Parkinsonism
It is an extra-pyramidal motor disorder characterized by rigidity, tremor and hypokinesia with secondary manifestations like defective posture and gait, mask-like face and sialorrhoea; dementia may accompany. If untreated the symptoms progress over several years to end-stage disease in which the patient is rigid, unable to move, unable to breathe properly; succumbs mostly to chest infections / embolism
Drugs used in Parkinsons Disease ( anti- Parkinson drugs) Ravish Yadav
detail and complete study on the topic of anti parkinson drug. the study is done under the guidance of faculty member. the learning content complete information of the topic
Drugs used in Parkinsons Disease ( anti- Parkinson drugs) Ravish Yadav
detail and complete study on the topic of anti parkinson drug. the study is done under the guidance of faculty member. the learning content complete information of the topic
Anti Parkinson Disease | PDF | Pharmacology | Assignment MrHotmaster1
An anti-parkinson is a type of drug which is intended to treat and relieve the symptoms of parkinson’s disease.
Most of these agents act by either increasing dopamine activity or reducing acetylcholine activity in the central nervous system.
In clinical practice, anti-cholinergic drugs, amantadine, and the anti-histamines have their primary use of treatment for medication induced parkinsonism, acute dystonia, and medication induced tremor.
This presentation provides information about parkinsonism or Parkinson disease and pathophysiology, classification, pharmacological action and side effects of Anti Parkinson drugs.
Pharmacotherapies for parkinsons diseaseBrian Piper
This seminar was delivered to 2nd year pharmacy students as part of 2 lectures for a pharmacology & toxicology class. This material accompanies Goodman & Gilman's (12e) chapter 22.
the presentation on anti parkinson drug contain their classification of drugs, mechanism of action. uses of drugs, side effect, causes, symptoms, additional symptoms, physiology, pathophysiology
BASIC PHARMACOLOGY REVISION NOTES BASED ON HIGH YEILD TOPIC AND LECTURE NOTES
ANTIPARKINSONIAN DRUGS
LEVODOPA DRUGS
PERIPHERAL DECARBOXYLASE INHIBITOR
COMT INHIBITOR
ENTACAPONE
TOLCAPONE
MAO B INHIBITORS
Anti Parkinson Disease | PDF | Pharmacology | Assignment MrHotmaster1
An anti-parkinson is a type of drug which is intended to treat and relieve the symptoms of parkinson’s disease.
Most of these agents act by either increasing dopamine activity or reducing acetylcholine activity in the central nervous system.
In clinical practice, anti-cholinergic drugs, amantadine, and the anti-histamines have their primary use of treatment for medication induced parkinsonism, acute dystonia, and medication induced tremor.
This presentation provides information about parkinsonism or Parkinson disease and pathophysiology, classification, pharmacological action and side effects of Anti Parkinson drugs.
Pharmacotherapies for parkinsons diseaseBrian Piper
This seminar was delivered to 2nd year pharmacy students as part of 2 lectures for a pharmacology & toxicology class. This material accompanies Goodman & Gilman's (12e) chapter 22.
the presentation on anti parkinson drug contain their classification of drugs, mechanism of action. uses of drugs, side effect, causes, symptoms, additional symptoms, physiology, pathophysiology
BASIC PHARMACOLOGY REVISION NOTES BASED ON HIGH YEILD TOPIC AND LECTURE NOTES
ANTIPARKINSONIAN DRUGS
LEVODOPA DRUGS
PERIPHERAL DECARBOXYLASE INHIBITOR
COMT INHIBITOR
ENTACAPONE
TOLCAPONE
MAO B INHIBITORS
It may contain a brief intoduction of disease, etiology, types of parkinson disease, clinical findings, dignosis, pathophysiology, treatment, drug classification and their mechanisms of actions.
Parkinson's disease (PD) is a neurodegenerative disorder that affects predominately dopamine-producing (“dopaminergic”) neurons in a specific area of the brain called substantia nigra. ... People with PD may experience: Tremor, mainly at rest and described as pill rolling tremor in hands .
