis of drought tolerance and key pathways involved. The document summarizes stress tolerance mechanisms in plants, including detoxification, chaperoning, late embryogenesis abundant proteins, osmoprotection, and water and ion movement. Case studies on transgenic crops with improved drought tolerance are also mentioned.
The document discusses various types of programmed cell death (PCD), including apoptosis, autophagy, paraptosis, autoschizis, oncosis, and necrosis. It provides details on the characteristics and mechanisms of apoptosis and autophagy. Apoptosis involves blebbing, cell shrinkage, nuclear fragmentation, and is mediated by caspases through the intrinsic and extrinsic pathways. Autophagy results in autophagosomic-lysosomal degradation of cytoplasmic contents and organelles. The document also discusses some plant-specific features of apoptosis and its role in pollen self-incompatibility.
This document discusses abiotic stress in plants. It defines plant stress and describes how environmental factors like water deficit, salinity, temperature extremes, and mineral deficiencies can stress plants. It explains how plants acclimate and adapt to stress through physiological and morphological changes. The document outlines various stress sensing, signaling pathways and hormonal responses in plants, as well as developmental and antioxidant mechanisms that help protect plants from abiotic stress. Developing crop varieties with enhanced stress tolerance is an important goal.
Programmed cell death (PCD) is an important physiological process in plants that involves the selective elimination of unwanted tissues through controlled cell destruction. There are two main types of PCD in plants - autolytic PCD, which involves rapid cytoplasm clearance after vacuole rupture, and non-autolytic PCD where death occurs prior to vacuole rupture. PCD plays essential roles in plant development and defense. The purpose of developmental PCD is to regulate cell division and shape tissues and organs. Defensive PCD helps control invading microbes. Biochemical changes involved in PCD regulation include the action of various proteases and the vacuole. PCD occurs in many developmental processes including reproduction, seed and root development, and senescence.
Systemic acquired resistance (SAR) is a whole-plant immune response that is activated upon localized infection by a pathogen. It provides long-lasting, broad-spectrum resistance against secondary infections. SAR involves the production of mobile signaling molecules like methyl salicylate, azelaic acid, and glycerol-3-phosphate in infected tissues that activate defenses in distant, uninfected tissues. This results in increased expression of pathogenesis-related proteins and other defenses. The NPR1 protein is a master regulator of the SAR response.
The document discusses meristematic tissues and apical meristems in plants. It summarizes that the shoot apical meristem (SAM) and root apical meristem (RAM) contain stem cells and are responsible for postembryonic growth. The SAM contains four distinct cell groups and is maintained by genes like SHOOT MERISTEMLESS, WUSCHEL, and CLAVATA1/3. The RAM contains a quiescent center and produces root cells. Key genes that regulate SAM and RAM development include MONOPTEROS and HOBBIT.
The document discusses systemic acquired resistance (SAR), which confers long-lasting protection against a broad spectrum of pathogens. SAR is induced by initial infection and involves the signaling molecule salicylic acid, leading to accumulation of pathogenesis-related proteins throughout the plant. Key regulators of SAR include NPR1, which is required for SAR, and salicylic acid, which is involved in transmitting the defense signal systemically.
The document discusses abiotic stress responses in plants, with a focus on drought stress. It defines abiotic stress and describes different types of drought stress and plant responses. It discusses the genetic basis of drought tolerance and key pathways involved. The document summarizes stress tolerance mechanisms in plants, including detoxification, chaperoning, late embryogenesis abundant proteins, osmoprotection, and water and ion movement. Case studies on transgenic crops with improved drought tolerance are also mentioned.
The document discusses various types of programmed cell death (PCD), including apoptosis, autophagy, paraptosis, autoschizis, oncosis, and necrosis. It provides details on the characteristics and mechanisms of apoptosis and autophagy. Apoptosis involves blebbing, cell shrinkage, nuclear fragmentation, and is mediated by caspases through the intrinsic and extrinsic pathways. Autophagy results in autophagosomic-lysosomal degradation of cytoplasmic contents and organelles. The document also discusses some plant-specific features of apoptosis and its role in pollen self-incompatibility.
This document discusses abiotic stress in plants. It defines plant stress and describes how environmental factors like water deficit, salinity, temperature extremes, and mineral deficiencies can stress plants. It explains how plants acclimate and adapt to stress through physiological and morphological changes. The document outlines various stress sensing, signaling pathways and hormonal responses in plants, as well as developmental and antioxidant mechanisms that help protect plants from abiotic stress. Developing crop varieties with enhanced stress tolerance is an important goal.
- Hypersensitivity is a plant defense mechanism characterized by rapid programmed cell death at the site of infection to prevent pathogen spread. It is initiated by the recognition of pathogen elicitors by plant resistance proteins.
- This triggers biochemical responses like reactive oxygen species production and phytoalexin accumulation that cause cell death around the infection site. This localized cell death limits the pathogen to a small area and prevents disease development.
- The hypersensitive response is an example of incompatible interactions between plants with specific resistance genes and pathogens with corresponding avirulence genes. It represents a successful defense strategy employed by plants.
ROLE OF GROWTH HORMONES IN PLANT DISEASE227777222an
Plant hormones such as salicylic acid, jasmonic acid, ethylene, abscisic acid, auxins, gibberellins and cytokinins play important roles in modulating plant defense responses and resistance or susceptibility to pathogens. These hormones interact through complex signaling pathways and can have positive or negative crosstalk depending on the pathogen, plant species, and environmental conditions. Salicylic acid is important for resistance to biotrophic pathogens while jasmonic acid and ethylene help defend against necrotrophs. Abscisic acid generally suppresses defenses against necrotrophs. Gibberellins can enhance susceptibility through jasmonic acid signaling. Cytokinins positively interact
1) Plant viruses use various transmission methods like insects, sap, seed, or nematodes to spread between plants since plants cannot move.
