This document discusses various types of liquid dosage forms including pharmaceutical solutions, galenicals, decoctions, infusions, percolations, douches, enemas, gargles, washes, juices, sprays, sweeteners, honey, mucilage, jellies, and non-aqueous solutions. Pharmaceutical solutions are homogenous mixtures that can be aqueous or non-aqueous depending on the solubility of the drug. Various extraction and preparation methods are covered for obtaining active ingredients from plants into liquid forms. The uses and formulations of different oral and topical liquid medications are also outlined.
A medicinal preparation which is prepared by extraction of crude vegetable drugs (active principles) with suitable solvent. The term is now used to denote standard preparations containing one or more active constituents of a plant and made by a process that leaves the inert and other undesirable constituents of the plant un-dissolved. This is known as Extraction.
A medicinal preparation which is prepared by extraction of crude vegetable drugs (active principles) with suitable solvent. The term is now used to denote standard preparations containing one or more active constituents of a plant and made by a process that leaves the inert and other undesirable constituents of the plant un-dissolved. This is known as Extraction.
In this presentation viewers will able to learn about liquids for external use such as liniments and lotions, liquids for oral cavity such as mouthwash, throat paints and gargles.
This practical manual is prepared for academic purpose only and contains introduction and detail methodology regarding determination of numbers of starch grains by Lycopodium spore method, along with dummy readings to facilitate understanding of calculations thereof.
In the changing scenario of pharmacy practice in India, for successful practice of
Hospital Pharmacy, the students are required to learn various skills like drug distribution,
drug dispensing, manufacturing of parenteral preparations, drug information, patient
counselling, and therapeutic drug monitoring for improved patient care
In this presentation viewers will able to learn about liquids for external use such as liniments and lotions, liquids for oral cavity such as mouthwash, throat paints and gargles.
This practical manual is prepared for academic purpose only and contains introduction and detail methodology regarding determination of numbers of starch grains by Lycopodium spore method, along with dummy readings to facilitate understanding of calculations thereof.
In the changing scenario of pharmacy practice in India, for successful practice of
Hospital Pharmacy, the students are required to learn various skills like drug distribution,
drug dispensing, manufacturing of parenteral preparations, drug information, patient
counselling, and therapeutic drug monitoring for improved patient care
A brief description of pharmaceutical dosage forms and their route of administration and typical process flow and manufacturing details. It may help new aspirants who wnts to knoiw aboute dosageforms and their administration routes.
This presentation describe that which components are employed or introduced in the solution to achieve best dosage form and to acquire chemical and physical stability of the solutions. After go through this presentation the individual will be able to understand the solution ingredients and their role in this dosage form.
This presentation describe that which components are employed or introduced in the solution to achieve best dosage form and to acquire chemical and physical stability of the solutions. After go through this presentation the individual will be able to understand the solution ingredients and their role in this dosage form.
Pharmaceutical Technology-I ,Lab manual
1. Preparation of percent solution and calculation.
2. Preparation of aromatic water.
3. Preparation of syrups.
a) Phenobarbitione-Na syrup.
b) Chlorpheniramine maleate syrup.
c) Promethazine-HCl syrup.
d) Iron syrup.
4. Preparation of suspensions
a) Paracetamol suspension
b) Antacid suspension
c) Chalk powder suspension
5. Preparation of emulsion and identification of type of emulsion
a) Primary emulsion by dry gum method and wet gum method
b) Castor oil emulsion
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
Liquid dosage forms
1. Liquid Dosage Forms
Dr. Basavaraj K. NanjwadeM. Pharm., Ph. D
Department of Pharmaceutics
Faculty of Pharmacy
Omer Al-Mukhtar University
Tobruk, Libya.
E-mail: nanjwadebk@gmail.com
15/04/2015 1
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
2. CONTENTS
15/04/2015 2
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
1. Pharmaceutical solutions
(a) Classifications.
(b) Aqueous solutions (waters and preparation).
(c) Peppermint water.
(d) Solutions and their preparations.
2. Galenicals and their preparations.
3. Decoction, infusion, percolation solutions.
4. Douches and Enemas.
5. Gargles, Washes, Juices and Sprays.
6. Sweetener or other viscid solutions.
7. Honey, Mucilage and Jellies.
8. Non-aqueous solutions (colloids).
9. Elixirs, Glycerites, Liniments.
10. Oleo vitamins-Spirits and drops.
3. 1. Pharmaceutical solutions
• Pharmaceutical solutions are a homogenous one-
phase system.
• Pharmaceutical solutions are liquid dosage forms that
prepared by dissolving the active ingredients in an
aqueous or non-aqueous solvents.
• Consists of one or several soluble substances (solute)
dissolved in vehicle (solvent).
• The vehicle is defined as the liquid in which the
active ingredients are dissolved or suspended.