Parkinson’s disease is a progressive disorder of the nervous system that, in the early stages, is characterized by mild signs that are often missed. These signs can be remembered by the mnemonic “SMART”
S = Shuffling-Gait
M = Mask-like Face
A = Akinesia
R = Rigidity
T = Tremor
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
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students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
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1. Parkinsonism
It is an extra-pyramidal motor disorder characterized by rigidity, tremor and hypokinesia
with secondary manifestations like defective posture and gait, mask-like face and
sialorrhoea; dementia may accompany. If untreated the symptoms progress over several
years to end-stage disease in which the patient is rigid, unable to move, unable to breathe
properly; succumbs mostly to chest infections / embolism
•First described by James Parkinson in 1817
•Majority of the cases are idiopathic, some are arteriosclerotic while post encephalitic are now
rare
•Wilson's disease (hepatolenticular degeneration) due to chronic copper poisoning, is a rare
cause
Reason behind the parkinsonism
Antiparkinsonian Drugs
•The most consistent lesion in PD is degeneration of neurones in the substantia nigra pars
compacta (SN-PC) and the nigrostriatal (dopaminergic) tract .
•This results in deficiency of dopamine (DA) in the striatum which controls muscle tone and
coordinates movements.
•An imbalance between dopaminergic (inhibitory) and cholinergic (excitatory) system in the
striatum occurs giving rise to the motor defect.
•Though the cholinergic system is not primarily affected, its suppression (by anticholinergics)
tends to restore balance
2. •Oxidation of DA by MAO-B and aldehyde dehydrogenasegenerates hydroxyl free radicals
(.
OH) in the presence of ferrous ions ((basal ganglia are rich in iron)
•Normally these free radicals are quenched by glutathione and other protective mechanisms
•Age related and otherwise acquired defect in protective mechanism allows the free
radicals to damage lipid membrane and DNA resulting in neuronal degeneration
• genetic predisposition may contribute to the high vulnerability of nigrostatal neurones
•Ageing induces defects in mitochondrial electron transport system
•A svnthetic toxin N-methyl-4-phenyl tetrahydropyridine (MPTP) which occurred as a
contaminant of some illicit drugs produces nigrostriatal degeneration and manifestation
similar to PD by impairing energy metabolism in dopaminergic neurones
•Drug-induced temporary parkinsonism due to neuroleptics, metoclopramide
(dopamine blockers
3. DA is present in the brain along with other monoamines
DOPA is the precursor of dopamine (DA)
CLASSIFICATION
I. Drugs affecting brain dopaminergic system
(a) Dopamine precursor : Levodopa (L-dopa)
(b) Peripheral decarboxylase inhibitors :Carbidopa, Benserazide.
(c) Dopaminergic agonists: Bromocriptine, Ropinirole, Pramipexole
(d) MAO-B inhibitor: Selegiline
(e) COMT inhibitors: Entacapone, Tolcapone
(f) Dopamine facilitator: Amantadine.
ll. Drugs affecting brain cholinergic system
(a) Central anticholinergics: Trihexyphenidyl (Benzhexol), Procyclidine, Biperiden
(b)Antihistaminics : Orphenadrine, Promethazine.
4.
5. LEVODOPA
Levodopa has a specific salutary effect in PD:
1.It is inactive by itself, but is the immediate precursor of the transmitter DA More than 95% of
an oral dose is decarboxylated in the peripheral tissues (mainly gut and liver).
2. DA thus formed acts on heart, blood vessels, other peripheral organs and on CTZ
(though located in the brain, i.e. floor of IV ventricle, it is not bound by blood-brain barrier).
3. About 1-2% of administered levodopa crosses to the brain, is taken up by the surviving
dopaminergic neurones converted to DA which is stored and released as a transmitter.
4. Brains of parkinsonian patients treated with levodopa till death had DA levels higher than
those not so treated. Further, those patients who had responded well had higher DA levels
than those who had responded poorly.
Pharmacological actions
A. CNS-
1. Levodopa hardly produces any effect in normal individuals or in patients with other
neurological diseases
2. Marked symptomatic improvement occurs in parkinsonian patients.
3. Hypokinesia and rigidity resolve first, later tremor as well.
4. Secondary symptoms of posture, gait, handwriting, speech, facial expression, mood, self care
and interest in life are gradually normalized.
