This document discusses drugs, dosage forms, and their importance. It begins by defining a drug as a chemical agent for treating disease in humans or animals. Dosage forms are means of delivering drugs to the body. Proper dosage forms are needed for accurate dosing, ease of administration, protection from degradation, and modifying drug effects. The document then covers various oral and topical dosage forms like tablets, capsules, liquids, ointments and creams. It describes their composition, characteristics and purposes. The goal is to educate students on preparation techniques and dosage form selection.
Liquid dosage forms are effective pharmaceutical products containing a mixture of active pharmaceutical ingredients (API/Drug) and non drug components (excipients). It is a dose of a drug used as a medicine for consumption or administration. Many liquid dosage forms are used in the pharmacy, but the most commonly used are syrup, suspension, and elixirs. The general category of liquid oral doses includes a broad range of dosage forms, broadly classified as monophasic and biphasic. Whereas dosage forms in both types comprise at least one drug, monophasic forms are homogeneous and completely dissolve in liquid, whereas biphasic forms in a vehicle do not dissolve.
Liquid dosage forms are effective pharmaceutical products containing a mixture of active pharmaceutical ingredients (API/Drug) and non drug components (excipients). It is a dose of a drug used as a medicine for consumption or administration. Many liquid dosage forms are used in the pharmacy, but the most commonly used are syrup, suspension, and elixirs. The general category of liquid oral doses includes a broad range of dosage forms, broadly classified as monophasic and biphasic. Whereas dosage forms in both types comprise at least one drug, monophasic forms are homogeneous and completely dissolve in liquid, whereas biphasic forms in a vehicle do not dissolve.
Dosage forms come in many types, depending on the method or route of administration. Solid dosage forms, semi-solid dosage forms, liquid dosage forms, and gaseous dosage forms are used for the diagnosis or treatment of the disease by various routes. Solid dosage forms are the most significant dosage forms in pharmaceuticals; it has one or more unit dose of medicament. The solid dosage form is the most commonly used and prescribed by doctors as compared to other dosage forms. It can be administered orally in the form of tablets, capsules, powders, etc. Of these, the tablet is one of the most commonly used oral solid dosage forms.
Basic principles of compounding and dispensing MANIKImran Nur Manik
Weight, measure and units calculation for compounding and dispensing. Fundamental operation in compounding. Good pharmaceutical practices in compounding and dispensing. Containers and closures for dispensed products. Responding to prescription, labeling of dispensed medications.
Dosage forms come in many types, depending on the method or route of administration. Solid dosage forms, semi-solid dosage forms, liquid dosage forms, and gaseous dosage forms are used for the diagnosis or treatment of the disease by various routes. Solid dosage forms are the most significant dosage forms in pharmaceuticals; it has one or more unit dose of medicament. The solid dosage form is the most commonly used and prescribed by doctors as compared to other dosage forms. It can be administered orally in the form of tablets, capsules, powders, etc. Of these, the tablet is one of the most commonly used oral solid dosage forms.
Basic principles of compounding and dispensing MANIKImran Nur Manik
Weight, measure and units calculation for compounding and dispensing. Fundamental operation in compounding. Good pharmaceutical practices in compounding and dispensing. Containers and closures for dispensed products. Responding to prescription, labeling of dispensed medications.
The means (or the form) by which drug molecules are delivered to sites of action within the body.
The drugs are rarely administered in their original pure state. They are administered in different dosage forms after converting them into a suitable formulation.
The dosage form is a combination of the drug and different kinds of non-drug compounds called “additives”.
Let's Know About Your Drugs ,,, Part - III ( Dosage Forms and Drug Delivery Systems) for study purpose pharmaceutical professional such as students and other specialized field. Presentation for "LEARN & EARN KNOWLEDGE" based.
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Making of preparations involves different techniques, shall train a learner to be competant enough to know the importance of solution in different dosage form.
