This document discusses targeted cancer therapy and provides several examples. It compares chemotherapy to targeted therapy, noting targeted therapy drugs inhibit more specific targets and include many oral agents. Examples discussed include Gleevec for CML targeting BCR-ABL fusion, EGFR mutations in lung cancer treated by drugs like Iressa, ALK rearrangements in lung cancer treated by crizotinib, BRAF mutations in melanoma treated by vemurafenib, and HER2-positive breast cancers treated by Herceptin. New immunotherapies and antibody-drug conjugates are also mentioned.
Introduction to Targeted Therapies in OncologyMohamed Abdulla
Describes the molecular background which represents the core for developing targeted therapies against specific biological events in malignant cellular clones.
Introduction to Targeted Therapies in OncologyMohamed Abdulla
Describes the molecular background which represents the core for developing targeted therapies against specific biological events in malignant cellular clones.
this slide contain information about antibody mediated anti-cancer therapy like antibody drug conjugates (ADC), Bispecific monoclonal antibody, Immuno-checkpoint therapy, biomarkers, mechanism of action of all 3 therapies, approved drugs of each category
An intensive material on the anticancer agents. Detailed idea of the various classes of anticancer and recent advances in each class. Newer anticancer drug delivery systems and the anticancer vaccines are also dealt in detail.
The combined use of radiation therapy and chemotherapy in cancer treatment is a logical and reasonable approach that has already proven beneficial for several malignancies.
Audio and slides for this presentation are available on YouTube: http://youtu.be/ozNSEND5PbE
Erica Mayer, MD, MPH, of the Susan F. Smith Center for Women's Cancers at Dana-Farber Cancer Institute, discusses triple-negative breast cancer and what makes it different from other forms of breast cancer. Mayer also talks about treatment options for triple-negative breast cancer and what you need to know about clinical trials for the disease.
this slide contain information about antibody mediated anti-cancer therapy like antibody drug conjugates (ADC), Bispecific monoclonal antibody, Immuno-checkpoint therapy, biomarkers, mechanism of action of all 3 therapies, approved drugs of each category
An intensive material on the anticancer agents. Detailed idea of the various classes of anticancer and recent advances in each class. Newer anticancer drug delivery systems and the anticancer vaccines are also dealt in detail.
The combined use of radiation therapy and chemotherapy in cancer treatment is a logical and reasonable approach that has already proven beneficial for several malignancies.
Audio and slides for this presentation are available on YouTube: http://youtu.be/ozNSEND5PbE
Erica Mayer, MD, MPH, of the Susan F. Smith Center for Women's Cancers at Dana-Farber Cancer Institute, discusses triple-negative breast cancer and what makes it different from other forms of breast cancer. Mayer also talks about treatment options for triple-negative breast cancer and what you need to know about clinical trials for the disease.
The engineered nanoparticles are effectively used for cancer treatment due to their targeted drug delivery approach. Download the Aranca report on Technology and Patent Research for current research trends and developments.
Nanotechnology and potential in Cancer therapy and treatmentladen12
this presentation focuses on new nanotechnology and it possible use in detection and therapy with cancer. it was prepared by final year biochemistry student at NCU.
A detailed ppt about cancer immunotherapy.
includes:-
Immunosurveillance and Immunoediting
Dentritic cell vaccines
Antibody therapy
Combined therapy
immune blockades
Cytokine therapy
T cell therapy
Include latest research finding about therapy.
Lung cancer is one of the most common types of cancer in the world and accounts for the most cancer-related deaths. Because of this, it is continuously studied for advancements in how to treat and manage it. This involves improved detection, which facilitates better treatment outcomes, and developments in the direct treatment of lung cancer.
Role of human papillomavirus and tumor suppressor genesishita1994
Oral cancer is synonymous to Squamous Cell Carcinoma (SCC) of oral mucosal origin that accounts for more than 90% of all malignant presentations at the aforementioned anatomical sites.
More than 300,000 new cases worldwide are being diagnosed with oral SCC (OSCC) annually.
Approximately, 30,000 (US) & 40,000(EUROPE).
Oral cancer is estimated by the WHO to be the 8th most common cancer worldwide.
In India & other Asian countries, oral & oropharyngeal carcinomas (OCs) comprise up to half of all malignancies, with this particularly high prevalence being attributed to the influence of carcinogens & region-specific epidemiological factors, especially tobacco & betel quid chewing.
Rare cancers are those affecting very small numbers and up to now have been poorly diagnosed, researched, funded, and treated, resulting in very high death rates even as morbidity for common cancers decline.
Diagnostic breakthroughs like genome sequencing make earlier stage diagnosis possible and breakthroughs in personalized treatment, including cell and gene therapies, provide new hope, including potential cures.
CCSN welcomed our host panelist Durhane Wong-Rieger, President & CEO of Canadian Organization for Rare Disorders and Chair of Rare Disease International. Durhane was joined by Lisa Machado, Founder and Chair of the CML Network for this engaging and educational webinar on the unique issues presented in rare cancers.