5. 'general alerting response’- effect of levodopa on behaviour
6. progresses to excitement , frank psychosis may occur. disproportionate increase in sexual
activity.
7. Levodopa has been used to - nonspecific 'awakening' effect in hepatic coma.
6. B. CVSB. CVS
1. The peripherally formed DA can cause tachycardia by acting on β adrenergic receptors
2. Though DA can stimulate vascular adrenergic receptors as well, rise in BP is not seen.
3. DA and NA formed in the brain decrease sympathetic outflow
4. DA formed in autonomic ganglia can impede ganglionic transmission.
C.C. CTZCTZ
1. Dopaminergic receptors are present in this area and DA acts as a excitatory
neurotransmitter.
2. The DA formed peripherally gains access to the CTZ without hindrance- elicits
nausea and vomiting.
D.D. EndocrineEndocrine
1. DA acts on pituitary mammotropes to inhibit prolactin release and on
somatotropes to increase GH release
2. Though prolactin levels in blood fall during levodopa therapy, increased GH levels
are not noted in parkinsonian patients
3. Probably the mechanisrns regulating GH secretion are altered in these patients
PHARMACOKINETICPHARMACOKINETIC
1.Levodopa is rapidly absorbed from the small intestines by utilizing the active
transport
2. Bioavailability of levodopa is affected by:
7. 3. Gastric emptying: if slow, levodopa is exposed to degrading enzymes present in gut wall
and liver for a longer time-less is available to penetrate blood-brain barrier.
4. Amino acids present in food compete for the same carrier for absorption: blood levels are
lower when taken with meals.
5. Levodopa undergoes high first pass metabolism in G.I. mucosa and liver
8. 6. About 1% of administered levodopa that enters brain, aided by amino acid carrier
mediated active transport across brain capillaries
7. The plasma t1/2
of levodopa is 1-2 hours.
8. Pyridoxal is a cofactor for the enzyme dopa-decarboxylase
9.The metabolites are excreted in urine mostly after conjugation.
ADVERSE EFFECTS
Side effects of levodopa therapy are frequent and often troublesome. Most are dose-related and
limit the dose that can be administered. but are usually reversible.
At the initiation of therapy
1. Nausea and vomiting- It occurs in almost every patient. Tolerance gradually develops and
then the dose can be progressively increased.(peripheral d2 receptor…>ctz)
2. Postural hypotension- It occurs in about 1/3 of patients, but is mostly asymptomatic; some
patients experience dizziness, few have fainting (alpha receptor)
3.Cardiac arrhythmia - due to β adrenergic action of peripherally formed DA;
4. Exacerbation of angina - more in patients with pre existing heart disease.
5. Alteration in taste sensation
After prolonged therapy
Abnormal movements,
Behavioral effects, Fluctuation in motor performance
9. Cautious use is needed in elderly; patients with ischaemic heart disease,
cerebrovascular, psychiatric, hepatic and renal disease, peptic ulcer and gout
Drug Interactions
1. levodopa + Pyridoxine- Abolishes therapeutic effect by enhancing peripheral
Decarboxylation of levodopa. Less is available to cross the blood brain. (metabolism)
2. levodopa +Phenothiazines/ butyrophenones/ metoclopramide - reverse therapeutic
effect of levodopa by blocking DA receptor (pharmacodynamic)
3. levodopa+ Domperidon- blocks levodopa induced nausea and vomiting without
abolishing its antiparkinsonian effect, because domperidone does not cross blood brain
barrier (domperidone inhibit pripheral d2 receptor)
4. levodopa + Reserpine- abolishes levodopa action by preventing entry of DA into
synaptic vesicles
5. Levodopa + Nonselective MAO inhibitors- prevent degradation of peripherally
synthesized DA and NA- hypertensive crisis can occur
6. Levodopa + Antihypertensives- postural hypotension is accentuated, reduce their
dose if levodopa is started.
