Programmed cell death (PCD) plays an important role in both plant development and defense against pathogens. In plants, PCD is crucial for development, occurring as cells die to form proper organs or structures. PCD also acts as a defense mechanism, restricting pathogen spread. Pathogens can manipulate PCD pathways in hosts, but in plants often activate PCD to promote their own growth, such as through toxins that induce cell death. PCD occurs during plant-pathogen interactions through localized hypersensitive response and membrane fusion reactions that protect against pathogens.