2) Plants have two main antiviral resistance mechanisms: R gene-mediated responses and RNA silencing. R genes confer resistance to specific viruses and trigger cell death and systemic resistance. RNA silencing uses small RNAs to degrade or inhibit viral RNA.
3) These mechanisms sometimes overlap when a viral protein can suppress RNA silencing and also be detected by an R gene product as an Avr protein. This indicates communication between the plant's antiviral defense pathways.
Hypersensitivity and its Mechanism summarizes the hypersensitive response (HR) in plants. The HR is a localized cell death response at the site of infection that limits pathogen growth and provides resistance. It involves the recognition of pathogen elicitors by plant receptors, which activates a biochemical reaction cascade and the production of reactive oxygen species and defense compounds. This leads to cell death in infected areas and the acquisition of systemic resistance in other plant tissues through signaling molecules like salicylic acid, jasmonic acid, and ethylene. The HR occurs through specific host-pathogen combinations and results in the depolarization of membranes and disintegration of cellular components at the infection site.
plant pathogen interaction
different types of pathogens
gene for gene hypothesis
direct receptor model
Elicitor receptor model
suppersor repressor model
gaurd hypothesis
This document discusses biological control of plant diseases. Biological control involves using living organisms to control pests. It has received more attention recently. Some advantages are that it is specific to pests and cheaper after initial costs. Disadvantages include narrow effectiveness and high start-up expenses. Biological control agents include parasitoids, pathogens, and predators. Parasitoids lay eggs on or in a host insect and kill it. Pathogens infect insects and kill them or affect future generations. Predators are larger than prey and eat several. The document also discusses antagonists that compete with or produce toxins against plant pathogens. Common release methods are inoculative, where small numbers are released to spread, and augmentation, where organisms are mass
Pathogenesis-related (PR) proteins are a diverse group of plant proteins that are produced in greater amounts when plants are infected by pathogens or exposed to stress. There are at least 14 families of PR proteins that differ in their functions, properties, and modes of action. Some key PR proteins include PR1, PR2, and PR3. PR1 proteins have antifungal properties and may disrupt fungal membranes. PR2 are β-1,3-glucanases that degrade fungal cell walls. PR3 are chitinases that break down chitin in fungal cell walls, weakening the walls and killing fungi.
1. The document discusses plant pathogens and the enzymes they secrete to degrade plant cell walls and tissues. It describes the primary components of cuticles, cell walls, and middle lamella that pathogens target, including cutin, cellulose, pectin, hemicellulose, and lignin.
2. The key cell wall-degrading enzymes produced by pathogens are discussed, such as cutinases, pectinases, cellulases, hemicellulases, lignin-degrading enzymes, and proteases. Examples are given of pathogens and the roles of specific enzymes in disease development.
3. Effects of pathogens on physiological processes like photosynthesis, translocation of water and nutrients, respiration,
Molecular basis of plant resistance and defense responses to pathogensSenthil Natesan
This document summarizes a study on the molecular mechanisms of plant defense responses to the tomato powdery mildew fungus Oidium neolycopersici. The study investigated three monogenic genes (Ol-1, ol-2, and Ol-4) that confer resistance to the fungus via different mechanisms. It found that reactive oxygen species and callose accumulation were associated with resistances from both dominant and recessive Ol genes. cDNA-AFLP profiling identified different expression classes of genes, with Class III genes specifically upregulated only during incompatible interactions. The study provides insights into the molecular interactions and defense signaling pathways involved in the plant-pathogen system.
The document summarizes the ABC model of flower development. It discusses (a) the transition from vegetative to reproductive phase controlled by genes like FT, LFY, and SOC1, (b) the formation of inflorescence meristems regulated by genes like WUS and STM that prevent stem cell differentiation, and (c) individual floral organ development governed by meristem identity, organ identity, and cadastral genes. The ABC model specifies floral organ identity through the combinatorial interactions of ABC genes like AP3, PI, AG, and AP2, and D class genes like FBP7 control ovule development. The ABC model is sufficient to convert meristems into flowers and applies broadly across flowering plants.
The sugar beets had bumps and growths that made them stunted. This is likely crown gall disease, caused by the soil bacteria Agrobacterium tumefaciens. A. tumefaciens contains a tumor-inducing plasmid that gets transferred to plant cells, integrating into the plant DNA and causing uncontrolled cell growth and gall formation through the production of auxin and cytokinin. The infected field should be replanted with cereal crops for a long time to decrease the A. tumefaciens population, and the antibiotic agrocin can be sprayed to further treat the field.
root microbial interaction for crop improvement seminar ppt Balaji Rathod
This document discusses root-microbial interactions and how they impact crop improvement. It covers how plant root exudates can influence both positive and negative interactions with other plants and microbes. On the plant-plant side, exudates can facilitate resource competition, allelopathy, or parasitic relationships. Positively, they may induce defenses in neighboring plants. With microbes, exudates enable symbiotic relationships like nitrogen fixation and mycorrhizal associations, but can also have antimicrobial effects against pathogens. A better understanding of these below-ground processes could help develop strategies to enhance soil health and crop yields.