10. 7. Levodopa + Atropine, and other anticholinergic drug- have additive antiparkinsonian
action with low doses of levodopa but retard its absorption, more time is available
for peripheral degradation- efficacy of levodopa is reduced
PERIPHERAL DECARBOXYLASE INHIBITORS
Carbidopa and benzserazide extracerebral DOPA decarboxylase inhibitor
1. Do not penetrate blood brain barrier and do not inhibit conversion of levedopa to
DA in the brain
2. along with levodopa, they increase its t1/2
in the periphery and make more of it
Available to cross blood brain barrier
Benefits of the combination are
1. The plasma t1/2
of levodopa is prolonged and dose is reduced to 1/4th
2. Systemic concentration of DA is reduced-nausea and vomiting are not Prominent –
therapeutic doses of levodopa can be attained quickly
3. Cardiac complications are minimized
4. Pyridoxine reversal of levodopa effect does not occur
5. 'On-off‘ effect is minimized since cerebral DA levels are more sustained
6. Degree of improvement may be higher
Combination of levodopa with carbidopa has been given the name 'Co-careldopa’
11. DOPAMINERGIC AGONISTS
1. The DA agonists can act on striatal DA receptors
2. who have largely lost the capacity to synthesize, store and release DA from levodopa
3. they are longer acting
Bromocriptine
1. It is an ergot derivative which acts as potent agonist on D2, but as partial agonist or antagonist
on D1receptors.
2. Improvement in parkinsonian symptoms occurs within 11/2
-
1 hr of an oral dose of
bromocriptine and lasts for 6-10 hours.
3. often produce intolerable side effects- vomiting, hallucinations, hypotension, nasal stuffiness,
conjunctival injection.
4. Marked fall in BP with the 'first dose' has occurred in some patients, especially those on
antihypertensive medication
5. In parkinsonism, bromocriptine is used only in late cases as a supplement to levodopa
6. starting with low doses (1.25 mg once at night) and gradually increasing as needed upto 5-10
mg thrice daily.
7. serves to improve control and smoothen 'end of dose' and 'on-off' fluctuations..
12. 8. Dyskinesias are less prominent with bromocriptine compared to levodopa
Ropinirole and Pramipexole
1. These are two recently developed nonergoline, selectiveD2 /D3receptor agonists with
negligible affinity for D1and non-dopaminergic receptors.
2. Pramipexole has relatively greater affinity for D3 receptors.
3. Better tolerated than levodopa with fewer gasrointestinal symptoms.
4. Ropinirole and pramipexole are now frequently used as monotherapy for early PD
5. Use of these DA agonists may be associated with slower rate of neuronal degeneration
6. newer DA agonists are effective alterative to levodopa and afford longer symptom-free
life to PD patients.
7. Ropinirole is rapidly absorbed orally, 40% plasma protein bound, extensively
metabolized, mainly by hepatic CYP1A2, to inactive metabolites.
8. Elimination rate- t1/2 -
6 hrs.
13. 9. longer acting than levodopa, useful in the management of motor fluctuations and reducing
frequency of on-off effect.
10. Side-effects are nausea, dizziness, hallucinations, and postural hypotension.
11. Episodes of day time sleep have been noted with ropinirole as well as pramipexole.
12. The higher incidence of hallucinations and sleepiness may disfavour their use in the
elderly.
13. Ropinirole has recently been approved for use in ‘restless leg syndrome'.
Ropinirole: Starting dose is 0.25 mg TDS, titrated to a maximum of 4-8 mg TDS. Early
cases generally require 1-2 mg TDS
ROPITOR 0.25, 0 5, 1.0, 2.0 mg tabs ROPITO & ROPARK, ROPEWAY 0.25, 0.5, 1.0,
20 mg tabs
.
14. MAO-B INHIBITOR
Selegiline (Deprenyl)
1. It is a selective and irreversible MAO-B inhibitor.
2. Two isoenzyme forms of MAO, termed MAO-A and MAO-B are recognized
3. both are present in periphera adrenergic structures and intestinal mucosal while the
latter predominates in the brain and blood platelets
4. Selegiline alone has mild antiparkinsonian action
5. Administered with levodopa, it prolongs levodopa action, attenuation motor
fluctuations and decrease wearing off effect.
