The document provides an overview of physical pharmaceutics, including the three primary states of matter (gaseous, liquid, and crystalline solids), properties of each state, and factors that influence changes between the states such as temperature, pressure, and intermolecular forces. It also discusses specific topics like vapor pressure, boiling point, melting point, polymorphism, and glassy states. Key concepts are defined, such as latent heat, sublimation, and liquid crystals. Examples are provided throughout to illustrate various states and properties.
This document discusses complex fluids, which exhibit both liquid-like and solid-like properties. Complex fluids include polymeric solutions, gels, foams, and granular materials. They have heterogeneous structures with fluctuations across different length and time scales. When molecules in a polymeric solution or melt become sufficiently crosslinked, a gel transition occurs where a macroscopic cluster forms, localizing the molecules. The dynamics of particles in complex fluids are highly nonlinear and irregular, alternating between solid-like arrested states and fluid-like behavior depending on factors like density, temperature, and external forces inducing flow. While complex fluids are common in nature, their material properties are not fully understood and more research is still needed.
State of matter and properties of matter (Part-6)(Relative humidity, Liquid ...Ms. Pooja Bhandare
RELATIVE HUMIDITY, Humidity, Wet and Dry Hygrometer, LIQUID COMPLEX, LIQUID CRYSTALS, Types of liquid crystals, GLASSY STATES, Characteristics glassy state, Types of glassy state, What is the Glass Transition Temperature?
Solubility of liquids in liquids, The term miscibility refers to the mutual solubility of the component of liquid - liquid system, Raoult’s Law, Raoult’s law may be mathematically expressed as: Ideal solution, Real solution
Solubility of Drugs (PHYSICAL PHARMACEUTICS-I)Rakesh Mishra
Solubility expressions, mechanisms of solute solvent interactions,solubility parameters, factors influencing
solubility of drugs, diffusion principles in biological systems, Raoult’s law, real solutions. Partially miscible
liquids(Phase equilibria, Phase rule, One , two and three component systems, ternary phase
diagram, Critical solution temperature and applications). Distribution law, its limitations and
applications
A coordination complex is formed via a Lewis acid-base reaction between a central metal ion and surrounding ligands. Common ligands donate lone electron pairs to form coordinate covalent bonds with the metal. Coordination complexes have altered physical and chemical properties compared to the individual components. Complexation can impact drug properties like solubility, stability, and pharmacokinetics, which are important considerations in drug delivery and activity.
This document discusses solubility of drugs and factors that influence drug solubility. It begins by listing topics that will be covered, including solubility expressions, mechanisms of solute-solvent interactions, ideal solubility parameters, solvation and association, quantitative approaches to factors influencing drug solubility, and principles of diffusion in biological systems. It then lists learning objectives which are to define solubility terms, understand solubility of gases, solids and liquids in liquids, and concepts such as Raoult's law, real solutions, phase diagrams and critical solution temperature. The document then discusses these topics in more detail over several pages.
Solvation and association (Solubility of drug Part -3)Ms. Pooja Bhandare
The document discusses solvation and association as factors that influence drug solubility. It defines solvation as the interaction of a solute with solvent molecules that leads to stabilization. Solvation is quantified by its dissolution rate. Solubility depends on an equilibrium between dissolution and precipitation rates. Solvent-solute interactions like hydrogen bonding, ion-dipole interactions, and van der Waals forces affect solvation. Solvation energy is determined by a balance of enthalpy, entropy, and temperature factors. Association occurs via chemical reactions where oppositely charged ions or molecules come together to form distinct chemical entities in solution. The extent of association depends on the dielectric constant of the solvent.
Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors
influencing solubility of drugs, diffusion principles in biological systems. Solubility
of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions)
Raoult’s law, real solutions. Partially miscible liquids, Critical solution temperature . Distribution law, its limitations and applications
This document discusses complex fluids, which exhibit both liquid-like and solid-like properties. Complex fluids include polymeric solutions, gels, foams, and granular materials. They have heterogeneous structures with fluctuations across different length and time scales. When molecules in a polymeric solution or melt become sufficiently crosslinked, a gel transition occurs where a macroscopic cluster forms, localizing the molecules. The dynamics of particles in complex fluids are highly nonlinear and irregular, alternating between solid-like arrested states and fluid-like behavior depending on factors like density, temperature, and external forces inducing flow. While complex fluids are common in nature, their material properties are not fully understood and more research is still needed.
State of matter and properties of matter (Part-6)(Relative humidity, Liquid ...Ms. Pooja Bhandare
RELATIVE HUMIDITY, Humidity, Wet and Dry Hygrometer, LIQUID COMPLEX, LIQUID CRYSTALS, Types of liquid crystals, GLASSY STATES, Characteristics glassy state, Types of glassy state, What is the Glass Transition Temperature?
Solubility of liquids in liquids, The term miscibility refers to the mutual solubility of the component of liquid - liquid system, Raoult’s Law, Raoult’s law may be mathematically expressed as: Ideal solution, Real solution
Solubility of Drugs (PHYSICAL PHARMACEUTICS-I)Rakesh Mishra
Solubility expressions, mechanisms of solute solvent interactions,solubility parameters, factors influencing
solubility of drugs, diffusion principles in biological systems, Raoult’s law, real solutions. Partially miscible
liquids(Phase equilibria, Phase rule, One , two and three component systems, ternary phase
diagram, Critical solution temperature and applications). Distribution law, its limitations and
applications
A coordination complex is formed via a Lewis acid-base reaction between a central metal ion and surrounding ligands. Common ligands donate lone electron pairs to form coordinate covalent bonds with the metal. Coordination complexes have altered physical and chemical properties compared to the individual components. Complexation can impact drug properties like solubility, stability, and pharmacokinetics, which are important considerations in drug delivery and activity.
This document discusses solubility of drugs and factors that influence drug solubility. It begins by listing topics that will be covered, including solubility expressions, mechanisms of solute-solvent interactions, ideal solubility parameters, solvation and association, quantitative approaches to factors influencing drug solubility, and principles of diffusion in biological systems. It then lists learning objectives which are to define solubility terms, understand solubility of gases, solids and liquids in liquids, and concepts such as Raoult's law, real solutions, phase diagrams and critical solution temperature. The document then discusses these topics in more detail over several pages.
Solvation and association (Solubility of drug Part -3)Ms. Pooja Bhandare
The document discusses solvation and association as factors that influence drug solubility. It defines solvation as the interaction of a solute with solvent molecules that leads to stabilization. Solvation is quantified by its dissolution rate. Solubility depends on an equilibrium between dissolution and precipitation rates. Solvent-solute interactions like hydrogen bonding, ion-dipole interactions, and van der Waals forces affect solvation. Solvation energy is determined by a balance of enthalpy, entropy, and temperature factors. Association occurs via chemical reactions where oppositely charged ions or molecules come together to form distinct chemical entities in solution. The extent of association depends on the dielectric constant of the solvent.
Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors
influencing solubility of drugs, diffusion principles in biological systems. Solubility
of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions)
Raoult’s law, real solutions. Partially miscible liquids, Critical solution temperature . Distribution law, its limitations and applications
Complexation and Protein Binding [Part-2](Method of analysis, Complexation a...Ms. Pooja Bhandare
This document discusses various methods for analyzing complexes, including continuous variation (Job's) method, distribution method, solubility method, pH titration method, and spectroscopy. The continuous variation method analyzes changes in physical properties like dielectric constant when complexes form to determine stoichiometric ratios. The distribution method examines how the distribution of a solute between immiscible liquids changes with complexation to estimate stability constants. The solubility method observes whether solubility increases or decreases with the addition of a complexing agent. pH titration is reliable for complexes that affect pH upon formation. Spectroscopy techniques like UV and NMR are also used to determine rate constants and equilibrium constants.