It will make learners understand the borderline concepts related with different system, shall train a students to be competent enough to know about the same.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
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India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
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Pharmaceutical drug and dosage forms
1. 1
Pharmaceutical
Drug & Dosage Forms
Asst. Prof. Om M. Bagade
M. Pharm, D. I. P. L, Ph
D Pursuing
Department of
Pharmaceutics
2. Objective:
To make students understand regarding the
Meaning of Drug, Dosage forms & their
methods of preparations & its importance.
Outcome:
Making of preparations involves different
techniques, shall train a students to be compe
tant enough to know about different dosage
form.
3. 3
Drug :
A drug may be defined as a chemical agent
intended for diagnosis, treatment, cure,
prevention of diseases in humans and
animals.
Dosage Form :
Dosage forms are the means by which drug
molecules are delivered to site of action
within the body.
4. 4
Need for dosage forms :
1. Accurate dose ( for smaller dose drugs e.g. Alprazolam 25
mg, Telmisartan 50 mg).
2. Easy to handle, easy to administer ( Because of definite size,
shape, strength) Example- Tablets are easy to handle,
Liquids are easy to swallow.
3. Greater accuracy when we compare tablet with
powder/liquids
4. Less microbial contamination ( Tablet is less prone as
compared to liquids)
4. Protection e.g. coated tablets, sealed ampoules.
5. Protection from gastric degradation ( Insulin administered as
Subcutaneous route).
5. 5
6. Masking taste and odour.
7. For rapid onset of action ( comparison of i.v injection
with tablet)
8. For local or systemic effects through body cavities. E.g.
eye drops, enemas, nasal drops
9. For local or systemic effects through topical
application e.g. ointment, creams, jellies .
7. To modify duration of action e.g dispersable tablets,
sustain release medication, Controlled release
medication.
8. Optimal drug action.
9. Insertion of drugs into body cavities ( e.g rectal,
vaginal)
10. To improve palatability ( colour, odour, taste)
6.
7. 7
I) According to Physical Form and Route of
AdministrationA) A) A) Route of administration
B) Physical form
Oral Solid
Topical Semisolid
Rectal liquid
Parenteral
Vaginal, Inhaled, Ophthalmic
II ) According to Sterility
a) Sterile Dosage forms- e.g. injections
b) Non-sterile Dosage forms- e.g. tablets, capsules, liquids
III ) According to Dose Accuracy-
a) Unit : Tab, Cap, Pow, Pills, Lozenges, Cachets
Types of Dosage Forms :
8.
9.
10.
11.
12.
13. 13
Oral dosage forms:
1. Tablet:
A tablet is a hard, compressed medication in round, oval or
square shape intended to be taken orally.
The excipients/ additives include:
a) Binders, glidants (flow aids) and lubricants to ensure
efficient tabletting process.
b) Disintegrants to ensure that the tablet breaks up in the
digestive tract.
c) Sweeteners or flavours to mask the taste of bad-tasting active
ingredients.
d) Pigments ( colors) to make uncoated tablets visually
attractive.
.
14. 14
1-Tablet (Cont.)
A coating may be applied to:
1. Mask the taste of the tablet's components.
2. Make the tablet smoother and easier to
swallow
3. Make it more resistant to the environment.
4. Extending its shelf life.
15. 15
2. Buccal and Sublingual Tablet:
a. Sublingual and buccal medications are administered
by placing them in the mouth, either below the
tongue (sublingual) or between the gum and the
cheek (buccal).
b. The medications dissolve rapidly and are absorbed
through the mucous membranes of the mouth, where
they enter into the bloodstream.
c. Avoid the acid and enzymatic environment of the
stomach and the drug metabolizing enzymes of the
liver.
16. 16
3. Effervescent Tablet:
Effervescent tablets are uncoated tablets that
generally contain acid substances (citric and
tartaric acids) and carbonates or bicarbonates and
which react rapidly in the presence of water by
releasing carbon dioxide.