This document discusses principles of disease control in agricultural microbiology. It outlines four main principles: 1) Avoidance/Exclusion to prevent import and spread of pathogens, 2) Eradiation to reduce pathogen amounts, 3) Protection to directly protect plants from infection, and 4) Resistant varieties that hinder pathogen development. Specific control methods are described under each principle, including quarantine, sanitation, crop rotation, biological and chemical controls, and genetic engineering to develop resistant varieties.
Programmed cell death in plants by shivanand b. koppadShivanand Koppad
This document discusses programmed cell death (PCD) in plants. It provides definitions of PCD and necrosis, and describes the differences between the two processes. PCD, also called apoptosis, is an actively controlled and genetically regulated process while necrosis is unregulated cell death in response to external stressors. The document outlines the history of studying PCD/apoptosis and discusses PCD pathways, regulators like caspases, and importance in plant development and response to the environment. It also provides a case study on PCD in tomato fruit in response to heat stress.
Brassinosteroids are a class of plant steroid hormones that were first discovered in rapeseed pollen in the 1960s. They influence many developmental processes similar to auxins. The most common brassinosteroid is brassinolide, which was first isolated from rapeseed in 1979. Brassinosteroids regulate processes like cell elongation, flowering, vascular development, photomorphogenesis, and stress tolerance. They are perceived by membrane receptors and signal through a phosphorylation cascade to regulate gene expression.
Plants have evolved chemical defenses like proteinase inhibitors and toxic compounds to protect themselves from damage. Jasmonic acid (JA) is a key signaling compound that induces these defenses. JA is synthesized from linolenic acid through the octadecanoid pathway. It regulates processes like growth, photosynthesis, and defense. JA signaling involves peptide signals like systemin and leads to both local and systemic responses in plants.
DEFENCE MECHANISM IN PLANTS AGAINST PATHOGENS (STRUCTURAL & BIOCHEMICAL) ansarishahid786
Plants have both structural and biochemical defense mechanisms against pathogens. Structural defenses include pre-existing traits like thick cuticles and presence of thick-walled cells, as well as induced responses like formation of cork layers and tyloses after infection. Biochemical defenses include pre-existing inhibitory compounds and enzymes, as well as induced responses like phytoalexins, hypersensitive response, and transgenic production of plantibodies after pathogen detection. Together these defenses provide multiple layers of protection against the wide variety of fungi, bacteria, viruses and other pathogens that plants encounter.
This document discusses bud dormancy in plants. It defines a bud as an undeveloped shoot that occurs in the axil of a leaf or stem tip. Buds can remain dormant for some time before developing. There are different types of buds based on location, status, morphology, and function. Terminal buds are at stem tips while axillary buds are in leaf axils. Resting buds form at the end of the growth season and will lie dormant until the next season starts. External factors like water, oxygen, and suitable temperatures can affect dormancy along with internal seed maturity and hormone levels.
Programmed cell death (PCD) plays an important role in both plant development and defense against pathogens. In plants, PCD is crucial for development, occurring as cells die to form proper organs or structures. PCD also acts as a defense mechanism, restricting pathogen spread. Pathogens can manipulate PCD pathways in hosts, but in plants often activate PCD to promote their own growth, such as through toxins that induce cell death. PCD occurs during plant-pathogen interactions through localized hypersensitive response and membrane fusion reactions that protect against pathogens.
1. Programmed cell death (PCD) plays an important role in plant development and defense against pathogens. PCD occurs through defined phases and is regulated by proteases and caspases.
2. Hypersensitive response (HR) is a type of PCD that plants use to restrict the growth and spread of pathogens. HR is characterized by rapid death of infected cells and the accumulation of antimicrobial compounds.
3. Expression of the baculovirus p35 gene, which inhibits caspases and blocks PCD, provided tomato plants with resistance to fungal pathogens by preventing disease-associated cell death. Blocking PCD benefited plants in this case by reducing susceptibility to disease.
- Hypersensitivity is a plant defense mechanism characterized by rapid programmed cell death at the site of infection to prevent pathogen spread. It is initiated by the recognition of pathogen elicitors by plant resistance proteins.
- This triggers biochemical responses like reactive oxygen species production and phytoalexin accumulation that cause cell death around the infection site. This localized cell death limits the pathogen to a small area and prevents disease development.
- The hypersensitive response is an example of incompatible interactions between plants with specific resistance genes and pathogens with corresponding avirulence genes. It represents a successful defense strategy employed by plants.
ROLE OF GROWTH HORMONES IN PLANT DISEASE227777222an
Plant hormones such as salicylic acid, jasmonic acid, ethylene, abscisic acid, auxins, gibberellins and cytokinins play important roles in modulating plant defense responses and resistance or susceptibility to pathogens. These hormones interact through complex signaling pathways and can have positive or negative crosstalk depending on the pathogen, plant species, and environmental conditions. Salicylic acid is important for resistance to biotrophic pathogens while jasmonic acid and ethylene help defend against necrotrophs. Abscisic acid generally suppresses defenses against necrotrophs. Gibberellins can enhance susceptibility through jasmonic acid signaling. Cytokinins positively interact
1) Plant viruses use various transmission methods like insects, sap, seed, or nematodes to spread between plants since plants cannot move.
2) Plants have two main antiviral resistance mechanisms: R gene-mediated responses and RNA silencing. R genes confer resistance to specific viruses and trigger cell death and systemic resistance. RNA silencing uses small RNAs to degrade or inhibit viral RNA.
3) These mechanisms sometimes overlap when a viral protein can suppress RNA silencing and also be detected by an R gene product as an Avr protein. This indicates communication between the plant's antiviral defense pathways.