The webinar was followed by a question & answer session.
Learn how hyperthermia treatments (thermal therapy) can dramatically improve your response to radiation or chemotherapy. There are several mechanisms for action with how this treatment works biologically, and some cancers respond better than others. Contact Cyrus Rafie at (888) 580-5900 or visit http://www.bhthermalmedicine.com
Join Fight CRC in a webinar about biomarkers. In this session, Dr. Chris Lieu will focus the discussion on the NTRK biomarker, in addition to ctDNA, and Next-Generation Sequencing.
- “Proceso por el cual se informa a los pacientes y a sus familiares de la posibilidad de padecer un cáncer, de la posibilidad de transmitirlo a las siguientes generaciones, de las medidas preventivas y terapéuticas que se pueden realizar, así como de la posibilidad de realizar una prueba genética”.
-El asesoramiento genético debe ser realizado en el seno de las unidades de consejo genético (UCG), que permitan manejar de manera global e integral todos los aspectos de dicha actividad (clínica, diagnóstico molecular, investigación,…).
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Targeted Therapy in Cancer
1. Xanit Hospital Internacional
Avenida de los Argonautas s/n, 29630, Benalmádena, Málaga. Tlf: 952 367 190 - Fax: 952 367 191 - www.xanit.net
Xanit Oncology InstituteXanit Oncology Institute
Targeted Therapy in CancerTargeted Therapy in Cancer
Dr Rafael Trujillo VilchezDr Rafael Trujillo Vilchez
Area de OncologArea de Oncologííaa
Hospital Xanit InternacionalHospital Xanit Internacional
2. Chemotherapy vs Targeted Therapy
• Chemotherapy:
– Drugs that effect cells that are doubling
– Not very specific
– Mostly intravenous, some oral agents
– Cytotoxic
• Targeted therapy:
– Drugs that inhibit a more specific target in cells
– Many are oral agents
– Mixture of cytostatic and cytotoxic
4. • If we use the analogy of pesticides: empiric therapy would
be “Raid” while targeted therapy is the “Roach Hotel.”
Dr. David Gandara
• A “smart” bomb versus a “cluster” bomb.
Dr. Nevin Murray
What is Targeted Therapy?
5. Structural variants
•Translocations
•Fusions
•Inversion
Copy number alterations
•Amplifications
•Deletions
•LOH
Point mutations & indels
•Missense
•Nonsense
•Splice site
•Frameshift
Gene expression
•Outlier expression
•Isoform usage
•Pathways & signatures
Wild type AGTGA
Mutant AGAGA
Adapted from: Roychowdhury et al. Sci Transl Med; 20122
15. EML4-ALK Mutation in
Lung Cancer
• Present in 3-5% of non-small cell lung cancer,
usually adenocarcinoma
• Mutation leads to formation of a fusion gene
that codes for an abnormal tyrosine kinase
receptor
16. ~250 kb ~300 kb
t(2;5) ALK gene
breakpoint region
2p23 regionTelomere Centromere
3’ 5’
FISH Assay for ALK Rearrangement*
Break-apart FISH assay
for ALK-fusion genes1
ALK 29.3
EML4 42.3
ALK break-apart FISH assay
[Courtesy John Iafrate, Massachusetts General Hospital]
1
Shaw AT et al. J Clin Oncol
2009;27:4247–4253
q36.1
q36.3
q37.2
q34
q32.1
q32.3
q33.2
q31.3
q24.3
q24.1
q23.2
q22.2
q22.1
q21.2
q14.3
q14.1
q12.3
q12.1
p12
p13.2
p14
p16.1
p16.3
p22.1
p23.2
p22.3
p24.1
p24.3
p25.2
q36.1
q36.3
q37.2
q34
q32.1
q32.3
q33.2
q31.3
q24.3
q24.1
q23.2
q22.2
q22.1
q21.2
q14.3
q14.1
q12.3
q12.1
p12
p13.2
p14
p16.1
p16.3
p22.1
p23.2
p22.3
p24.1
p24.3
p25.2
Split signal
Non-split signal
*Assay is positive if rearrangements can be detected in ≥15% of cells
FISH = fluorescence in situ hybridization
20. Her-2/neu
• About 25% of breast cancer cases are
associated with a amplification of the genes
coding for a cell surface receptor called Her-
2/neu
• These cells may a 1000 fold increase in the
number of these receptors over normal breast
cells
• Associated with rapid growth
we will first review three types of drugs that can be used as targeted therapies—small molecules, antibodies, and vaccines.
The best target for therapy is a molecule or pathway that is present in cancer cells and absent in normal cells.
The Philadelphia chromosome was first discovered and described in 1960 by Peter Nowell from University of Pennsylvania School of Medicine[8] and David Hungerford from the Fox Chase Cancer Center
The exact chromosomal defect in Philadelphia chromosome is a translocation, in which parts of two chromosomes, 9 and 22, swap places. The result is that a fusion gene is created by juxtapositioning the Abl1 gene on chromosome 9 (region q34) to a part of the BCR ("breakpoint cluster region") gene on chromosome 22 (region q11)
The BRAF mutation causes cells to proliferate without any control or normal programmed cell death (apoptosis). Approximately 50% of melanoma cells have the mutated BRAF gene. It is more common in the young and more likely present in metastatic disease compared with primary melanoma.