6. Adverse effects
i) Postural hypotension, confusion, accentuation of levodopa induced involuntary
movements and psychosis.
ii) Contraindicated in patients with convulsive disorder
iii) Selegeline interacts with pethidine causing, excitement, rigidity, hyperthermia,
respiratory depression
iv) It may also interact with tricyclic antidepressants and selective serotonin reuptake
inhibitors.
ELDEPRYL 5, 10 mg tab; SELERIN,
Dose; 5 mg with breakfast and with lunch
15. COMT INHIBITORS
1. Two selective, potent and reversible COMT inhibitors Entacapone and Tolcapone have
been introduced as adjuvants to levodopa-carbidopa for advanced PD.
2. When peripheral decarboxylation of levodopa is blocked by carbidopa / benserazide, it is
mainly metabolized by COMT to 3-O-methyldopa
3. Blockade of this pathway by entacapone / tolcapone prolongs the t1/2 of levodopa and
allows a larger fraction of administered dose to cross to brain.
4. Since COMT plays a role in the degradation of DA in brain as well, COMT inhibitors
could preserve DA formed in the striatum and supplement the peripheral effect.
5. However, entacapone acts only in the periphery (probably because of short duration of
action -2 hr)
6. Both entacapone and tolcapone enhance and prolong the therapeutic effect of levodopa-
carbidopa in advanced and fluctuating PD
7. They may be used to smoothen 'wearing off', increase 'on' time, decrease 'off' time,
improve activities of daily living and allow levodopa dose to be reduced. They are not
indicated in early PD cases
8. Tolcapone: 100-200 mg BD or TDS
9. Worsening of levodopa adverse effects such as nausea, vomiting, dyskinesia, postural
hypotension, hallucinations, etc. occurs often when a COMT inhibitor is added.
However, this can be minimized by adjustment of levodopa dose
10. Other prominent side effect is diarrhoea in 10-18% patients (less with entacapone and
yellow orange discoloration of urine
16. 11. Because of reports of acute fatal hepatitis and rhabdomyolysis, tolcapone has been
suspended in Europe and Canada, while in USA its use is allowed only in those not
responding to entacapone.
12. Entacapone is not hepatotoxic.
DOPAMINE FACILITATOR
Amantadine :
1. Developed as an antiviral drug for prophylaxis of influenza A2, it was found
serendipitously to benefit parkinsonism.
2. It acts rapidly but has lower efficacy than levodopa. though higher than anticholinergics
3. However, tolerance develops over months and the efficacy is lost
4. Amantadine appears to act by promoting presynaptic synthesis and release of DA in brain.
5. Action on NMDA type of glutamate receptors, through which the striatal dopaminergic
system exerts its influence is now considered to be more important.
6. Amantadine can be used in milder cases, or in short courses to supplement levodopa for
advanced cases. In the latter situation, it servesto suppress motor fluctuations and abnormal
movements.
7. Fixed dose of 100 mg BD is used (not titrated according to response). Effect of a single
dose lasts 8-12 hours
17. Side effects : These are generally not serious:
a) insomnia, b) dizziness, c) confusion, d) nightmares,
anticholinergic effects and rarely hallucinations. A characteristic side effect due to local release
of CAs resulting in vasoconstriction is livedo reticularis and edema of ankles
Side effects are accentuated when it is combined with anticholinergics.
CENTRAL ANTICHOLINERGICS
1. These are drugs having a higher central : peripheral anticholinergic action ratio than
atropine, but the pharmacological profile is similar to it.
2. Certain H1, antihistaminics have significant central anticholinergic property.
3. All anticholinergics produce 70-25% improvement in clinical features, lasting 4-8
hours after a single dose.
4. The overall efficacy is much lower than levodopa. However, they are cheap and produce
less side effects than levodopa.
5 Anticholinergics are the only drugs effective in drug (phenothiazine) induced parkinsonism.
livedo reticularis- A common cutaneous finding consisting of a mottled reticulated
vascular pattern that appears like a lace-like purplish discoloration of the lower extremities