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01
CONTENTS 
• Definition 
• Synthesis pathway 
• Application 
• Advantages 
• Challenges 
• Conclusion 
DEFAULT STYLES 02
DEFINITION 
• New biological fluorescence material 
• Nanoparticle 
• Size : close to Bohr radius 10 nm 
• Shape : Spherical 
• Material : fluorescent semiconductor nanocrystal 
• Made up : Group 12 and 16 elements 
DEFAULT STYLES 03
http://Chemistry.about.com
https://www.photonics.com
SYNTHESIS PATHWAY 
• 2 pathways : liquid phase & organic phase 
• Restriction in organic phase 
– High temperature 
– Complicated step 
– High cost 
– Poor stability 
DEFAULT STYLES 06
…cont 
• Liquid phase synthesis (more convenient) 
– Metal ions 
– Modified reagents 
– Tellurium (Te) source 
– Sulfur (S) or Selenium (Se) source 
– Auxiliary reagent 
– Heat 
DEFAULT STYLES 07
• Tumor diagnosis 
– QD-IgG & Cy3-IgG 
• Drug delivery 
– Cancer therapy 
• Drug screening 
– Mark target molecule 
08 
APPLICATION 
Hu M, Yan J, He Y. Ultrasensitive, multiplexed detection of 
cancer biomarkers directly in serum by using a quantum 
dot-based microfluidic protein hip. ACS 
Nano,2010,4(1):488-494.
Cancer cell 
DNA degradation 
uv 
Quantum dot 
Drug molecule 
Antibody 
09
ADVANTAGES 
• Good quantum effect 
– Broad & consecutive excitation spectra 
– Tunable size-dependant emission 
– Strong resistance to photo bleaching capacity 
DEFAULT STYLES 10
• Biocompatibility 
– Water solubility 
– High self producing rate of fluorescent dots 
– Stability of colloidal particle 
– Lower nonspecific adsorption 
• Biological coupling 
– Unstable coupling after UV irradiation 
• Biotoxicity 
– Aqueous environment release Cd ion 
11 
CHALLENGES
CONCLUSION 
• Many advantages 
– Biochemistry 
– Target molecule labeling 
– Fluorescent probe 
• High prospect to develop 
DEFAULT STYLES 12
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Production of Quantum Dots

  • 1. 01
  • 2. CONTENTS • Definition • Synthesis pathway • Application • Advantages • Challenges • Conclusion DEFAULT STYLES 02
  • 3. DEFINITION • New biological fluorescence material • Nanoparticle • Size : close to Bohr radius 10 nm • Shape : Spherical • Material : fluorescent semiconductor nanocrystal • Made up : Group 12 and 16 elements DEFAULT STYLES 03
  • 6. SYNTHESIS PATHWAY • 2 pathways : liquid phase & organic phase • Restriction in organic phase – High temperature – Complicated step – High cost – Poor stability DEFAULT STYLES 06
  • 7. …cont • Liquid phase synthesis (more convenient) – Metal ions – Modified reagents – Tellurium (Te) source – Sulfur (S) or Selenium (Se) source – Auxiliary reagent – Heat DEFAULT STYLES 07
  • 8. • Tumor diagnosis – QD-IgG & Cy3-IgG • Drug delivery – Cancer therapy • Drug screening – Mark target molecule 08 APPLICATION Hu M, Yan J, He Y. Ultrasensitive, multiplexed detection of cancer biomarkers directly in serum by using a quantum dot-based microfluidic protein hip. ACS Nano,2010,4(1):488-494.
  • 9. Cancer cell DNA degradation uv Quantum dot Drug molecule Antibody 09
  • 10. ADVANTAGES • Good quantum effect – Broad & consecutive excitation spectra – Tunable size-dependant emission – Strong resistance to photo bleaching capacity DEFAULT STYLES 10
  • 11. • Biocompatibility – Water solubility – High self producing rate of fluorescent dots – Stability of colloidal particle – Lower nonspecific adsorption • Biological coupling – Unstable coupling after UV irradiation • Biotoxicity – Aqueous environment release Cd ion 11 CHALLENGES
  • 12. CONCLUSION • Many advantages – Biochemistry – Target molecule labeling – Fluorescent probe • High prospect to develop DEFAULT STYLES 12