Hypersensitivity and its Mechanism summarizes the hypersensitive response (HR) in plants. The HR is a localized cell death response at the site of infection that limits pathogen growth and provides resistance. It involves the recognition of pathogen elicitors by plant receptors, which activates a biochemical reaction cascade and the production of reactive oxygen species and defense compounds. This leads to cell death in infected areas and the acquisition of systemic resistance in other plant tissues through signaling molecules like salicylic acid, jasmonic acid, and ethylene. The HR occurs through specific host-pathogen combinations and results in the depolarization of membranes and disintegration of cellular components at the infection site.
plant pathogen interaction
different types of pathogens
gene for gene hypothesis
direct receptor model
Elicitor receptor model
suppersor repressor model
gaurd hypothesis
This document discusses biological control of plant diseases. Biological control involves using living organisms to control pests. It has received more attention recently. Some advantages are that it is specific to pests and cheaper after initial costs. Disadvantages include narrow effectiveness and high start-up expenses. Biological control agents include parasitoids, pathogens, and predators. Parasitoids lay eggs on or in a host insect and kill it. Pathogens infect insects and kill them or affect future generations. Predators are larger than prey and eat several. The document also discusses antagonists that compete with or produce toxins against plant pathogens. Common release methods are inoculative, where small numbers are released to spread, and augmentation, where organisms are mass
Pathogenesis-related (PR) proteins are a diverse group of plant proteins that are produced in greater amounts when plants are infected by pathogens or exposed to stress. There are at least 14 families of PR proteins that differ in their functions, properties, and modes of action. Some key PR proteins include PR1, PR2, and PR3. PR1 proteins have antifungal properties and may disrupt fungal membranes. PR2 are β-1,3-glucanases that degrade fungal cell walls. PR3 are chitinases that break down chitin in fungal cell walls, weakening the walls and killing fungi.
1. The document discusses plant pathogens and the enzymes they secrete to degrade plant cell walls and tissues. It describes the primary components of cuticles, cell walls, and middle lamella that pathogens target, including cutin, cellulose, pectin, hemicellulose, and lignin.
2. The key cell wall-degrading enzymes produced by pathogens are discussed, such as cutinases, pectinases, cellulases, hemicellulases, lignin-degrading enzymes, and proteases. Examples are given of pathogens and the roles of specific enzymes in disease development.
3. Effects of pathogens on physiological processes like photosynthesis, translocation of water and nutrients, respiration,
Molecular basis of plant resistance and defense responses to pathogensSenthil Natesan
This document summarizes a study on the molecular mechanisms of plant defense responses to the tomato powdery mildew fungus Oidium neolycopersici. The study investigated three monogenic genes (Ol-1, ol-2, and Ol-4) that confer resistance to the fungus via different mechanisms. It found that reactive oxygen species and callose accumulation were associated with resistances from both dominant and recessive Ol genes. cDNA-AFLP profiling identified different expression classes of genes, with Class III genes specifically upregulated only during incompatible interactions. The study provides insights into the molecular interactions and defense signaling pathways involved in the plant-pathogen system.
The document summarizes the ABC model of flower development. It discusses (a) the transition from vegetative to reproductive phase controlled by genes like FT, LFY, and SOC1, (b) the formation of inflorescence meristems regulated by genes like WUS and STM that prevent stem cell differentiation, and (c) individual floral organ development governed by meristem identity, organ identity, and cadastral genes. The ABC model specifies floral organ identity through the combinatorial interactions of ABC genes like AP3, PI, AG, and AP2, and D class genes like FBP7 control ovule development. The ABC model is sufficient to convert meristems into flowers and applies broadly across flowering plants.
The sugar beets had bumps and growths that made them stunted. This is likely crown gall disease, caused by the soil bacteria Agrobacterium tumefaciens. A. tumefaciens contains a tumor-inducing plasmid that gets transferred to plant cells, integrating into the plant DNA and causing uncontrolled cell growth and gall formation through the production of auxin and cytokinin. The infected field should be replanted with cereal crops for a long time to decrease the A. tumefaciens population, and the antibiotic agrocin can be sprayed to further treat the field.
root microbial interaction for crop improvement seminar ppt Balaji Rathod
This document discusses root-microbial interactions and how they impact crop improvement. It covers how plant root exudates can influence both positive and negative interactions with other plants and microbes. On the plant-plant side, exudates can facilitate resource competition, allelopathy, or parasitic relationships. Positively, they may induce defenses in neighboring plants. With microbes, exudates enable symbiotic relationships like nitrogen fixation and mycorrhizal associations, but can also have antimicrobial effects against pathogens. A better understanding of these below-ground processes could help develop strategies to enhance soil health and crop yields.
This document discusses principles of disease control in agricultural microbiology. It outlines four main principles: 1) Avoidance/Exclusion to prevent import and spread of pathogens, 2) Eradiation to reduce pathogen amounts, 3) Protection to directly protect plants from infection, and 4) Resistant varieties that hinder pathogen development. Specific control methods are described under each principle, including quarantine, sanitation, crop rotation, biological and chemical controls, and genetic engineering to develop resistant varieties.
Programmed cell death in plants by shivanand b. koppadShivanand Koppad
This document discusses programmed cell death (PCD) in plants. It provides definitions of PCD and necrosis, and describes the differences between the two processes. PCD, also called apoptosis, is an actively controlled and genetically regulated process while necrosis is unregulated cell death in response to external stressors. The document outlines the history of studying PCD/apoptosis and discusses PCD pathways, regulators like caspases, and importance in plant development and response to the environment. It also provides a case study on PCD in tomato fruit in response to heat stress.
