A 25-year-old male presented with a painful, sustained erection for 2 days. His history included splenomegaly. Examination found an erect, tender penis and enlarged spleen. Tests showed leukemia. Dark blood was aspirated from his cavernosa, and distal shunts were created to drain blood and induce flaccidity. He was diagnosed with ischemic priapism caused by leukemia-induced sickle cell disease and thrombocytosis. Distal shunting successfully treated his priapism.