Priapism is an abnormal, persistent erection unrelated to sexual stimulation. There are two types - low-flow (ischemic) and high-flow (non-ischemic). Low-flow priapism is more common and results from failure of venous outflow, trapping blood in the penis. If not treated promptly, it can lead to fibrosis and erectile dysfunction. Causes include sickle cell disease, medications, and trauma. Treatment involves differentiating the type and using medical or surgical methods to resolve the erection like irrigation, drugs, or shunt placement. Prognosis depends on duration, with early intervention providing the best chance of functional recovery.

1. Priapism

2. Background
• Priapism is defined as an abnormal
persistent erection of the penis. It is an
involuntary prolonged erection unrelated
to sexual stimulation and unrelieved by
ejaculation. As with many medical
emergencies, the saying "time is tissue"
holds true for priapism. This condition is a
true urologic emergency, and early
intervention allows the best chance for
functional recovery.[1]

3. Pathophysiology
• The penis is composed of 3 corporeal
bodies: 2 corpora cavernosa and 1 corpus
spongiosum. Erection is the result of
smooth-muscle relaxation and increased
arterial flow into the corpora cavernosa,
causing engorgement and rigidity (see
image below).
• Priapism. Corporeal relaxation causes
external pressure on the emissary veins
exiting the tunica albuginea, trapping
blood in the penis and causing erection.

5. • Engorgement of the corpora cavernosa
compresses the venous outflow tracts (ie,
subtunical venules), trapping blood within
the corpora cavernosa. The major
neurotransmitter that controls erection is
nitric oxide, which is secreted by the
endothelium that lines the corpora
cavernosa (see image below).

6. • These events occur in both normal and
pathologic erections. The pathophysiology
of priapism involves failure of
detumescence and is the result of the
underregulation of arterial inflow (ie, high
flow) or, more commonly, the failure of
venous outflow (ie, low flow). Priapism
typically involves engorgement of corpora
cavernosa. The corpus spongiosum is
typically not engorged.

7. • Priapism must be defined as either a low-
flow (ischemic) or a high-flow
(nonischemic) type because the causes
and treatments for these 2 types are
different. Low-flow priapism, which is by
far the most common type, is a failure of
the detumescence mechanism due to (1)
an excessive release of neurotransmitters,

8. • 2) blockage of draining venules (eg,
mechanical interference in sickle cell
crisis, leukemia, or excessive use of
intravenous parenteral lipids), (3) paralysis
of the intrinsic detumescence mechanism,
or (4) prolonged relaxation of the
intracavernous smooth muscles (most
often caused by the use of exogenous
smooth-muscle relaxants such as
injectable intracavernosal prostaglandin
E1).

9. • Prolonged low-flow priapism leads to a
painful ischemic state, which can cause
fibrosis of the corporeal smooth muscle
and cavernosal artery thrombosis. The
degree of ischemia is a function of the
number of emissary veins and the
duration of occlusion. Light-microscopy
studies conducted early on demonstrated
that corporeal tissue becomes thickened,
edematous, and fibrotic after days of
priapism.

10. Epidemiology
• Frequency
The frequency of priapism depends on
the population being considered. The
combination of intracavernosal agents and
other drugs is the cause of approximately
21-80% of all adult priapism. Agents used
to treat erectile dysfunction are common
causes of adult priapism in the Western
world. The overall rate of priapism in
persons using these agents ranges from
0.05-6%.

11. • At other centers, sickle cell disease (SCD)
and sickle cell trait predominate as the
cause of adult priapism. The rate of
priapism in adults with SCD is as high as
89%. Approximately two thirds of all
pediatric patients who have priapism also
have SCD. The rate of priapism among
children with SCD is as high as 27%.

12. • Mortality/Morbidity
• Priapism is painful at onset. Corporeal
fibrosis due to persistent priapism can
result in deep-tissue infections of the
penis.
• The major chronic morbidity associated
with all types of priapism is persistent
erectile dysfunction and impotence.
• The duration of symptoms is the most
important factor affecting outcome. A
recent Scandinavian study reported that
92% of patients with priapism for less than

13. • Race
• Priapism is common in African Americans
with SCD.
• Sex
• Priapism occurs exclusively in males.
• Age
• Priapism can occur in males of any age
group, with peaks at age 5-10 years and
20-50 years.
• Among patients with SCD, the prevalence
is higher in men aged 19-21 years.