• Solvent: greater quantity (water), Solute: smaller quantity (sugar)
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
3
4. (a) Classifications
1. Aqueous solutions: water is the most widely used
as a solvent.
2. Non-aqueous solutions: If the drugs insoluble
(griseofluvin) or unstable (e.g. methylpenicillin) in
aqueous systems, it is necessary to use alternative
systems such as oils, alcohols, liquid paraffin,
glycerol.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
4
5. (b) Aqueous solutions
(waters and preparation)
• Aqueous solutions are the most prevalent of the oral
solutions. Drugs are dissolved in water along with
any necessary flavorings, preservatives, or buffering
salts.
• Distilled or purified water should always be used
when preparing pharmaceutical solutions.
The following are examples of aqueous pharmaceutical solutions.
• Syrups e.g. Syrup USP, Wild Cherry Syrup USP.
• Aromatic waters e.g. Peppermint Water, USP.
• Mucilages e.g. Acacia Mucilage; Tragacanth Mucilage.
• Aqueous acids
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
5
6. (c) Peppermint water
Formula (Ref. U.S.P. XVII)
Peppermint oil -------------02 ml
Purified water to add -----1000 ml
• Method of preparation: It is prepared by dissolving
2 ml of peppermint oil in purified water by occasional
shaking for twelve hours or overnight. It is then
filtered.
• Use: As a flavoring agent and carminative
• Dose: 15 to 30 ml
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
6
7. (d) Solutions and their
preparations
• Definition: When two or more liquid substances are
mixed together chemically and physically, a
homogeneous mixture is obtained. This mixture or the
product is termed as solution.
• Sometimes, alcohol or glycerine is added as a
preservative or to facilitate in getting a clear solution
• It is presumed that the particles of the substances go to
the their molecular dimensions. Depending upon the
size of the dispersed particles, the product is termed as
either true solution, colloidal solution or suspension.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
7
8. (d) Solutions and their
preparations
1. Coal Tar Solution
2. Cresol with Soap Solution
3. Formaldehyde Solution
4. Hydrogen Peroxide Solution
5. Aqueous Iodine Solution
6. Weak Iodine Solutions
7. Strong Ammonium Acetate Solution
8. Surgical Chlorinated Soda Solution
9. Chloroxylenol Solution
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar
University, Tobruk, Libya.
8
9. 2. Galenicals and their
preparations
• Medicines prepared according to the formulae of Galen.
• A medicinal preparation composed mainly of herbal or
vegetable matter.
• It is prepared by extraction of crude vegetable drugs
(active principles) with suitable solvents.
• The term is now used to denote standard preparations
containing one or more active constituents of a plant and
made by a process that leaves the inert and other
undesirable constituents of the plant un-dissolved.
• E.g. Infusions, Decoctions, Fluid extracts, Semisolid
extracts, Dry extracts, Tinctures, Medical oils.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
9
10. Decoction solutions
• In this process, the drug is boiled with water for a
stated period usually 10 minutes. After boiling, the
liquid is strained and water is passed through the
content of the strainer to make the required volume.
• This process is mainly used for vegetable drugs of
hard and woody nature having thermo stable water
soluble constituents.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
10
11. Infusion solutions
• It consists of pouring water over the drugs and then
allowing it to keep in contact with water for the stated
period, usually 15 minutes, with occasional stirring
and finally filtering off the liquid.
• The marc is not pressed. The boiling water is
commonly used as a solvent, since it has a greater
solvent action than cold water.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
11
12. Percolation solutions
• This method uses a percolator (coffee maker).
• The powdered material is packed in the percolator.
• Enough solvent is then poured to soak the powder.
• Then more solvent is poured and allowed to percolate
through the material.
• The extract is collected in a receiver.
• The process is continued until extraction is complete.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
12
13. Douches
• A douche is a medicated solution meant for rinsing a
body cavities, such as eyes, ear or nasal cavities for
cleaning or removing the foreign particles or
discharges from them.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar
University, Tobruk, Libya.
13
14. Enemas
• Enemas are aqueous or oily solutions, as well as
emulsions and suspensions, are available for the
rectal administration of medicaments for cleansing,
diagnostic or therapeutic reasons.
• A variety of drug are formulated as enemas and are
used to treatment conditions such as constipation or
ulcerative colitis.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
14
15. • Gargles are aqueous solutions used to prevent or treat
throat infections.
• They are usually available in concentrated form with
direction for dilution with warm water before use.
• They are brought into intimate contact with the mucous
membrane of the throat and are allowed to remain in
contact with it for a few seconds, before they are thrown
out of the mouth.
• They are used to relieve soreness in mild throat infection.
• It also stimulates secretion of saliva which relieves
dryness.
• Example:- Potassium Chloride and Phenol gargle
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
15
Gargles
16. Washes (Mouth Washes)
• These are aqueous solutions with a pleasant taste and
odour used to make clean and deodorise the buccal
activity.