Quantitative approach to the to the factor influcing solubility of drug; (Sol...Ms. Pooja Bhandare
Quantitative approach to the to the factor influcing solubility of drugs, Temperature,Nature of solvent, The boiling point of the liquids and the melting point of solids,Crystal properties:
Particle size (surface area ) of drug particles: The influence of substituent’s in molecular structures, Molecular size:
. pH :
This document provides information on complexation and protein binding. It defines complexation as the association between two or more molecules to form a non-bonded entity through interactions like coordination bonds, van der Waals forces, hydrogen bonds, etc. It classifies complexes into metal complexes, organic molecular complexes, and inclusion complexes. It also discusses ligand types, methods of analyzing complexes, and applications of complexation. The document then defines protein binding and discusses factors that affect binding like drug and protein properties, drug interactions, and patient factors. It explains kinetics of protein binding and methods to determine binding constants and sites like direct plots, Scatchard plots, and others.
This document discusses various physicochemical properties of drug molecules that are important for product development, including refractive index, optical rotation, dielectric constant, dipole moment, and dissociation constant. It provides definitions and measurement techniques for each property, as well as their applications in areas like product formulation, storage conditions, identification of substances, and understanding acid-base equilibria. Measurement of these properties allows for characterization of drug molecules and optimization of drug products.
State of matter and properties of matter (Part-2) (Latent Heat, Vapour pressu...Ms. Pooja Bhandare
Latent Heat, Vapour pressure, Factor affecting vapour pressure, Surface area, Types of molecule, Temperature and Intermolecular forces, Sublimation Critical point
States of matter and properties of matterJILSHA123
States of matter and properties of matter, latent heat, vapour pressure, aerosols - inhalers, sublimation critical point, eutectic mixtures, gas laws, Gibbs phase rule, crystalline structures, 3rd b.pharmacy, sanjo college of pharmaceutical studies, palakkad, kerala
This document discusses pH, buffers, and isotonic solutions. It begins by defining pH as a measure of hydrogen ion concentration in water using Sorensen's pH scale. It then describes two methods for determining pH: the calorimetric method which compares a solution's color to standard buffers and indicators, and the electrometric method which uses a pH meter. The document also discusses buffers and their importance in biological and pharmaceutical systems like blood, tears, and injections to maintain optimal pH levels. Factors that can influence a buffer's pH like temperature, dilution, and ionic strength are also covered.
Physical pharmacy i third semester (unit-i) solubility of drugMs. Pooja Bhandare
Physical pharmaceutics is the study of physicochemical properties of drug molecules in designing dosage forms. This document discusses the definitions and concepts related to solubility of drugs. It defines key terms like solute, solvent, saturated solution, and explains how solubility is expressed quantitatively and qualitatively. The mechanisms of solute-solvent interactions are discussed based on the nature of solvents being polar, non-polar or semi-polar. Specific examples are provided to illustrate solubility principles for different classes of solvents.
State of matter and properties of matter (Part-7)(Solid-crystalline, Amorpho...Ms. Pooja Bhandare
CRYSTALLINE SOLID, Types of Crystalline solid, AMORPHOUS SOLID, Difference between crystalline solid and amorphous solid, Why does the amorphous form of drug have better bioavaibility that crystalline couterpaerts?, Polymorphism,
TYPES OF POLYMORPHISM, PROPERTY OF POLYMORPHS, Methods of preparation of Polymorphs, Methods to determine Polymorphism Characterization of Polymorphs, Pharmaceutical Application
This PDF file content is about States of matter and its Properties as per the PCI syllabus for B.Pharm Second year for the subject Physical Pharmaceutics
State of matter and properties of matter (Part-3) (Eutectic mixture)Ms. Pooja Bhandare
This document discusses eutectic mixtures, which are mixtures of two or more phases that have the lowest melting point. A eutectic mixture is formed at a specific composition where the phases simultaneously crystallize from a molten solution. The term comes from the Greek word meaning "easily melted". Eutectic mixtures can be formed between APIs, APIs and excipients, or excipients. Below the eutectic temperature, the mixture exists as a solid, while above it exists as a liquid. Eutectic mixtures have various applications in the pharmaceutical industry, such as improving drug solubility and bioavailability for different routes of administration like oral, transdermal, parental, and nasal delivery.
Complexation and Protein Binding [Part-1](Introduction and Classification an...Ms. Pooja Bhandare
Complexation: Classification of complexation:
Metal ion or co-ordination complexes :
Inorganic type Organic molecular complexes :
Quinhydrone type
Picric acid type
Caffeine and other drug complexes
Polymer type
Inclusion or occlusion compound
Channel lattice type
Layer type
Monomolecular type
Macromolecular type
Chelates
Olefin type
Aromatic type
Pi (п) complexes
Sigma (б) complexes
Sandwich complexes
This document provides an overview of states of matter and polymorphism. It discusses the three main states of matter - gases, liquids, and solids - and how their molecular arrangements differ. Solids can exist in crystalline or amorphous forms, with crystalline solids possessing long-range molecular order. Polymorphism, where a substance can exist in multiple crystal structures, is described. The importance of polymorphism in pharmaceutical industry is highlighted, as different solid forms can impact properties like solubility, dissolution rate, and bioavailability. Specific drug examples like carbamazepine and ritonavir and their polymorphic forms are mentioned.
This document discusses distillation, which is a process used to separate mixtures based on differences in their boiling points. It defines distillation and provides examples of its applications. It then classifies different types of distillation, including simple distillation, fractional distillation, vacuum distillation, and molecular distillation. For each type, it provides a brief overview of the principle, construction, working, and some applications. The document is presented by an assistant professor and provides detailed information on various distillation methods.
States of matter can exist in different phases. The three most common states are solid, liquid, and gas. Solids maintain a fixed shape and volume, liquids maintain a volume but take the shape of their container, and gases expand freely to fill their container. Other states include plasma, which is an ionized gas, and Bose-Einstein condensates that form at very low temperatures. The state of matter depends on factors like temperature, pressure, and molecular interactions.
The document discusses the three main states of matter - solids, liquids, and gases. It describes the characteristics of each state, including that solids have the strongest intermolecular forces and definite shape/volume, liquids have definite mass and volume but no definite shape, and gases have indefinite shape and volume and their molecules move rapidly in random motion. Factors like temperature and pressure can cause a substance to transition between these different states. The document also summarizes several gas laws and theories including Boyle's law, Charles' law, the kinetic molecular theory, the ideal gas equation, and Dalton's law of partial pressures.
Complexation and Protein Binding [Part-2](Method of analysis, Complexation a...Ms. Pooja Bhandare
This document discusses various methods for analyzing complexes, including continuous variation (Job's) method, distribution method, solubility method, pH titration method, and spectroscopy. The continuous variation method analyzes changes in physical properties like dielectric constant when complexes form to determine stoichiometric ratios. The distribution method examines how the distribution of a solute between immiscible liquids changes with complexation to estimate stability constants. The solubility method observes whether solubility increases or decreases with the addition of a complexing agent. pH titration is reliable for complexes that affect pH upon formation. Spectroscopy techniques like UV and NMR are also used to determine rate constants and equilibrium constants.
