Ayurvedic Formulation: Asava, Arishta, Avaleha, Ghrita, Taila, Gutika
Concept of Detoxification: Panchkarma
Final Year B.Pharm (Sem-VIII) Pharmacognosy-III (Mumbai University Syllabus
The concept of beauty and cosmetics is as ancient as mankind and civilization. Women are obsessed with looking beautiful. So, they use various beauty products that have herbs to look charming and young. Indian herbs and its significance are popular worldwide. An herbal cosmetic have growing demand in the world market and is an invaluable gift of nature. Herbal formulations always have attracted considerable attention because of their good activity and comparatively lesser or nil side effects with synthetic drugs. Herbs and spices have been used in maintaining and enhancing human beauty.
Ayurvedic Formulation: Asava, Arishta, Avaleha, Ghrita, Taila, Gutika
Concept of Detoxification: Panchkarma
Final Year B.Pharm (Sem-VIII) Pharmacognosy-III (Mumbai University Syllabus
The concept of beauty and cosmetics is as ancient as mankind and civilization. Women are obsessed with looking beautiful. So, they use various beauty products that have herbs to look charming and young. Indian herbs and its significance are popular worldwide. An herbal cosmetic have growing demand in the world market and is an invaluable gift of nature. Herbal formulations always have attracted considerable attention because of their good activity and comparatively lesser or nil side effects with synthetic drugs. Herbs and spices have been used in maintaining and enhancing human beauty.
In this power points viewer will be able to know the meaning of Pharmacopoeia and its coposition. History behind the different pharmacopoeia and popular pharmacopoeia existing world wide in herbal medicines. List of different pharmacopoeias also has been included.
Bio pharmaceutical classification System [BCS]Sagar Savale
The Biopharmaceutical Classification System was first developed by in 1995, by Amidon et al & his colleagues.
Definition:
“The Biopharmaceutical Classification System is a scientific framework for classifying a drug substance based on its aqueous solubility & intestinal permeability & dissolution rate”.
To saved time fast screening is required so drug substances are classified on basis of solubility and permeability. This classification is called Biopharmaceutical Classification System
Drug discovery and development process of anti diabetic plants, Prof. Dr. Basavaraj K. Nanjwade, KLE University College of Pharmacy, Belgavi/Belgaum, Karnataka, India.
In this power points viewer will be able to know the meaning of Pharmacopoeia and its coposition. History behind the different pharmacopoeia and popular pharmacopoeia existing world wide in herbal medicines. List of different pharmacopoeias also has been included.
Bio pharmaceutical classification System [BCS]Sagar Savale
The Biopharmaceutical Classification System was first developed by in 1995, by Amidon et al & his colleagues.
Definition:
“The Biopharmaceutical Classification System is a scientific framework for classifying a drug substance based on its aqueous solubility & intestinal permeability & dissolution rate”.
To saved time fast screening is required so drug substances are classified on basis of solubility and permeability. This classification is called Biopharmaceutical Classification System
Drug discovery and development process of anti diabetic plants, Prof. Dr. Basavaraj K. Nanjwade, KLE University College of Pharmacy, Belgavi/Belgaum, Karnataka, India.
Effect of Piper crocatum Extract Against Weight Loss and Liver Enzyme Levels ...iosrphr_editor
Piper crocatum is one of Indonesian medicinal plant that contain flavonoids, tannins, alkaloids, and saponins. Aims of this study were to evaluate the effect of Piper crocatum aqueous extract against a decrease in body weight (BW) and the activity of enzymes involved in lipid metabolism (AMPK, ACC, FAS) in liver obese rats. This study used four groups of Sprague dawley rat (n = 6), including normal group (N), obese controls (OC), Piper crocatum extract dose 1260 mg/kgBW (PcA), and Piper crocatum extract dose of 1890 mg/kgBW (PcB). Measurement of metabolic liver enzyme levels (AMPK, ACC, FAS) are using ELISA kit (CusabioTM). Results of this study showed that the PcA group produce the highest reduction in body weight (4.52%), and the lowest levels of ACC (9.13 ng/g) and FAS (360.68 ng/g) which was significantly different from obese control group (95% CI). Piper crocatum extract can't activate AMPK. The highest levels in rat liver AMPK is in N group with 8.42 ng/g, but this value is not significantly different from other groups.
