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Preparation of suppository
This document describes three methods for preparing suppositories: molding, compression, and hand rolling and shaping. Molding involves melting the base, adding any medication, pouring the melt into molds, allowing it to cool and harden, and removing the formed suppositories. Compression uses a machine to compress a mixture of base and ingredients into shaped suppositories. Hand rolling is the oldest method and involves mixing medication into a base, rolling it into rods by hand, cutting the rods, and shaping the pieces. Each method has advantages like simplicity or avoiding heating, and disadvantages like possible air entrapment or requiring special skills.
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Preparation of suppository
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- 2. TYPES OF SUPPOSITORY Suppositoriesare prepared by three methods:- • Molding • Compression • Hand rolling and shaping
- 3. MOLDING Melting the base Incorporating any required medicament Pouringthe melt into molds Allowing the melt to cool and congeal into suppositories Removing the formed suppository from the mold The steps in molding include :-
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- 5. ADVANTAGES • It isa simple process • More elegant than hand rolling • No solid sedimentation in the base
- 8. Compression:- Base and other formulativeingredients are mixed Suppository mass is placed in a cylinder The cylinder is closed,pressure is applied on one end When mold is filled ,movable end plate is removed The formed suppositories are ejected The steps are:-
- 9. ADVANTAGES • It isa simple method. • It gives suppositories that are more elegant than hand molded suppositories. • In this method sedimentation of solids in the base is prevented. • Suitable for heat labile medicaments.
- 10. DISADVANTAGES • Air entrapmentmay take place. • This air may cause weight variation. • The drug and/or the base may be oxidized by this air.
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- 12. HAND ROLLING ANDSHAPING The drug is made into fine powdef Incorporated into supoository base By trituration and kneading Mass is rolled into rod shaped by fingures Rods are cut into pieces Desired shape is given by hands • It is the oldest and simplest method. The steps involve :-
- 13. ADVANTAGES • It hasthe advantage of avoiding the necessity of heating the cocoa butter • No heating • No Mold Preparation
- 14. DISADVANTAGES • Manupilation requiresconsiderable skill • Appearance is not elegant