This document discusses the use of nanoparticles in drug delivery systems. Nanoparticles can be used to more precisely control the release of drugs in the body over time compared to traditional drug dosing. Magnetic nanoparticles are particularly useful as they can be guided to specific target sites in the body using external magnetic fields. The document outlines various methods for synthesizing magnetic nanoparticles and functionalizing them for drug delivery applications. Characterization techniques are also discussed for analyzing the nanoparticles. The document concludes that magnetic nanoparticles have the potential to improve drug targeting and control drug release while maintaining low toxicity.

1. Nanoparticle in Drug Delivery System (NDDS)
By: Hashem Ghezelsofla

2. 2
Drug delivery systems
Nanoparticle in Drug Delivery System

3. 3
Drug levels in the blood with
(a) traditional drug dosing and
(b) controlled-delivery dosing
Advantages of targeted drug delivery system
Nanoparticle in Drug Delivery System

4. Nanoparticles as a drug delivery system
Nanoparticle in Drug Delivery System

5.  Magnetic Drug Targeting (MDT)
 Magnetic Targeted Carriers (MTC)
Nanoparticle in Drug Delivery System

6. application of
magnetic
nanoparticles in
medicine
Diagnosis
Invitro
Bio-Sensing
Cell
separation
Transfection
Biological
separation
Enzyme
stabilizationInvivo
MRI
Therapy
Drug delivery
Hyperthermia
Magnetic nanoparticles are used for a wide range of clinical applications
Nanoparticle in Drug Delivery System

7. Nanoparticle in Drug Delivery System

8. Magnetic nanoparticles in drug delivery
Nanoparticle in Drug Delivery System
 Particle size 3-30 nm
 Particle size distribution 10-20%
 Dissolved in water
 Dextran
 Kitosan

9. Magnetic nanoparticles in medical applications
Nanoparticle in Drug Delivery System

10. Processes of magnetic particles preparation for drug delivery
Nanoparticle in Drug Delivery System

11. Methods for Magnetic Nanoparticles (MNPs) Synthesis
Reduction
Copercipitation
Reverse
microemulsion
polyol
Thermal
Decomposition
Sonochemical Hydrothermal Microwave
Nanoparticle in Drug Delivery System

12. Copercipitation method
Nanoparticle in Drug Delivery System

13. Reverse microemulsion synthesis method
Nanoparticle in Drug Delivery System

14. Polyol synthesis method
Nanoparticle in Drug Delivery System

15. Thermal decomposition method
Nanoparticle in Drug Delivery System

16. Design of nanoparticles for bioapplications
 Biocompatibility
 Size (10- 20 nm)
 Secretion (PEG)
 Stable
Nanoparticle in Drug Delivery System

17. Methods for Magnetic Nanoparticle Synthesis and Functionalization
 Insitu
 Post synthetic coating
 Direct exchange
 Ligand exchange
Nanoparticle in Drug Delivery System

18. Characterization
techniques for
nanomaterials
(XRD) X-ray
diffraction
DLS (dynamic light
scattering)
zeta potential
VSM(vibrating-sample
magnetometer)
Squid magnetometer
IR
Spectroscopy
TEM (Transmission
electron microscopy)
TGA (Themal
Gravimetry Analysis)
XPS (X-ray photoelectron
spectroscopy)
Mössbauer
spectroscopy
Nanoparticle in Drug Delivery System

19. XRD (X-ray diffraction)
DLS (dynamic light scattering)
Zeta potential
Nanoparticle in Drug Delivery System

20. VSM (vibrating-sample magnetometer)
Squid magnetometer
Nanoparticle in Drug Delivery System

21. TGA(Themal Gravimetry Analysis) XPS (X-ray photoelectron spectroscopy)
Mössbauer spectroscopy
Nanoparticle in Drug Delivery System

22. Targeted Drug
Delivery
Passive
Targeting
EPR(enhanced
permeability and
retention)
Physical features
Nano carrier size
linkage
Localised
delivery
Active Targeting
Antibodies
Ligands
Aptamers
Nanoparticle in Drug Delivery System

23. Nanoparticle–biomolecule conjugate
 Nucleic acids
 antibody
 Peptides
 Proteins
 Phospholipides
 Carbohydrates
 Hormons
 aptamer
Nanoparticle in Drug Delivery System

24. Targeted drug delivery agents
Nanoparticle in Drug Delivery System

25. Applications of Magnetic Nanoparticles in Targeted Drug Delivery System
 Magnetic nanoparticles as the nucleus for delivering targeted drugs
 A High Field Gradient Magnet for Magnetic Drug Targeting
 Enzyme-responsive nanoparticles for drug release
 change in thephysiological condition (PH- Temperature)
 MRI
Nanoparticle in Drug Delivery System

26. Applications of Magnetic Nanoparticles in Targeted Drug Delivery System
 Hyperthermia directed specifically to cancer cells through the use of magnetic nanoparticles heated
with alternating magnetic fields has been used as a novel cancer therapy
Nanoparticle in Drug Delivery System

27. Nanoparticle in Drug Delivery System

28. Magnetic Assisted Transfection
Nanoparticle in Drug Delivery System

29. Magnetically-triggered drug release system. Schematics of nanoparticles, molecular machines, assembly and remote-
controlled drug release. The particles and machines are not drawn to scale (reproduced with permission from [142],
Copyright 2010, American Chemical Society).
Druge release + Hyperthermia
Nanoparticle in Drug Delivery System

30. Conclusions
30
• Improve the medicinal and therapeutic properties
• Transfer the drug to a specified amount
• Transferring medicine to a specific place in the body
• The effects of medications and the distribution of
medicine in the body
 The ability to control the movement of
magnetic particles in the body is possible
using an external magnetic field.
 Due to their low toxicity, these particles are
used in various branches, including
medicine, MRI and hyperthermia and gene
therapy and DNA transducer.
Nanoparticle in Drug Delivery System