This is Sumaiya Nahid hail from Chittagong, Bangladesh.It's my M.Pharm (Thesis) presentation slide. This is the total display of my hard works.I tried my best to summarize my one year enthusiastic workings.Any suggestions and corrections will be cordially accepted. Thank you all.
Some stimuli, including specific foods, seem to have enough particularities to make a difference even if their potential to exert an influence a priori appears to be limited. This is the case of yogurt whose consumption is low relative to the amount of daily food consumed but that has been shown to be independently related to reduced body weight and fat. Numerous factors may explain a beneficial effect of yogurt on body weight stability and metabolic fitness. Cohort studies show that the consumption of dairy including yogurt is related to a reduced intake of high fat-high sugar foods, suggesting that the benefits of dairy food may be due to a decrease in the potential negative effects of unhealthy eating. The ability of yogurt to promote a negative energy balance is also likely explained by the satiating and thermogenic effects of some of its nutrients, e.g. calcium and proteins, via mechanisms involving gut hormones. Yogurt has a matrix that can accommodate structural changes affecting energy intake independently of its nutrient content. For instance, we recently demonstrated that the increase in the whey/casein ratio in a yogurt matched for volume and energy and protein content as a control yogurt significantly decreased subsequent energy intake to a much greater extent than the energy content of the yogurt preload. The presence of bacteria in yogurt represents another factor that may explain the effects of yogurt consumption on energy balance and its components. In this regard, recent data suggest that the supplementation of some probiotics facilitates appetite control and accentuates body weight loss in the context of a weight-reducing program. Finally, our recent analyses of relevant data in the Quebec Family Study reveal that yogurt consumption may be the signature of a global healthy lifestyle and food-related personal profile. Female yogurt consumers are more physically active, report a reduced percent energy intake as fat and display a lower disinhibition score than non-yogurt consumers. Taken together, yogurt has numerous features that may globally explain the decreased proneness of yogurt consumers towards excess body fat.
Paracetamol is a commonly used analgesic and antipyretic drug, but at a high dose level, it leads
to deleterious side effects. The need to investigate new hepatoprotective drugs is driven by the
lack of safety and efficiency of existing medications. A newly synthesized compound 2′, 3′-
dihydroxybenzylidene (DHB) was evaluated in the present study for its antioxidant, hepatoprotective and nephroprotective potential compared to ascorbic acid in paracetamol intoxicated rats. DHB and ascorbic acid were evaluated against 2, 2-diphenyl-1-picrylhydrazyl (DPPH)
for assessment of the antioxidant potential. Male albino rats (n = 20) were categorized into 5
groups with 4 rats each and the test compounds were administered for 14 days consecutively. On
day 15th, the rats were anesthetized, and blood was collected through heart puncture for the
evaluation of hematological and serological parameters. Subsequently, the rats were dissected for
the histopathology of liver and kidney. Alanine Transaminase (ALT), Alkaline Phosphatase (ALP),
Serum Bilirubin (SBR), Cholesterol level and Renal Function Tests (RFTs) showed a substantial
increase in the paracetamol treated group. Healing in liver and kidney tissues was observed in the
DHB treated groups compared to paracetamol intoxicated group. The hemoglobin (HB), mean
corpuscular hemoglobin (MCH), RBCs and mean corpuscular hemoglobin concentration (MCHC)
were found to be significantly elevated, while the total leukocyte count (TLC), platelets (PLT) and
neutrophils significantly decreased in the DHB treated group compared to the paracetamol
intoxicated group. It is concluded that DHB possesses antioxidant, hepatoprotective, neuroprotective, and anti-inflammatory potential against paracetamol induced hepatotoxicity and
nephrotoxicity in rats.