. They are intended to be dissolved or dispersed in
water before use providing:
A. Very rapid tablet dispersion and dissolution.
B. Pleasant tasting carbonated drink.
17. 17
4. Chewable tablet:
1. They are tablets that chewed prior to swallowing.
2. They are designed for administration to children e.g.
vitamin products.
5. Enteric coated tablet:
They have delay release features, they are designed to
pass unchanged through stomach to intestine
6. Immediate Release tablet:
I.R tablets are designed to disintegrate and release their
medication with no special rate controlling feature
such as coating.
18. 18
5. Capsule:
A Capsules are solid dosage forms in which drug along with the
dditives are enclosed in a small shell of gelatin.
Advantage: mask the unpleasant taste of its contents.
Two main types :
1. Hard-Shelled Capsules, which are normally used for dry,
powdered ingredients.
Hard empty capsule shells are made of gelatin, sugar, and
water.
2. Soft-Shelled Capsules, primarily used for oils and for active
ingredients that are dissolved or suspended in oil.
Soft shelled capsule are made of gelatin to which glycerin/
Sorbitol has been added.
Soft gelatin capsuleHard gelatin capsule
19. 19
6. Lozenge/ Trouches :
Lozenges are round disc, oblong, triangular, shaped solid
dosage forms intended to be sucked.
It is a solid preparation consisting of high proportion of
sugar ( Sweetening agent) and gum (Base )
along with the drug.
The gum gives strength and cohesiveness to the lozenge
and facilitating slow release of the medicament.
It is used to medicate the mouth and throat for the slow
administration of indigestion or cough remedies.
20. 20
7. Pastilles :
They are solid medicated preparations designed to dissolve
slowly in the mouth.
They are softer than lozenges and their bases are either
glycerol and gelatin, or acacia and sugar.
8. Dental Cones :
1. A tablet form intended to be placed in the empty socket
following a tooth extraction, for preventing the local
multiplication of pathogenic bacteria associated with
tooth extractions.
2. - The cones may contain an antibiotic or antiseptic drugs.
21. 21
9. Pills:
Non compressed dosage form.
Pills are oral dosage forms which consist of
spherical masses prepared from one or more
medicaments incorporated with inert excipients
intended for oral use.
Pills are now rarely used.
Smallness and spherical shape are easy to
swallow.
22. 22
10. Granules:
Consist of solid, dry aggregates of powder particles
often supplied in single-dose sachets.
Some granules are placed on the tongue and
swallowed with water, others are intended to be
dissolved in water before taking.
Effervescent granules evolve carbon dioxide when
added to water.
23. 23
11. Powder (Oral) :
Two kinds of powder intended for internal use.
1. Bulk Powders are multi-dose preparations consisting of solid,
loose, dry particles of varying degrees of fineness. Contain one
or more active ingredients ( Drug), with or without excipients
and, if necessary, coloring matter and flavoring substances.
Usually contain non-potent medicaments such as antacids
since the patient measures a dose by volume using a 5ml
medicine spoon.
The powder is then usually dispersed in water or, in the case
of effervescent powders, dissolved before taking.
2. Divided Powders are single-dose preparation of powder ( for
example, a small sachet) that are intended to be issued to the
24. 24
12. Powders for mixtures:
1. The mixed powders may be stored in dry form
and mixture prepared by the pharmacist when
required for dispensing , by suspending the
powders in the appropriate vehicle.
2. ( Dry powder for reconstitutuion)
25.
26. 26
13. Liquid Preparations:
a. Oral solution:
Oral solutions are clear Liquid preparations for oral use
containing one or more active ingredients dissolved in a
suitable vehicle.
b. Oral emulsion:
Oral emulsions are stabilized oil-in-water dispersions,
either or both phases of which may contain dissolved solids.
c. Oral suspension:
1. Oral suspensions are Liquid preparations for oral use
containing one or more active ingredients suspended in a
suitable vehicle.
2. Oral suspensions may show a sediment which is readily
dispersed on shaking to give a uniform suspension which
27. 27
13. Liquid preparations (Cont.):
d. Syrup:
A. It is a concentrated aqueous solution of a sugar, usually
sucrose. Or It is sweet viscous saturated solution of sucrose.