Brassinosteroids are a class of plant steroid hormones that were first discovered in rapeseed pollen in the 1960s. They influence many developmental processes similar to auxins. The most common brassinosteroid is brassinolide, which was first isolated from rapeseed in 1979. Brassinosteroids regulate processes like cell elongation, flowering, vascular development, photomorphogenesis, and stress tolerance. They are perceived by membrane receptors and signal through a phosphorylation cascade to regulate gene expression.
Plants have evolved chemical defenses like proteinase inhibitors and toxic compounds to protect themselves from damage. Jasmonic acid (JA) is a key signaling compound that induces these defenses. JA is synthesized from linolenic acid through the octadecanoid pathway. It regulates processes like growth, photosynthesis, and defense. JA signaling involves peptide signals like systemin and leads to both local and systemic responses in plants.
DEFENCE MECHANISM IN PLANTS AGAINST PATHOGENS (STRUCTURAL & BIOCHEMICAL) ansarishahid786
Plants have both structural and biochemical defense mechanisms against pathogens. Structural defenses include pre-existing traits like thick cuticles and presence of thick-walled cells, as well as induced responses like formation of cork layers and tyloses after infection. Biochemical defenses include pre-existing inhibitory compounds and enzymes, as well as induced responses like phytoalexins, hypersensitive response, and transgenic production of plantibodies after pathogen detection. Together these defenses provide multiple layers of protection against the wide variety of fungi, bacteria, viruses and other pathogens that plants encounter.
This document discusses bud dormancy in plants. It defines a bud as an undeveloped shoot that occurs in the axil of a leaf or stem tip. Buds can remain dormant for some time before developing. There are different types of buds based on location, status, morphology, and function. Terminal buds are at stem tips while axillary buds are in leaf axils. Resting buds form at the end of the growth season and will lie dormant until the next season starts. External factors like water, oxygen, and suitable temperatures can affect dormancy along with internal seed maturity and hormone levels.
Programmed cell death (PCD) plays an important role in both plant development and defense against pathogens. In plants, PCD is crucial for development, occurring as cells die to form proper organs or structures. PCD also acts as a defense mechanism, restricting pathogen spread. Pathogens can manipulate PCD pathways in hosts, but in plants often activate PCD to promote their own growth, such as through toxins that induce cell death. PCD occurs during plant-pathogen interactions through localized hypersensitive response and membrane fusion reactions that protect against pathogens.
1. Programmed cell death (PCD) plays an important role in plant development and defense against pathogens. PCD occurs through defined phases and is regulated by proteases and caspases.
2. Hypersensitive response (HR) is a type of PCD that plants use to restrict the growth and spread of pathogens. HR is characterized by rapid death of infected cells and the accumulation of antimicrobial compounds.
3. Expression of the baculovirus p35 gene, which inhibits caspases and blocks PCD, provided tomato plants with resistance to fungal pathogens by preventing disease-associated cell death. Blocking PCD benefited plants in this case by reducing susceptibility to disease.
Plants have developed several induced biochemical defenses against pathogens. These include:
1. The hypersensitive response, which involves rapid cell death at the infection site to restrict pathogen growth. This is triggered by specific recognition of pathogen virulence factors.
2. The production of reactive oxygen species and antimicrobial metabolites directly kill pathogens. Defense genes are also induced to produce pathogenesis-related proteins.
3. A hypersensitive response ultimately limits pathogen growth to the initial infection site and induces systemic acquired resistance throughout the plant via signaling molecules like salicylic acid, making the plant more resistant to a wide range of pathogens.
The document discusses different types of cell death, including programmed cell death mechanisms like apoptosis and autophagy. It notes that cell death is tightly regulated and important for development, health, and eliminating damaged or infected cells. The major types of cell death covered are apoptosis (genetically programmed suicide), autophagy (housekeeping role), necrosis (unprogrammed trauma-induced death), and necroptosis (programmed necrosis).
Radiation. Plants Immunity. Toxicity of Plants after irradiation.Dmitri Popov
A high level of Plant Vacuolar Protease, activated after moderate and high doses of radiation, possible playing role as radiation toxin and can induce development of Acute Radiation Syndromes in mammals after ingestion.
Programmed cell death (PCD) occurs in plants for development and defense. PCD is needed for natural development, removing unwanted cells, and shaping organs. It also helps defend against pathogens by restricting infection. PCD can be autolytic, involving clearance of cytoplasm, or non-autolytic. Key morphological changes include blebbing, shrinkage, and DNA fragmentation. PCD plays roles in seed development, germination, root growth, and the hypersensitive response against pathogens.
Cell death, also known as programmed cell death (PCD), is an important process in multicellular organisms whereby cells undergo an regulated death process. There are three main types of cell death - apoptosis, necrosis, and autophagy. Apoptosis is a tightly regulated form of cell death that plays a key role in development and homeostasis. Necrosis is unregulated cell death that results in inflammation. PCD is important in plants for processes like formation of xylem vessels, senescence, and the hypersensitive response to pathogens. Many pathogens have evolved ways to suppress PCD to promote infection.
This document summarizes programmed cell death or apoptosis. It discusses the distinct modalities of programmed cell death including apoptosis, autophagy and necroptosis. It covers the role of programmed cell death in disease, the mechanisms and molecular regulators involved in different types of cell death, methods to detect programmed cell death, and the therapeutic potential of modulating programmed cell death pathways.