Quantitative approach to the to the factor influcing solubility of drug; (Sol...Ms. Pooja Bhandare
Quantitative approach to the to the factor influcing solubility of drugs, Temperature,Nature of solvent, The boiling point of the liquids and the melting point of solids,Crystal properties:
Particle size (surface area ) of drug particles: The influence of substituent’s in molecular structures, Molecular size:
. pH :
This document provides information on complexation and protein binding. It defines complexation as the association between two or more molecules to form a non-bonded entity through interactions like coordination bonds, van der Waals forces, hydrogen bonds, etc. It classifies complexes into metal complexes, organic molecular complexes, and inclusion complexes. It also discusses ligand types, methods of analyzing complexes, and applications of complexation. The document then defines protein binding and discusses factors that affect binding like drug and protein properties, drug interactions, and patient factors. It explains kinetics of protein binding and methods to determine binding constants and sites like direct plots, Scatchard plots, and others.
This document discusses various physicochemical properties of drug molecules that are important for product development, including refractive index, optical rotation, dielectric constant, dipole moment, and dissociation constant. It provides definitions and measurement techniques for each property, as well as their applications in areas like product formulation, storage conditions, identification of substances, and understanding acid-base equilibria. Measurement of these properties allows for characterization of drug molecules and optimization of drug products.
State of matter and properties of matter (Part-2) (Latent Heat, Vapour pressu...Ms. Pooja Bhandare
Latent Heat, Vapour pressure, Factor affecting vapour pressure, Surface area, Types of molecule, Temperature and Intermolecular forces, Sublimation Critical point
States of matter and properties of matterJILSHA123
States of matter and properties of matter, latent heat, vapour pressure, aerosols - inhalers, sublimation critical point, eutectic mixtures, gas laws, Gibbs phase rule, crystalline structures, 3rd b.pharmacy, sanjo college of pharmaceutical studies, palakkad, kerala
This document discusses pH, buffers, and isotonic solutions. It begins by defining pH as a measure of hydrogen ion concentration in water using Sorensen's pH scale. It then describes two methods for determining pH: the calorimetric method which compares a solution's color to standard buffers and indicators, and the electrometric method which uses a pH meter. The document also discusses buffers and their importance in biological and pharmaceutical systems like blood, tears, and injections to maintain optimal pH levels. Factors that can influence a buffer's pH like temperature, dilution, and ionic strength are also covered.
Physical pharmacy i third semester (unit-i) solubility of drugMs. Pooja Bhandare
Physical pharmaceutics is the study of physicochemical properties of drug molecules in designing dosage forms. This document discusses the definitions and concepts related to solubility of drugs. It defines key terms like solute, solvent, saturated solution, and explains how solubility is expressed quantitatively and qualitatively. The mechanisms of solute-solvent interactions are discussed based on the nature of solvents being polar, non-polar or semi-polar. Specific examples are provided to illustrate solubility principles for different classes of solvents.
State of matter and properties of matter (Part-7)(Solid-crystalline, Amorpho...Ms. Pooja Bhandare
CRYSTALLINE SOLID, Types of Crystalline solid, AMORPHOUS SOLID, Difference between crystalline solid and amorphous solid, Why does the amorphous form of drug have better bioavaibility that crystalline couterpaerts?, Polymorphism,
TYPES OF POLYMORPHISM, PROPERTY OF POLYMORPHS, Methods of preparation of Polymorphs, Methods to determine Polymorphism Characterization of Polymorphs, Pharmaceutical Application
This PDF file content is about States of matter and its Properties as per the PCI syllabus for B.Pharm Second year for the subject Physical Pharmaceutics
State of matter and properties of matter (Part-3) (Eutectic mixture)Ms. Pooja Bhandare
This document discusses eutectic mixtures, which are mixtures of two or more phases that have the lowest melting point. A eutectic mixture is formed at a specific composition where the phases simultaneously crystallize from a molten solution. The term comes from the Greek word meaning "easily melted". Eutectic mixtures can be formed between APIs, APIs and excipients, or excipients. Below the eutectic temperature, the mixture exists as a solid, while above it exists as a liquid. Eutectic mixtures have various applications in the pharmaceutical industry, such as improving drug solubility and bioavailability for different routes of administration like oral, transdermal, parental, and nasal delivery.
Complexation and Protein Binding [Part-1](Introduction and Classification an...Ms. Pooja Bhandare
Complexation: Classification of complexation:
Metal ion or co-ordination complexes :
Inorganic type Organic molecular complexes :
Quinhydrone type
Picric acid type
Caffeine and other drug complexes
Polymer type
Inclusion or occlusion compound
Channel lattice type
Layer type
Monomolecular type
Macromolecular type
Chelates
Olefin type
Aromatic type
Pi (п) complexes
Sigma (б) complexes
Sandwich complexes
This document provides an overview of states of matter and polymorphism. It discusses the three main states of matter - gases, liquids, and solids - and how their molecular arrangements differ. Solids can exist in crystalline or amorphous forms, with crystalline solids possessing long-range molecular order. Polymorphism, where a substance can exist in multiple crystal structures, is described. The importance of polymorphism in pharmaceutical industry is highlighted, as different solid forms can impact properties like solubility, dissolution rate, and bioavailability. Specific drug examples like carbamazepine and ritonavir and their polymorphic forms are mentioned.
This document discusses distillation, which is a process used to separate mixtures based on differences in their boiling points. It defines distillation and provides examples of its applications. It then classifies different types of distillation, including simple distillation, fractional distillation, vacuum distillation, and molecular distillation. For each type, it provides a brief overview of the principle, construction, working, and some applications. The document is presented by an assistant professor and provides detailed information on various distillation methods.
States of matter can exist in different phases. The three most common states are solid, liquid, and gas. Solids maintain a fixed shape and volume, liquids maintain a volume but take the shape of their container, and gases expand freely to fill their container. Other states include plasma, which is an ionized gas, and Bose-Einstein condensates that form at very low temperatures. The state of matter depends on factors like temperature, pressure, and molecular interactions.
The document discusses the three main states of matter - solids, liquids, and gases. It describes the characteristics of each state, including that solids have the strongest intermolecular forces and definite shape/volume, liquids have definite mass and volume but no definite shape, and gases have indefinite shape and volume and their molecules move rapidly in random motion. Factors like temperature and pressure can cause a substance to transition between these different states. The document also summarizes several gas laws and theories including Boyle's law, Charles' law, the kinetic molecular theory, the ideal gas equation, and Dalton's law of partial pressures.
This document discusses the three common states of matter - solids, liquids, and gases. It explains that the state depends on factors like intermolecular forces and temperature. Gases have the weakest intermolecular forces. The behavior of gases is described by the ideal gas law and Vander Waals equation. Liquids are intermediate between solids and gases. Phase changes between states are also discussed, along with concepts like vapor pressure, boiling point, and melting point. Polymorphism and liquid crystals are mentioned as examples of unusual solid forms.
The document discusses the four states of matter and physical and chemical changes that matter undergoes. It provides details on the kinetic molecular theory explanation for differences between solids, liquids, and gases. Physical changes alter a substance's state or form without changing its chemical makeup, while chemical changes create new substances. The document also discusses plasma as the fourth state of matter and its many applications in manufacturing, medicine, and waste processing.
Ch 1 Matter in Our Surroundings Slide show 3.pptRajveerKaushal1
- Matter exists in solid, liquid, gas, and plasma states and undergoes physical and chemical changes. Physical changes alter a substance's state or form without changing its chemical makeup, while chemical changes create new substances.
- Substances can be elements, compounds, or mixtures. Elements cannot be broken down further, while compounds have a fixed composition and can be decomposed into simpler substances through chemical changes. Mixtures are combinations of substances that are not chemically bonded and have variable compositions.
- Plasma, the fourth state of matter, consists of free-floating ions and electrons. It is created by applying energy to strip electrons from atoms and can be controlled using electric and magnetic fields. Plasma research aids in understanding
The document discusses the three states of matter - solids, liquids, and gases. It describes their key properties and how matter can transition between these states through phase changes like melting, boiling, condensation, and sublimation. These phase transitions involve heat, with specific amounts of heat absorbed or released during changes of state, such as the heat of fusion required for melting and the higher heat of vaporization required for boiling. The document also covers gas properties like pressure and different pressure units.