14. • History
• Patients with priapism report a persistent
erection. The symptoms depend on the
type of priapism and the duration of
engorgement.
• Low-flow, ischemic-type priapism is
generally painful, although the pain may
disappear with prolonged priapism.
• High-flow, nonischemic priapism is
generally not painful. This type of priapism
is associated with blunt or penetrating
injury to the perineum. It may manifest in

15. – Erection: Duration of longer than 4 hours is
consistent with priapism.
– Duration of pain
– Similar prior episodes
– Genitourinary (GU) trauma
– Medical history (eg, sickle cell disease [SCD]):
Onset occurs during sleep, when relative
oxygenation decreases.

16. – Medication and/or recreational drug use,
especially the antidepressant trazodone,
intracavernosal injections of prostaglandin E1
used to treat impotence, and illicit cocaine
injection into the penis
– History of malignancy (prostate cancer)
– Penile prosthesis: The permanent erection
that occurs with some penile prostheses may
mimic priapism.
– Recent urologic surgery

17. • Aspects of history in high-flow priapism
are as follows:
– Not painful
– May be sexually active
– Straddle injury usually the initiating event
– Chronic recurrent presentation
– Generally not caused by medication

18. • Aspects of history in high-flow priapism
are as follows:
– Not painful
– May be sexually active
– Straddle injury usually the initiating event
– Chronic recurrent presentation
– Generally not caused by medication

19. • Aspects of history of low-flow priapism are
as follows:
– Painful
– Inactive sexually and without desire
– No history of trauma
– Usually presents to emergency department
(ED) within hours
– Associated with substance abuse or
vasoactive penile injections
– Rarely caused by leukemia, fat embolism,
acute spinal cord injury, or (extremely rare)
cancer metastases to the corporeal bodies

20. • Physical
• Obvious erection is the key physical
finding in any case of priapism. Penile
priapism generally involves only the paired
corpora cavernosa, with the glans and
corpora spongiosum remaining flaccid or
softly distended without rigidity.

21. • Careful physical examination may reveal
specific causal factors. Remember that no
single pathology excludes all others;
therefore, a thorough history and physical
examination should address the patient as
a whole.

22. • Aspects of the physical examination are
as follows:
– Penile color, rigidity, and sensation (soft glans
vs firm glans)
– Penile discharge, lesions, or both
– Evidence of local trauma
– Presence of prosthetic devices: Hardware
malfunction may cause pseudopriapism.
– Regional lymphadenopathy (ie, metastatic
disease)

23. • Aspects of the physical examination
consistent with high-flow priapism are as
follows:
– Adequate arterial flow
– Well-oxygenated corpora
– Evidence of trauma

24. • Aspects of the physical examination
consistent with low-flow priapism are as
follows:
– Rigid erection
– Ischemic corpora as indicated by dark blood
upon corporeal aspiration
– No evidence of trauma

25. Causes
• Priapism can result from idiopathic or
secondary causes. In the United States,
the most common cause of priapism in the
adult population involves agents used to
treat erectile dysfunction. The most
common cause of priapism in the pediatric
population is SCD. Internationally, the
most common cause is idiopathic.

26. • Uncommonly, both low- and high-flow
priapism are idiopathic in nature.
• Secondary causes of low-flow priapism
are as follows:
– Thromboembolic/hypercoagulable states
• Sickle cell anemia (SCD) - Polycythemia: A recent
study found that, in unscreened children with SCD,
priapism was the first presentation in 0.5% of
cases.[3]

27. • Thalassemia
• Total parenteral nutrition
• Fabry disease
• Dialysis
• Vasculitis
• Fat embolism (after multiple long-bone fractures or
after iatrogenic intravenous lipids as part of total
parenteral nutrition)

28. – Neurogenic disease
• Spinal cord stenosis (ie, trauma to the medulla)
• Autonomic neuropathy and cauda equina
compression
– Neoplastic disease (metastatic to the penis or
obstructive to venous outflow)
• Prostate cancer and GU (highest risk) bladder
cancer
• Hematological (leukemia)
• Renal carcinoma
• Melanoma