The document discusses innate immunity, which is the first line of defense against infection. It has no memory and acts quickly through physical, chemical, and biological barriers as well as cellular and soluble components. Pattern recognition receptors recognize pathogen associated molecular patterns to initiate innate immune responses without prior exposure. Phagocytic cells play a key role through mechanisms like phagocytosis, respiratory burst, and degranulation to destroy pathogens intracellularly or extracellularly. Inflammation is induced as a secondary response to aid in pathogen elimination and tissue repair.
Innate immunity recognizes pathogens through pattern recognition receptors (PRRs) that detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). PRRs include Toll-like receptors, NOD-like receptors, RIG-I-like receptors, and lectins that recognize highly conserved microbial structures. Recognition of PAMPs/DAMPs by PRRs activates signaling cascades that initiate innate immune responses such as phagocytosis, inflammation, and antigen presentation.
host microbial interaction and toll like receptorsSaiBaba790008
This document provides an overview of host-microbial interactions in periodontitis. It discusses the microbial, immunological, and molecular aspects of this interaction. On the microbial side, it describes how bacteria can adhere to and invade host tissues, as well as evade the host immune response. It also explains how bacteria can directly or indirectly cause tissue damage through virulence factors and enzymes. On the immunological side, it discusses the role of pattern recognition receptors like Toll-like receptors and NOD-like receptors in recognizing microbial patterns and initiating inflammation. It also summarizes the acute bacterial challenge phase where the epithelium responds to bacteria and the early stages of the immune response.
Antibody and cell mediated immunity of fish and shellfishNaveen Rajeshwar B
1) The document discusses the antibody and cell-mediated immunity defenses in fish and shellfish. It describes the specific immune system of fish, which includes humoral antibody systems utilizing B cells and cell-mediated immunity utilizing T cells.
2) In shellfish, the innate immune system is primary, lacking an adaptive immune system. Cellular defenses include haemocytosis, phagocytosis, encapsulation, clotting, and the proPO system. Humoral defenses include lysozymes, antimicrobial peptides, and lectins.
3) The specific immune system of fish has both humoral defenses utilizing B cells to produce antibodies, and cell-mediated defenses utilizing T cells. B cells differentiate into plasma cells and memory cells
Plants face both abiotic stresses like drought, heat and salinity as well as biotic stresses from other living organisms like herbivores, fungi and bacteria. In response to biotic stress, plants have developed defense strategies including producing secondary metabolites and activating immune responses. One response is hypersensitive response (HR) where cells near the infection site undergo programmed cell death (PCD) to limit the spread of pathogens. HR involves producing pathogenesis-related proteins, phytoalexins, and changing cell wall composition. It is triggered by oxidative bursts of reactive oxygen species and nitric oxide that induce PCD through signaling pathways.
Drugs affecting gastrointestinal function: Drugs for Constipation & Diarrhoea...jhabarola
The innate immune system provides the first line of defense against pathogens. It recognizes pathogens through pattern recognition receptors (PRRs) that detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). The main PRRs are Toll-like receptors, NOD-like receptors, RIG-I-like receptors, and lectins. Recognition of PAMPs/DAMPs by PRRs activates innate immune responses like phagocytosis, inflammation, and antigen presentation. Innate immunity has no immunological memory and acts through physical, chemical, and cellular barriers against pathogens in a nonspecific manner.
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Programmed cell death (pcd)
1. Doctoral Seminar II
Course No. Pl. PATH-692
Programmed Cell Death (PCD)
Presented by
Sharad Shroff
Ph.D. Scholar
Department of Plant Pathology
2. Introduction
• Plants possess an innate program for controlled
cellular demise is accomplished by activation of
genetically regulated cell suicide machinery that
requires the active participation of the cell in a suicide
process known as programmed cell death (PCD).
• In mammals, a genetically regulated, signal
transduction–dependent programmed cell death
process, commonly referred to as apoptosis.
3. Definition of Programmed cell death
(PCD)
• Programmed cell death (PCD) has been defined as
a sequence of (potentially interruptible) events
that lead to the controlled and organized
destruction of the cell.
(Lockshin and Zakeri, 2004)
The term apoptosis –A Greek word originally means that
‘’fall of the leaf or leaf falling’’ .
(John et al., 1972)
4. What is the purpose of this PCD ?
Developmental PCD
Essential for successful development & growth of complex
multicellular organisms.
Regulates the rate of cell division.
Shaping of cells, tissues & organs.
Defensive PCD
Control of cell populations & defense against invading microbes.
PCD is needed to destroy the cells that represent a threat to the
integrity of the organism.
7. Regulation of PCD in Plants
• Plant Proteases
Metacaspases: A family of cysteine proteases in plants that are most similar
to animal caspases.
Subtilisin-like serine proteases.
VPE family of protease
• Bcl-2-associated athanogene (BAG) family: an evolutionarily conserved
family of co-chaperones in mammals and plants distinguished by a
characteristic BAG domain that mediates direct interaction with HSP70.
• Hypersensitive mediated PCD: Rapid, localized plant cell death upon contact
with avirulent pathogens.
• Necrotrophic pathogen mediated cell death: Death of cell caused by
hydrolytic enzymes and host selective toxins.
8. Family of Plant protease
The Plant protease family can be subdivided into
• Metacaspases
Type 1 Metacaspases (AtMC 1, AtMC 2)
Type 2 Metacaspases (AtMC 4, AtMC 9)
• Subtilisin-like serine proteases.
• VPE family of protease
9.
10. Metacaspase medaited PCD
• Pesudomonas syringae AtMC1 and -2 are positive
and negative regulators of HR-PCD, respectively.