The document discusses states of matter and pharmaceutical materials. It begins by comparing gases, liquids, and solids, noting that solids have molecules in close contact that do not move. It then discusses intermolecular forces, ideal gas laws, liquefaction of gases, and the solid state including crystals, unit cells, polymorphism, and amorphous solids. It notes that polymorphism can impact properties like solubility, melting point, and bioavailability which are important for pharmaceutical processes and drug performance.
Matter can exist in different states and undergo physical or chemical changes. Physical changes alter a substance's state without changing its chemical makeup, while chemical changes form new substances. Properties like density and melting point can be used to identify pure substances and distinguish them from mixtures of multiple components.
Matter exists in various states and undergoes physical and chemical changes. Physical changes alter a substance's state without changing its chemical makeup, while chemical changes form new substances. Substances have consistent compositions and properties, whereas mixtures are combinations of substances that can be separated. Common states of matter include solids, liquids, and gases.
Matter exists in various states including solid, liquid, and gas. Physical changes alter the state of matter without changing its chemical composition, while chemical changes form new substances. Properties such as density and melting point can be used to identify substances and determine if a change is physical or chemical.
Solid State of matter,
Crystalline, Amorphous & Polymorphism Forms,
Classification of solid state of matter On the basis of Internal Structure,
PHYSICAL PHARMACEUTICS-I,
Habet,
B.Pharm,
Matter exists in three main states: solid, liquid, and gas. Solids have a definite shape and volume, while liquids have a definite volume but no fixed shape. Gases occupy the total volume of their container and have no definite shape. The state of matter depends on pressure and temperature conditions, with solids having the least molecular movement, liquids faster vibrations within a region, and gases the highest kinetic energy.
This document provides an introduction to general chemistry. It defines chemistry as the study of matter and its transformations. Matter is anything that has mass and occupies space, and can exist in different states such as solid, liquid, gas, and plasma. The document discusses physical and chemical properties of matter, as well as physical and chemical changes. It classifies matter as either pure substances like elements and compounds, or mixtures that are either homogeneous or heterogeneous. The key concepts covered include the states of matter, phase changes, and the classification of matter.
This document discusses the structure and properties of solids. It explains that solids have a definite shape and volume because their constituent particles are arranged in a fixed, repeating pattern called a crystal lattice. This lattice structure gives rise to properties like rigidity and anisotropy in crystalline solids. The document also describes different types of solids based on the nature of bonding forces between particles - molecular, ionic, metallic and covalent solids. Each type of solid exhibits distinct physical and electrical properties depending on the bonding forces present.
This document discusses key concepts about the four states of matter - solid, liquid, gas, and plasma. It explains their characteristics based on how tightly or loosely packed the particles are and how much energy they possess. Phase changes like melting, freezing, vaporization, and condensation are defined. The effects of heat, pressure, and dissolving substances on boiling points and freezing points are summarized. In particular, it's noted that pressure and dissolving substances raise boiling points and lower freezing points, while heat raises both boiling and freezing points.
This document provides an introduction to general chemistry concepts. It begins with defining chemistry and discussing its branches, including analytical chemistry, physical chemistry, organic chemistry, and inorganic chemistry. It then discusses the importance of chemistry for nurses, focusing on understanding drug composition and properties, diagnosis, disease mechanisms, and sterilization. The document also defines matter and the three states of matter - solid, liquid, and gas. It provides examples and descriptions of the properties and changes between each state. Finally, it classifies matter as either pure substances like elements and compounds, or impure substances like mixtures, and provides brief definitions of each.
This document discusses the three common states of matter - solid, liquid, and gas. It provides properties and examples for each state. Solids have a definite volume and shape, liquids have a definite volume but no shape, and gases have no definite volume or shape. The strength of intermolecular forces determines if a substance is a solid, liquid or gas, with solids having the strongest forces and gases the weakest. A phase change, such as melting or boiling, occurs when heating or cooling provides enough energy for molecules to overcome these intermolecular forces.
This document provides an overview of matter and its properties according to the ICSE curriculum for upper primary classes. It defines matter as anything that occupies space, has mass and volume, and can be sensed. All matter is composed of molecules, which are made up of atoms. Matter can exist in three states - solid, liquid, and gas - depending on the strength of intermolecular forces and the distance between molecules. Changes in state, such as melting, boiling, and sublimation, occur when matter gains or loses heat. Heating matter can also cause chemical changes in addition to physical changes like expansion and changes in state.
ONT-3 discusses chemical disinfectants and their uses. It provides 3 types of disinfection: prophylactic disinfection which includes sterilization methods like chlorination; therapeutic disinfection to treat infected tissues; and terminal disinfection during and after patient care to disinfect surfaces. Common chemical disinfectants discussed include chlorine, iodine, phenol, heavy metals like mercury and copper, and alcohols. Physical methods like heat and radiation are also mentioned.
The document summarizes key aspects of the endocrine system. It describes the main endocrine glands and hormones they secrete, including the pituitary gland, thyroid gland, adrenal gland, pancreas, ovaries, and testes. It provides details on hormones like growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, follicle stimulating hormone, luteinizing hormone, and antidiuretic hormone. It also discusses disorders of the pituitary gland such as gigantism and acromegaly.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms for those who already suffer from conditions like anxiety and depression.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
This document provides information about an individual. C. Shilpaja holds an M.Pharm. and PhD and works as an Assistant Professor in the Department of Pharmaceutics at SVCP.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help boost feelings of calmness, happiness and focus.
The document summarizes reactions of naphthalene, anthracene and phenanthrene. It discusses oxidation, reduction, addition and electrophilic substitution reactions of naphthalene. For anthracene, it describes its synthesis via Friedel-Crafts reactions and Diels-Alder reactions. Electrophilic substitution reactions of anthracene are also outlined. Phenanthrene synthesis is explained using Haworth and Pschorr syntheses.
This document discusses semi-solid dosage forms, including their definition, advantages, disadvantages, and ideal properties. It describes various types of semi-solid dosage forms such as ointments, pastes, creams, gels, and foams. It covers the ingredients used to prepare these forms, such as bases, preservatives, emulsifiers, and antioxidants. It also discusses factors that influence drug penetration through the skin from these dosage forms and different preparation methods for ointments specifically, including incorporation, fusion, and chemical reaction methods.
This is a one paragraph document that appears to be the heading for a paper on "COMPLEXATION" written by C. Shilpaja, who has an M.Pharm and is pursuing a PhD. She is an Assistant Professor in the Department of Pharmaceutics at SVCP.
Drying is defined as the removal of liquid, usually water, from a material through the application of heat. It is commonly the last stage of a manufacturing process. There are a few key differences between drying and evaporation - drying typically involves removing small amounts of water from solids, while evaporation removes larger amounts of water from liquids. Some common equipment used in drying include drum dryers, spray dryers, tray dryers, fluidized bed dryers, vacuum dryers, and freeze dryers. Drying has several important applications and benefits, such as preserving products, preparing bulk drugs, improving product handling characteristics, and achieving uniform particle size and flow.
Distillation is a process that separates mixtures into their component parts based on differences in their boiling points. It involves vaporizing a liquid mixture and condensing the vapor to obtain purified fractions. There are several types of distillation processes that can be used for applications like purification of organic solvents, separation of drugs and petroleum products, and recovery of volatile oils and solvents. Key distillation types discussed in the document include simple, fractional, steam, molecular, and falling film distillation. Each type has slightly different equipment setup and operating principles for achieving separation of mixtures.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help boost feelings of calmness, happiness and focus.
