1. Radiological imaging of
diffuse lung disease.
Dr/ ABD ALLAH NAZEER. MD.

2. Diffuse Interstitial Lung Disease.
Diffuse interstitial lung disease is a group of lung diseases that
affects the connective tissue that forms the support structure of the
air sacs, or alveoli, of the lungs.
During inhalation, the alveoli fill with air. Oxygen within the air
passes through the walls of the alveoli into the blood stream. In
reverse fashion, carbon dioxide passes from the blood into the
alveoli and is exhaled. When affected by an interstitial lung disease,
the tissue supporting the air sacs—called the interstitium—becomes
inflamed and stiff, making it difficult for air sacs to fully expand,
limiting the delivery of oxygen to the body and the removal of
carbon dioxide from the body. As the disease progresses, the tissue
scars and thickens the alveolar walls, further decreasing lung
function.
This inflammation of the interstitium is typically diffuse, meaning it
occurs throughout both lungs rather than being confined to one
area.

3. The diseases in this group include idiopathic pulmonary fibrosis (IPF),
acute interstitial pneumonia (AIP), cryptogenic organizing pneumonia
(COP) and non-specific interstitial pneumonia (NSIP). Some forms of
interstitial pneumonia are related to the inhalation of cigarette
smoke and occur as a spectrum of injury that includes respiratory
bronchiolitis-interstitial lung disease and desquamative interstitial
pneumonia. Others are associated with multi-systemic diseases such
as rheumatoid arthritis, scleroderma, dermatomyositis and
asbestosis. Occasionally prior drug exposure can result in interstitial
lung disease, such as the anti-cancer drug Bleomycin.
Shortness of breath and a dry cough are the most common symptoms
of diffuse interstitial lung disease. As the disease progresses, weight
loss, muscle and joint pain and fatigue may also occur. At a more
advanced stage, individuals may develop an enlarged heart, an
enlargement of the fingertips called clubbing, and cyanosis—a blue
coloration in the lips, skin and fingernails as a result of reduced
oxygen levels in the blood.

9. How is diffuse interstitial lung disease evaluated.
To diagnose and determine the cause of interstitial lung disease, a physician will
need to perform a physical examination and order diagnostic tests, including:
Blood tests: These are focused on identifying autoimmune diseases such as
lupus and rheumatoid arthritis which can result in interstitial lung disease as a
result.
Spirometry: This is a test of lung function, in which the patient exhales quickly
and forcefully through a tube connected to a machine that measures how much
air the lungs can hold and how quickly the air moves in and out of the lungs.
Spirometry can help determine if there is an issue with air getting into the lungs
(restriction, such as fibrosis) versus air getting out of the lungs (obstruction,
such as asthma).
Pulse oximetry: This test uses a small device placed on a finger tip to measure
the oxygen saturation of the blood. It shines a specific wavelength of light
though the end of the finger painlessly to measure the amount of oxygen in the
blood.
Chest x-ray : The patterns of lung damage associated with various types of
interstitial lung disease are often identifiable on a chest x-ray. Chest x-rays may
also be used to track the progression of the disease.

10. CT imaging of the chest : Computed tomography (CT) scanning,
particularly a specific technique known as high resolution CT, is used
to see the fine detail of the interstitium where the disease is occurring.
Based on the imaging appearance, a diagnosis (specifically idiopathic
pulmonary fibrosis) can sometimes be confirmed, thus avoiding the
need for lung biopsy. The CT scan can also help determine the extent
of damage to the lungs and help determine appropriate treatment.
Bronchoscopy and biopsy: In this procedure, a very small sample of
tissue is removed from the lung using a small, flexible tube called a
bronchoscope that is passed through the mouth or nose and into the
lungs.
Surgical biopsy: A surgical biopsy is often needed to obtain a larger
sample tissue than is possible with bronchoscopy. During this
procedure, surgical instruments and a small camera are inserted
through two or three small incisions between the ribs that allow a
physician to see and remove tissue samples from the lungs.

16. X-Ray chest.
It is important modality for diagnosis of ILDs.
The correlation between the radiographic pattern and the stage of the
disease(clinical or histological) is generally poor.
Review all previous film to assess the rate of changes on disease
activity.
Honeycombing correlated a poor prognosis.
X-Ray limitations:
X-Ray chest is normal in 10-15% of symptomatic patients with
infiltrative lung disease.
The X-Ray sensitivity and a specificity of 80% for detection of DPLD.
The X-Ray can provide a confident diagnosis in 25% of cases.
A diffuse ground glass pattern- early in the disease, progress,- nodules,
linear (reticular) infiltrate, or a combination.
- Infiltrate become coarser and lung volume is lost- honeycomb pattern.

21. CT pattern of diffuse lung diseases.
Four major patterns (ground-glass opacity, nodular
opacity, reticular opacity, and honeycombing) on thin-
section computed tomographic images were identified.

26. Idiopathic Pulmonary Fibrosis with subpleural reticular marking, traction
bronchiectasis and honeycombing in a lower lobe distribution.

27. HRCT cross-sectional view showing a pattern of peripheral reticulation
and honeycomb change that is diagnostic of the presence of UIP.

28. Idiopathic Pulmonary Fibrosis with subpleural reticular marking, traction
bronchiectasis and honeycombing in a lower lobe distribution.

29. Idiopathic Pulmonary Fibrosis with subpleural reticular marking, traction
bronchiectasis and honeycombing in a lower lobe distribution.

30. Hypersensitivity Pneumonitis.

31. Hypersensitivity Pneumonitis

32. Drug-related lung disease.

33. Drug-related lung disease.

44. Sarcoidosis HRCT: Hilar and mediastinal lymphadenopathy, beaded
appearance and thickening of brochovascular bundles, nodules along bronchi

47. Alveolar Proteinosis.

49. 2 cases alveolar proteinosis.

50. Alveolar proteinosis

57. Non specific Interstitial Pneumonia.

59. Desquamative interstitial pneumonia.

60. Organizing Pneumonia.

61. Organizing Pneumonia.

62. Organizing Pneumonia.

64. Esinophilic granuloma.

66. Langerhans cell histiocytosis

67. Lymphomatoid granulomatosis (LYG)

68. 2 cases of bronchoalveolar carcinoma

69. 2 cases of bronchoalveolar carcinoma.

70. Thank You.