• One of the most highly expressed type 2
metacaspase genes in Arabidopsis, Arabidopsis
thaliana Metacaspase 4 (AtMC4), is a positive
regulator of cell death induced by numerous
abiotic an biotic stresses.
• .
11. VPE family of protease
• Another family of plant proteases implicated in PCD is the
vacuolar processing enzyme (VPE) family of cysteine
proteases.
• This VPE is a positive regulator of HR induced by TMV
through its role in vacuolar collapse.
• The Arabidopsis δVPE protein is implicated in
developmental PCD of the inner integument layer of the
seed coat that occurs during embryo development.
12. Subtilisin-like serine proteases
• Subtilisin-like serine proteases (subtilases or
saspases) with caspase-like activity have also
garnered interest for their potential role in plant
PCD regulation.
• The first of the subtilases characterized from
plants, SAS-1 and -2, were purified from
extracellular extracts of Avena sativa (oat)
challenged with the PCD inducing fungal toxin
victorin.
13. Localization of Protease in Plant Cell
• Proteolytic enzymes that are involved in
PCD are localized in different compartments
of plant cells:
The cytoplasm (metacaspases),
The vacuoles (VPE),
The intercellular fluid (phytaspases)
14.
15. Role of Vacuoles in PCD
• The vacuole tonoplast can fuse with the plasmalemma to
release vacuolar contents extracellularly, or it can
disintegrate to release its contents to the cytosol.
• The vacuole also plays a crucial role in autophagic cell
death.
• During viral infection, the tonoplast is lysed with the
release of lytic enzymes of vacuoles into the cytosol.
Induction of rapid cell death pathways may be an effective
way of cleansing cytoplasm from viral growth.
• Sudden release of vacuolar contents into the cytoplasm
causes rapid cell death as was also noted for the HR
response to TMV in tobacco.
16. BAG family and role in PCD
• The role of Arabidopsis BAG family proteins in abiotic and biotic stress
responses and cell death modulation.
• The functions of BAG 1–3 are unknown.
• BAG 4 is involved in cell death inhibition in response to abiotic stress and binds
HSP70 molecular chaperones.
• BAG 5 forms a complex with CaM/HSC70 and regulates plant senescence.
• BAG 6 is proteolytically activated via aspartyl protease activity and links fungal
or chitin perception to the induction of autophagy.
• The ER-localized BAG 7 binds the molecular chaperone BIP2 and is an essential
component of the unfolded protein response.
18. Hypersensitive response
mediated PCD
• Rapid, localized plant cell death upon contact with
avirulent pathogens. HR is considered to be a key
component of multifaceted plant defense responses to
restrict attempted infection by avirulent pathogens.
• Rapid - within 24 h.
.
• HR also contributes to the establishment of the long-
lasting systemic acquired resistance against subsequent
attack by a broad range of normally virulent pathogens.
19.
20. Mechanism Of Hypersensitive
Response Includes
• Ion flux (Increase in Ca+ ion in cytosol due to
activation of several ion channels)
• Oxidative bust (production of reactive oxygen species)
• Disruption of cell membranes opening of ion channels
• Cross linking of phenolics with cell wall component
• Production of anti-microbial phytoalexins and PR
protein
• Apoptosis (programmed cell death).
22. Disruption of Cell Membranes
Opening of Ion Channels
• The earliest detectable cellular events are ion fluxes
across the plasma membrane and a burst of oxygen
metabolism.
• Elicitor increases the open probability of plasma
membrane located ion channel and may thereby
stimulate elevated cytosolic calcium levels, as well as
activate additional ion channels and pumps.
• Mediated through the regulation of plasma
membrane-bound enzymes. These include changes
in Ca2+-ATPase and H+- ATPase activities.
23. 23
A simplified model for the potential coupling of Plasma
membrane depolarization and Ca2+ Influx.
24. Reactive oxygen species in
cell death processes
• Transient elevation of cytosolic calcium levels
necessary for elicitor stimulation of the oxidative
burst.
• Extracellular generation of ROS is a central
component of the plants defense machinery.
• ROS act as direct toxicants to pathogens, catalyze
early reinforcement of physical barriers and are
involved in signaling later defense reactions, such as
phytoalexin synthesis and defense gene activation,
programmed cell death and protective reactions .
26. Cyclic nucleotides may act as second messengers for NO
signaling.
In tobacco nitric oxide synthase (NOS)-like activity was
strongly correlated with the expression of PR-1
NO------------ phytoalexins, PAL, SA
Both NO & SA----------- PR-1
26
27. Endogenous secondary signals in
plant disease resistance
• Salicylic acid: Plays a critical role in the activation of
defense responses.
• Increases in the levels of SA and its conjugates have
been associated with the activation of resistance
responses in a wide variety of plant species.
• These increases slightly precede or parallel the
expression of PR genes in both the infected tissue as
well as the uninfected tissues exhibiting SAR.
28. Necrosis is different from
Programmed cell death (PCD)
• Plant PCD occur as a function of pathogen invasion; these
include the hypersensitive response (HR), cell death–
inducing toxins, and responses to necrotrophic pathogens.
• In contrast to PCD, necrosis is most commonly defined as
cell death that results from exposure to highly toxic
compounds, Enzymatic degradation, severe cold or heat
stress, or traumatic injury that leads to immediate damage
to membranes or cellular organelles.
• The key distinction is that necrosis does not require the
active participation of the cell in its own demise.
31. Necrotrophic Fungal Pathogens and
Host Cell Death
• Necrotrophic fungi kill host tissue using a plethora of toxins and
lytic enzymes to achieve pathogenic success.