This presentation includes basic of PCOS their pathology and treatment and also Ayurveda correlation of PCOS and Ayurvedic line of treatment mentioned in classics.
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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How to Build a Module in Odoo 17 Using the Scaffold MethodCeline George
Odoo provides an option for creating a module by using a single line command. By using this command the user can make a whole structure of a module. It is very easy for a beginner to make a module. There is no need to make each file manually. This slide will show how to create a module using the scaffold method.
Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
বিসিএস ও ব্যাংক এর লিখিত পরীক্ষা ...+এছাড়া মাধ্যমিক ও উচ্চমাধ্যমিকের স্টুডেন্টদের জন্য অনেক কাজে আসবে ...
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
Main Java[All of the Base Concepts}.docxadhitya5119
This is part 1 of my Java Learning Journey. This Contains Custom methods, classes, constructors, packages, multithreading , try- catch block, finally block and more.
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
1. PHYSICAL PHARMACEUTICS-I (Theory), 3rd SEMESTER
Subject Code- BP302T, Syllabus of PCI for Unit-II
Gayatri College of Pharmacy, Sambalpur
Notes prepared by Dr.Prasanta Kumar biswal, Assoc.Prof. &H.O.D in
Pharmaceutics
States of Matter and properties of matter: State of matter, changes in the state of matter, latent
heats, vapour pressure, sublimation critical point, eutectic mixtures, gases, aerosols– inhalers,
relative humidity, liquid complexes, liquid crystals, glassy states, solid crystalline, amorphous &
polymorphism.
Physicochemical properties of drug molecules: Refractive index, optical rotation, dielectric
constant, dipole moment, dissociation constant, determinations and applications
Unit 2: State of matter
Matter exists in one of the three states-solid liquid or gas. Two factors usually determined the
state in which matter exist. One is the intensity of intermolecular force and the other is the
temperature. Solid have the strongest intermolecular force and the gases have the weakest.
Matters can be classified into various ways like physical, chemical, and general classifications.
Physical classifications:
Solid-Ex: tablet , capsule
Liquid-Ex: oral syrup
Gas-Ex:aerosol
Plasma
Chemical classifications:
Pure substance like element and compound
Mixture like homogeneous and heterogeneous
Gaseous, liquids and crystalline solids are the three primary state of matter of phases. The
molecules atoms and ions in the solid state are held in close proximity by intermolecular, inter
atomic or ionic the atoms in the solid can oscillate only about fixed positions. As the temperature
increase the atoms in the solid can oscillate only about fixed positions. As the temperature of a
solid substance is raised, the atoms acquire sufficient energy to disrupt the ordered arranged of
the lattice and pass into the liquid form. Finally when sufficient energy is supplied the atoms or
2. molecules pass into the gaseous state. Solid with high vapour pressure, such as iodine and
camphor can pass directly from the solid to the gaseous state without melting at room
temperature. This process is known as sublimation, and the reserve process that is condensation
to the solid state, may be referred to as disposition.
Certain molecules frequently exhibit a 4th phase come more properly termed as mesophase
(Greek meso means= middle), which lies between the liquid and crystalline States. This so-called
liquid crystalline state is discussed later. Supercritical fluids are also considered as mesophase, in
this case is state of matter that exist under high pressure and temperature and has properties that
are intermediate between those of liquids and gases supercritical fluids which also be discussed
later because of their increased utilization and pharmaceutical agent processing.
The Gaseous State
The physical behaviour of gaseous is independent of chemical nature of the molecules. Therefore
almost all gases respond in an identical way to the variations in pressure, temperature and
volume. Since the molecules in a gas are always in a state of vigorous and rapid motion, these
travel in random parts, collide with one another and with the wall of the container in which they
are confined. These tend to occupy completely all the space available in the container and exert a
pressure on the wall of the container.
The general behaviour of gases with variation of pressure volume and temperature can be given
by the ideal gases equation.
PV =nRT for 'n' moles of ideal gas
Where P is the pressure, v is the volume, n is the number of moles of gas, R is a gas constant and
T is the absolute temperature.
From the ideal gas law it is clear that the volume of a gas is directly proportional to the number
of moles of the gas and to the absolute temperature and is inverse proportion to the pressure.
Real and actual gases usually deviate from ideal behaviour as the molecules tend to attract one
another. The deviation from the ideal behavior becomes significant when the pressure becomes
very high and the temperature very low. At ordinary temperature and pressure these gases obey
the law sufficiently accurately.
The Liquid State
The liquid state may be considered as an intermediate state as matter goes from the solid state to
the gaseous state. Liquid can be considered as highly compressed gases or slightly released
solids. The molecules of a gas are in a state of constant motion owning to their kinetic energy
which is proportional to the absolute temperature of the gas. When the gas is cooled its kinetic
energy is gradually reduced. As the temperature is being reduced, a state is reach where the
molecules almost lose their kinetic energy and are not able to overcome the force of attraction.
As a result the gas molecules come closer and ultimately the gas gets converted into the liquid
state. Liquefaction of a gas can also be brought about by increasing the pressure on the gas.
However pressure is effective only below a certain temperature. This temperature is called
3. critical temperature and can be defined as the temperature above which a gas cannot be liquefied
even if very high pressure is applied. The critical pressure is the pressure required to liquify a gas
at its critical temperature. The critical temperature of gas is 374 degree Celsius or 647 degree
Kelvin and its critical pressure is 218 atmospheres.
The Solid State
The most important property of the solid state is the high degree of order in which solid
substances exist. Their structure may be crystalline and lattice like or non-crystalline such as
glass which are not lattice like or only partly lattice like. However even the non-crystalline solids
have much more orders than liquid and gases. The molecules of a solid are held together by
strong bonds which imparts a high melting point to these substances. In order to their decreasing
strengths, these include metallic bonds, ionic bonds, valence bonds and molecular bonds.
There are two types of solid Crystalline Solid and Amorphous Solid
Crystalline solid:
The crystalline solids are of six types according to bond length and bond angle determined by x-
ray crystallography methods.
The structural unit of crystalline solid is arranged in fixed geometric patterns for letters.
Crystalline solid generally exhibits a different shape and an orderly arrangement of units. These
generally have a sharp melting point. The various crystalline solids have been divided into six
distances formed. This includes in the tabular form.
Table 1(Shape and examples of crystalline solid)
Shape Example
Cubic NaCl
Tetragonal Urea
Hexagonal Iodoform
Rhombic Iodine
Monoclinic Sucrose
Triclinic Boric acid
Amorphous Solid
Unlike crystalline solids, the structural units in amorphous solids are arranged in a random
manner. Amorphous solid may be considered as super cooled liquids. Example of solids includes
4. glass wood plastic etc. Amorphous solids do not have a sharp melting point and melt within
some narrow range of temperature. These are in general more soluble than crystalline solids
Polymorphism
Many substances may exist in more than one crystalline or amorphous form. This phenomenon
where compounds exist in more than one crystalline and or amorphous form is termed as
polymorphism and different crystalline or amorphous forms are known as polymorphs or this is
known as modification or polymorphic forms. The various forms usually arise through packing of
the molecules in different arrays within the crystal or by difference in the orientation or
conformation of the molecules at lattice sites.
Different polymorphic forms of a substance usually exhibit different melting points, x-ray
diffraction patterns, solubilities, dissolution behavior, stability and biological activity. A number
ofpharmacologicalactivesubstancessuchaschloramphenicol, novobiocin, sulphonamides,
barbiturates, steroids such as cortisone, testosterone, prednisolone etc, have been shown to
exhibit a number of polymorphic forms different in their solubility, stability and pharmacological
activity. Many organic substances such as tristearin and theobroma oil also exhibit
polymorphism. Theobroma oil (cocoa butter) exhibits four different polymorphic forms viz., α,
β, β’and γ forms differing in their respective melting points.