Asrt malaysia itm rice bran projects presentationAmr Helal
Rice bran , instead of using as animal feed, was stablized , studied from the phytochemical , pharmacological, toxicological and formulation points of view. It is developed to be used in bakery, nutraceutical, cosmoceutical preparations with soild scientific proof of evidence.
The global radiation oncology market size reached US$ 8.1 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 14.5 Billion by 2032, exhibiting a growth rate (CAGR) of 6.5% during 2024-2032.
More Info:- https://www.imarcgroup.com/radiation-oncology-market
KEY Points of Leicester travel clinic In London doc.docxNX Healthcare
In order to protect visitors' safety and wellbeing, Travel Clinic Leicester offers a wide range of travel-related health treatments, including individualized counseling and vaccines. Our team of medical experts specializes in getting people ready for international travel, with a particular emphasis on vaccines and health consultations to prevent travel-related illnesses. We provide a range of travel-related services, such as health concerns unique to a trip, prevention of malaria, and travel-related medical supplies. Our clinic is dedicated to providing top-notch care, keeping abreast of the most recent recommendations for vaccinations and travel health precautions. The goal of Travel Clinic Leicester is to keep you safe and well-rested no matter what kind of travel you choose—business, pleasure, or adventure.
Cold Sores: Causes, Treatments, and Prevention Strategies | The Lifesciences ...The Lifesciences Magazine
Cold Sores, medically known as herpes labialis, are caused by the herpes simplex virus (HSV). HSV-1 is primarily responsible for cold sores, although HSV-2 can also contribute in some cases.
The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
COVID-19 PCR tests remain a critical component of safe and responsible travel in 2024. They ensure compliance with international travel regulations, help detect and control the spread of new variants, protect vulnerable populations, and provide peace of mind. As we continue to navigate the complexities of global travel during the pandemic, PCR testing stands as a key measure to keep everyone safe and healthy. Whether you are planning a business trip, a family vacation, or an international adventure, incorporating PCR testing into your travel plans is a prudent and necessary step. Visit us at https://www.globaltravelclinics.com/
Letter to MREC - application to conduct studyAzreen Aj
Application to conduct study on research title 'Awareness and knowledge of oral cancer and precancer among dental outpatient in Klinik Pergigian Merlimau, Melaka'
This document is designed as an introductory to medical students,nursing students,midwives or other healthcare trainees to improve their understanding about how health system in Sri Lanka cares children health.
1. Polyherbal Formulations for Diabetes
Prof. Dr. Basavaraj K. Nanjwade. M.Pharm., Ph.D.
Department of Pharmaceutics
KLE University College of Pharmacy
Belgaum, Karnataka , India
E-mail: bknanjwade@yahoo.co.in
Cell No: 00919742431000
3. Introduction
• Plant formulation and combined extracts of plants are used a
drug of choice rather than individual. Various herbal
formulations such as diamed, coagent db, Diasulin, and
hyponidd, are well known for their antidiabetic effects.
• Polyherbal formulation of Annona squamosa and Nigella
sativa is composed of medicinal plants (Table 1), which are
traditionally used for antidiabetic and antihyperlipidemic
activity. The present investigation was undertaken to study the
effect of the polyherbal formulation of Annona sqamosa and
Nigella sativa on lipidperoxidation and tissue lipid profile in
streptozotocin induced diabetic rats.
7 September 2011 14th ACC and ANRAP, Bangkok 3
4. Research Background
• Polyherbal formulation of Annona squamosa and Nigella
sativa on blood glucose, plasma insulin, tissue lipid profile,
and lipidperoxidation in streptozotocin induced diabetic rats.
Aqueous extract of Polyherbal formulation of Annona
squamosa and Nigella sativa was administered orally (200
mg/kg body weight) for 30 days.