29. – Pharmacologic causes
• Intracavernosal agents - Papaverine,
phentolamine, prostaglandin E1
• Intraurethral pellets (ie, medicated urethral system
for erection with intracavernosal prostaglandin E1)
• Antihypertensives - Ganglion-blocking agents (eg,
guanethidine), arterial vasodilators (eg,
hydralazine), alpha-antagonists (eg, prazosin),
calcium channel blockers

30. • Psychotropics - Phenothiazine, butyrophenones,
hypnotics (eg, mesoridazine, perphenazine),
trazodone, selective serotonin reuptake inhibitors
(eg, fluoxetine, sertraline)[4]
• Anticoagulants - Heparin, warfarin
• Recreational drugs - Cocaine, marijuana, ethanol
• Hormones - Gonadotropin-releasing hormone
(GnRH), tamoxifen, testosterone

31. • Herbal medicine - Ginkgo biloba with concurrent
use of antipsychotic agents[5]
• Miscellaneous medications - Metoclopramide,
omeprazole, penile injection of cocaine, epidural
infusion of morphine and bupivacaine[6]
• Secondary causes of high-flow priapism
are as follows:
– GU trauma
• Straddle injury
• Intracavernous injections with direct cavernosal

32. • Other causes of priapism (rare) are as
follows:
– Amyloidosis (massive amyloid infiltration)
– Gout (one case report)
– Carbon monoxide poisoning
– Malaria
– Black widow spider venom
– Asplenia

33. Laboratory Studies
• Complete blood cell count: This is
performed to determine if the patient has
anemia, leukocytosis, or thrombocytosis.
• Plasma thromboplastin or activated partial
thromboplastin time: Priapism may require
surgical intervention if medical treatment
fails.

34. • Blood type and hold: Exchange
transfusion may be necessary to treat
underlying sickle cell disease (SCD).
• PBG measurement
– Test results allow differentiation between
high- and low-flow priapism.
– Low-flow PBG findings may include a pH of
less than 7.0, a PCO2 of greater than 60 mm
Hg, and a PO2 of less than 30 mm Hg.
Variation depends on duration.
– High-flow PBG findings should reflect normal
arterial values.

35. Imaging Studies
• Perform penile duplex Doppler
ultrasonography to help identify and locate
a fistula in patients with high-flow
priapism.
• Perform pelvic angiography to help
confirm the fistula location, followed by
embolization in patients with high-flow
priapism.

36. • Perform chest radiography or CT scanning
if the history is consistent with a malignant
or metastatic condition.
• Other Tests
• Perform an ECG if the patient is older than
55 years, has a history of cardiac disease,
or is a possible surgical candidate.

37. Treatment
Medical Care
• All cases of priapism require prompt
consultation with a GU medicine
specialist. When treating priapism in the
ED, physicians must first differentiate
between the high- and low-flow varieties.
With appropriate training and protocols,
ED personnel may begin treatment with
saline irrigation and injection of alpha-
agonist drugs such as phenylephrine.

38. Surgical Care
• A transglanular to corpus cavernosal
scalpel or needle-core biopsy (Ebbehoj or
Winter technique) is the first reasonable
approach for refractory cases (see image
below). A unilateral shunt is often
effective. Bilateral shunts are used only if
necessary (usually apparent after 10 min).
Priapism. Winter shunt placed by biopsy
needle, usually under local anesthetic.

40. • The El-Ghorab procedure is a more
aggressive open surgical cavernosal
shunt and is indicated if the Winter shunt
fails.
• Quackel shunts are cavernosal-
spongiosum shunts (unilateral or bilateral)
and are performed via a perineal
approach (see image below). Such shunts
are rarely effective if a more distal shunt
has already failed (eg, El-Ghorab
procedure) because thrombosis of the

42. • already esent.[11]
Priapism. Proximal
cavernosal-spongiosum shunt (Quackel
shunt) surgically connects the proximal
corpora cavernosa to the corpora
spongiosum

43. • A Grayhack shunt is a
cavernosal-saphenous
vein shunt (rarely
necessary or indicated;
see image below).
Priapism. Proximal
cavernosal-saphenous
shunt (Grayhack shunt)
surgically connects the
proximal corpora
cavernosum to the
saphenous vein.

44. • Consultations
• Urologist
• Cardiologist (for patients with cardiac
disease or hypertension)
• Hematologist (priapism as a complication
of SCD)
•

45. Thank you