Liquid Crystals
In addition to the three States of matter, some asymmetric molecules often exhibit a fourth state
known as a liquid crystalline state or mesophase. Liquid crystals possess some of the properties
of liquid and some of solids. For example liquid crystal possesses the property of mobility and
rotation and thus can be considered to have the flow properties of liquid. On the other hand,
these also possess the properties of birefringence, a property of associated with solid crystals.
The birefringence, the light passing through a material is divided into two components with
different velocities and hence different refractive index.
The two main types of structure of liquid crystal are the smectic (soap or grease like) and
nematic (thread like). In the smectic state, the molecules are mobile in two direction and show
rotation about one axis. In the nematic state, the molecules are mobile in three dimensions. A
third type known as the cholesteric crystals exist but may be considered as a special case of the
nematic type.
The liquid crystalline state is found widespread in nature-in nerve, brain tissue and blood vessels.
Atherosclerosis thought to result from the desposition of liquid in the liquid crystalline state on
the wall of blood vessels. The three components of bile, the cholesterol, the bile salt and water
when present in a definite proportion can result in the formation of smectic crystals and these
may be involved in the formation of gall stones. Certain smectic crystals are believed to be
involved in the stabilization of emulsion and have been used for the solubilization of water in
soluble materials.
Glassy state
5. All the glass is considered to be a non-conducting transparent solid, it is actually a type of solid
matter. It can neither be considered as a typical solid nor a typical liquid. The atoms and
molecules in most solids are arranged in an orderly manner whereas in Glassy materials these are
highly disorder .Glassy materials however, have some short range order as in the case of
polymers. Glassy materials also do not have a specific melting point but these slowly and
gradually liquefy on heating. Structurally Glassy materials can be considered to be made up of a
random selection of polyhedral molecules linked together at their corners. Certain materials can
easily be converted to a Glassy state while other pose great difficulty and certain materials
cannot be converted at all. Although the theory behind this behaviour is not very clear, it has
been shown that material which can be converted to glassy state have a very high viscosity at
their melting point which inhibits the formation of an ordered structure
Although the most common materials which can be converted to Glassy state are the metal
oxides ,even materials such as Steel can be converted to the Glassy state if it is cooled very
quickly. This technique produces glasses since the material solidifies even before it gets chances
to develop a crystalline structure.
Change in the state of matter
The molecules, atoms or ions in a solid are strongly held in close proximity by intermolecular,
interatomic or ionic forces respectively. The particles of the solid can oxalate only about fixed
position. As the temperature of a solid substance is raised the particles acquire sufficient energy
to disrupt the order arrangement and pass into the liquid state. On further increasing the
temperature the molecules pass into the gaseous state. In gaseous state the intermolecular forces
are reduced to almost negligible. Sometimes a change of state occurs directly from solid state to
the gaseous state and this is termed as sublimation.
As solid changes to a liquid state and then to gaseous state common heat is absorbed and the at
enthalpy heat content of the material increases. Does the enthalpy of a liquid is greater than that
of a solid and the enthalpy of a gas is greater than that of this liquid. The entropy (degree of
molecular randomness) of the material also increases as it goes from a solid to a liquid and to
gas.
Latent heat
When is change in the state of a material occurs, the temperature usually remains constant but
heat is absorbed. This heat which results in the change of matter without increasing the
temperature is called the latent heat. When this heat results in the change of state from a solid to
liquid it is known as the latent heat of fusion. For example the heat required to change ice to
water at 00C is the latent heat of fusion. Likewise the latent heat of vaporization is the quantity of
heat absorbed when a change of state from liquid to vapour occurs at its boiling point without
changing the temperature of the material. For example the heat required to change water to
vapour at 100 0 C is the latent heat of vaporization.
Vapour pressure
6. When a liquid is kept in a closed evacuated container, molecules from its surface continuously
leave and go into the free space above it. This is known as the process of vaporization. Some
molecules however return to the surface depending on their concentration in the vapour (the
process of condensation). Eventually a condition of equilibrium gets established when the rate of
escape of molecules becomes equal to the rate of return. The vapour is then said to be saturated
and the pressure exerted by vapour at equilibrium is known as the vapour pressure
The vapour pressure of a liquid depends on the temperature and not on amount of liquid or
vapour as long as both liquid and vapour are present and equilibrium is maintained. As the
temperature is raised, more of the liquid goes into the vapour state and the vapour pressure
increases. As the temperature is raised further, the density of the vapour increases while that of
liquid decreases. Eventually, the densities of both the phases become equal and the two phases
cannot be distinguished. The temperature at which this happens is known as the critical
temperature and above this the temperature; there is no liquid-phase.
Boiling point
When a liquid is heated in an open vessel, the vapour pressure above it increases. On further
heating, its vapour pressure becomes equal to the atmospheric pressure. The temperature at
which the vapour pressure of a liquid equals the external or atmospheric pressure is known as its
boiling point. At the boiling point all the absorbed it is used to change the liquid to the vapour
state and there is no rise in the temperature of the liquid until it is completely vaporized.
Different liquids have different boiling point.
If the external pressure above the surface of a liquid is decrease or increase the boiling point
of the liquid is also decreased or increased.
Melting point and freezing point
The temperature at which a solid passes into liquid state under atmospheric pressure is known as
its melting point. The melting point is referred to as freezing point if the liquid passes into the
solid-state. The melting or freezing point of a crystalline substance is actually the temperature at
which the pure liquid and solid coexist in equilibrium. In practice this point is taken as the
temperature of the equilibrium mixture at an external pressure of 1atm.
Vapour pressure of a mixture of liquids
In the case of miscible liquids (solution of a liquid in liquid), the partial vapour pressure exerted
by each components is proportional to its molar concentration in the mixture solution. The total
vapour pressure P is given by :
P=PA+PB=PoAXA+PoBXB
When XA and XB are mole fraction of components A and B respectively
PoA & PoB are the vapour pressure exerted by the pure components A and B respectively.
7. PA and PB are the partial vapour pressure exerted by A and B respectively in the liquid mixture
in the case of a mixture containing two miscible liquids each liquid exerts it own vapour pressure
independently of the others. The total vapour pressure P is then given by:
P=PoA +PoB
Sublimation
Sublimation is defined as the process of transformation of solids directly into the vapour phase
without passing into the intermediate liquid-phase. A number of substances including camphor,
menthol, naphthalene, etc., exhibit the phenomenon of sublimation. Other substances such as
ices can also be forced to exhibit the phenomenon of sublimation by varying the temperature and
pressure; the process being adopted during freeze drying of heat labile substances
.
Fig. 1: Phase diagram illustrating the principle of sublimation
Principle:
Latest considered the phase diagram for a substance as shown in fig .1
The curves AO represent the melting point of the solid phase of the substance at different
pressure. Along the curve AO, the solid exists in equilibrium with its liquid phase. To the left of
the curve the substance exist in the solid state while to the right; it is in the liquid state. BO
represents the vapour pressure of the liquid form of the substance at various temperatures. This
curve is known as the vapour pressure of the liquid. Above this curve, the materials exist in the
form of liquid while below it, only the vapour from exists. The curve CO represents the vapour
pressure of the solid at various temperatures and is also known as the Sublimation curve. To the
left of the curve, only solid exists while to the right, only the vapour form is stable. However
8. there exists one point (O) where all the three phases of the material are in equilibrium with each
other and this is known as the triple point. For pure water this corresponds to a pressure of 610
N/m² and a temperature of 0.0075°C
Now let us consider a point 'X' below the triple point where the substance is present in the form
of a solid. If heat is applied to the substance at this point it will pass directly into the vapour
phase without passing through the liquid state. This is the process of sublimation.
