Sex, drugs and rock’n’roll
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This document discusses Parkinson's disease and the role of dopamine. It describes how Parkinson's is caused by low dopamine levels in the brain and discusses common symptoms like tremors and rigidity. It outlines treatments for Parkinson's like L-dopa which provides dopamine to the brain, but can cause side effects over time like uncontrolled movements. The document also addresses issues like impulse control disorders and dopamine dysregulation syndrome that some patients experience due to long-term dopamine replacement therapy.
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Editor's Notes
- The ventral tegmental area (VTA) cells project to limbic (mesolimbic projection) and cortical (mesocortical projection) areas. Neurons of the substantia nigra project to the striatum (nigrostriatal projection). In PD, dopaminergic nerve cells in the substantia nigra develop nerve cell loss, and its degeneration and the resulting striatal dopamine depletion are responsible for most of the motor abnormalities.
- Clinically, PD is characterized by three cardinal symptoms: resting tremor, bradykinesia (generalized slowness of movements) and muscle rigidity.
- PD is the most common movement disorder affecting 1-2 % of the general population over the age of 65 years, and it is the second most common neurodegenerative disorder after Alzheimer´s disease (AD). Tanner, CM et al. Epidemiology and genetics of Parkinson´s disease. In: Watts RL, Koller WC, ed. Movement Disorders, Neurologic principles and practice. New York: McGrawhill, pp. 137-152, 1997 .