• The different doses of Polyherbal formulation on blood
glucose and plasma insulin in diabetic rats were studied and
the levels of lipid peroxides and tissue lipids were also
estimated in streptozotocin induced diabetic rats. The effects
were compared with tolbutamide. Treatment with Polyherbal
formulation and tolbutamide resulted in a significant reduction
of blood glucose and increase in plasma insulin.
7 September 2011 14th ACC and ANRAP, Bangkok 4
7. Material and methods
• Animals
• Preparation of drug
• Chemicals
• Drug administration
• Streptozotocin-induced diabetes
• Experimental design
• Biochemical analysis
7 September 2011 14th ACC and ANRAP, Bangkok 7
8. Experimental design
• In the experiment, a total of 42 rats (30
diabetic surviving rats, 12 normal rats)
were used.
• The rats were divided into seven groups of
six rats each after the induction of
streptozotocin diabetes.
7 September 2011 14th ACC and ANRAP, Bangkok 8
9. Experimental design
• Group1: Normal treated rats
• Group 2:Normal rats given aqueous solution of Polyherbal
formulation (200 mg/kg body weight) daily using an
intragastric tube for 30 days.
• Group 3:Diabetic control rats.
• Group 4: Diabetic rats given aqueous solution of Polyherbal
formulation (50 mg/kg body weight) daily using an
intragastric tube for 30 days.
7 September 2011 14th ACC and ANRAP, Bangkok 9
10. Experimental design
• Group 5: Diabetic rats given aqueous solution of Polyherbal
formulation (100 mg/kg body weight) daily using an
intragastric tube for 30 days.
• Group 6: Diabetic rats given aqueous solution of Polyherbal
formulation (200 mg/kg body weight) daily using an
intragastric tube for 30 days.
• Group 7: Diabetic rats given aqueous solution of Tolbutamide
(250 mg/kg body weight) daily using an intragastric tube for
30 days.
7 September 2011 14th ACC and ANRAP, Bangkok 10
11. Biochemical analysis
• Estimation of blood glucose and plasma insulin
• Estimation of lipid peroxidation
• Estimation of lipids
i. Lipids
ii. For total cholesterol estimation
iii. Fro triglycerides estimation
iv. Phopholipids content
v. Free fatty acids
vi. Statistical analysis
7 September 2011 14th ACC and ANRAP, Bangkok 11
12. Table 1: Polyherbal Formulation of Annona Squamosa and
Nigella sativa (Composition and Concentration)
Sl. No Botanical Name Common
Name
Family Part
used
Conc.
1. Annona
squamosa
Sharifa Annonnacceae Mature
d fruits
50
2. Nigella sative Kalonji Ranunculaceae seeds 50
7 September 2011 14th ACC and ANRAP, Bangkok 12
13. Group Fasting blood glucose
(mg/dI)
Plasma insulin (IU/ml)
Normal 81.04 ± 2.29 11.26 ± 0.96
Diabetic control 262.24 ± 22.23 3.48 ± 0.69
Diabetic + Polyherbal
formulation (50 mg/kg)
209.58 ± 12.46 5.59 ± 0.34
Diabetic + Polyherbal
formulation (100 mg/kg)
155.58 ± 11.69 6.03 ± 0.45
Diabetic + Polyherbal
formulation (200 mg/kg)
104.16 ± 6.56 7.15 ± 0.45
Diabetic + Tolbutamide
(250 mg/kg)
110.65 ± 9.35 6.32 ± 0.48
7 September 2011 14th ACC and ANRAP, Bangkok 13
Table 2: Changes in blood glucose and plasma insulin
levels of control and experimental animals
14. Groups TBARS Hydroperoxide
Liver Kidney Liver Kidney