Locations and types of the 134 epidermal growth factor receptor (EGFR) gene mutations detected in lung cancers. The structure of the EGFR gene is shown at left, and the locations and types of the mutations in the tyrosine kinase (TK) domain are shown at right. All mutations were located within exons 18–21, which encode the N lobe and part of the C lobe of EGFR (shaded area of the gene on the left, which is presented in magnified form on the right). Three major types of mutations (shown in bold) formed 94% of the 134 mutations detected and consisted of deletions in exon 19 immediately 5′ of the αC-helix (11 types, labeled Δ1–Δ11), duplications and/or insertions in exon 20 immediately 3′ of the αC-helix (eight types labeled D1–D8), and a single-point mutation, L858R (labeled M1), in the A-loop. The remaining 6% of mutations consisted of missense mutations in the P-loop in exon 18 (six types labeled M2–M7), in the αC-helix in exon 20 (a single type labeled M8), or in the A-loop in exon 21 (a single type labeled M9).
The EML4-ALK fusion gene is responsible for approximately 3-5% of non-small-cell lung cancer(NSCLC). The vast majority of cases are adenocarcinomas.
Through an unknown mechanism, cells with this mutation can no longer control their growth cycle, leading to uncontrolled proliferation and the potential for cancer.
The next best target for therapy is a molecule that is present more frequently in cancer cells compared to normal cells. In this case, it may be possible to adjust the dose of a drug so that cancer cells are killed more often than nearby normal cells.
Other possible targets for therapy include molecules that are present on both cancer cells and normal cells, but the patient's body can replace the normal cells that get destroyed.
Second, they can also be used as delivery vehicles, guiding radioactive molecules or toxins to the cancer cells.
an antibody-drug conjugate that works by binding to CD30 proteins on the surface of Hodgkin lymphoma cells. The ADC then forms a complex with CD30 and enters the cell. Inside the cell, the ADC’s chemotherapy component is released and kills the cancer cell. [
Third, antibodies attached to a cell can trigger an immune response that destroys the cell.
Ipilimumab or Yervoy is a monoclonal antibody against the CTLA-4 receptor on T cells (white blood cells that fight cancer). By blocking this receptor the T cell remains activated against cancer cells such as melanoma.
Two phase III trials have shown a survival benefit over traditional melanoma treatment in the form of Dacarbazine or a peptide vaccine. The most recent presented at ASCO in June 2011 showed higher survival rates at 1 year (47.3% v’s 36.3%), 2 years (28.5% v’s 17.9%) and at 3 years (20.8% v’s 11.6%).
Unlike other targeted therapies, therapeutic cancer vaccines do not act specifically on pathways in cancer cells. Instead, they act broadly by trying to activate the body's immune system to make it recognize and attack cancer cells.
Eg: interleukin 2
Developed based on concept of antigen-presenting cells (APCs), which include dendritic cells, macrophages and B lymphocytes
APCs from patients blood are harvested by leukapheresis, sent to drug company (Dendreon), where they are incubated with recombinant fusion protein antigen containing PAP (prostatic acid phosphatase) and GM-CSF (granulocyte-macrophage colony-stimulating factor) ● These antigen-loaded APCs are infused into patient, and may prime a T-cell mediated immune response against prostatic cancer cells (J Clin Oncol 2006;24:3089)
Sin duda, los directivos influyen notablemente en el grado de felicidad de las personas en el trabajo, pero la responsabilidad definitiva es de cada uno. Los directivos tienen tres obligaciones respecto de la felicidad en el lugar del trabajo:
1.- Lograr la satisfacción para sí.
Un líder feliz es un modelo natural para sus empleados y contagia la buena disposición por naturaleza propia. El insatisfecho no puede crear la atmósfera de alegría para que la gente rinda al máximo en su trabajo.
2.- Conocer a su gente y ocuparse de ellos.
No pueden estar a cargo de personas sin demostrar interés en ellos y conocerlos profundamente.
3.- Crear una atmósfera que ayude a la gente sentirse feliz.
Abierta, positiva, con espíritu de equipo…
Condiciones que la empresa debe de asegurar para que la felicidad sea posible.
Condiciones mínimas:
- Generar condiciones de trabajos seguros y sanos
- Remuneraciones acordes a responsabilidades
Otros factores que las empresas pueden estimular cuando se trata de hacer la empresa un lugar donde la felicidad sea más probable son:
- Preocuparse por generar espacios que mejoren la calidad de vida de las personas
- Generación y entrega de estímulos que puede hacer felices a su personal, materializados en viajes, premios, fiestas, guarderías…
- Compatibilización de horarios de trabajo con los de la familia (Conciliación).