Eutectic mixture
Certain substances such as menthol, thymol, camphor, phenol, salol etc, when mixed in a
particular portion tend to liquify due to reduction in their respective melting points. Mixtures of
such substances are known as eutectic mixture. (Greek meaning:; Eutectic-easy melting )
Fig 2 phase diagram showing a eutectic system
Principle:
Let us consider two substances A and B. In fig 2, the point A and B represent the melting point
of the two components. As increasing quantities of B are added to A, the freezing point of A falls
along the curve AC. Similarly, as increasing quantities of A are added to B, the freezing point of
B falls along the curve BC. At a particular composition C, known as a eutectic point, the mixture
of the two substances has the lowest melting point. This composition of the two substances is
known as the eutectic mixture. Below the eutectic temperature the mixture of the two substances
will exist as solid while above it, the mixture will convert into a liquid.
9. In pharmaceutical practice, eutectic mixtures are difficult to dispense in the form of a powder. In
order to incorporate such materials in a powder, it is essential to first mix each ingredient
separately with an inert diluent such as light magnesium oxide, magnesium carbonate, starch,
kaolin etc. followed by gentle blending of the different positions. Alternative the eutectic
materials can first be triturated together in order to force them to liquify. The liquid can then be
adsorbed on an inert diluents.
The phenomenon of eutectic formation has also been used in pharmaceutical practice to improve
the dissolution behaviour of certain drugs. For example eutectic mixture of Aspirin -
acetaminophen (37% and 63% respectively), urea – acetaminophen (46% and 54% respectively)
and griseofulvin-succinic acid (55% and 45% respectively) dissolve rapidly than the drugs alone
or their simple mixtures.
Aerosols
Liquefaction of a gas can be achieved by applying pressure on it and keep the temperature below
the critical temperature. When the pressure is reduced, the molecules expand and the liquid
reverts back to the gaseous state. Aerosols are based on the principle of reversible change of state
on the application and release of pressure. In pharmaceutical aerosols, a drug is dissolved or
suspended in a propellant, a material which exists as a liquid under the pressure conditions
prevalent inside the container but gets converted to a gas under normal atmospheric conditions.
The container is designed in such a manner that on depressing a valve, some of the drug-
propellant mixture is expelled out due to the excess pressure inside the container. The propellant
used in such a products are generally fluorinated hydrocarbons although gases such as nitrogen
and carbon dioxide and also being used.
The aerosol containers are filled either by cooling the propellant and drug to a low temperature
within the container which is then sealed with the valve. Alternatively, the drug is sealed in the
container at room temperature and the required quantity of propellant is forced into the container
under pressure. In both the cases, when the container is at room temperature, part of the
propellant is in the gaseous state and exerts pressure necessary to extrude the drug while the
remaining is in the liquid state and provides a solution or suspension vehicle for the drug.
Inhalers
An inhaler is a device holding a medicine that you take by breathing in(inhaling). Inhalers are
often used to treat chronic obstructive pulmonary disease (COPD).There are three types of
Inhalers:
Metered -dose inhalers
10. Dry powder inhaler
Nebulizers
Relative humidity:
It is a ratio, expressed in percent, the amount of atmospheric moisture present relative to the
amount that would be present if the air is saturated.
Since the later amount is dependent on temperature. Relative humidity is a function of both
moisture content and temperature. Relative humidity is derived from the associated temperature
and dew point for the indicator hour
11. Liquid complexes:
Complex fluids are binary mixtures that have coexistence between two phases: Solid- liquid
(suspension and solution of macromolecules such as polymers) solid-gas (granular), liquid-gas
(foams) or liquid-liquid (emulsions). They exhibit usual mechanical responses to applied stress
or strain due to the geometrical constraints that the phases coexistence imposes. The mechanical
response includes transitions between solid like and fluid like behavior as well as fluctuations.
Their mechanical properties can be attributed to characteristics such as high disorder, caging and
clustering on multiple length scales.
Shaving cream is an example of a complex fluid. Without stress the foam appears to be a solid: it
does not flow and can support (very) light loads. However, when adequate stress is applied,
shaving cream flows easily like a fluid. On the level of individual bubbles the flow is due to the
rearrangement of small collections of bubbles. On this scale the flow is not smooth, but instead
consists of fluctuations due to rearrangement of the bubbles and release of stress.
12. Physico chemical property of drug molecules:
A study of physical property of drug molecules is very important for product formulation and it
often leads to better understanding of interrelationship between molecular structure and drug
action.
Significance
Arrangement of an atom in the drug molecules can be obtained.
By studying the physical and chemical properties the structure of the drug molecules can
be determined.
Solubility of a compound can be determined.
It gives an idea how a compound can be measures qualitatively and quantitatively.
Classifications
The physical properties can be classified as:
1. Additive property
2. Constitutive property
3. Colligative property
Additive property: They are derived from the sum of the properties of the individual atoms
or the functional groups within the molecules.
Example. Molecular weight
Constitutive properties: The constitutive property depends on the structural arrangement within
the molecules.
Example. Optical rotation
Colligative properties: The colligative property depends on the number of particles.
Example.1.Lowering of volatile point.
2. Elevation of boiling point.3.Depression of freezing point.
The various physical properties of drug to be studied in this chapter are.
Refractive index
Optical rotation
Dielectric constant
Dipole moment
Dissociation constant
Refractive index
If the light enters the denser substance at an angle 1 part of the wave shows down more quickly
as if pass the interface and this produces a bending of the wave towards the interphase. This
phenomenon is called refraction. If light enters a less dense substance, it is refracted away from
13. the interface rather than towards it. The relative value of this effect between two substance is
given by the refractive index or Snell’s laws.
Snell's law
Refractive index of a medium is given by the Snell’s law.
n= sini/sinr=velocity of light in air (vacuum)/velocity of light in medium
Where i angle of incidence when light travels through air
r =angle of refraction
Refractive index varies with the wavelength of light and temperature. Usually the velocity of the
light in air is also higher.
Refractive index of the liquid at 25°C
Substances. RI value
Carbon tetrachloride. 1.4603
Toluene 1.4969
A-methyl naphthalene. 1.6176
Water. 1.3325
Abbes refractometer is commonly used for the determination of refractive index. Liquids and
mixtures of liquids possesses a characteristic refractive index
For example, carbon tetrachloride has a lower refractive index and benzene has a high refractive
index. When benzene as added for carbon tetrachloride the refractive index of carbon
tetrachloride increases. And the proportion of benzene increasing refractive index also increases
linearly.
The principle is used to find the percent composition of benzene in carbon tetrachloride.
Refractive index of the unknown mixture can be determined experimentally
Applications
Refractive index can be used to identify a substance, to measure its purity and to determine the
concentration of one substance dissolved in another.
Optical rotation
Polychromatic light
The light which contains rays of different wavelength.
Monochromatic light.
The light which contains rays of only wavelengths.
14. Polarized light.
When a ray of light is passed through a Nichols prism, that emerges out has vibration restricted
to one plane and is called as polarized ray and the light in which vibration are restricted to one
plane is called plane polarized light
Optical activity
When a monochromatic polarized beam of light is passed through a solution of a substance in the
plane of the polarized light is turned through a certain angle, such substance is said to be optical
active and the phenomenon is called as optical activity.
If the plan of polarized light is turned to the right of the substance is called dextrorotatory and if
it is done to the left it is called levo-rotary. The d and l form are non super imposable and are
mirror image of each other. The optical activity is due to a symmetric carbon atoms or chiral
carbon. They are called enantiomers. If equal amount off d and l are mixed, then the solution is
racemic mixture and it is optically inactive.