Normal 0.58 ± 0.066 0.68 ± 0.05 70.38 ± 4.54 55.34 ± 4.55
Diabetic +
Polyherbal
formulation
(200 mg/kg)
0.56 ± 0.079 0.78 ± 0.06 68.59 ± 5.14 52.48 ± 4.75
Diabetic
control
1.54 ± 0.06 1.65 ± 0.12 99.98 ± 5.98 78.29 ± 4.58
Diabetic +
Polyherbal
formulation
(200 mg/kg)
0.64 ± 0.053 0.97 ± 0.07 80.55 ± 5.69 60.99 ± 4.78
Diabetic +
Tolbutamide
(250 mg/kg)
0.67 ± 0.088 1.02 ± 0.08 84.35 ± 5.45 62.45 ± 5.56
7 September 2011 14th ACC and ANRAP, Bangkok 14
Table 3: Changes in levels of TBARS and Hydroperoxides
in liver and kidney of control and experimental animals
15. Table 4: Changes in levels of cholestrol, free fatty acids, triglycerides
and phospholipids in liver of control and experimental animals
( mg/100g wet. tissue)
Groups Cholesterol Free fatty acids Triglycerides Phospholipids
Normal 335.44 ± 18.90 606.10 ± 1.76 344.50 ± 23.20 1598.00 ± 19.30
Normal +
Polyherbal
formulation
(200 mg/kg)
328.38 ± 5.74 601.93 ± 9.00 341.10 ± 21.00 1593.10 ± 24.10
Diabetic control 496.56 ± 13.10 921.60 ± 44.60 622.50 ± 18.80 1858.60 ± 18.70
Diabetic +
Polyherbal
formulation
(200mg/kg)
398.65 ± 17.54 769.16 ± 3.30 456.25 ± 17.30 1718.80 ± 14.40
Diabetic +
Tolbutamide
(250 mg/kg)
405.21 ± 9.79 802.80 ± 3.77 530.80 ± 35.70 1769.30 ± 17.60
7 September 2011 14th ACC and ANRAP, Bangkok 15
16. Groups Cholesterol Free fatty acids Triglycerides Phospholopids
Normal +
Polyherbal
formulation
(200 mg/kg)
372.08±8.28 432.51±1.60 278.75±14.60 1442.50±43.30
Diabetic control 546.90±23.80 743.00±5.70 501.10±34.10 2041.50±33.60
Diabetic+Polyher
bal formulation
(200 mg/kg)
435.20±12.18 556.80±8.50 382.90±9.28 1684.00±28.80
Diabetic+
Tolbutamide
(250 mg/kg)
449.90±13.49 600.30±3.40 438.66±39.30 1819.30±34.70
7 September 2011 14th ACC and ANRAP, Bangkok 16
Table 5: Changes in levels of cholestrol, free fatty acids, triglycerides
and phospholipids in kidney of control and experimental animals
( mg/100g wet. tissue)
17. Conclusion
• Polyherbal formulation of Annona squamosa and
Nigella sativa, exert a significant antihyperlipidemic.
This could be due to combined effect of Annona
squamosa and Nigella sativa. Hence the
antihyperlipidemic effect of polyherbal formulation
of Annona squamosa and Nigella sativa in particular
could be considered as of possible therapeutic value
7 September 2011 14th ACC and ANRAP, Bangkok 17
18. Liposomes
7 September 2011 14th ACC and ANRAP, Bangkok 18
– Spherical vesicles with a phospholipid bilayer
Hydrophilic
HydrophobicHydrophobic
23. Lipid Peroxidation
• Most phospholipid liposomes contain
unsaturated acyl chains as part of their
molecular structure and susceptible to
oxidative degradation. It can be minimized by
the use of animal derived lipids like egg PC,
which has less saturated lipids, use of light
resistant containers, use of antioxidants are
useful in minimizing oxidation.
7 September 2011 14th ACC and ANRAP, Bangkok 23
24. Diabetic Current Research
• Mangifera indica(stem,fruits,etc) – Anacardiaceae – Mango
• Gossypiumherbaceum(flowers,etc ) – Malvaceae – Cotton
• Cocos nucifera(roots,etc) – Arecaceae – Coconut
• Lawsonia inermis(bark,etc) – Lythraceae - Mendhi
7 September 2011 2414th ACC and ANRAP, Bangkok