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Complexation and protein binding

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A coordination complex is formed via a Lewis acid-base reaction between a central metal ion and surrounding ligands. Common ligands donate lone electron pairs to form coordinate covalent bonds with the metal. Coordination complexes have altered physical and chemical properties compared to the individual components. Complexation can impact drug properties like solubility, stability, and pharmacokinetics, which are important considerations in drug delivery and activity.

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EDTA Ethylenediamine ligand, binding to a central metal ion with two bonds Natural occuring chelates: chlorophyll, hemoglobin, albumin
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[object Object],COLD TEMPERATURE HOT TEMPERATURE Molar complex or organic coordination compound Formation of salt or complexation Secondary valence bond(not clear bond but rather attraction b/n 2 molecules Primary valence bond Weak donor-acceptor Charge transfer
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[object Object],[object Object],D ···A D+ ···A- Weak Donor-acceptor complex or molecular complex Charge transfer complex London dispersion forces and dipole-dipole intrn Resonance
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[object Object],[object Object],[object Object],[object Object],Elimination Metabolites enzymes + drug Plasma Drug + Protein Drug - Protein Tissues Drug + Receptor Drug - Receptor
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