Example: Tartaric acid. The d and l form are enantiomorphs and meso form is optically inactive.
A polarimeter is used to measure optical activity.
EXPLANATION:
Fig.3.Polarimeter
Light passes through lens A which makes the light rays parallel and enter the Nichol prism B.
The light emerges out as the plane polarised light and then passed through the sample and then
the analyzer D, E and F are the telescopic lenses which shows the field as two unequal
illuminated halves. The analyzer is rotated to a point when the two halves appear uniformly dark.
15. The reading can be taken at this point. The direct reading gives the optical rotation. This method
is also called as the half shadow measurement.
Specific rotation
Specific rotation is the angle of rotation of the plane of polarised light caused by 1 decimeter
columns of solution containing 1 gram of the substance per cubic centimeter.
Where α-specific rotation
a -angle of rotation
l –length of column
C- Concentration of solution
Applications
The value of specific rotation can be used to identify the compound
Example: lactic acid can exist as dextro and levo form. The specific rotation at 25OC using
sodium light is +3.8O dextro isomer and -3.8O for Levo isomer.
Optical rotation changes as a function of the wavelength of light. By varying the wavelength of
light, the specific rotation for an optical active substance will change. A graph of specific
rotation versus wavelength shows an inflection and then passed through zero at the wavelength
of maximum absorption of polarised light. This change is specific rotation is known as a cotton
effect. Compounds whose specific rotation show maximum before passing through zero as the
wavelength of polarized light becomes smaller are said to be show a positive cotton effect.
Whereas if α show a maximum after passing through zero of approaching shorter wavelength the
compound shows a negative cotton effect . Enantiomers can be characterized by the cotton
effect. This is used for the structural examination of organic compounds. For example it is
possible to distinguish between two standards with keto groups at position 3 and 17 using rotary
discretion curves
Dielectric constant:
The capacitance of the answer filled with some materials CX divided by the reference standard Co
is referred as the dielectric constant (ε)
ε =CX /Co
16. Derivation
Considered two parallel plate separated by some medium across a distance of the and connected
to a battery electric city will flow from the light plate to the right until the potential differences
of the plates is usually to that of the battery supplying the initial potential differences. The
Capacitance of the condenser (c) in Farads is then equal to the quantity of electric charges q in
coulombs stored on the plates divided by the potential differences V between the plates
Fig.4.Measurement of dielectric constant
C= q/V
If water fills the space, the capacity CX is given by:
ε = qx / Vx
When water fills the space capacitance Cx is given by;
Cx =qx/Vx
When water fills the space the capacitance is increased; the capacitance for water or any other
liquid fuels on the space and the capacitance when vacuum feels the space gives the dielectric
constant of water or for any other liquid.
ε =CX/Co
17. Dielectric constant of the liquid at 25°
Substance. Dielectric constant
Formamide. 110.00
Water. 78.50
Methanol. 32.60
Carbon Tetrachloride. 2.23
Dielectric constant can be determined by Oscillometry in which the frequency of a signal is kept
constant by electrical changing the capacitance between the parallel plates. The liquid whose
dielectric constant is being measured is placed in glass container between the two plates during
the experiment. The dielectric constant of solvent mixture can be related to drug solubility
Dielectric constant of drug molecules can be related to drug plate’s concentration.
Application
1. The ease of solution of salt soluble like water & glycerin bi explain based on high
dielectric constant.
2. More polar is the solvent higher the dielectric constant.
3. Dielectric constants are related dipole-dipole interactions and full induced dipole-dipole
interaction.
4. Solvents with large dipole moment will have large dielectric constant.
5. As the temperature increases the dielectric constant of dipolar solvent will tend to
decrease.
Dipole moment
An electric dipole is a system of positive and negative charge separated by a finite distance.
If positive and negative charges are + Q and -Q are separated by a distance 1 then the dipole
moment is given as: µ= QI
Debye is the unit of dipole moment=10-18 esu x cm
Where esu indicates electrostatic unit of charge
Applications
1.To confirm the structure of the molecule.
Examples:
a) Benzene and carbon tetrachloride are symmetrical molecules and the dipole moment is
zero.
b) Water molecule has a dipole moment of 1.85 D. So there is an angle of 108O between
the OH bonds of the water molecules.
c) Dipole moment of carbon dioxide is zero and this shows that it is a linear molecule.
[O=C=O]
18. d) The dipole moment of Para dichlorobenzene is zero and of meta dichlorobenzene is
2.6D.
2. Dipole moment can be used to distinguish between the cis and trans forms.
a) Trans dichloroethylene has dipole moment of zero and cis has 2.95D.
3. The insecticidal activity can be measured from dipole moment. Lower the value greater
will be lipoidal solubility and greater will be the toxicity.
Example: DDT ( Para isomer) has a dipole moment of 1.1 D
The para isomer of DDT has a smallest dipole moment of 1.10 whereas the meta isomer has a
dipole moment of 1.55 and ortho isomer 1.90. Because of the smallest dipole moment the para
form shows greater activity. It can easily penetrate into the lipoidal membrane of the insect and
attack the enzyme present in the insect lower dipole moment means greater insecticidal action
4. Dipole moment can be used to determine the percentage ion character of a covalent
bond.
Examples In case of HCl, dipole moment is 6.1D, if it is fully ionic. But the practical value is
1.0 4D
Dissociation constant
Acid and bases can ionize in water to give their respective conjugate base and conjugate acid.
According to law of mass action a ratio of ionized molecule to unionized molecule can be given.
This ratio is called as ionization constant or dissociation constant.
For an acid
H A + H2O <=====>A-- +H3O+
Ka =acidity constant= [A-][ H3O+]/ [H A]
For a base
B + H2O <==> BH++ OH--
Kb = basicity constant = [OH-] (BH+)/[B]
Ionization of water
H2O +H2O<====>H3O+ + OH--
Kw= [ H3O+] [OH--]/[H2O]
Kw= KbxKa
It is also called as ionic product of water.
Dissociation constant of the liquid
19. Substance.
Acetic acid
Boric acid
Ammonia
Caffeine
Dissociation constant
1.75 x 10---5
5.8 x 10--10
1.74 x 10---5
4.1 x 10--14
Determination of dissociation constant
There are various methods like conductivity method, visible or UV absorption spectrometer,
potentiometer etc.Potentiometeric pH is most widely used
Dissociation constant of acid
Ka= [H3O+] [A--]/ [HA]
When equimolar concentration of salt A- and an acid [HA] are present, the Ka--- dissociation
constant is numerically equal to the hydronium ion concentration.
Ka= [H3O+] when [A-] = [HA]
Method
PH of the solution containing equimolar concentration of the acid and a strong base salt of the
acid may measured. At one concentration equal to pKa. From pKa , ka may calculated. pKa is
the negative logarithm of dissociation constant.
Applications
Dissociation constant are related to physiological and pharmaceutical activities, solubility, rate of
the solution, side of binding (protein binding) and rate absorption of the drug.
Example: Rate and extent absorption of weakly acidic drugs take place from the stomach region
as the amount of unionized drug available is more from stomach. Similarly the absorption of the
weak bases is better from the intestine
20. Reference:
1. Martin’s Physical Pharmacy and Pharmaceutical Sciences, Patrick J.
Sinko,PhD,RPh,sixth edition
2. Physical Pharmacy,S.P.Agarwal,R.Khanna, fourth edition
3. Laboratory Manual of Physical Pharmaceutics,C.V.S.Subrahmanyam,J.Thimma settee,
second edition
4. Faculty of Pharmaceutical Sciences - PDM University) Bahadurgarh, Delhi NCR, first
edition. (www.pdm.ac.in/pharmacy)