B. Flavored syrups are a convenient form of masking
disagreeable tastes.
e. Elixir:
A. It is pleasantly flavored, sweetened clear hydro-alcoholic
liquid oral preparation of potent or nauseous drugs.
B. The vehicle may contain a high proportion of antimicrobial
preservatives which confers the stability of the preparation.
28. 28
13. Liquid Preparations (Cont.):
f. Linctuses:
Linctuses are viscous, liquid oral preparations that are
usually prescribed for the relief of cough.
They usually contain a high proportion of syrup and
glycerol which have a demulcent effect on the membranes
of the throat.
The dose volume is small (5ml) and, to prolong the
demulcent action, they should be taken undiluted.
g. Oral drops ( Paediatric Drop):
Oral drops are Liquid preparations for oral use that are
intended to be administered in small volumes with the aid
of a suitable measuring device. They may be solutions,
suspensions or emulsions.
29. 29
13. Liquid preparations (Cont.):
h. Gargles:
They are aqueous solutions used in the prevention or
treatment of throat infections.
Usually they are prepared in a concentrated solution with
directions for the patient to dilute with warm water before
use.
Gargles are used to relieve soreness in mild throat
infection.
i. Mouthwashes:
These are similar to gargles but are used for oral hygiene and
30. 30
J. Glycerites :
Glycerite are viscous, it contain higher
proportion of glycerin intended to be
applied externally.
The drugs mostly used are antiseptic.
31.
32. 32
Topical Dosage Forms:
1. Ointments:
Ointments are semi-solid, greasy preparations for
application to the skin, rectum or nasal mucosa.
The base is usually
a) Oleaginous Base
b) Absorption base
c) Emulsifying Base
d) Water soluble base.
Ointments may be used as emollients or to apply
suspended or dissolved medicaments to the skin.
33. 33
Topical Dosage Forms (Cont.):
2. Creams:
Creams are semi-solid emulsions, that is mixtures of oil and
water.
A. Oil-in-water (O/W) : which are composed of small
droplets of oil dispersed in a continuous aqueous phase.
Oil-in-water creams are more comfortable and cosmetically
acceptable as they are less greasy and more easily washed
off using water.
B. Water-in-oil (W/O) : which are composed of small
droplets of water dispersed in a continuous oily phase.
These are more difficult to handle but many drugs which are
incorporated into creams are hydrophobic and will be
released more readily from a water-in-oil cream than an
oil-in-water cream.
These are also more moisturising as they provide an oily
barrier which reduces water loss from the stratum
34. 34
Topical dosage forms (Cont.):
3. Gels (Jellies) :
Gels are semisolid system in which a liquid phase is
constrained within a natural or synthetic gum having a
high degree of physical or chemical cross-linking.
They are used for medication, lubrication and some
miscellaneous applications like carrier for spermicidal
agents to be used intra vaginally .
4. Poultice :
It is soft, viscous, pasty preparation for external use. They
are applied to skin while they are hot. Poultice must retain
heat for a considerable time because they are intended to
supply warmth to inflamed parts of body.
E.g. Kaolin poultice (B. P. C.)
35. 35
Topical dosage forms (Cont.):
5. Pastes :
Pastes are basically ointments into which a high
percentage of insoluble solid has been added ( 20 to
50 %)
There are two types of paste:
a) Fatty pastes (e.g: leaser's paste) .
b) Non greasy pastes ( e g: - bassorin paste).
36. 36
Topical dosage forms (Cont.):
6. Dusting powders:
These are free flowing very fine powders for
external use.
Not for use on open wounds unless the
powders are sterilized.
37. 37
Topical dosage forms (Cont.):
7- Transdermal patch:
-A transdermal patch or skin patch is a medicated
adhesive patch that is placed on the skin to deliver a
specific dose of medication through the skin into the
bloodstream.