• A classic example is victorin-induced PCD imposed by the fungal
pathogen Cochliobolus victoriae.
• Victorin is a host-selective toxin that is required for
susceptibility to this pathogen and the development of Victoria
blight disease in oats.
• Victorin sensitivity is genetically conditioned by the Vb gene,
which paradoxically has been proposed to be inseparable from
an R gene (Pc2) that controls HR-PCD against another fungal
pathogen,
32. Victoria blight of oat
Causal Organism- Cochliobolus victoriae
Necrosis caused by
Host specific Victorin toxin
33. Signaling pathway of Necrotrophs
• Generally it is assumed that no gene for gene resistance for
necrotrophic pathogen.
• PRRs(Perception of Recognition Receptors) involves in perception of
necrotrophic pathogens such as Receptor like protein Kinases (RLKs).
• Host selective toxins (HSTs) and Hydrolytic enzymes are considered as
efficient weaponry of necrotrophic fungi and the diseases caused by
Necrotrophs are manifested by the appearance of necrotic lesion.
• The defense response to necrotrophic pathogen conferred by RLKs,
defensin, Phytoalexin and JA/ET signaling.
(John et. al. 2003)
34. Contd….
• JA and Ethylene Signaling mediated defense responses are
expected to play key roles in resistance to necrotrophic
pathogens.
• JA and Ethylene Signaling leads to activation of defense related
genes i.e. PDF 1,2 which reduce hyphal elongation and triggering
of fungi permeability to suppress the necrotrophic fungi growth.
• HR response is extreme level of susceptibility for necrotrophic
pathogen.
• The high level of HR activated in biotrophs plant pathosystem
may also provide entry for Necrotrophs in the local
environment.
(John et. al. 2003)
36. Hypersensitive Response By
Bacterial Pathogens
• Bacteria like Pseudomonas syringae inject effector
proteins (bacterial avirulence and virulence proteins)
into plant cells using the Type-III secretion system.
• Plants that are resistant to the bacteria have resistance
proteins that recognize the effector proteins and cause
the infected cell to commit suicide
(apoptosis/PCD/Hypersensitive Response).
• Prevents the bacteria from infecting the rest of the
plant by directly killing them and depleting nutrients.
38. The Hrp pathway
• A type III secretion pathway, broadly conserved among
gram negative pathogens of plants and animals.
• Macromolecular structure, Hrp pilus, acts as conduit for
traffic (called needle complex in animal pathogens).
• Encoded by clustered hrp genes.
• Required for hypersensitive reaction and pathogenicity.
• Expression induced in plant and in defined minimal media.
• Capable of delivering proteins into host cells Secretes and
delivers “effector proteins”.
a) virulence factors
b) avirulence factors
39.
40. How Mechanism of PCD
Regulation different in Plants
then Mammals ?
45. Extrinsic apoptotic pathway in
mammals
• There are two major pathway routes for
mammalian PCD: so-called intrinsic and
extrinsic pathways.
• In brief, the extrinsic pathway is mediated by
extracellular “death” receptors that bind
various activating ligands, leading to
cytoplasmic processing and activation of
upstream caspases, which activate downstream
caspases, leading to cellular execution.
46. Intrinsic apoptotic pathways
• The intrinsic apoptotic pathway in animals is generally
associated with the mitochondrion, It is switched on in the
case of internal cell defects(DNA damage, various stresses,
cytotoxic agents).
• Regulation of this pathway involves a large group of
protein from BCl-2 family which includes both pro and anti
apoptotic proteins.
• Cytochrome c loss in mammals occurs through the
mitochondrial permeability transition pore complex when
a death-promoting protein, such as Bax (proapoptotic Bcl-2
family member), induces the opening of the mitochondrial
voltage-dependent anion channel (VDAC).
47. Contd….
• The subsequent release of cytochrome c stimulates the
formation of an apoptosome complex in mammals,
which is composed of cytochrome c, procaspase-9, and
apoptotic protease-activating factor 1 (APAF-1).
• After activation in apoptosome complex caspase 9
triggers the processing of caspase 2, -3,-6,-7, -8.
• APAF-1 is related to the NB-LRR family of proteins, of
which plant R genes are also notable members.
48. APOPTOTIC FEATURES ANIMALS PLANTS
Cell shrinkage Yes Yes
Chromatin condensation Yes Yes
Phosphotidylserine externalization Yes Yes
DNA laddering Yes Yes
TUNELS-DNA cleavage Yes Yes
Caspases Yes No
Mitochondria permabilization Yes Yes
Mitochondria depolarization Yes Yes
Cytochrome c release Yes Yes
Cytochrome c–dependent activation of cell
death
Yes No
Apoptotic bodies Yes Yes
Vacuole leakage and fusion with
plasmalemma
No Yes
FEATURES ASSOCIATED WITH ANIMAL AND
PLANT APOPTOTIC CELL DEATH
49. References
Kabbage M. et. al. (2017): The Life and Death of a Plant
Cell. Annual Review of Plant Biology. 2017. 68:375–404.
Martin B. et. al. (2013): Centrality of Host Cell Death in
Plant-Microbe Interactions. Annual Review of
Phytopathology. 2013. 51:543–70
John M. et. al. (2003) Plant disease resistance genes:
recent insights and Potential applications. Trends in
Biotechnology Vol. 21 No.4 April 2013. 178-183.
Agrios G N; Plant Pathology. Elsevier Academic Press,
Burlington, MA, 2005.