• These are similar to gargles but are used specifically
to treat conditions of the mouth.
• Generally they contain antibacterial agents, alcohol,
glycerin, sweetening agents, flavouring agents and
colouring agents.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar
University, Tobruk, Libya.
16
17. Juices
• Juices are the liquid preparation containing
medicament meant for oral cavity.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar
University, Tobruk, Libya.
17
18. Sprays
• Sprays are preparations of drugs in which may be
aqueous, alcoholic or glycerin.
• They are supplied to the mucous membrane of nose
or throat with an atomizer.
• The throat-sprays must be sprayed from a special type
of atomizer known as nebulizer., which removes large
droplets by a baffling system.
• Only fine droplets are required so that they may reach
the lungs.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar
University, Tobruk, Libya.
18
19. 6. Sweetener or other
viscid solutions
• Sweetener can be sugar or non-sugar based, and is
used to improve the taste and sometimes the feel of a
liquid or chewable solid dosage form.
• To change the flavor, or mouth feel of a liquid.
• To improve the flavor of a chewable solid.
• Sugar based: Sucrose.
• Non-sugar based: Aspartame, Maltose, Sorbitol,
Sucralose.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
19
20. Honey
• Honey’s are thick liquid preparations somewhat allied
to the syrups, differing in that honey, instead of
syrup, is used as a base.
• Viscid solution: simple syrup.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
20
21. Mucilage
• The mucilage is a thick, viscid, adhesive liquids,
produced by dispersing gum in water or by extracting
the mucilaginous principles from vegetable
substances with water.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
21
22. Jellies
• Jellies are transparent or translucent, non-greasy,
semi-solid preparations mainly used for external
application to the skin.
• These are also used for lubricating catheters, surgical
gloves and rectal thermometers.
• The substances like gelatin, starch, tragacanth,
sodium alginate and cellulose derivative are used in
the preparation of jellies.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
22
23. 8. Non-aqueous solutions
(colloids)
• Non-aqueous colloidal dispersions are of high
importance to a wide range of industries.
• Oil based colloidal dispersions offer unique
challenges in formulation and managing the stability
of a colloidal dispersion in a non-polar environment
requires different strategies to those employed for
aqueous analogues.
• Successful formulation allows us access to a range of
unique properties such as solubility, polarity,
viscosity and density.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
23
24. Elixirs
• The terms mixture and elixir are often confused
although an elixir refers strictly to a solution of a
potent or nauseous drug.
• If the active agent is sensitive to moisture it may be
formulated as a falvoured powder or granulation by
the pharmaceutical industry and then simply
dissolved in water immediately prior to
administration.
• Dosage is usually given using a 5 ml medicine spoon
although smaller volumes can be given using a
volumetric dropper.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
24
25. Glycerites
• Glycerites are preparations that uses glycerin to
extract the constituents from an herb.
• Glycerin is both a solvent and a preservative and
good for preparing children’s remedies because of its
sweet taste and lack of alcohol.
• Such preparations can be stirred into juice.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
25
26. Liniments
• Liniments are liquid and semi-liquid preparations meant for
application to the skin.
• Liniments are usually applied to the skin with friction and
rubbing of the skin.
• The liniments may be alcoholic or oily solutions or emulsion.
• Alcohol helps in the penetration of medicaments into the skin
and also increase its counter-irritant or rubefacient action.
• Arachis oil is used in some liniments which spread more easily
on the skin.
• Soap is also included as ingredients in some the liniments
which helps in easy application of liniment on the skin.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
26
27. Oleo-vitamins
• These are fish-liver oils diluted with edible vegetable
oil or solutions of the indicated vitamins or vitamin
concentrates (usually Vitamin A and Vitamin D) in
fish-liver oil.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
27
28. Spirits
• Spirits are alcoholic or hydroalcoholic solutions of
volatile substances and contain 50% to 90% of alcohol.
• The high alcoholic contents maintain water-insoluble oils
in solution. If water is added to a spirit the oil acts
separated.
• Some spirits are used as flavouring agents e.g. compound
orange spirit, cardamum spirits etc. and some spirits are
used as medicinal agents e.g. aromatic ammonia spirit.
• Spirits are prepared by dissolving the volatile substances
in ethanol 90 % except aromatic spirit, prepared by
distillation method.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar
University, Tobruk, Libya.
28
29. Drops
• Ear Drops: These are simple solutions of drugs in
either water, glycerol, propylene glycol or
alcohol/water mixtures for local use and include
antibiotics, antiseptics, cleansing solutions and wax
softeners.
• Nasal Drops: Nasal drops should also be made
isotonic with nasal secretions using sodium chloride
and viscosity can also be modified using cellulose
derivatives if necessary.
• Eye Drops: Eye drops are saline-containing drops
used as an ocular route to administer.
15/04/2015
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
29