-An advantage of a transdermal drug delivery route
over other types such as oral, topical, etc is that it
provides a controlled release of the medicament into the
patient.
-The first commercially available patch was
scopolamine.
-Diclofenac Na transdermal patch is available in indian
38. 38
Topical dosage forms (Cont.):
8-Plasters:
- Plasters are solid or semisolid masses adhere to the
skin when spread upon cotton felt line or muslin
as a backing material and they are mainly used to,
A- Afford protection and mechanical support.
B- Furnish an occlusive action.
C- Bring medication into close contact with the
surface of the skin.
39. 39
Topical dosage forms (Cont.):
9- Liniments:
- Liniments are solution or emulsion in an aqueous
or oily vehicle intended for massage onto
unbroken skin.
- They may be alcoholic or oily solutions or
emulsions.
- Most are massaged into the unbroken skin (e.g.
counter-irritant, Rubefacient).
- Liniments should not be applied to broken skin.
40. 40
10-Lotions:
- These are fluid preparations (aqueous) for
external application without friction.
- They are either dabbed on the skin or
applied on a suitable dressing and covered
with a waterproof dressing to reduce
evaporation.
41. 41
11- Collodion:
Collodions are non-aqueous solution of pyroxylin in
ether or alcohol, with or without medicament intended
for massage onto unbroken skin.
-Its generic name is pyroxylin solution.
-It is highly flammable.
- As the solvent evaporates, it dries to form a film. Film
repels water and prevent contact of water with minor
cuts and wounds.
42. 42
12- Paints :
- Paints are liquids for application to the skin or
mucous membranes.
- Skin paints contain volatile solvent that
evaporates quickly to leave a dry resinous film of
medicament.
- Throat paints are more viscous due to a high
content of glycerol, designed to prolong contact
of the medicament with the affected site.
43. 43
13- Pressurized dispensers (aerosol sprays):
- Several different types of pharmaceutical product may be
packaged in pressurized dispensers, known as aerosols.
- Surface sprays produce droplets of 100 um diameter or
greater.
- May be used as surface disinfectants, wound or burn
dressing, relieve irritation of bites.
- Spray-on dusting powders are also available from
pressurized containers.
44. 44
Rectal dosage forms:
1- Suppository:
It is a small solid medicated mass, usually
cone-shaped, that is inserted either into the
rectum (rectal suppository), vagina (vaginal
suppository or pessaries) where it melts at
body temperature .
45. 45
2- Enema:
An enema is the procedure of introducing liquids into
the rectum and colon via the anus.
Types of enema:
1- Evacuant enema: used as a bowel stimulant to treat
constipation. E.g. soft soap enema & Magnessium
sulphate enema.
- The volume of evacuant enemas may reach up to 2
liters.
- They should be warmed to body temperature before
administration.
46. 46
2- Retention enema:
- Their volume does not exceed 100 ml.
- No warming needed.
- May exert:
A- Local effect: e.g. a barium enema is used as a
contrast substance in the radiological imaging of the
bowel.
B- Systemic effect:
e.g. the administration of substances into the
bloodstream. This may be done in situations where it
is impossible to deliver a medication by mouth, such
as antiemetics.
e.g. nutrient enema which contains carbohydrates,
vitamins & minerals.
47. 47
Vaginal dosage forms:
1- Pessary:
- Pessaries are solid medicated preparations designed for
insertion into the vagina where they melt or dissolve.
- There are three types:
A- Moulded pessaries: they are cone shaped and prepared in a
similar way to moulded suppositories.
B- Compressed pessaries: made in a variety of shapes and are
prepared by compression in a similar manner to oral tablets.
C- Vaginal capsules: are similar to soft gelatin oral
Capsules differing only in size and shape.
48. 48
Sterile Dosage forms
Sterile Dosage forms are completely free from
microorganisms.
These includes injections, eye preparations
( opthalmic), vaccines, blood product etc.
I) Parentral Dosage forms-
Word parenteral- Greek word- para ( Besides),
enteron (Gut).
