Medicated chewing gum (MCG) is a novel drug delivery system that contains pharmacologically active ingredients in a masticatory gum base. MCG provides advantages over other delivery systems such as fast onset of action, higher bioavailability, and improved patient compliance. The manufacturing process involves softening or melting gum base ingredients and mixing in sweeteners, flavors, and active pharmaceutical ingredients. Release of the API from MCG can be affected by factors like contact time, physicochemical properties of the API, and formulation components. MCG has applications for local oral treatments and systemic drug delivery via absorption in the oral mucosa.