49. 49
Parenteral dosage forms:
Definition- A parentral can be defined as sterile fluid that does
not utilize gastrointestinal tract for entry into body tissues
and is packed in a manner suitable for administration by
hypodermic injection.
Injection are sterile, pyrogen free preparation intended to be
administered in the skin layers, muscle, veins or in
particular organ for rapid drug action.
There are several methods of injection, including:
1-An intravenous injection:
It is a liquid administered directly into the bloodstream via a
vein.
It is advantageous when a rapid onset of action is needed.
50. 50
2- Intramuscular injection:
-It is the injection of a substance directly into a muscle.
- Many vaccines are administered intramuscularly.
-Depending on the chemical properties of the drug, the
medication may either be absorbed fairly quickly or more
gradually.
- Intramuscular injections are often given in the deltoid,
vastus lateralis, ventrogluteal and dorsogluteal muscles.
-small volume fluid up to 2 ml is injected
51. 51
3- Subcutaneous injection:
given by injecting a fluid into the subcutaneous
tissue, layer of skin directly below the dermis and epidermis
Subcutaneous injections are highly effective in administering
vaccines and such medications as insulin.
small volume fluid up to 2 ml is injected
4 - Intradermal injection:
only small volume fluid up to 0.1 ml is injected into superficial
layer of skin
5 - Intracardiac injection:
Intracardiac injections are given into heart, usually in
emergency situation such as cardiac arrest.
52. 52
II) Inhaled dosage forms:
1- Inhaler :
- Inhalers are solutions, suspensions or emulsion of drugs in
a mixture of inert propellants held under pressure in an
aerosol dispenser.
- Release of a dose of the medicament in the form of
droplets of 50 um diameter or less from the container
through a spring-loaded valve incorporating a metering
device. The patient then inhales the released drug through
a mouthpiece.
- In some types, the valve is actuated by finger pressure, in
other types the valve is actuated by the patient breathing in
through the mouthpiece.
- It is commonly used to treat asthma and other respiratory
53. 53
2- Nebulizer or (atomizer):
A nebulizer is a device used to administer medication to
people in forms of a liquid mist to the airways.
- It is commonly used in treating asthma, and other
respiratory diseases.
54. 54
III) Ophthalmic dosage forms:
1- Eye drops:
Eye drops sterile, saline-containing drops used as a vehicle to
administer medication in the eye.
Depending on the condition being treated, they may contain drugs
such as steroids, antihistamines or topical anesthetics.
Eye drops sometimes do not have medications in them and are only
lubricating and tear-replacing solutions.
2- Ophthalmic ointment & gel:
These are sterile semi-solid
Preparations intended for application
to the conjunctiva or eyelid margin.
3- Ocuserts : They are inserted into the cul-de-sac of eye. It is an
elliptical device designed for continous release of pilocarpin follwing
placement in cul-de-sac .
55. 55
They are small, rod shaped, sterile solid mass consisting of
drug with or without excipients / additives put in place
by injection or incision into body tissues.
Example- Polifeprosan 20 is used to control local delivery
of carmustine.
III Implants :
56. 56
Otic dosage forms:
1- Ear drops:
- Ear drops are solutions, suspensions or emulsions of
drug in water, glycerin, propylene glycol that are
instilled into the ear with a dropper.
- It is used to treat or prevent ear infections, especially
infections of the outer ear and ear canal, removal of ear
wax.
57. 57
Nasal dosage forms:
1- Nasal Drops and Sprays:
Nasal solutions are aqueous or oily monophasic liquid
rendered isotonic and slightly buffered to maintain
pH of 5.5 to 6.5.
The use of oily nasal drops should be avoided because of
possible damage to the cilia of the nasal mucosa.
58. What Do you Think about
following . . .
Q.1. Define Drug and different Dosage forms.
Q.2. Explain in detail the merits and demerits of
each dosage form?
Q.3. State the importance of Dosage forms in
pharmacy?